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Σάββατο 1 Οκτωβρίου 2016
Scholar : These new articles for Annals of the American Association of Geographers are available online
Scholar : These new articles for Atmospheric and Oceanic Science Letters are available online
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Scholar : These new articles for The American Journal of Drug and Alcohol Abuse are available online
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Unmet oral health needs among persons with intellectual disability
Publication date: December 2016
Source:Research in Developmental Disabilities, Volume 59
Author(s): Bojan B. Petrovic, Tamara O. Peric, Dejan L.J. Markovic, Branislav B. Bajkin, Djorde Petrovic, Duska B. Blagojevic, Sanja Vujkov
The aim of this study was to examine the factors affecting oral health status among intellectually disabled individuals in Serbia. The sample population was categorized according to age, sex, living arrangements, general health and the level of intellectual disability (ID). The diagnosis of dental caries was performed using the DMFT/dmft criteria. The oral hygiene and gingival health were assessed with the plaque index (Silness&Löe) and gingival index (Löe&Silness), respectively. Descriptive analysis, step-wise and logistic regression were performed to analyze related influential factors for caries presence, number of extracted teeth, teeth restored, the oral hygiene level and the extent of gingival inflammation. Odds ratios for caries were significantly higher among adult persons with ID, in persons with co-occurring developmental disorders (DDS) and increased with the level of ID. Group with DDS was associated with a 1.6 times greater odds of untreated decay, while the institutionalization was associated with 2.4 times greater odds of untreated decay. Institutionalization and co-occurring disabilities have been found to be significantly associated with a higher probability of developing gingivitis. Targeting oral health services to individuals with ID are encouraged and may help to reduce overall negative effect on oral and general health associated with delayed treatments, chronic dental pain, emergency dental care, tooth loss and advanced periodontal disease.
http://ift.tt/2dIjSUX
Determining protein biomarkers for DLBCL using FFPE tissues from HIV negative and HIV positive patients
Abstract
DLBCL is the most common lymphoma subtype occurring in older populations as well as in younger HIV infected patients. The current treatment options for DLBCL are effective for most patients yet the relapse rate is high. While many biomarkers for DLBCL exist, they are not in clinical use due to low sensitivity and specificity. In addition, these biomarkers have not been studied in the HIV context. Therefore, the identification of new biomarkers for HIV negative and HIV positive DLBCL, may lead to a better understanding of the disease pathology and better therapeutic design. Protein biomarkers for DLBCL were determined using MALDI imaging mass spectrometry (IMS) and characterised using LC–MS. The expression of one of the biomarkers, heat shock protein (Hsp) 70, was confirmed on a separate cohort of samples using immunohistochemistry. The biomarkers identified in the study consisted of four protein clusters including glycolytic enzymes, ribosomal proteins, histones and collagen. These proteins could differentiate between control and tumour tissue, and the DLBCL immunohistochemical subtypes in both cohorts. The majority (41/52) of samples in the confirmation cohort were negative for Hsp70 expression. The HIV positive DLBCL cases had a higher percentage of cases expressing Hsp70 than their HIV negative counterparts. The non-GC subtype also frequently overexpressed Hsp70, confirming MALDI IMS data. The expression of Hsp70 did not correlate with survival in both the HIV negative and HIV positive cohort. This study identified potential biomarkers for HIV negative and HIV positive DLBCL from FFPE tissue sections. These may be used as diagnostic and prognostic markers complementary to current clinical management programmes for DLBCL.
http://ift.tt/2cJCwcS
Lipopolysaccharide and IL-1β coordinate a synergy on cytokine production by upregulating MyD88 expression in human gingival fibroblasts
Source:Molecular Immunology, Volume 79
Author(s): Colleen W. Brinson, Zhongyang Lu, Yanchun Li, Maria F. Lopes-Virella, Yan Huang
Both lipopolysaccharide (LPS) and interleukin (IL)-1β activate the MyD88-dependent signaling pathways to stimulate proinflammatory cytokine expression. However, it remains unknown how LPS and IL-1β interact with each other to coordinate the stimulation. In this study, we sought to investigate the interaction between LPS and IL-1β on MyD88-dependent signaling pathways in human gingival fibroblasts (HGFs). Results showed that LPS derived from Porphyromonas gingivalis (Pg LPS) and IL-1β cooperatively stimulated mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NFκB) signaling pathways, and subsequent expression of proinflammatory cytokine expression. Furthermore, our results showed that Pg LPS and IL-1β exerted a synergy on MyD88 expression and knockdown of MyD88 expression by small interfering RNA diminished the synergistic effect of Pg LPS and IL-1β on IL-6 expression, suggesting that upregulation of MyD88 is involved in the coordinated stimulation by Pg LPS and IL-1β of proinflammatory cytokine expression. Finally, our results showed that pharmacological inhibitors for MAPK and NFκB significantly reduced IL-6 secretion stimulated by Pg LPS and IL-1β, indicating that the MyD88-dependent MAPK and NFκB signaling pathways are essential for the upregulation of proinflammatory cytokine expression by Pg LPS and IL-1β. Taken together, this study showed that LPS and IL-1β coordinate a synergy on cytokine production by upregulating MyD88 expression in HGFs.
http://ift.tt/2dkQ8h6
Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis
Source:Molecular Immunology
Author(s): Virginie Deswaerte, Saleela M. Ruwanpura, Brendan J. Jenkins
Over the last decade it has emerged that inflammasome complexes provide a pivotal platform for the host innate immune system to respond to exogenous infectious microbes (viruses, bacteria, fungi) and non-infectious environmental agents (cigarette smoke, pollution), as well as endogenous "danger" signals. Upon the canonical activation of inflammasomes, a key effector function is to catalyze, via caspase-1, the maturation of the potent pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which, in addition to chronic inflammatory responses have also been intimately linked to the inflammatory form of lytic cell death, pyroptosis. However, recent evidence suggests that inflammasomes exhibit marked pleiotropism beyond their canonical functions, whereby their activation can also influence a large number of cellular responses including proliferation, apoptosis, autophagy and metabolism. It is therefore not surprising that the dysregulated expression and/or activation of inflammasomes is increasingly implicated in numerous disease states, such as chronic auto-inflammatory and autoimmune disorders, metabolic syndrome, neurodegenerative and cardiovascular diseases, as well as cancer. In this review we will highlight recent advancements in our understanding of the transcriptional regulation of genes encoding inflammasome-associated innate immune receptors, and the impact on a variety of cellular responses during disease pathogenesis.
http://ift.tt/2dOR1AX
Insight into the role of TSLP in inflammatory bowel diseases
Source:Autoimmunity Reviews
Author(s): Jae Hyon Park, Dong Yeon Jeong, Laurent Peyrin-Biroulet, Michael Eisenhut, Jae Il Shin
Proinflammatory cytokines are thought to modulate pathogeneses of various inflammatory bowel diseases (IBDs). Thymic stromal lymphopoietin (TSLP), which has been studied in various allergic diseases such as asthma, atopic dermatitis (AD) and eosinophilic esophagitis (EoE), has been less considered to be involved in IBDs. However, mucosal dendritic cells (DCs) induced by various cytokines including TSLP were reported to cause polarization of T cell toward Th2 response, the differentiation of regulatory T-cell (Treg), and secretion of IgA by B cells. In this review, we discuss the concept that decreased TSLP has the potential to accelerate the development of Th1 response dominant diseases such as the Crohn's disease (CD) while increased TSLP has the potential to lead to a development of Th2 cell dominant diseases such the ulcerative colitis (UC). To examine TSLP's role as a potential determining factor for differentiating UC and CD, we analyzed the effects of other genes regulated by TSLP in regards to the UC and CD pathogeneses using data from online open access resources such as NetPath, GeneMania, and the String database. Our findings indicate that TSLP is a key mediator in the pathogenesis of IBDs and that further studies are needed to evaluate its role.
