Segmental 18 F-FDG-PET/CT in a single pulmonary nodule: a better cost/effectiveness strategy

http://ift.tt/2dSV9zU

Abstract: Suture Materials Containing the Antimicrobial Taurolidine

No abstract available

http://ift.tt/2dD2Dsa

Cellular Neurothekeoma: A Rare Tumor with a Common Clinical Presentation

Summary: Neurothekeomas are rare benign tumors commonly found on the head, neck, and upper extremities of women and younger individuals. They are thought to be of nerve sheath origin and usually present as painless, slow growing masses. We present a case of cellular neurothekeoma on the nasal ala of an 8-year-old girl with no previous history of trauma or piercings. Differential diagnosis, treatment options, and special considerations regarding potentially atypical characteristics are discussed.

http://ift.tt/2c0NMpz

Correction of Facial Deformity in Sturge–Weber Syndrome

Background: Although previous studies have reported soft-tissue management in surgical treatment of Sturge–Weber syndrome (SWS), there are few reports describing facial bone surgery in this patient group. The purpose of this study is to examine the validity of our multidisciplinary algorithm for correcting facial deformities associated with SWS. To the best of our knowledge, this is the first study on orthognathic surgery for SWS patients. Methods: A retrospective chart review included 2 SWS patients who completed the surgical treatment algorithm. Radiographic and clinical data were recorded, and a treatment algorithm was derived. Results: According to the Roach classification, the first patient was classified as type I presenting with both facial and leptomeningeal vascular anomalies without glaucoma and the second patient as type II presenting only with a hemifacial capillary malformation. Considering positive findings in seizure history and intracranial vascular anomalies in the first case, the anesthetic management was modified to omit hypotensive anesthesia because of the potential risk of intracranial pressure elevation. Primarily, both patients underwent 2-jaw orthognathic surgery and facial bone contouring including genioplasty, zygomatic reduction, buccal fat pad removal, and masseter reduction without major complications. In the second step, the volume and distribution of facial soft tissues were altered by surgical resection and reposition. Both patients were satisfied with the surgical result. Conclusions: Our multidisciplinary algorithm can systematically detect potential risk factors. Correction of the asymmetric face by successive bone and soft-tissue surgery enables the patients to reduce their psychosocial burden and increase their quality of life.

http://ift.tt/2c0O28k

Pathological Model of Hemangioma—New Thinking on Hemangioma Classification

No abstract available

http://ift.tt/2c0Px6q

Botulinum Toxin A: Dose-dependent Effect on Reepithelialization and Angiogenesis

Background: Botulinum (neuro)toxin A (BoNT) is widely used in the field of plastic and reconstructive surgery. Among treatment of pain, hyperhidrosis, or aesthetic purposes, it is also used to enhance wound healing and prevent excessive scar formation. Some clinical data already exist, but only little is known on a cellular level. The aim of this study was to evaluate the effect of BoNT on cells essential for wound healing in vitro. Therefore, primary human keratinocytes and endothelial cells were treated with different concentrations of BoNT and tested on proliferation, migration, and angiogenic behavior. Methods: BoNT was exposed to human keratinocytes and endothelial cells in a low (1 IU/mL), medium (10 IU/mL), and high (20 IU/mL) concentrations in cell culture. Proliferation and migration of the 2 cell types were observed and also the angiogenic potential of endothelial cells in vitro. Results: BoNT 20 IU/mL negatively influenced proliferation and migration of keratinocytes but not those of endothelial cells. Angiogenesis in vitro was less effective with the highest BoNT concentrations tested. Low concentrations of BoNT supported sprouting of endothelial cells. Conclusions: High concentrations of botulinum toxin interfered with wound closure as keratinocytes' proliferation and migration were deteriorated. Furthermore, BoNT concentrations of 20 IU/mL constrain in vitro vessel formation but do not influence proliferation or migration of endothelial cells.

http://ift.tt/2cMCYXW

The clinical importance of thyroid nodules is related to excluding malignancy (4.0 to 6.5% of all thyroid nodules)

​https://sfaki.blogspot.gr/2016/10/thyroid-nodule-update-on-diagnosis-and.html

Table 1

Increased risk of malignancy in thyroid nodule on history and physical exam [1, 3, 13]

- History of childhood head/neck irradiation [113]

- Total body irradiation for bone marrow transplantation [114]

- Exposure to ionizing radiation from fallout in childhood or adolescence [115, 116]

- Family history of PTC, MTC, or thyroid cancer syndrome (e.g., Cowden's syndrome, familial polyposis, Carney complex, multiple endocrine neoplasia [MEN] 2, Werner syndrome) [117]

- Enlarging nodule/rapid nodule growth

- Cervical lymphadenopathy

- Fixed nodule to surrounding tissue

- Vocal cord paralysis/hoarseness

Table 2

Recommendations for diagnostic FNA based on size and US features [1, 35, 36, 37, 85, 86, 118, 119, 120]

A. Nodules ≥ 1 cm with intermediate or high suspicion US pattern

B. Nodules ≥ 1.5 cm with low suspicion US pattern

C. Nodules ≥ 2 cm with very low suspicion US pattern (e.g., spongiform). Observation an alternate option.

D. For nodules that do not meet the above criteria, FNA is not required, including nodules < 1 cm (with some exceptions) and purely cystic nodules.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Peptidomics of the zebrafish Danio rerio: In search for neuropeptides

Publication date: Available online 2 October 2016
Source:Journal of Proteomics
Author(s): Kristien A. Van Camp, Geert Baggerman, Ronny Blust, Steven J. Husson
(Neuro)peptides are small messenger molecules that are derived from larger, inactive precursor proteins by the highly controlled action of processing enzymes. These biologically active peptides can be found in all metazoan species where they orchestrate a wide variety of physiological processes. Obviously, detailed knowledge on the actual peptide sequences, including the potential existence of truncated versions or presence of post-translation modifications, is of high importance when studying their function. A peptidomics approach therefore aims to identify and characterize the endogenously present peptide complement of a defined tissue or organism using liquid chromatography and mass spectrometry. While the zebrafish Danio rerio is considered as an important aquatic model for medical research, neuroscience, development and ecotoxicology, very little is known about their peptidergic signaling cascades. We therefore set out to biochemically characterize endogenously present (neuro)peptides from the zebrafish brain. This peptidomics setup yielded >60 different peptides in addition to various truncated versions.SignificanceThough the zebrafish is a well-established model organism to study vertebrate biology and gene functions in either a medical or (eco)toxicological context, very little knowledge about neuropeptidergic signaling cascades is available. We therefore set out to characterize endogenously present peptides from the zebrafish brain using a peptidomics setup yielding a total number of 105 peptide identifications. To our knowledge, it is the first attempt to biochemically isolate and characterize neuropeptides from a fish species in a high-throughput manner. This archive of identified endogenous peptides is likely to aid further functional elucidation of defined neuropeptidergic signaling systems (e.g. characterization of cognate G-protein coupled receptors). Furthermore, our methodology allows studying the changes in peptide expression in response to changes in the organism or the environment using differential peptidomics.