http://ift.tt/2dwI0sd
Self-reported attentional and motor impulsivity are related to age at first methamphetamine use
Source:Addictive Behaviors, Volume 65
Author(s): Anita Cservenka, Lara A. Ray
IntroductionMethamphetamine (MA) users report higher levels of impulsivity relative to healthy controls, which may either result from, or precede, their substance use. Further, there is evidence that female MA users may be more impulsive than male MA users prior to MA use. Thus, the goal of the current study was to determine whether different subtraits of self-reported impulsivity are significantly related to age at first MA use, controlling for total years of MA use.MethodsA community sample of MA users was recruited for this study (N=157; 113 males, 44 females). The Barratt Impulsiveness Scale (BIS-11) was used to assess self-reported impulsivity on three subscales (Attentional, Motor, Non-planning). Age at first MA use served as the dependent variable in a series of multiple regression models with BIS-11 subscales, sex, and their interaction as independent variables, controlling for total years of MA use.ResultsAttentional and Motor impulsivity were significantly related to age at first MA use when controlling for total years of MA use (Attentional: p=0.008; Motor: p=0.003).ConclusionsIndividuals who reported higher Attentional and Motor impulsivity started using MA at an earlier age, which could suggest that impulsivity levels may be an important marker of vulnerability towards MA use. These findings indicate that prevention efforts may be targeted towards individuals who report high levels of Attentional and Motor impulsivity, as they may be at greatest risk for earlier initiation of MA use.
http://ift.tt/2cTzKF7
Racial and ethnic differences in associations between psychological distress and the presence of binge drinking: Results from the California health interview survey
Source:Addictive Behaviors, Volume 65
Author(s): Bongki Woo, Kaipeng Wang, Thanh Tran
IntroductionRacial and ethnic minorities often suffer from poorer health than Whites given their exposure to more stressors and fewer resources that buffer the effects of stress. Given that alcohol is often consumed to alleviate the negative moods, the present study hypothesized that psychological distress may impact the involvement in binge drinking differently across racial and ethnic groups.MethodsWe used data from the California Health Interview Survey (CHIS) from 2007 to 2012. The sample consisted of 130,556 adults including African Americans (N=6541), Asians (N=13,508), Latinos (N=18,128), and Whites (N=92,379). Binary logistic regression analysis was used with consideration for complex survey design.ResultsThe results indicated that psychological distress was significantly associated with binge drinking across all racial and ethnic groups. However, this association differed by race and ethnicity adjusting for age, gender, marital status, education, poverty, and employment status. The results revealed that psychological distress had the largest effect on binge drinking for Asian Americans, particularly Filipinos and South Asians, compared to Whites.ConclusionsThis study highlights the importance of examining racial and ethnic differences in the impacts of psychological distress on alcohol consumption. Future research is needed to better understand the potential factors that mediate the effects of psychological distress on binge drinking specific to each racial and ethnic group in order to develop culturally sensitive interventions and hence decrease the alcohol-related racial health disparities.
http://ift.tt/2dwEz4T
Chronic hyperglycemia affects bone metabolism in adult zebrafish scale model
Abstract
Type II diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia that induce other pathologies including diabetic retinopathy and bone disease. The mechanisms implicated in bone alterations induced by type II diabetes mellitus have been debated for years and are not yet clear because there are other factors involved that hide bone mineral density alterations. Despite this, it is well known that chronic hyperglycemia affects bone health causing fragility, mechanical strength reduction and increased propensity of fractures because of impaired bone matrix microstructure and aberrant bone cells function. Adult Danio rerio (zebrafish) represents a powerful model to study glucose and bone metabolism. Then, the aim of this study was to evaluate bone effects of chronic hyperglycemia in a new type II diabetes mellitus zebrafish model created by glucose administration in the water. Fish blood glucose levels have been monitored in time course experiments and basal glycemia was found increased. After 1 month treatment, the morphology of the retinal blood vessels showed abnormalities resembling to the human diabetic retinopathy. The adult bone metabolism has been evaluated in fish using the scales as read-out system. The scales of glucose-treated fish didn't depose new mineralized matrix and shown bone resorption lacunae associated with an intense osteoclast activity. In addition, hyperglycemic fish scales have shown a significant decrease of alkaline phosphatase activity and increase of tartrate-resistant acid phosphatase activity, in association with alterations in other bone-specific markers. These data indicates an imbalance in bone metabolism, which leads to the osteoporotic-like phenotype visualized through scale mineral matrix staining. The zebrafish model of hyperglycemic damage can contribute to elucidate in vivo the molecular mechanisms of metabolic changes, which influence the bone tissues regulation in human diabetic patients.
http://ift.tt/2dz6W7I
Vitamin D and gallstone disease—A population-based study
Abstract
Gallstone disease is highly prevalent in the general population and is a major gastrointestinal cause of hospital admissions. The objectives were to determine whether circulating levels of 25-hydroxyvitamin D were associated to ultrasound proven gallstones or cholecystectomy in a general population sample. Determinants of vitamin D status were also explored. A random sample of 4130 people from the population of Copenhagen with ages 41–71 years were invited (N = 4130) and 2650 participants were included. Ultrasound examinations were performed to assess gallstone status and blood samples were drawn to assess 25-hydroxyvitamin D and biomarkers of renal and hepatic function. Gallstone disease was found in 422 participants. Associations were estimated by logistic regression models. Levels of 25-hydroxyvitamin D was not significantly associated with gallstone disease. Time of birth during low vitamin D exposure was associated with gallstone disease (gallstone prevalence 18.0 versus 14.4 %, odds ratio 1.33, 95 % confidence interval [1.07; 1.65]). Highest quartile of cystatin C was significantly associated with gallstone disease (gallstone prevalence 22.1 versus 12.0 %, odds ratio 1.53, 95 % confidence interval [1.08; 2.18]). Serum levels of creatinine and alanine amino transferase were not associated with gallstone disease. Sensitivity analyses excluding participants with cholecystectomy did not alter results significantly. No association between 25-hydroxyvitamin D and gallstone disease was identified. Findings suggest gallstones to be associated to low vitamin D exposure in utero and to renal failure suggesting that vitamin D might have an impact on gallstone disease. Future studies should explore associations for vitamin D and gallstone disease prospectively.
http://ift.tt/2cIU5de
Title page / Editorial Board
Source:Cancer Epidemiology, Volume 44
http://ift.tt/2dkASkg
Table of contents
Source:Cancer Epidemiology, Volume 44
http://ift.tt/2dOzZ6h
Response to Letter to the Editor: Vitamin D status may help explain racial disparities in breast cancer hospitalization outcomes
Source:Cancer Epidemiology
Author(s): Tomi Akinyemiju, Swati Sakhuja, Neomi Vin-Raviv
http://ift.tt/2dkAfqP
Comparison of quadrant-specific breast cancer incidence trends in the United States and England between 1975 and 2013
Source:Cancer Epidemiology, Volume 44
Author(s): C.J. Bright, D.W. Rea, A. Francis, R.G. Feltbower
BackgroundUK breast cancer incidence rates suggest that upper outer quadrant (UOQ) cancers have risen disproportionately compared with other areas over time. We aimed to provide a comparison of the trend in quadrant-specific breast cancer incidence between the United States (US) and England, and determine whether a disproportionate UOQ increase is present.MethodsSurveillance Epidemiology and End Results (SEER) cancer registry data were obtained on 630,007 female breast cancers from 1975 to 2013. English cancer registry data were obtained on 1,121,134 female breast cancers from 1979 to 2013. Temporal incidence changes were analysed using negative binomial regression. Interaction terms determined whether incidence changes were similar between sites.ResultsEnglish breast cancer incidence in the UOQ rose significantly from 13% to 28% from 1979 to 2013 whereas no significant increase was observed among SEER data. The significant interaction between quadrant and year of diagnosis (p<0.001) in both SEER and English data indicates that breast cancer incidence in each quadrant changed at a different rate. Incidence in the UOQ rose disproportionately compared to the nipple (SEER IRR=0.81, p<0.001; England IRR=0.78, p<0.001) and axillary tail (SEER IRR=0.87, p=0.018; England IRR=0.69, p<0.001) in both SEER and England. In addition, incidence rose disproportionately in the UOQ compared to non-site-specific tumours in England (Overlapping lesions IRR=0.81, p=0.002; NOS IRR=0.78, p<0.001). The proportion of non-site-specific tumours was substantially higher in England than SEER throughout the study period (62% in England; 39% in SEER).ConclusionsBreast cancer incidence in the UOQ increased disproportionately compared to non-site-specific tumours in England but not in SEER, likely due to the decrease in non-site-specific tumours observed in England over time. There may be real differences in incidence between the two countries, possibly due to differences in aetiology, but is much more likely to be an artefact of changing data collection methods and improvements in site coding in either country.
http://ift.tt/2dOBn8J
A comparative analysis of chaotic particle swarm optimizations for detecting single nucleotide polymorphism barcodes
Source:Artificial Intelligence in Medicine
Author(s): Li-Yeh Chuang, Sin-Hua Moi, Yu-Da Lin, Cheng-Hong Yang
ObjectiveEvolutionary algorithms could overcome the computational limitations for the statistical evaluation of large datasets for high-order single nucleotide polymorphism (SNP) barcodes. Previous studies have proposed several chaotic particle swarm optimization (CPSO) methods to detect SNP barcodes for disease analysis (e.g., for breast cancer and chronic diseases). This work evaluated additional chaotic maps combined with the particle swarm optimization (PSO) method to detect SNP barcodes using a high-dimensional dataset.Methods and materialNine chaotic maps were used to improve PSO method results and compared the searching ability amongst all CPSO methods. The XOR and ZZ disease models were used to compare all chaotic maps combined with PSO method. Efficacy evaluations of CPSO methods were based on statistical values from the chi-square test (χ2).ResultsThe results showed that chaotic maps could improve the searching ability of PSO method when population are trapped in the local optimum. The minor allele frequency (MAF) indicated that, amongst all CPSO methods, the numbers of SNPs, sample size, and the highest χ2 value in all datasets were found in the Sinai chaotic map combined with PSO method. We used the simple linear regression results of the gbest values in all generations to compare the all methods. Sinai chaotic map combined with PSO method provided the highest β values (β ≥ 0.32 in XOR disease model and β ≥ 0.04 in ZZ disease model) and the significant p-value (p-value < 0.001 in both the XOR and ZZ disease models).ConclusionThe Sinai chaotic map was found to effectively enhance the fitness values (χ2) of PSO method, indicating that the Sinai chaotic map combined with PSO method is more effective at detecting potential SNP barcodes in both the XOR and ZZ disease models.
http://ift.tt/2dkxl5E
Automated segmentation of white matter fiber bundles using diffusion tensor imaging data and a new density based clustering algorithm
Source:Artificial Intelligence in Medicine
Author(s): Tahereh Kamali, Daniel Stashuk
ObjectiveRobust and accurate segmentation of brain white matter (WM) fiber bundles assists in diagnosing and assessing progression or remission of neuropsychiatric diseases such as schizophrenia, autism and depression. Supervised segmentation methods are infeasible in most applications since generating gold standards is too costly. Hence, there is a growing interest in designing unsupervised methods: However, most conventional unsupervised methods: require the number of clusters be known in advance which is not possible in most applications. The purpose of this study is to design an unsupervised segmentation algorithm for brain white matter fiber bundles which can automatically segment fiber bundles using intrinsic diffusion tensor imaging data information without considering any prior information or assumption about data distributions.Methods and MaterialHere, a new density based clustering algorithm called neighborhood distance entropy consistency (NDEC), is proposed which discovers natural clusters within data by simultaneously utilizing both local and global density information. The performance of NDEC is compared with other state of the art clustering algorithms including chameleon, spectral clustering, DBSCAN and k-means using Johns Hopkins University publicly available diffusion tensor imaging data.ResultsThe performance of NDEC and other employed clustering algorithms were evaluated using dice ratio as an external evaluation criteria and density based clustering validation (DBCV) index as an internal evaluation metric. Across all employed clustering algorithms, NDEC obtained the highest average dice ratio (0.94) and DBCV value (0.71).ConclusionsNDEC can find clusters with arbitrary shapes and densities and consequently can be used for WM fiber bundle segmentation where there is no distinct boundary between various bundles. NDEC may also be used as an effective tool in other pattern recognition and medical diagnostic systems in which discovering natural clusters within data is a necessity.
http://ift.tt/2dOxtwA
Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy
Publication date: December 2016
Source:Neurobiology of Aging, Volume 48
Author(s): Timothy Rittman, Mikail Rubinov, Petra E. Vértes, Ameera X. Patel, Cedric E. Ginestet, Boyd C.P. Ghosh, Roger A. Barker, Maria Grazia Spillantini, Edward T. Bullmore, James B. Rowe
Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional magnetic resonance imaging in progressive supranuclear palsy, Parkinson disease, and healthy subjects (n = 128), we examined functional brain networks and measured the connection strength between 471 gray matter regions. We obtained MAPT and SNCA microarray expression data in healthy subjects from the Allen brain atlas. Regional connectivity varied according to the normal expression of MAPT. The regional expression of MAPT correlated with the proportionate loss of regional connectivity in Parkinson's disease. Executive cognition was impaired in proportion to the loss of hub connectivity. These effects were not seen with SNCA, suggesting that alpha-synuclein pathology is not mediated through global network properties. The results establish a link between regional MAPT expression and selective vulnerability of functional brain networks to neurodegeneration.
http://ift.tt/2dzx51P
Emerging roles of the neurotrophin receptor TrkC in synapse organization
Source:Neuroscience Research
Author(s): Yusuke Naito, Alfred Kihoon Lee, Hideto Takahashi
Tropomyosin-receptor-kinase (Trk) receptors have been extensively studied for their roles in kinase-dependent signaling cascades in nervous system development. Synapse organization is coordinated by trans-synaptic interactions of various cell adhesion proteins, a representative example of which is the Neurexin-Neuroligin complex. Recently, a novel role for TrkC as a synapse organizing protein has been established. Post-synaptic TrkC binds to pre-synaptic type-IIa receptor-type protein tyrosine phosphatase sigma (PTPσ). TrkC-PTPσ specifically induces excitatory synapses in a kinase domain-independent manner. TrkC has distinct extracellular domains for PTPσ- and NT-3-binding and thus may bind both ligands simultaneously. Indeed, NT-3 enhances the TrkC-PTPσ interaction, thus facilitating synapse induction at the pre-synaptic side and increasing pre-synaptic vesicle recycling in a kinase-independent fashion. A crystal structure study has revealed the detailed structure of the TrkC-PTPσ complex as well as competitive modulation of TrkC-mediated synaptogenesis by heparan sulfate proteoglycans (HSPGs), which bind the same domain of TrkC as PTPσ. Thus, there is strong evidence supporting a role for the TrkC-PTPσ complex in mechanisms underlying the fine turning of neural connectivity. Furthermore, disruption of the TrkC-PTPσ complex may be the underlying cause of certain psychiatric disorders caused by mutations in the gene encoding TrkC (NTRK3), supporting its role in cognitive functions.