Graphical abstract

http://ift.tt/2dAzfxb

Beyond the survival and death of the deltamethrin-threatened pollen beetle Meligethes aeneus: An in-depth proteomic study employing a transcriptome database

Publication date: Available online 2 October 2016
Source:Journal of Proteomics
Author(s): Tomas Erban, Karel Harant, Julie Chalupnikova, Frantisek Kocourek, Jitka Stara
Insecticide resistance is an increasingly global problem that hampers pest control. We sought the mechanism responsible for survival following pyrethroid treatment and the factors connected to paralysis/death of the pollen beetle Meligethes aeneus through a proteome-level analysis using nanoLC coupled with Orbitrap Fusion™ Tribrid™ mass spectrometry. A tolerant field population of beetles was treated with deltamethrin, and the ensuing proteome changes were observed in the survivors (resistant), dead (paralyzed) and control-treated beetles. The protein database consisted of the translated transcriptome, and the resulting changes were manually annotated via BLASTP. We identified a number of high-abundance changes in which there were several dominant proteins, e.g., the electron carrier cytochrome b5, ribosomal proteins 60S RPL28, 40S RPS23 and RPS26, eIF4E-transporter, anoxia up-regulated protein, 2 isoforms of vitellogenin and pathogenesis-related protein 5. Deltamethrin detoxification was influenced by different cytochromes P450, which were likely boosted by increased cytochrome b5, but glutathione-S-transferase ε and UDP-glucuronosyltransferases also contributed. Moreover, we observed changes in proteins related to RNA interference, RNA binding and epigenetic modifications. The high changes in ribosomal proteins and associated factors suggest specific control of translation. Overall, we showed modulation of expression processes by epigenetic markers, alternative splicing and translation. Future functional studies will benefit.Biological significanceInsects develop pesticide resistance, which has become one of the key issues in plant protection. This growing resistance increases the demand for pesticide applications and the development of new substances. Knowledge in the field regarding the resistance mechanism and its responses to pesticide treatment provides us the opportunity to propose a solution for this issue. Although the pollen beetle Meligethes aeneus was effectively controlled with pyrethroids for many years, there have been reports of increasing resistance. We show protein changes including production of isoforms in response to deltamethrin at the protein level. These results illustrate the insect's survival state as a resistant beetle and in its paralyzed state (evaluated as dead) relative to resistant individuals.

Graphical abstract

http://ift.tt/2dAyiVU

Growth of flower-like SnO2 crystal and performance as photoanode in dye-sensitized solar cells

Publication date: 15 December 2016
Source:Materials & Design, Volume 112
Author(s): Tao Qi, Qian Wang, Yongchao Zhang, Di Wang, Renqiang Yang, Wei Zheng
The tin dioxide crystal with three dimensional flower-like structures had been synthesized in the typical hydrothermal route. The crystals grown for different hydrothermal time was characterized through X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and selected area electron diffraction (SAED) to investigate the growing mechanism of the self-assembled structure. The flower-like architecture consists of independent SnO2 single-crystal nanorods which grow along c-axes direction with enclosed (110) lattice faces. The growing mechanism based on thermodynamics and dynamics have been proposed to discuss the growing process. The flower-like SnO2 crystal has higher specific surface area and more stable spatial structure. When the flower-like SnO2 nanocrystal was used as the photoanode in dye-sensitized solar cells, the photoelectric conversion efficiency (PCE) was four times higher than that of spherical SnO2 nanocrystal photoanode solar cells.

Graphical abstract

http://ift.tt/2dCOTxl

Preparation and characterization of β-SiAlON/TiN nanocomposites sintered by spark plasma sintering and pressureless sintering

Publication date: 15 December 2016
Source:Materials & Design, Volume 112
Author(s): Kh. A. Nekouee, R. Azari Khosroshahi
In this research, β-SiAlON/TiN nanocomposites were synthesized from Si3N4, Al2O3, AlN and TiO2 powders by the combination of mechanical alloying and the subsequent pressureless and spark plasma sintering. The effects of submicron and nanometer size TiO2 precursors on the microstructure, phase composition and mechanical properties of the SiAlON composites were investigated. Majority of Si3N4 particles were transformed into nanometer size which were embedded in the amorphous phase. Spark plasma sintering of the β-SiAlON/TiN powder at temperatures as low as 1750°C resulted in full density ceramics. In addition, it was observed that sintered bodies by pressureless sintering, had lower mechanical properties than the spark plasma sintered samples. Moreover, spark plasma sintered samples demonstrated optimal friction coefficient of 0.6.

Graphical abstract

http://ift.tt/2dCNvuX

Fabrication of lithium manganese oxide nanoribbons by electrospinning: A general strategy and formation mechanism

Publication date: 15 December 2016
Source:Materials & Design, Volume 112
Author(s): Guorui Yang, Ling Wang, Jianan Wang, Wei Wei, Wei Yan
Various lithium manganese oxides (LMOs), including LiMn2O4, Li4Mn5O12 and Li2MnO3, nanoribbons with excellent continuities have been fabricated by the electrospinning method, as Li4Mn5O12 was chosen as a model to illustrate this topic in detail. Both scanning electron microscopy and transmission electron microscopy observations showed that Li4Mn5O12 structures were well-defined one-dimensional nanoribbons. The X-ray diffraction results exhibited that the regular ribbon-like nanostructures possessed highly crystalline structures without any detectable impurities, while their nanoparticle counterparts prepared by a sol-gel route were introduced several foreign impurities. Moreover, such nanoribbons also demonstrate larger surface areas compared with the nanoparticles. The temperature-dependent experiment has been adopted in an attempt to trail the growth process of the nanoribbons, and a possible formation mechanism was proposed based on it.

Graphical abstract

http://ift.tt/2dCNt65

Chemical characterization and toxicity of particulate matter emissions from roadside trash combustion in urban India

Publication date: December 2016
Source:Atmospheric Environment, Volume 147
Author(s): Heidi Vreeland, James J. Schauer, Armistead G. Russell, Julian D. Marshall, Akihiro Fushimi, Grishma Jain, Karthik Sethuraman, Vishal Verma, Sachi N. Tripathi, Michael H. Bergin
Roadside trash burning is largely unexamined as a factor that influences air quality, radiative forcing, and human health even though it is ubiquitously practiced across many global regions, including throughout India. The objective of this research is to examine characteristics and redox activity of fine particulate matter (PM2.5) associated with roadside trash burning in Bangalore, India. Emissions from smoldering and flaming roadside trash piles (n = 24) were analyzed for organic and elemental carbon (OC/EC), brown carbon (BrC), and toxicity (i.e. redox activity, measured via the dithiothreitol "DTT" assay). A subset of samples (n = 8) were further assessed for toxicity by a cellular assay (macrophage assay) and also analyzed for trace organic compounds. Results show high variability of chemical composition and toxicity between trash-burning emissions, and characteristic differences from ambient samples. OC/EC ratios for trash-burning emissions range from 0.8 to 1500, while ambient OC/EC ratios were observed at 5.4 ± 1.8. Trace organic compound analyses indicate that emissions from trash-burning piles were frequently composed of aromatic di-acids (likely from burning plastics) and levoglucosan (an indicator of biomass burning), while the ambient sample showed high response from alkanes indicating notable representation from vehicular exhaust. Volume-normalized DTT results (i.e., redox activity normalized by the volume of air pulled through the filter during sampling) were, unsurprisingly, extremely elevated in all trash-burning samples. Interestingly, DTT results suggest that on a per-mass basis, fresh trash-burning emissions are an order of magnitude less redox-active than ambient air (13.4 ± 14.8 pmol/min/μgOC for trash burning; 107 ± 25 pmol/min/μgOC for ambient). However, overall results indicate that near trash-burning sources, exposure to redox-active PM can be extremely high.

Graphical abstract

http://ift.tt/2dJdsIL

Evaluation of the representativeness of ground-based visibility for analysing the spatial and temporal variability of aerosol optical thickness in China

Publication date: December 2016
Source:Atmospheric Environment, Volume 147
Author(s): Zhao Yang Zhang, Man Sing Wong, Kwon Ho Lee
Although visibility is a widely-used indicator to quantify the aerosol loadings, only a few studies have been analyzed the representativeness of visibility in deriving Aerosol Optical Thickness (AOT). In this paper, ground-based visibility, MODerate-resolution Imaging Spectroradiometer (MODIS) and Multi-angle Imaging SpectroRadiometer (MISR) monthly AOT products between July 2002 and December 2014 were analyzed in order to extract the dominant modes of variability using the Singular Value Decomposition (SVD) method. The method has significant merit to reduce data dimension and examine both spatial and temporal variability simultaneously. Results indicated that the satellite retrieved AOTs agreed well with ground-based visibility in terms of inter-annual variability. The correlation coefficients in the first deseasonalized mode are greater than 0.65 between visibility and satellite AOT products. However, large differences were observed in the seasonal variability between ground-based visibility and AOT. In addition, Aerosol vertical distribution from LIdar climatology of Vertical Aerosol Structure for space-based lidar simulation studies (LIVAS) and cloud data from ground-based meteorological station were used to investigate the seasonal variability disagreement. The AOT values derived from LIVAS extinction coefficients between 0 and 500 m above surface have a stronger relationship with visibility, than total column AOT with visibility. It also indicates that seasonal variation of aerosol vertical distribution is the main cause of the disagreement between two parameters, and the uncertainties of satellite products also contribute to the disagreement. Results in this study highlighted that the visibility observation could only be used to depict the inter-annual AOT and more ancillary information could be used for studying seasonal AOT variation.