http://ift.tt/2cJj13Y
Scholar : Molecular Medicine Reports - Volume:14 Number:4
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| TABLE OF CONTENTS October 2016 |
Notch signaling in cerebrovascular diseases (Review)Zhiyou Cai, Bin Zhao, Yanqing Deng, Shouqin Shangguan, Faming Zhou, Wenqing Zhou, Xiaoli Li, Yanfeng Li, Guanghui Chen View Abstract ❯ |
Endocannabinoid system: Role in depression, reward and pain control (Review)Wen‑Juan Huang, Wei‑Wei Chen, Xia Zhang View Abstract ❯ |
Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phasePeiyan Liu, Yueling Sun, Guangbin Qiu, Hongkun Jiang, Guangrong Qiu View Abstract ❯ |
A novel variant of androgen receptor is associated with idiopathic azoospermiaLisha Mou, Yaoting Gui View Abstract ❯ |
Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivoYuqi Shi, Zhilong He, Zhenyu Jia, Chunfang Xu View Abstract ❯ |
Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesisXing Chen, Xiao‑Ming Hou, You‑Fei Fan, Yu‑Ting Jin, Yu‑Lin Wang View Abstract ❯ |
Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell lineJae Song, Mei Piao, Xia Han, Kyoung Kang, Hee Kang, Weon Yoon, Mi Ko, Nam Lee, Mi Lee, Sungwook Chae, Jin Hyun View Abstract ❯ |
Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophagesHui Yan, Shuai Wang, Zhenwei Li, Zewei Sun, Jie Zan, Wenting Zhao, Yanyun Pan, Zhen Wang, Mingjie Wu, Jianhua Zhu View Abstract ❯ |
Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinomaMin Ye, Qundan Wu, Min Zhang, Jinbei Huang View Abstract ❯ |
Nicotinic α7 receptor inhibits the acylation stimulating protein‑induced production of monocyte chemoattractant protein‑1 and keratinocyte‑derived chemokine in adipocytes by modulating the p38 kinase and nuclear factor‑κB signaling pathwaysZhou‑Yang Jiao, Jing Wu, Chao Liu, Bing Wen, Wen‑Zeng Zhao, Xin‑Ling Du View Abstract ❯ |
A technical application of quantitative next generation sequencing for chimerism evaluationMichelangelo Aloisio, Danilo Licastro, Luciana Caenazzo, Valentina Torboli, Angela D'Eustacchio, Giovanni Severini, Emmanouil Athanasakis View Abstract ❯ |
miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancerLiangfeng Guo, Jianhui Yuan, Ni Xie, Huisheng Wu, Weicai Chen, Shufen Song, Xianming Wang View Abstract ❯ |
Toll‑like receptor 4 contributes to acute kidney injury after cardiopulmonary resuscitation in miceQingsong Zhang, Gang Li, Li Xu, Qian Li, Qianyan Wang, Yue Zhang, Qing Zhang, Peng Sun View Abstract ❯ |
Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinomaZhi‑Yuan Deng, Yue‑Hong Wang, Hong‑Zhi Quan, Ou‑Sheng Liu, Yi‑Ping Li, Yuan Li, Wu Zhu, Krishna Munnee, Zhan‑Gui Tang View Abstract ❯ |
FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitisHua Qian, Xiaoyue Guan, Zhuan Bian View Abstract ❯ |
Quantum dot-based molecular imaging of cancer cell growth using a clone formation assayXia‑Fei Geng, Min Fang, Shao‑Ping Liu, Yan Li View Abstract ❯ |
Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell deathRuichao Huo, Lili Wang, Peijuan Liu, Yong Zhao, Caiqin Zhang, Bing Bai, Xueying Liu, Changhong Shi, Sanhua Wei, Hai Zhang View Abstract ❯ |
MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinomaLi Qian, Longlong Lin, Yufeng Du, Xiaoyan Hao, Yuze Zhao, Xuejun Liu View Abstract ❯ |
Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activationMiran Yoo, Sang‑Jin Lee, Yong Kim, Dong‑Wan Seo, Nam‑In Baek, Jae‑Ha Ryu, Jong‑Sun Kang, Gyu‑Un Bae View Abstract ❯ |
Effect of autophagy induced by dexamethasone on senescence in chondrocytesEnxing Xue, Yu Zhang, Bing Song, Jun Xiao, Zhanjun Shi View Abstract ❯ |
Human tonsil‑derived mesenchymal stromal cells enhanced myelopoiesis in a mouse model of allogeneic bone marrow transplantationJung‑Hwa Ryu, Minhwa Park, Bo‑Kyung Kim, Yu‑Hee Kim, So‑Youn Woo, Kyung‑Ha Ryu View Abstract ❯ |
Analysis of gene expression profile identifies potential biomarkers for atherosclerosisLuran Liu, Yan Liu, Chang Liu, Zhuobo Zhang, Yaojun Du, Hao Zhao View Abstract ❯ |
Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cellsWen‑Xiang Li, Meng‑Xuan Yang, Xin‑Qiang Hong, Tian‑Geng Dong, Tuo Yi, Sheng‑Li Lin, Xin‑Yu Qin, Wei‑Xin Niu View Abstract ❯ |
Possible role of the Ec peptide of IGF‑1Ec in cartilage repairNikolaos Armakolas, Andreas Dimakakos, Athanasios Armakolas, Athanasios Antonopoulos, Michael Koutsilieris View Abstract ❯ |
Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in ratsYani Liu, Xiaomei Luo, Chunxiao Yang, Tingyu Yang, Jiali Zhou, Shaojun Shi View Abstract ❯ |
Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in miceShunyi Wang, Dongliang Ren View Abstract ❯ |
Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga miceMyung Kang, Se‑Young Choung View Abstract ❯ |
Mesenchymal stem cells in corneal neovascularization: Comparison of different application routesEmma Ghazaryan, Yan Zhang, Yuxi He, Xin Liu, Ying Li, Jianan Xie, Guanfang Su View Abstract ❯ |
The study on mechanism of the modified Chinese herbal compound, jianpijiedu, on a mouse model of hepatic carcinoma cachexiaBaoguo Sun, Haoxuan Luo, Liuxiang Deng, Shijun Zhang, Zexiong Chen View Abstract ❯ |
Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout miceHui Han, Yanjia Chen, Jinzhou Zhu, Jingwei Ni, Jiateng Sun, Ruiyan Zhang View Abstract ❯ |
A novel missense mutation of the GRK1 gene in Oguchi diseaseMehmet Teke, Mehmet Citirik, Serkan Kabacam, Suleyman Demircan, Mehmet Alikasifoglu View Abstract ❯ |
Reprogramming A375 cells to induced‑resembled neuronal cells by structured overexpression of specific transcription genesHengzhu Zhang, Min Wei, Yangyang Jiang, Xiaodong Wang, Lei She, Zhengcun Yan, Lun Dong, Lujun Pang, Xingdong Wang View Abstract ❯ |
KIF21A mutation in two Chinese families with congenital fibrosis of the extraocular muscles type 1 and 3Jingchang Chen, Qingqing Ye, Daming Deng, Jianhua Yan, Houbian Lin, Tao Shen, Ying Lin View Abstract ❯ |
Hypolipidemic effects of HVC1 in a high cholesterol diet‑induced rat model of hyperlipidemiaChae‑Yun Kim, Kyung‑Sook Chung, Se‑Yun Cheon, Kyungjin Lee, Inhye Ham, Ho‑Young Choi, Yong Cho, Byoung‑Heon Cho, So Mok, Hyo‑Jin An View Abstract ❯ |
Overexpression of CD44 is associated with the occurrence and migration of non-small cell lung cancerGuanghu Li, Yufei Gao, Yongsheng Cui, Tao Zhang, Rui Cui, Yang Jiang, Jingwei Shi View Abstract ❯ |
Identification of distinct genes associated with seawater aspiration‑induced acute lung injury by gene expression profile analysisWei Liu, Lei Pan, Minlong Zhang, Liyan Bo, Congcong Li, Qingqing Liu, Li Wang, Faguang Jin View Abstract ❯ |
Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cellsAiqing Zhang, Wei He, Huimin Shi, Xiaodan Huang, Guozhong Ji View Abstract ❯ |
Potential fluid biomarkers for pathological brain changes in Alzheimer's disease: Implication for the screening of cognitive frailtyQingwei Ruan, Grazia D'Onofrio, Daniele Sancarlo, Antonio Greco, Zhuowei Yu View Abstract ❯ |
Paris saponin VII suppresses osteosarcoma cell migration and invasion by inhibiting MMP‑2/9 production via the p38 MAPK signaling pathwayGong Cheng, Fengguang Gao, Xiujiang Sun, Haiyong Bi, Yonglin Zhu View Abstract ❯ |
Ameliorative effects of Artemisia argyi Folium extract on 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like lesions in BALB/c miceHyoung‑Min Han, Seung‑Ju Kim, Jong‑Sik Kim, Bum Kim, Hai Lee, Yong Lee, Kyung‑Hwa Kang View Abstract ❯ |
Age‑dependent increase in the expression of antioxidant‑like protein‑1 in the gerbil hippocampusJin‑A Park, Joon Park, Ji Ahn, Jong‑Dai Kim, Moo‑Ho Won, Choong‑Hyun Lee View Abstract ❯ |
Epidermal growth factor receptor kinase substrate 8 promotes the metastasis of cervical cancer via the epithelial-mesenchymal transitionQian Li, Wei Bao, Qiong Fan, Wen‑Jing Shi, Zhu‑Nan Li, Ying Xu, Dan Wu View Abstract ❯ |
Curcumin attenuates cyclosporine A‑induced renal fibrosis by inhibiting hypermethylation of the klotho promoterYing Hu, Lijun Mou, Fuye Yang, Haiyan Tu, Wanbing Lin View Abstract ❯ |
Dose response of dexmedetomidine‑induced resistance to hypoxia in miceWanying Pan, Xiaoxiao Hua, Yueting Wang, Ruixian Guo, Jingfu Chen, Liqiu Mo View Abstract ❯ |
Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1Ting Xiang, Zhangbin Yang, Baoguo Sun, Haoxuan Luo, Shijun Zhang, Bin Ren, Xiaoling Chen, Xin Zhou, Zexiong Chen View Abstract ❯ |
Molecular genetic analysis and phenotypic characteristics of a consanguineous family with glycogen storage disease type IaYili Lu, Liyin Wang, Jun Li, Beibei Wu, Huiping Wu, Yue Luo, Zi‑Bing Jin, Xiaoou Shan View Abstract ❯ |
Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cellsMin Ryu, Ha Chung View Abstract ❯ |
HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9Shi‑Wei Chen, Qing Zhang, Zhi‑Feng Xu, Hai‑Ping Wang, Yi Shi, Feng Xu, Wen‑Jian Zhang, Ping Wang, Yong Li View Abstract ❯ |
Characterization of multidrug‑resistant osteosarcoma sublines and the molecular mechanisms of resistanceJian‑Zeng Yang, Shu‑Rong Ma, Xiao‑Li Rong, Mei‑Ju Zhu, Qiu‑Ye Ji, Ling‑Jie Meng, Yi‑Yao Gao, Yu‑Dan Yang, Yan Wang View Abstract ❯ |
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse modelWeiwei Yang, Liping She, Kun Yu, Shan Yan, Xuefeng Zhang, Xiaoyi Tian, Shuren Ma, Xiwen Zhang View Abstract ❯ |
Let‑7 miRNAs sensitize breast cancer stem cells to radiation‑induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathwayHuifang Sun, Changmao Ding, Huiyu Zhang, Jianbo Gao View Abstract ❯ |
Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet miceYi Wang, Li‑Ming Liu, Li Wei, Wei‑Wei Ye, Xiang‑Ying Meng, Feng Chen, Qian Xiao, Jian‑Yang Chen, Yong Zhou View Abstract ❯ |
Sphingomyelin synthase 2 affects CD14‑associated induction of NF‑κB by lipopolysaccharides in acute lung injury in miceShidong Hu, Yi Ding, Jie Gong, Nianlong Yan View Abstract ❯ |
A novel TBX20 loss‑of‑function mutation contributes to adult‑onset dilated cardiomyopathy or congenital atrial septal defectYi‑Meng Zhou, Xiao‑Yong Dai, Ri‑Tai Huang, Song Xue, Ying‑Jia Xu, Xing‑Biao Qiu, Yi‑Qing Yang View Abstract ❯ |
Correlation between low tapasin expression and impaired CD8+ T‑cell function in patients with chronic hepatitis BYuyan Tang, Jieling Wang, Yi Zhang, Meng Zhuo, Linlin Song, Zhenghao Tang, Guoqing Zang, Xiaohua Chen, Yongsheng Yu View Abstract ❯ |
Inflammation has a role in urethane‑induced lung cancer in C57BL/6J miceCai Xu, Lingyu Zhou, Lei Lu, Ting Chen, Siyu Wei, Xiaojing Lin, Xuemei Lian View Abstract ❯ |
TRIF is a regulator of TLR2-induced foam cell formationBin Huang, Dae‑Weon Park, Suk‑Hwan Baek View Abstract ❯ |
Distribution of fibroblast growth factors and their roles in skin fibroblast cell migrationYong Song, Yu Zhu, Jian Ding, Fei Zhou, Ji Xue, Jin Jung, Zhi Li, Wei Gao View Abstract ❯ |
miR‑205 suppresses cell proliferation, invasion, and metastasis via regulation of the PTEN/AKT pathway in renal cell carcinomaHuiqiang Wang, Bin Chen, Bo Duan, Jiaxin Zheng, Xinyi Wu View Abstract ❯ |
Identification of microRNA profiles associated with refractory primary biliary cirrhosisTeppei Sakamoto, Asahiro Morishita, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Hirohiro Yoneyama, Hisakazu Iwama, Takashi Himoto, Tsutomu Masaki View Abstract ❯ |
PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screeningShaoxing Zhu, Yipeng Xu, Mei Song, Guiping Chen, Hua Wang, Yang Zhao, Zongping Wang, Fangyin Li View Abstract ❯ |
Distal hereditary motor neuropathy type 7B with Dynactin 1 mutationSun Hwang, Eun Kim, Young Hong, Jaesoon Joo, Sung Kim, Soo Nam, Hyun Hong, Seung Kim, Kiwook Oh, Jeong‑Geun Lim, Jeong Cho, Ki Chung, Byung‑Ok Choi View Abstract ❯ |