http://ift.tt/2dJe1SY

Gas-phase ozonolysis of β-ocimene: Temperature dependent rate coefficients and product distribution

Publication date: December 2016
Source:Atmospheric Environment, Volume 147
Author(s): Elizabeth Gaona-Colmán, María B. Blanco, Ian Barnes, Mariano A. Teruel
Rate coefficients for the reaction of β-ocimene with O3 molecules have been determined over the temperature range 288–311 K at 750 Torr total pressure of nitrogen using the relative rate technique. The investigations were performed in a large volume reaction vessel using long-path in-situ Fourier transformed infrared (FTIR) spectroscopy to monitor the reactants and products. A value of k(β-ocimene + O3) = (3.74 ± 0.92) × 10⁻¹⁶ cm³ molecule⁻¹ s⁻¹ has been obtained for the reaction at 298 K. The temperature dependence of the reaction is best described by the Arrhenius expression k = (1.94 ± 0.02) × 10⁻¹⁴ exp [(−1181 ± 51)/T] cm³ molecule⁻¹ s⁻¹. In addition, a product study has been carried out at 298 K in 750 Torr of synthetic air and the following products with yields in molar % were observed: formaldehyde (36 ± 2), acetone (15 ± 1), methylglyoxal (9.5 ± 0.4) and hydroxyacetone (19 ± 1). The formation of formaldehyde can be explained by the addition of O3 to the C1C2 double bond of the β-ocimene. Addition of O3 to the C6C7 double bond leads to the formation of acetone and the CH3C·(OO·)CH3 biradical, which can through isomerization/stabilization form methylglyoxal (hydroperoxide channel) and hydroxyacetone. The formed products will contribute to the formation of PAN and derivatives in polluted environments and also the oxidation capacity of the atmosphere.

Graphical abstract

http://ift.tt/2dJdGzI

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis

Publication date: Available online 2 October 2016
Source:Journal of Autoimmunity
Author(s): Magdalena Paterka, Jan Oliver Voss, Johannes Werr, Eva Reuter, Sophia Franck, Tina Leuenberger, Josephine Herz, Helena Radbruch, Tobias Bopp, Volker Siffrin, Frauke Zipp
Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully understood. Here, we demonstrate that conditional ablation of DCs during the priming phase of myelin-specific T cells in experimental autoimmune encephalomyelitis (EAE) selectively aborts inducible Treg (iTreg) induction, whereas generation of T helper (Th)1/17 cells is unaltered. DCs facilitate iTreg induction by creating a milieu with high levels of interleukin (IL)-2 due to a strong proliferative response. In the absence of DCs, B220⁺ B cells take over priming of Th17 cells in the place of antigen-presenting cells (APCs), but not the induction of iTreg, thus leading to unregulated, severe autoimmunity.



http://ift.tt/2dCC9qw

Nonischemic left ventricular scar and cardiac sudden death in the young

Publication date: December 2016
Source:Human Pathology, Volume 58
Author(s): Cira R.T. di Gioia, Carla Giordano, Bruna Cerbelli, Annalinda Pisano, Elena Perli, Enrico De Dominicis, Barbara Poscolieri, Vincenzo Palmieri, Costantino Ciallella, Paolo Zeppilli, Giulia d'Amati
Nonischemic left ventricular scar (NLVS) is a pattern of myocardial injury characterized by midventricular and/or subepicardial gadolinium hyperenhancement at cardiac magnetic resonance, in absence of significant coronary artery disease. We aimed to evaluate the prevalence of NLVS in juvenile sudden cardiac death and to ascertain its etiology at autopsy. We examined 281 consecutive cases of sudden death of subjects aged 1 to 35 years. NLVS was defined as a thin, gray rim of subepicardial and/or midmyocardial scar in the left ventricular free wall and/or the septum, in absence of significant stenosis of coronary arteries. NLVS was the most frequent finding (25%) in sudden deaths occurring during sports. Myocardial scar was localized most frequently within the left ventricular posterior wall and affected the subepicardial myocardium, often extending to the midventricular layer. On histology, it consisted of fibrous or fibroadipose tissue. Right ventricular involvement was always present. Patchy lymphocytic infiltrates were frequent. Genetic and molecular analyses clarified the etiology of NLVS in a subset of cases. Electrocardiographic (ECG) recordings were available in more than half of subjects. The most frequent abnormality was the presence of low QRS voltages (<0.5 mV) in limb leads. In serial ECG tracings, the decrease in QRS voltages appeared, in some way, progressive. NLVS is the most frequent morphologic substrate of juvenile cardiac sudden death in sports. It can be suspected based on ECG findings. Autopsy study and clinical screening of family members are required to differentiate between arrhythmogenic right ventricular cardiomyopathy/dysplasia and chronic acquired myocarditis.



http://ift.tt/2dKxFu9

A neural mechanism of cognitive control for resolving conflict between abstract task rules

Publication date: Available online 1 October 2016
Source:Cortex
Author(s): Yi-Shin Sheu, Susan M. Courtney
Conflict between multiple sensory stimuli or potential motor responses is thought to be resolved via bias signals from prefrontal cortex. However, population codes in the prefrontal cortex also represent abstract information, such as task rules. How is conflict between active abstract representations resolved? We used functional neuroimaging to investigate the mechanism responsible for resolving conflict between abstract representations of task rules. Participants performed two different tasks based on a cue. We manipulated the degree of conflict at the task-rule level by training participants to associate the color andshape dimensions of the cue with either the same task rule (congruent cues) or different ones (incongruent cues). Phonological and semantic tasks were used in which performance depended on learned, abstract representations of information, rather than sensory features of the target stimulus or on any habituated stimulus-response associations. In addition, these tasks activate distinct regions that allowed us to measure magnitude of conflict between tasks. We found that incongruent cues were associated with increased activity in several cognitive control areas, including the inferior frontal gyrus, inferior parietal lobule, insula, and subcortical regions. Conflict between abstract representations appears to be resolved by rule-specific activity in the inferior frontal gyrus that is correlated with enhanced activity related to the relevant information. Furthermore, multivoxel pattern analysis of the activity in the inferior frontal gyrus was shown to carry information about both the currently relevant rule (semantic/phonological) and the currently relevant cue context (color/shape). Similar to models of attentional selection of conflicting sensory or motor representations, the current findings indicate part of the frontal cortex provides a bias signal, representing task rules, that enhances task-relevant information. However, the frontal cortex can also be the target of these bias signals in order to enhance abstract representations that are independent of particular stimuli or motor responses.



http://ift.tt/2dnFFBF

Deficit in emotional learning in neurotrimin knockout mice

Publication date: 15 January 2017
Source:Behavioural Brain Research SreeTestContent1, Volume 317
Author(s): Timur Mazitov, Aleksandr Bregin, Mari-Anne Philips, Jürgen Innos, Eero Vasar
Neurotrimin (Ntm) belongs to the IgLON family of cell adhesion molecules with Lsamp, Obcam and kilon that regulate the outgrowth of neurites mostly by forming heterodimers. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease and tumours. This study provides an initial behavioural and pharmacological characterization of the phenotype of Ntm-deficient mice. We expected to see at least some overlap with the phenotype of Lsamp-deficient mice as Ntm and Lsamp are the main interaction partners in the IgLON family and are colocalized in some brain regions. However, Ntm-deficient mice displayed none of the deviations in behaviour that we have previously shown in Lsamp-deficient mice, but differently from Lsamp-deficient mice, had a deficit in emotional learning in the active avoidance task. The only overlap was decreased sensitivity to the locomotor stimulating effect of amphetamine in both knockout models. Thus, despite being interaction partners, on the behavioural level Lsamp seems to play a much more central role than Ntm and the roles of these two proteins seem to be complementary rather than overlapping.