S1PR1 mediates anti‑apoptotic/pro‑proliferative processes in human acute myeloid leukemia cellsXiao‑Qian Xu, Chong‑Mei Huang, Yi‑Fan Zhang, Li Chen, Hui Cheng, Jian‑Min Wang View Abstract ❯ |
The protective role of p72 in doxorubicin‑induced cardiomyocytes injury in vitroBin Lin, Feng Wang, Jiaxiang Wang, Chengyang Xu, Hui Zhao, Zhaoyun Cheng, Deguang Feng View Abstract ❯ |
Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosisShouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wang View Abstract ❯ |
Lycorine protects cartilage through suppressing the expression of matrix metalloprotenases in rat chondrocytes and in a mouse osteoarthritis modelShuai Chen, Xiang‑Qian Fang, Jian‑Feng Zhang, Yan Ma, Xiao‑Zhen Tang, Zhi‑Jie Zhou, Ji‑Ying Wang, An Qin, Shun‑Wu Fan View Abstract ❯ |
Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activitiesJun Peng, Xingfeng Ren, Tianbiao Lan, Yan Chen, Ziyun Shao, Cheng Yang View Abstract ❯ |
Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathwaysLi‑Yan Wang, Zhi‑Jun Tang, Yu‑Zeng Han View Abstract ❯ |
Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampusYi Wei, Junhua Hu, Yubing Liang, Yuling Zhong, Dan He, Yi Qin, Li Li, Jing Chen, Qiang Xiao, Yubo Xie View Abstract ❯ |
miR‑483‑5p promotes growth, invasion and self‑renewal of gastric cancer stem cells by Wnt/β‑catenin signalingKai Wu, Longan Ma, Jinxiang Zhu View Abstract ❯ |
Collagen regulates transforming growth factor-β receptors of HL-1 cardiomyocytes through activation of stretch and integrin signalingYen‑Yu Lu, Yung‑Kuo Lin, Yu‑Hsun Kao, Cheng‑Chih Chung, Yung‑Hsin Yeh, Shih‑Ann Chen, Yi‑Jen Chen View Abstract ❯ |
Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathwayXiaojun Zhu, Qianqian Cao, Xia Li, Zhengping Wang View Abstract ❯ |
Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani womenAyesha Mazhar, Farrukh Jamil, Qamar Bashir, Munawar Ahmad, Misbah Masood, Imrana Tanvir, Naeem Rashid, Abdul Waheed, Muhammad Afzal, Muhammad Tariq View Abstract ❯ |
Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathwayHongbing Gu, Runbi Ji, Xu Zhang, Mei Wang, Wei Zhu, Hui Qian, Yongchang Chen, Pengcheng Jiang, Wenrong Xu View Abstract ❯ |
Plasma heme oxygenase-1 is decreased in peripheral artery disease patientsSalvatore Signorelli, Guido Li Volsi, Valerio Fiore, Marco Mangiafico, Ignazio Barbagallo, Rosalba Parenti, Manfredi Rizzo, Giovanni Li Volti View Abstract ❯ |
Inhibitory effects of B‑cell translocation gene 2 on skin cancer cells via the Wnt/β‑catenin signaling pathwayShou‑Song Gao, Xiao‑Hong Yang, Meng Wang View Abstract ❯ |
Decitabine enhances bortezomib treatment in RPMI 8226 multiple myeloma cellsYang Cao, Guo‑Qiang Qiu, Hao‑Qing Wu, Zhi‑Lin Wang, Yan Lin, Wei Wu, Xiao‑Bao Xie, Wei‑Ying Gu View Abstract ❯ |
Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting β-catenin signalingXuan Yin, Xiong‑Wei Yu, Pan Zhu, Yuan‑Ming Zhang, Xiao‑Hong Zhang, Feng Wang, Jin‑Jie Zhang, Wang Yan, Yang Xi, Jian‑Bo Wan, Jing‑Xuan Kang, Zu‑Quan Zou, Shi‑Zhong Bu View Abstract ❯ |
Expression of early and late cellular damage markers by ARPE-19 cells following prolonged treatment with UV-A radiationGiuseppe Tringali, Beatrice Sampaolese, Maria Clementi View Abstract ❯ |
C‑reactive protein/oxidized low density lipoprotein/β2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑activated protein kinase and nuclear factor‑κB signaling pathwaysJie Wang, Mei‑Jun Feng, Rui Zhang, De‑Min Yu, Sai‑Jun Zhou, Rui Chen, Pei Yu View Abstract ❯ |
Differential activation of c‑Fos in the paraventricular nuclei of the hypothalamus and thalamus following myocardial infarction in ratsHyun‑Jin Tae, Seung Park, Jeong Cho, In Kim, Ji Ahn, Joon Park, Moo‑Ho Won, Bai Chen, Bich‑Na Shin, Myoung Shin, Choong Lee, Seongkweon Hong, Jae‑Chul Lee, Jun Cho View Abstract ❯ |
Histone deacetylase enzyme silencing using shRNAs enhances radiosensitivity of SW579 thyroid cancer cellsYe Wang, Tao Jin, Xueming Dai, Dongwang Yan, Zhihai Peng View Abstract ❯ |
Notch 2 signaling contributes to cell growth, anti-apoptosis and metastasis in laryngeal squamous cell carcinomaYou Zou, Fang Fang, Yong‑Jun Ding, Meng‑Yuan Dai, Xing Yi, Chen Chen, Ze‑Zhang Tao, Shi‑Ming Chen View Abstract ❯ |
Severity of pancreatitis‑associated intestinal mucosal barrier injury is reduced following treatment with the NADPH oxidase inhibitor apocyninWenhong Deng, Ablikim Abliz, Sheng Xu, Rongze Sun, Wenyi Guo, Qiao Shi, Jia Yu, Weixing Wang View Abstract ❯ |
Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatmentLongwei Hu, Jing Han, Xi Yang, Yang Wang, Hongya Pan, Liqun Xu View Abstract ❯ |
ZFAT gene variant association with multiple sclerosis in the Arabian Gulf population: A genetic basis for gender-associated susceptibilitySonia Bourguiba‑Hachemi, Tebah Ashkanani, Fatema Kadhem, Wassim Almawi, Raed Alroughani, M. Fathallah View Abstract ❯ |
Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancerWei Zhang, Hua Xiong, Yanmei Zou, Sanpeng Xu, Lanping Quan, Xianglin Yuan, Ningzhi Xu, Yihua Wang View Abstract ❯ |
Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathwayYu‑Lun Wang, Gen‑Yi Sun, Ying Zhang, Jia‑Jun He, Shen Zheng, Jing‑Na Lin View Abstract ❯ |
The differentiation potential of gingival mesenchymal stem cells induced by apical tooth germ cell‑conditioned mediumYan Chen, Hongwei Liu View Abstract ❯ |
Pro‑neurogenic effects of andrographolide on RSC96 Schwann cells in vitroFuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao View Abstract ❯ |
Protective effect of active perfusion in porcine models of acute myocardial ischemiaZanxiang Feng, Zhifu Mao, Shengjun Dong, Baohui Liu View Abstract ❯ |
Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunctionYang Mu, Wen‑Jie Yan, Tai‑Lang Yin, Jing Yang View Abstract ❯ |