http://ift.tt/2dBZZTg

The role of microRNAs in colorectal cancer

Publication date: December 2016
Source:Biomedicine & Pharmacotherapy, Volume 84
Author(s): Ali Mohammadi, Behzad Mansoori, Behzad Baradaran
Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are small 19 to 22 nucleotides of RNA that engage in the regulation of cell differentiation, apoptosis, and cell cycle progression. MicroRNAs are similar to small interfering RNA (siRNA), that post-transcriptionally regulate gene expression and control various cellular mechanisms. They are important factors in the carcinogenesis of CRC, one of the most important factors includes microRNA. MicroRNAs have been linked to CRC development, and these molecules have been recently studied as new potential biomarkers in diagnosis and treatment of CRC. Specific microRNA expression patterns help distinguish CRC from other colon related disease, and may be used as a prognostication factor in patients after treatment with different chemotherapy drugs. More over the newest molecular therapy via tumor suppressor micro RNA replacement can be new insight in molecular therapy of CRC. This review summarizes the potential roles of microRNAs as potential biomarkers for CRC diagnosis, and treatment.



http://ift.tt/2dzsBqY

DNA vaccine encoding molecular chaperone GroEL of Edwardsiella tarda confers protective efficacy against edwardsiellosis

Publication date: November 2016
Source:Molecular Immunology, Volume 79
Author(s): Fuguo Liu, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
In the present study, molecular chaperone GroEL of Edwardsiella tarda was found both react with flounder (Paralichthys olivaceus) anti-recombinant GroEL (rGroEL) and anti-E. tarda antibodies, and it was both detected in the outer membrane and the secretome. To evaluate the vaccine potential of GroEL, pCI-neo-GFP-GroEL (pCG-GroEL) was prepared and used to vaccinate healthy flounder, and immune protective effects were investigated. The results showed that pCG-GroEL produced an RPS of 60% following E. tarda challenge at week 5 after immunization. Moreover, GroEL transcripts and GFP-tagged GroEL could be detected in vaccinated flounder after immunization with pCG-GroEL, and the GFP-tagged GroEL could be also detected in HINAE cells after transfection with pCG-GroEL. Meanwhile, the immune response of flounder induced by pCG-GroEL was investigated, and the results showed that: (1) the levels of specific serum antibodies against E. tarda induced by pCG-GroEL were significantly higher than other groups at 3–5 week post vaccination; (2) pCG-GroEL could induce the proliferation of sIg+ lymphocytes, and the levels of sIg+ lymphocytes in blood, spleen and pronephros of pCG-GroEL vaccinated fish were significantly increased compared with the PBS vaccinated fish at 3w, 2w and 2w after immunization, respectively; (3) MHCIα, MHCIIα, CD4-1, CD8α, IL-1β and TNF-α were significantly induced by immunization with pCG-GroEL, and the mRNA levels of CD4-1 and CD8α rapidly increased in pCG-GroEL vaccinated fish after challenge with E. tarda. Taking together, pCG-GroEL could elicit highly protective effects against E. tarda and induce strong immune response of flounder, suggesting that GroEL was a promising vaccine candidate.



http://ift.tt/2djU2ra

Correspondence between adolescent and informant reports of substance use: Findings from the Philadelphia Neurodevelopmental Cohort

Publication date: February 2017
Source:Addictive Behaviors, Volume 65
Author(s): Jason D. Jones, J. Cobb Scott, Monica E. Calkins, Kosha Ruparel, Tyler M. Moore, Ruben C. Gur, Raquel E. Gur
Inclusion of collateral informant reports is common in adolescent psychopathology research and clinical assessment, yet few studies have examined agreement on ratings of adolescent substance use or factors that may be associated with reporter agreement. The present study aimed to extend prior work on the correspondence between adolescent and informant reports of adolescent substance use with data from a large (n=5214), diverse, community-based sample of youth aged 11–17 (mean age=14.53, SD=1.98; 52% female). Specifically, we examined: (a) agreement between adolescent and collateral informant reports of adolescent use of alcohol, marijuana, cocaine, inhalants, and stimulants and (b) potential correlates of reporter agreement. Agreement ranged from low (κ=0.007, p=0.053) for inhalant use to moderate (κ=0.414, p<0.001) for marijuana use. Disagreements were mainly driven by collateral underestimation of adolescent substance use. Older adolescent age was associated with poorer agreement across all substances (Odds Ratios [ORs]≤0.80, ps<0.05) except inhalants (OR=1.28, p<0.001). Reporter agreement on alcohol and marijuana use was lower for male than female adolescents (ORs≤0.85, ps<0.05). Adolescent psychopathology was associated with poorer agreement on all substances (ORs≤0.62, ps<0.01). For alcohol and marijuana, past year frequency of use was associated with better reporter agreement (ORs≥1.54, ps<0.001). For marijuana, older age at first use was related to poorer agreement (OR=0.81, p=0.01). Our results suggest that collateral reports of adolescent substance use may be ineffective proxies for adolescent self-reports in community samples, particularly for low base rate substances. Findings also highlight important factors to consider when collecting substance use information from multiple informants.



http://ift.tt/2dRtAag

Beverage-specific patterns of 5+ alcoholic drink consumption by young adults in the U.S.

Publication date: February 2017
Source:Addictive Behaviors, Volume 65
Author(s): Stephanie A. Stern, Yvonne M. Terry-McElrath, Megan E. Patrick
Young adult binge drinking prevalence has been widely researched. However, beverage-specific binge drinking rates for beer, liquor, wine, and wine coolers have not yet been documented for this age group. This study examines consumption of specific beverages (i.e., 5+ drinks in a row in the past two weeks) by young adults aged 19/20. Data from the national Monitoring the Future study were collected one or two years after high school from 2004 to 2014 (n=2004). Logistic regression was used to examine associations between beverage-specific 5+ drinking and gender, race/ethnicity, parent education, college status, and cohort year. Overall 5+ drinking in the past two weeks was reported by 31.4% of young adults. Beverage-specific 5+ drinking was most common with liquor (22.6%) and beer (22.4%), followed by wine (4.5%) and wine coolers (3.0%). Men were more likely than women to engage in 5+ drinking with beer and liquor; women were more likely than men to do so with wine and wine coolers. Beverage-specific patterns differed by college attendance. Compared to four-year college students, two-year college/votech students were less likely to have 5+ drinks of liquor or wine, and more likely to have 5+ wine coolers; those not in college were less likely to have 5+ drinks of liquor and more likely to have 5+ wine coolers. Differences in beverage-specific 5+ drinking by gender and college enrollment suggest that intervention efforts should focus on the beverages that are most commonly consumed at high levels within specific early young adult populations.



http://ift.tt/2dnqfgm

Alcohol detoxification completion, acceptance of referral to substance abuse treatment, and entry into substance abuse treatment among Alaska Native people

Publication date: February 2017
Source:Addictive Behaviors, Volume 65
Author(s): Ursula Running Bear, Janette Beals, Douglas K. Novins, Spero M. Manson
BackgroundLittle is known about factors associated with detoxification treatment completion and the transition to substance abuse treatment following detoxification among Alaska Native people. This study examined 3 critical points on the substance abuse continuum of care (alcohol detoxification completion, acceptance of referral to substance abuse treatment, entry into substance abuse treatment following detoxification).MethodsThe retrospective cohort included 383 adult Alaska Native patients admitted to a tribally owned and managed inpatient detoxification unit. Three multiple logistic regression models estimated the adjusted associations of each outcome separately with demographic/psychosocial characteristics, clinical characteristics, use related behaviors, and health care utilization.ResultsSeventy-five percent completed detoxification treatment. Higher global assessment functioning scores, longer lengths of stay, and older ages of first alcohol use were associated with completing detoxification. A secondary drug diagnosis was associated with not completing detoxification. Thirty-six percent accepted a referral to substance abuse treatment following detoxification. Men, those with legal problems, and those with a longer length of stay were more likely to accept a referral to substance abuse treatment. Fifty-eight percent had a confirmed entry into a substance abuse treatment program at discharge. Length of stay was the only variable associated with substance abuse treatment entry.ConclusionsServices like motivational interviewing, counseling, development of therapeutic alliance, monetary incentives, and contingency management are effective in linking patients to services after detoxification. These should be considered, along with the factors associated with each point on the continuum of care when linking patients to follow-up services.



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Brain Networks and α-Oscillations: Structural and Functional Foundations of Cognitive Control

Publication date: Available online 1 October 2016
Source:Trends in Cognitive Sciences
Author(s): Sepideh Sadaghiani, Andreas Kleinschmidt
The most salient electrical signal measured from the human brain is the α-rhythm, neural activity oscillating at ∼100ms intervals. Recent findings challenge the longstanding dogma of α-band oscillations as the signature of a passively idling brain state but diverge in terms of interpretation. Despite firm correlations with behavior, the mechanistic role of the α-rhythm in brain function remains debated. We suggest that three large-scale brain networks involved in different facets of top-down cognitive control differentially modulate α-oscillations, ranging from power within and synchrony between brain regions. Thereby, these networks selectively influence local signal processing, widespread information exchange, and ultimately perception and behavior.



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Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe

Publication date: Available online 1 October 2016
Source:Journal of Neuroscience Methods
Author(s): Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
BackgroundFunctional magnetic resonance imaging (fMRI) in mice is typically performed under anesthesia due to difficulties in holding the head of awake mice stably with a conventional three-point fixation method that uses a tooth-bar and earplugs. Although some studies have succeeded in fMRI in awake mice by attaching a head-post on the skull, this cannot be applied to fMRI using a high signal-to-noise ratio (SNR) cryogenic MRI-detector, CryoProbe, because it covers the head of a mouse closely.New methodWe developed head-fixation implements for awake mice that are applicable to fMRI using CryoProbe.ResultsA head-bar was surgically attached to the skull of a mouse that was then habituated to a mock fMRI-environment, two hours/day for eight days with physiological examinations of body-weight, fecal weight, electromyogram (EMG), and electrocardiogram. EMG power decreased with just one day of habituation, whereas heart rate decreased after at least seven days of habituation. Estimated head motions of awake mice during fMRI were significantly smaller than a voxel size. Unexpectedly, temporal SNR of fMRI signals for awake mice was higher than that for anesthetized mice held by a conventional method. Functional connectivity in the brain of both anesthetized and awake mice showed bilateral and unilateral networks.Comparison with existing method(s)fMRI using CryoProbe had been performed on anesthetized mice previously. Our method does not use anesthetics during habituation or fMRI.ConclusionOur method would be beneficial for translational research using fMRI in mice and humans because human fMRI is typically performed without anesthetics.



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Nanotheranostic Approaches for the Management of Bloodstream Bacterial Infections (Manuscript id # JN2016292)

Publication date: Available online 1 October 2016
Source:Nanomedicine: Nanotechnology, Biology and Medicine
Author(s): Pramod Jagtap, Venkataraman Sritharan, Shalini Gupta
Bloodstream bacterial infections are a serious threat to global public health and economy. The recent figures released by National Center for Health Statistics indicate that more than a million Americans get affected by it each year and the sepsis mortality alone is about 28–50%.¹ Robust and affordable point-of-care medical technologies are, therefore, urgently needed for rapid decision-making to initiate appropriate line of treatment. Current techniques based on blood culture and serology do not have quick turnaround times or adequate sensitivities for early intervention. Moreover, antimicrobial resistance poses a great challenge in the fight towards effective bacterial infection management. Nanotheranostics is emerging as a novel strategy combining solutions for rapid diagnosis and treatment in a more personalized way. This review highlights the recent advances made in theranosis of bloodstream bacterial infections using different classes of nanomaterials and bioreceptors, and discusses present challenges and future way forward.

Graphical abstract

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MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study

Publication date: December 2016
Source:Cancer Epidemiology, Volume 45
Author(s): Erin C. Peckham-Gregory, Dharma R. Thapa, Jeremy Martinson, Priya Duggal, Sudhir Penugonda, Jay H. Bream, Po-Yin Chang, Sugandha Dandekar, Shen-Chih Chang, Roger Detels, Otoniel Martínez-Maza, Zuo-Feng Zhang, Shehnaz K. Hussain
BackgroundMicroRNAs, small non-coding RNAs involved in gene regulation, are implicated in lymphomagenesis. We evaluated whether genetic variations in microRNA coding regions, binding sites, or biogenesis genes (collectively referred to as miRNA-SNPs) were associated with risk of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL), and serum levels of four lymphoma-related microRNAs.MethodsTwenty-five miRNA-SNPs were genotyped in 180 AIDS-NHL cases and 529 HIV-infected matched controls from the Multicenter AIDS Cohort Study (MACS), and real-time polymerase chain reaction was used to quantify serum microRNA levels. Adjusted odds ratios (ORs) estimated using conditional logistic regression evaluated associations between miRNA-SNPs and AIDS-NHL risk. A semi-Bayes shrinkage approach was employed to reduce likelihood of false-positive associations. Adjusted mean ratios (MR) calculated using linear regression assessed associations between miRNA-SNPs and serum microRNA levels.ResultsDDX20 rs197412, a non-synonymous miRNA biogenesis gene SNP, was associated with AIDS-NHL risk (OR=1.34 per minor allele; 95% CI: 1.02–1.75), and higher miRNA-222 serum levels nearing statistical significance (MR=1.21 per minor allele; 95% CI: 0.98–1.49). MiRNA-196a2 rs11614913 was associated with decreased central nervous system (CNS) AIDS-NHL (CT vs. CC OR=0.52; 95% CI: 0.27–0.99). The minor allele of HIF1A rs2057482, which creates a miRNA-196a2 binding site, was associated with systemic AIDS-NHL risk (OR=1.73 per minor allele; 95% CI: 1.12–2.67), and decreased CNS AIDS-NHL risk (OR=0.49 per minor allele; 95% CI: 0.25–0.94).ConclusionsThis study suggests that a few miRNA-SNPs are associated with AIDS-NHL risk and may modulate miRNA expression. These results support a role for miRNA in AIDS-NHL and may highlight pathways to be targeted for risk stratification or therapeutics.



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Scholar : Oncology Letters - Volume:12 Number:4

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TABLE OF CONTENTS October 2016 Volume 12 Issue 4

Involvement of macrophage migration inhibitory factor in cancer and novel therapeutic targets (Review) Nadège Kindt, Fabrice Journe, Guy Laurent, Sven Saussez View Abstract ❯

Cancer stem cells as a potential therapeutic target in thyroid carcinoma (Review) Luisa Vicari, Cristina Colarossi, Dario Giuffrida, Ruggero De Maria, Lorenzo Memeo View Abstract ❯

Re-irradiation alternatives for recurrent high-grade glioma (Review) Yuanli Dong, Chengrui Fu, Hui Guan, Tianyi Zhang, Zicheng Zhang, Tao Zhou, Baosheng Li View Abstract ❯

Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review) Judit Fazekas, Irene Fürdös, Josef Singer, Erika Jensen‑Jarolim View Abstract ❯

Role of Yes-associated protein in cancer: An update (Review) Ramazan Abylkassov, Yingqiu Xie View Abstract ❯

Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches (Review) Wen‑Juan Huang, Wei‑Wei Chen, Xia Zhang View Abstract ❯

MicroRNAs and PIWI-interacting RNAs in oncology (Review) Yong Liu View Abstract ❯

Thermal ablation in cancer (Review) Yong Liu, Cheng-Song Cao, Yang Yu, Ya-Meng Si View Abstract ❯