Impact of siRNA targeting of β-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damageXiaoying Zhang, Cuicui Zhu, Qiong Luo, Jv Dong, Lv Liu, Min Li, Hongtao Zhu, Xiangping Ma, Jun Wang View Abstract ❯ |
Upregulation of retinoic acid receptor-β reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosisHong‑Yue Ren, Bo Chen, Gui‑Li Huang, Yu Liu, Dong‑Yan Shen View Abstract ❯ |
Development of a model based on biochemical, real‑time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis BShi‑Hao Xu, Qiao Li, Yuan‑Ping Hu, Li Ying View Abstract ❯ |
Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathwaysWei Shang, Ling‑Jie Zhao, Xiao‑Lei Dong, Zhi‑Ming Zhao, Jing Li, Bei‑Bei Zhang, Hui Cai View Abstract ❯ |
Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cellsWei‑Wei Zhang, Shu‑Hui Zhan, Chang‑Xin Geng, Xin Sun, Mert Erkan, Jörg Kleeff, Xiang‑Jun Xie View Abstract ❯ |
In vitro antitumor activity of the ethyl acetate extract of Potentilla chinensis in osteosarcoma cancer cellsGuang Wan, Jin‑Gang Tao, Guo‑Dong Wang, Shen‑Peng Liu, Hong‑Xing Zhao, Qiu‑Dong Liang View Abstract ❯ |
A novel KMT2D mutation resulting in Kabuki syndrome: A case reportJun Lu, Guiling Mo, Yaojun Ling, Lijuan Ji View Abstract ❯ |
Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitroChangbo Shen, Wei Cheng, Pingping Yu, Li Wang, Lulin Zhou, Li Zeng, Qin Yang View Abstract ❯ |
Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytesJunghyun Kim, Chan‑Sik Kim, Eunjin Sohn, Jin Kim View Abstract ❯ |
Liraglutide attenuates the osteoblastic differentiation of MC3T3‑E1 cells by modulating AMPK/mTOR signalingXiong‑Ke Hu, Xin‑Hua Yin, Hong‑Qi Zhang, Chao‑Feng Guo, Ming‑Xing Tang View Abstract ❯ |
Fibronectin expression is critical for liver fibrogenesis in vivo and in vitroXiao‑Ya Liu, Rui‑Xia Liu, Fei Hou, Li‑Jian Cui, Chun-Yun Li, Cheng Chi, Entong Yi, Yan Wen, Cheng‑Hong Yin View Abstract ❯ |
Expressing human SHOX in Shox2SHOX KI/KI mice leads to congenital osteoarthritis‑like disease of the temporomandibular joint in postnatal miceWenna Liang, Xihai Li, Houhuang Chen, Xiang Shao, Xuejuan Lin, Jianying Shen, Shanshan Ding, Jie Kang, Candong Li View Abstract ❯ |
Resveratrol attenuates acute kidney injury by inhibiting death receptor‑mediated apoptotic pathways in a cisplatin‑induced rat modelQiufa Hao, Xiaoyan Xiao, Junhui Zhen, Jinbo Feng, Chun Song, Bei Jiang, Zhao Hu View Abstract ❯ |
Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injuryYang Wang, Chunhu Zhang, Weijun Peng, Zian Xia, Pingping Gan, Wei Huang, Yafei Shi, Rong Fan View Abstract ❯ |
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organsChanghwan Ahn, Da‑Hye Shin, Dongoh Lee, Su‑Myung Kang, Ju‑Hyung Seok, Hee Kang, Eui‑Bae Jeung View Abstract ❯ |
Antiviral activities of atractylon from Atractylodis RhizomaYang Cheng, Jing‑Yin Mai, Tian‑Lu Hou, Jian Ping, Jian‑Jie Chen View Abstract ❯ |
Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stressYing Liang, Jian Wang, Haiqing Gao, Quanzhen Wang, Jun Zhang, Jie Qiu View Abstract ❯ |
Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survivalYong Bae, Chi Choi, Kyeong Nam, Ji Song, Jae Lee View Abstract ❯ |
shRNA‑mediated silencing of TARBP2 inhibits NCI‑H1299 non‑small cell lung cancer cell invasion and migration via the JNK/STAT3/AKT pathwayYue Shi, Duo Zuo, Xia Wang, Meng Han, Yan Wu View Abstract ❯ |
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3Yaoguang Wang, Xiaokai Yang, Weide Ma, Jinxin Li, Qingyuan Zhang, Shuqi Xia, Hai Wang, Chenghui Zhang, Xiaomin Xu, Jiayong Zheng View Abstract ❯ |
Haptoglobin protein and mRNA expression in psoriasis and its clinical significanceFu-Jun Tian, Ying-Ying Zhang, Li-Qian Liu, Ying Xiong, Zong-Shan Wang, Shou-Zhong Wang View Abstract ❯ |
Heparin inhibits the inflammation and proliferation of human rheumatoid arthritis fibroblast‑like synoviocytes through the NF‑κB pathwayLi Qi, Xiaoli Zhang, Xiaofei Wang View Abstract ❯ |
Anti‑inflammatory effects of Ciwujianoside C3, extracted from the leaves of Acanthopanax henryi (Oliv.) Harms, on LPS‑stimulated RAW 264.7 cellsDa‑Hye Kang, Ok‑Hwa Kang, Zhi Li, Su‑Hyun Mun, Yun‑Soo Seo, Ryong Kong, Zhou Tian, Xiangqian Liu, Dong‑Yeul Kwon View Abstract ❯ |
Expression of far upstream element binding protein 1 in B‑cell non‑Hodgkin lymphoma is correlated with tumor growth and cell‑adhesion mediated drug resistanceYuejiao Huang, Xiaohong Xu, Lili Ji, Yuchan Wang, Shitao Wang, Jie Tang, Xianting Huang, Xiaojing Yang, Yunhua He, Song He, Chun Cheng View Abstract ❯ |
Osteoprotective effects of osthole in a mouse model of 5/6 nephrectomy through inhibiting osteoclast formationXiaofeng Li, Chunchun Xue, Libo Wang, Dezhi Tang, Jian Huang, Yongjian Zhao, Yan Chen, Dongfeng Zhao, Qi Shi, Yongjun Wang, Bing Shu View Abstract ❯ |
Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cellsJun Lee, Ho Jung, Yong‑Seok Han, Yeo Yoon, Chul Yun, Hwa Sun, Hyun Cho, Sang Lee View Abstract ❯ |
Bioinformatics analysis of gene expression profiles of dermatomyositisLiang‑Yuan Chen, Zhao‑Lei Cui, Fan‑Cui Hua, Weng‑Jing Yang, Ye Bai, Feng‑Hua Lan View Abstract ❯ |
Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumorsLucas Bidinotto, Carlos Véo, Edgar Loaiza, Alessandra De França, Adriana Lorenzi, Luciana Rosa, Cristina De Oliveira, José Levi, Cristovam Scapulatempo‑Neto, Adhemar Longatto‑Filho, Rui Reis View Abstract ❯ |
Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathwayHong‑Fei Xu, Xiao‑Yun Fang, Shao‑Hua Zhu, Xue‑Hua Xu, Zhi‑Xiang Zhang, Zu‑Feng Wang, Zi‑Qin Zhao, Yu‑Jie Ding, Lu‑Yang Tao View Abstract ❯ |
Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysisZhikui Gao, Ran Liu, Juan Liao, Miao Yang, Enchun Pan, Lihong Yin, Yuepu Pu View Abstract ❯ |