Expression of microRNA‑181 determines response to treatment with azacitidine and predicts survival in elderly patients with acute myeloid leukaemia Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Rafał Poręba, Grzegorz Mazur, Kazimierz Kuliczkowski View Abstract ❯

miR‑186 suppressed CYLD expression and promoted cell proliferation in human melanoma Haijiang Qiu, Suirong Yuan, Xiaohe Lu View Abstract ❯

Two novel susceptibility loci for non‑small cell lung cancer map to low‑density lipoprotein receptor‑related protein 5 Ying Wang, Yongjun Zhang, Meiyu Fang, Wenglong Bao, Dehou Deng View Abstract ❯

Whole‑exome sequencing identifies variants in invasive pituitary adenomas Xiaolei Lan, Hua Gao, Fei Wang, Jie Feng, Jiwei Bai, Peng Zhao, Lei Cao, Songbai Gui, Lei Gong, Yazhuo Zhang View Abstract ❯

Mechanism analysis of colorectal cancer according to the microRNA expression profile Hong Li, Huichao Zhang, Gang Lu, Qingjing Li, Jifeng Gu, Yuan Song, Shejun Gao, Yawen Ding View Abstract ❯

Antitumor effects of the hyaluronan inhibitor 4-methylumbelliferone on pancreatic cancer Eri Yoshida, Daisuke Kudo, Hayato Nagase, Hiroshi Shimoda, Shinichiro Suto, Mika Negishi, Ikuko Kakizaki, Masahiko Endo, Kenichi Hakamada View Abstract ❯

Celecoxib exhibits an anti‑gastric cancer effect by targeting focal adhesion and leukocyte transendothelial migration‑associated genes Guo‑Hua Jin, Wei Xu, Yang Shi, Li‑Bo Wang View Abstract ❯

Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion Friederike Hoellen, Annika Waldmann, Constanze Banz‑Jansen, Achim Rody, Maria Heide, Frank Köster, Julika Ribbat‑Idel, Christoph Thorns, Maximilian Gebhard, Martina Oberländer, Jens Habermann, Marc Thill View Abstract ❯

High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer Xiangxiang Zheng, Haibo Hu, Shiting Li View Abstract ❯

Combined use of free light chain and heavy/light chain ratios allow diagnosis and monitoring of patients with monoclonal gammopathies: Experience of a single institute, with three exemplar case reports Alfredo Gagliardi, Claudio Carbone, Angela Russo, Rosanna Cuccurullo, Anna Lucania, Paola Cioppa, Gabriella Misso, Michele Caraglia, Catello Tommasino, Lucia Mastrullo View Abstract ❯

Caveolin‑1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters Xuening Zhao, Gang Yu, Xuemin Yu, Juan Wang, Xinliang Pan View Abstract ❯

Identification of genes involved in Epstein‑Barr virus‑associated nasopharyngeal carcinoma Junguo Wang, Fang Mei, Xia Gao, Shoulin Wang View Abstract ❯

Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer Jing Zhang, Kundong Zhang, Lisheng Zhou, Weidong Wu, Tao Jiang, Jun Cao, Kejian Huang, Zhengjun Qiu, Chen Huang View Abstract ❯

Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels Giovanni Barillari, Clelia Palladino, Ilaria Bacigalupo, Patrizia Leone, Mario Falchi, Barbara Ensoli View Abstract ❯

Genetic landscape of a case of extraovarian peritoneal serous papillary carcinoma Zhongping Cheng, Weihong Yang, Jing Guo, Ning Luo, Li Chen, Yan Xie, Xiaoyan Qu, Liping Hu, Hong Dai, Xiaoming Zuo View Abstract ❯

Matrix metalloproteinase expression and molecular interaction network analysis in gastric cancer Jianting Xu, Changyong E, Yongfang Yao, Shuangchun Ren, Guoqing Wang, Haofan Jin View Abstract ❯

SREBP‑1 is an independent prognostic marker and promotes invasion and migration in breast cancer Jisheng Bao, Liping Zhu, Qi Zhu, Jianhua Su, Menglan Liu, Wei Huang View Abstract ❯

Negative pathology of ureteral carcinoma significantly delaying the diagnosis of the primary tumor of osteoblastic metastases: A case report and review of the literature Ya‑Lan Wu, Yong‑Mei Liu, Hui‑Jiao Chen, Yong‑Sheng Wang, You Lu View Abstract ❯

Increase of T and B cells and altered BACH2 expression patterns in bone marrow trephines of imatinib‑treated patients with chronic myelogenous leukaemia Maximilian Von Laffert, Mathias Hänel, Manfred Dietel, Ioannis Anagnostopoulos, Korinna Jöhrens View Abstract ❯

Expression and prognostic significance of CTBP2 in human gliomas Yong Wang, Shusheng Che, Gang Cai, Yuchao He, Jialei Chen, Wei Xu View Abstract ❯

Association between SET expression and glioblastoma cell apoptosis and proliferation Kunyan He, Lihong Shi, Tingting Jiang, Qiang Li, Yao Chen, Chuan Meng View Abstract ❯

Expression of FoxM1 and the EMT-associated protein E‑cadherin in gastric cancer and its clinical significance Jing Zhang, Xiao‑Yu Chen, Ke‑Jian Huang, Wei‑Dong Wu, Tao Jiang, Jun Cao, Li‑Sheng Zhou, Zheng‑Jun Qiu, Chen Huang View Abstract ❯

Ultrasonic features of papillary thyroid microcarcinoma coexisting with a thyroid abnormality Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang View Abstract ❯

Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene Xiaofeng Wang, Lu Chen, Zhongdi Xiao, Yali Wang, Tiemei Liu, Tianfu Zhang, Yucheng Zhang View Abstract ❯

Effect of API‑1 and FR180204 on cell proliferation and apoptosis in human DLD‑1 and LoVo colorectal cancer cells Atiye Saglam, Ebru Alp, Zubeyir Elmazoglu, Emine Menevse View Abstract ❯

Clinical analysis of 47 cases of solitary fibrous tumor Wei Ge, De‑Cai Yu, Gang Chen, Yi‑Tao Ding View Abstract ❯

Evaluation of automated breast volume scanner for breast conservation surgery in ductal carcinoma in situ Anqian Huang, Luoxi Zhu, Yanjuan Tan, Jian Liu, Jingjing Xiang, Qingqing Zhu, Lingyun Bao View Abstract ❯

Stem cell growth factor receptor in canine vs. feline osteosarcomas Birgitt Wolfesberger, Andrea Fuchs‑Baumgartinger, Juraj Hlavaty, Florian Meyer, Martin Hofer, Ralf Steinborn, Christiane Gebhard, Ingrid Walter View Abstract ❯

The HIV‑protease inhibitor saquinavir reduces proliferation, invasion and clonogenicity in cervical cancer cell lines Elisabetta Bandiera, Paola Todeschini, Chiara Romani, Laura Zanotti, Eugenio Erba, Benedetta Colmegna, Eliana Bignotti, Alessandro Santin, Enrico Sartori, Franco Odicino, Sergio Pecorelli, Renata Tassi, Antonella Ravaggi View Abstract ❯

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer Xiao-Ming Shen, You-You Xia, Lian Lian, Chong Zhou, Xiang-Li Li, Shu-Guang Han, Yan Zheng, Fei-Ran Gong, Min Tao, Zhong-Qi Mao, Wei Li View Abstract ❯

Significance of stem cell marker Nanog gene in the diagnosis and prognosis of lung cancer Zeng Liu, Jing Zhang, Honggang Kang, Guiming Sun, Baozhong Wang, Yanwen Wang, Mengxiang Yang View Abstract ❯

Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy Yongqiang Zhan, Lisha Mou, Kangwen Cheng, Chengyou Wang, Xuesong Deng, Junren Chen, Zhibing Fan, Yong Ni View Abstract ❯

Comparison of the accuracy of 99mTc‑3P4‑RGD2 SPECT and CT in diagnosing solitary pulmonary nodules Haishan Zhang, Shi Gao, Bin Chen, Guanghui Cheng View Abstract ❯

Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma Lei Deng, Pengju Xiong, Yunhui Luo, Xiao Bu, Suokai Qian, Wuzhao Zhong View Abstract ❯

miRNA‑335 and miRNA‑182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin Deming Ou, Ying Wu, Jun Liu, Xiaomei Lao, Sien Zhang, Guiqing Liao View Abstract ❯

miR‑101 inhibits glioma cell invasion via the downregulation of COX‑2 Chunyang Ma, Chuanyi Zheng, Enqi Bai, Kun Yang View Abstract ❯

Glioma coexisting with angiographically occult cerebrovascular malformation: A case report Junhui Chen, Lei Chen, Chunlei Zhang, Jianqing He, Peipei Li, Jingxu Zhou, Jun Zhu, Yuhai Wang View Abstract ❯

Effects of ZNF139 on gastric cancer cells and mice with gastric tumors Hong‑Feng Nie, Yong Li, Zhen‑Xing Li, Ji‑Xing Mu, Jin‑Sheng Wang View Abstract ❯

Prognostic significance of CD168 overexpression in colorectal cancer Ke Wang, Tao Zhang View Abstract ❯

Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells Tomohiko Fukuda, Katsutoshi Oda, Osamu Wada‑Hiraike, Kenbun Sone, Kanako Inaba, Yuji Ikeda, Chinami Makii, Aki Miyasaka, Tomoko Kashiyama, Michihiro Tanikawa, Takahide Arimoto, Tetsu Yano, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii View Abstract ❯

MicroRNA-486-5p enhances hepatocellular carcinoma tumor suppression through repression of IGF-1R and its downstream mTOR, STAT3 and c-Myc Rana Youness, Hend El-Tayebi, Reem Assal, Karim Hosny, Gamal Esmat, Ahmed Abdelaziz View Abstract ❯

17AAG‑induced internalisation of HER2‑specific Affibody molecules Lovisa Göstring, Sture Lindegren, Lars Gedda View Abstract ❯

Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomide Thais Sales, Fernando Resende, Natália Chaves, Simoneide Titze-De-Almeida, Sônia Báo, Marcella Brettas, Ricardo Titze‑De‑Almeida View Abstract ❯

Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients Katarina Kalavska, Michal Chovanec, Miriam Zatovicova, Martina Takacova, Paulina Gronesova, Daniela Svetlovska, Magdalena Baratova, Vera Miskovska, Jana Obertova, Patrik Palacka, Jan Rajec, Zuzana Sycova‑Mila, Zuzana Cierna, Karol Kajo, Stanislav Spanik, Pavel Babal, Jozef Mardiak, Silvia Pastorekova, Michal Mego View Abstract ❯

Cisplatin‑resistant osteosarcoma cells possess cancer stem cell properties in a mouse model Jian Yang, Weichun Guo, Lu Wang, Ling Yu, Hongjun Mei, Shuo Fang, Peng Ji, Yang Liu, Gaiwei Liu, Qi Song View Abstract ❯

Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer Qingyu Shi, Tong Liu, Xianyu Zhang, Jingshu Geng, Xiaohui He, Ming Nu, Da Pang View Abstract ❯

Methylation pattern of CDH1 promoter and its association with CDH1 gene expression in cytological cervical specimens Veronika Holubeková, Andrea Mendelová, Marián Grendár, Sandra Meršaková, Ivana Kapustová, Karin Jašek, Andrea Vaňochová, Jan Danko, Zora Lasabová View Abstract ❯

Cerebellar hemangioblastoma mimicking an aneurysm: A case report and literature review Yu‑Chen Ji, Yan Li, Jing‑Xia Hu, Hong‑Bo Zhang, Peng‑Xiang Yan, Huan‑Cong Zuo View Abstract ❯

Co‑evolution of tumor‑associated macrophages and tumor neo‑vessels during cervical cancer invasion Shuting Jiang, Yuehong Yang, Min Fang, Xianglang Li, Xiuxue Yuan, Jingping Yuan View Abstract ❯

Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF‑κB signaling in murine breast cancer cells Ying Xu, Dongming Wu, Yuanchun Fan, Peigeng Li, Hongfei Du, Jiao Shi, Dan Wang, Xiaoping Zhou View Abstract ❯

Ki‑67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells Yanxia Bai, Yuan Shao, Huajing Li, Wanli Xue, Fang Quan, Shengli Wu View Abstract ❯

BCAT1 promotes tumor cell migration and invasion in hepatocellular carcinoma Meng Xu, Qingquan Liu, Yuli Jia, Kangsheng Tu, Yingmin Yao, Qingguang Liu, Cheng Guo View Abstract ❯

Genetic analysis and clinical investigation of a pedigree with multiple endocrine neoplasia type 2A: A case report Hong‑Jin Zou, Yu‑Shu Li, Zhong‑Yan Shan View Abstract ❯

Perioperative stroke in a patient undergoing surgery for oral cancer: A case report Shintaro Sukegawa, Takahiro Kanno, Kengo Kanai, Toshiko Mandai, Akane Shibata, Yuka Takahashi, Yuji Hirata, Yoshihiko Furuki View Abstract ❯

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis Hong Chen, Jingjing Wang, Hong Yang, Dan Chen, Panpan Li View Abstract ❯

SPAG9 is overexpressed in osteosarcoma, and regulates cell proliferation and invasion through regulation of JunD Chi Xiao, Lin Fu, Chongnan Yan, Fenyong Shou, Qi Liu, Lei Li, Shaoqian Cui, Jingzhu Duan, Guoxin Jin, Jianhua Chen, Yuanming Bian, Xu Wang, Huan Wang View Abstract ❯

Tazarotene‑induced gene 2 is associated with poor survival in non‑small cell lung cancer Qi Cai, Zhongwei Huang, Lei Qi, Ting Wang, Yanbo Shen, Jian'an Huang View Abstract ❯

Functional redundancy of the Notch pathway in ovarian cancer cell lines Fernanda Silva, Ana Félix, Jacinta Serpa View Abstract ❯

Primitive neuroectodermal tumor originating from the lung: A case report Xin Jin, Jianfeng Cao, Yong Liu, Fang Bian, Qingqing Zhao, Yan Wang, Xu Lv, Yayong Huang View Abstract ❯

Multidisciplinary collaboration in gallbladder carcinoma treatment: A case report and literature review Zheng‑Yun Zou, Jing Yan, Yu‑Zheng Zhuge, Jun Chen, Xiao‑Ping Qian, Bao‑Rui Liu View Abstract ❯

V8 induces apoptosis and the endoplasmic reticulum stress response in human multiple myeloma RPMI 8226 cells via the PERK‑eIF2α‑ATF4 signaling pathway Yaping Zhong, Yonggang Zhang, Ping Wang, Hongxiu Gao, Chunling Xu, Hui Li View Abstract ❯

Expression of early growth response gene‑1 in precancerous lesions of gastric cancer Seon‑Young Park, Ji‑Young Kim, Su‑Mi Lee, Jin Chung, Kyung‑Hwa Lee, Chung‑Hwan Jun, Chang‑Hwan Park, Hyun‑Soo Kim, Sung‑Kyu Choi, Jong‑Sun Rew, Young‑Do Jung, Yong Lee View Abstract ❯

Paraneoplastic Morvan's syndrome following surgical treatment of recurrent thymoma: A case report Edvina Galié, Rosaria Renna, Domenico Plantone, Andrea Pace, Mirella Marino, Bruno Jandolo, Tatiana Koudriavtseva View Abstract ❯

Molecular expression of vascular endothelial growth factor, prokineticin receptor‑1 and other biomarkers in infiltrating canalicular carcinoma of the breast Angélica Morales, Sumiko Morimoto, Felipe Vilchis, Natsuko Taniyama, Claudia Bautista, Carlos Robles, Enrique Bargalló View Abstract ❯

Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer Min Jang, Hyun Kang, Ki Jang, Seung Paik, Wan Kim View Abstract ❯

Fluorescence in situ hybridization testing of chromosomes 6, 8, 9 and 11 in melanocytic tumors is difficult to automate and reveals tumor heterogeneity in melanomas Arnaud Uguen, Marie Uguen, Matthieu Talagas, Eric Gobin, Pascale Marcorelles, Marc De Braekeleer View Abstract ❯