Proteomic analysis of selective cytotoxic anticancer properties of flavonoids isolated from Citrus platymamma on A549 human lung cancer cellsArulkumar Nagappan, Venu Venkatarame Gowda Saralamma, Gyeong Hong, Ho Lee, Sung Shin, Eun Kim, Won Lee, Gon Kim View Abstract ❯ |
Identification of differentially expressed genes affecting hair and cashmere growth in the Laiwu black goat by microarrayJinshan Zhao, Hegang Li, Kaidong Liu, Baoxun Zhang, Peipei Li, Jianning He, Ming Cheng, Wei De, Jifeng Liu, Yaofeng Zhao, Lihua Yang, Nan Liu View Abstract ❯ |
Effects of tongxinluo on angiogenesis in the carotid adventitia of hyperlipidemic rabbitsJianhua Zhou, Bingfeng Cao, Weiping Ju, Sen Liu, Jianguang Song, Lixia Liu View Abstract ❯ |
Matrine induces the hepatic differentiation of WB-F344 rat hepatic progenitor cells and inhibits Jagged 1/HES1 signalingZhiyun Yang, Li Wang, Xianbo Wang View Abstract ❯ |
Nkx2.5/CARP signaling pathway contributes to the regulation of ion channel remodeling induced by rapid pacing in rat atrial myocytesWei Wang, Yun Zhu, Jianguang Yi, Wei Cheng View Abstract ❯ |
p53, Bcl-2 and cox-2 are involved in berberine hydrochloride-induced apoptosis of HeLa229 cellsHai‑Yan Wang, Hai‑Zhong Yu, Sheng‑Mou Huang, Yu‑Lan Zheng View Abstract ❯ |
Comparison of bone marrow tissue- and adipose tissue-derived mesenchymal stem cells in the treatment of sepsis in a murine model of lipopolysaccharide-induced sepsisHao Ou, Shangping Zhao, Yue Peng, Xuefei Xiao, Qianlu Wang, Huaizeng Liu, Xianzhong Xiao, Mingshi Yang View Abstract ❯ |
Effects of hydrogen sulfide on the expression of alkaline phosphatase, osteocalcin and collagen type I in human periodontal ligament cells induced by tension force stimulationJing Qin, Yongmei Hua View Abstract ❯ |
S100B suppresses the differentiation of C3H/10T1/2 murine embryonic mesenchymal cells into osteoblastsDong Li, Kaihua Li, Gang Chen, Jianlong Xia, Ting Yang, Ping Cai, Chen Yao, Yongjiang Yang, Shichang Yan, Rihua Zhang, Hui Chen View Abstract ❯ |
Co‑culture of fibroblast‑like synoviocytes with umbilical cord‑mesenchymal stem cells inhibits expression of pro‑inflammatory proteins, induces apoptosis and promotes chondrogenesisJingqi Zeng, Fan Wang, Minzhi Mao View Abstract ❯ |
Effect of high-fat diet-induced obesity on the Akt/FoxO/Smad signaling pathway and the follicular development of the mouse ovaryYanqing Wu, Zhenghong Zhang, Xinghui Liao, Lingbin Qi, Yiping Liu, Zhengchao Wang View Abstract ❯ |
Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathwayOu Lv, Fenggang Zhou, Yongri Zheng, Qingsong Li, Jianjiao Wang, Yulan Zhu View Abstract ❯ |
Regulation of the pacemaker activities in cultured interstitial cells of Cajal by Citrus unshiu peel extractsJi Shim, Soo Lee, Huijin Gim, Hyun Kim, Taewon Han, Jae Kim, Eun Lim, Yun Kim, Byung Kim View Abstract ❯ |
Inhibiting the role of Skp2 suppresses cell proliferation and tumorigenesis of human gastric cancer cells via the upregulation of p27kip1Yanguang Wen, Kuansong Wang, Kaiyan Yang View Abstract ❯ |
Activation of mTOR signaling leads to orthopedic surgery-induced cognitive decline in mice through β-amyloid accumulation and tau phosphorylationWenzhen Shen, Keliang Lu, Jiawan Wang, Anshi Wu, Yun Yue View Abstract ❯ |
Myeloid-derived suppressor cells are elevated in patients with psoriasis and produce various moleculesDan Ilkovitch, Laura Ferris View Abstract ❯ |
Iodine regulates G2/M progression induced by CCL21/CCR7 interaction in primary cultures of papillary thyroid cancer cells with RET/PTC expressionYou‑Yuan Zhang, Ze‑Bing Liu, Xuan‑Guang Ye, Wei‑Min Ren View Abstract ❯ |
Structure and antioxidant activity of a novel polysaccharide derived from Amanita caesareaYuanxiu Zhu, Xiang Ding, Mei Wang, Yiling Hou, Wanru Hou, Changwu Yue View Abstract ❯ |
SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cellsEun Choi, Seung‑Mi Kim, Seung‑Woo Hong, Jai‑Hee Moon, Jae‑Sik Shin, Jeong Kim, Ih‑Yeon Hwang, Soo‑A Jung, Dae‑Hee Lee, Eun Lee, Seul Lee, Hyunwoo Kim, Daejin Kim, Yeong Kim, Youn Choi, Hyo Kim, Hyeong Choi, Sung‑Gook Cho, Jeong Kim, Kyu Kim, Yong Hong, Won Lee, Jung Lee, Tae Kim, Seong‑Gyu Ko, Dong‑Hoon Jin View Abstract ❯ |
Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cellsKang Xu, Xiaofei Wang, Qianshi Zhang, Anjing Liang, Haipeng Zhu, Dongsheng Huang, Chunhai Li, Wei Ye View Abstract ❯ |
Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytesMagdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa Jankowska View Abstract ❯ |
Role of histone modification in 12‑lipoxygenase‑associated p21 gene regulationYingchun Cui, Nian Liu, Fuzhe Ma, Weixia Sun, Hao Wu, Zhonggao Xu, Hang Yuan View Abstract ❯ |
Berberine induces pacemaker potential inhibition via cGMP-dependent ATP-sensitive K+ channels by stimulating mu/delta opioid receptors in cultured interstitial cells of Cajal from mouse small intestineHyun Kim, Hyungwoo Kim, Myeong Jung, Young Kwon, Byung Kim View Abstract ❯ |
Effects of endomorphin-1 postconditioning on myocardial ischemia/reperfusion injury and myocardial cell apoptosis in a rat modelWei‑Ping Zhang, Qiao‑Feng Zong, Qin Gao, Ying Yu, Xiao‑Yu Gu, Ya Wang, Zheng‑Hong Li, Min Ge View Abstract ❯ |
Inhibiting autophagy promotes endoplasmic reticulum stress and the ROS‑induced nod‑like receptor 3‑dependent proinflammatory response in HepG2 cellsJia‑Jing Yin, Guangying Xie, Ning Zhang, Yanbo Li View Abstract ❯ |
[Retracted] Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growthChun‑Tao Liu, Ying Xin, Chun‑Yan Tong, Bing Li, Hong‑Li Bao, Cai‑Yun Zhang, Xue‑Hui Wang View Abstract ❯ |
| 6-8 October, 2016, Metropolitan Hotel, Athens, Greece 21st World Congress on Advances in Oncology & 19th International Symposium on Molecular Medicine |
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