Killian‑Jamieson diverticulum mimicking a calcified thyroid nodule on ultrasonography: A case report and literature review Li Cao, Junna Ge, Donghui Zhao, Shangtong Lei View Abstract ❯

Novel dynamin 2 mutations in adult T‑cell acute lymphoblastic leukemia Zheng Ge, Min Li, Gang Zhao, Lichan Xiao, Yan Gu, Xilian Zhou, Michael Yu, Jianyong Li, Sinisa Dovat, Chunhua Song View Abstract ❯

ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan Hoang Tuy, Hisanori Shiomi, Ken Mukaisho, Shigeyuki Naka, Tomoharu Shimizu, Hiromichi Sonoda, Eiji Mekata, Yoshihiro Endo, Yoshimasa Kurumi, Hiroyuki Sugihara, Masaji Tani, Tohru Tani View Abstract ❯

Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway Wen Zheng, Shiliu Lu, Haolei Cai, Muxing Kang, Wenjie Qin, Chao Li, Yulian Wu View Abstract ❯

Misdiagnosed infantile rhabdomyofibrosarcoma: A case report Tao Pan, Ken Chen, Run‑Song Jiang, Zheng‑Yan Zhao View Abstract ❯

Aneurysmal bone cyst of the metatarsal: A case report Jiangyinzi Shang, Runsheng Guo, Ping Zhan, Chuwen Chen, Jing Kan, Hucheng Liu, Min Dai View Abstract ❯

Primary gastrointestinal stromal tumor of the liver: A case report and review of the literature Xiaobin Cheng, Dong Chen, Wenbin Chen, Qinsong Sheng View Abstract ❯

Immunohistochemical patterns in the differential diagnosis of rhinopharyngeal granulocytic sarcoma Elena Cantone, Michele Cavaliere, Antonella Di Lullo, Elia Guadagno, Maurizio Iengo View Abstract ❯

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B‑cell lymphoma from high and low endemic infectious disease regions Therese Högfeldt, Crystal Jaing, Kevin Mc Loughlin, James Thissen, Shea Gardner, Abeer Bahnassy, Baback Gharizadeh, Joachim Lundahl, Anders Österborg, Anna Porwit, Abdel‑Rahman Zekri, Hussein Khaled, Håkan Mellstedt, Ali Moshfegh View Abstract ❯

Iodine‑125 irradiation inhibits invasion of gastric cancer cells by reactivating microRNA‑181c expression Yong Yang, Zhen‑Huan Ma, Xiao‑Gang Li, Wan‑Fu Zhang, Jia Wan, Ling‑Juan Du, Guo‑Jian Li, Guo‑Kai Yang, Ping Lu View Abstract ❯

Leucine zipper, down regulated in cancer‑1 gene expression in prostate cancer Michele Salemi, Nunziata Barone, Sandro La Vignera, Rosita Condorelli, Domenico Recupero, Antonio Galia, Filippo Fraggetta, Anna Aiello, Pietro Pepe, Roberto Castiglione, Enzo Vicari, Aldo Calogero View Abstract ❯

IgM multiple myeloma with an extremely rare non‑aggressive presentation: A case report Thomas Greuter, Martin Browne, Corina Dommann‑Scherrer, Daniel Binder, Christoph Renner, Ursula Kapp View Abstract ❯

Aspirin may inhibit angiogenesis and induce autophagy by inhibiting mTOR signaling pathway in murine hepatocarcinoma and sarcoma models Qianqian Zhao, Zhaopeng Wang, Zhaoxia Wang, Licun Wu, Weidong Zhang View Abstract ❯

Promoter methylation and downregulated expression of the TBX15 gene in ovarian carcinoma Gaia Gozzi, Sonia Chelbi, Paola Manni, Loredana Alberti, Sergio Fonda, Sara Saponaro, Luca Fabbiani, Francesco Rivasi, Jean Benhattar, Lorena Losi View Abstract ❯

Soluble purified recombinant C2ORF40 protein inhibits tumor cell growth in vivo by decreasing telomerase activity in esophageal squamous cell carcinoma Linwei Li, Xiaoyan Li, Wenyu Wang, Tianhui Gao, Yun Zhou, Shixin Lu View Abstract ❯

Rapid increase in cystic volume of an anaplastic astrocytoma misdiagnosed as neurocysticercosis: A case report Hong‑Jiang Li, Hong‑Xiu Han, Dong‑Fu Feng View Abstract ❯

4‑isothiocyanate‑2, 2, 6, 6‑tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation Yuanyuan Liu, Jing Gao, Shuangsheng Huang, Lamei Hu, Zhiqiang Wang, Zheyuan Wang, Xiao Chen, Xiaoyu Zhang, Wenguang Li View Abstract ❯

Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring Jie Zhang, Cai Liu, Yun Wan, Li Peng, Wen Li, Jia Qiu View Abstract ❯

Thymoquinone chemosensitizes colon cancer cells through inhibition of NF‑κB Lida Zhang, Yangqiu Bai, Yuxiu Yang View Abstract ❯

RNA‑seq analysis identifies key long non‑coding RNAs connected to the pathogenesis of alcohol‑associated head and neck squamous cell carcinoma Vicky Yu, Pranav Singh, Elham Rahimy, Hao Zheng, Selena Kuo, Elizabeth Kim, Jessica Wang‑Rodriguez, Weg Ongkeko View Abstract ❯

Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker Nadja Apelt, Jochen Hubertus, Doris Mayr, Norbert Graf, Rhoikos Furtwängler, Dietrich Von Schweinitz, Roland Kappler View Abstract ❯

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma Jieyu Wang, Nan Jia, Qing Li, Chao Wang, Xiang Tao, Keqin Hua, Weiwei Feng View Abstract ❯

Radial forearm and forehead flap reconstruction following resection of a nasal arteriovenous malformation: A case report Chih‑Shin Lin, Yung‑Song Lin, Bor‑Shyh Lin, Ching‑Feng Lien, Ching‑Feng Liu View Abstract ❯

Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder Tuba Avcilar, Deniz Kirac, Deniz Ergec, Gulsah Koc, Korkut Ulucan, Zehra Kaya, Elif Kaspar, Levent Turkeri, Ahmet Guney View Abstract ❯

Anti‑cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin‑1 in prostate cancer Wen‑Tao Gai, Da‑Peng Yu, Xin‑Sheng Wang, Pei‑Tao Wang View Abstract ❯

Side population cells from long-term passage non-small cell lung cancer cells display loss of cancer stem cell-like properties and chemoradioresistance Hao Gu, Xin‑Yu Wu, Rui‑Tai Fan, Xin Wang, You‑Zhong Guo, Rui Wang View Abstract ❯

Eupatilin induces human renal cancer cell apoptosis via ROS‑mediated MAPK and PI3K/AKT signaling pathways Wei‑Feng Zhong, Xiao‑Hong Wang, Bin Pan, Feng Li, Lu Kuang, Ze‑Xuan Su View Abstract ❯

Inhibition of γ‑secretase activity synergistically enhances tumour necrosis factor‑related apoptosis‑inducing ligand induced apoptosis in T‑cell acute lymphoblastic leukemia cells via upregulation of death receptor 5 Lisa Greene, Seema Nathwani, Daniela Zisterer View Abstract ❯

Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1 Deyao Wu, Xiaobing Niu, Huixing Pan, Yunfeng Zhou, Zichun Zhang, Ping Qu, Jian Zhou View Abstract ❯

A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli‑mediated transcription in pancreatic cancer cells Hwa Lee, Qian Wu, Hua Li, Gyu‑Un Bae, An Kim, Jae‑Ha Ryu View Abstract ❯

Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells Sheng Hu, Qiang Zhou, Wan‑Rui Wu, Yi‑Xing Duan, Zhi‑Yong Gao, Yuan‑Wei Li, Qiang Lu View Abstract ❯

Rescuing defective tumor‑infiltrating T‑cell proliferation in glioblastoma patients Song Han, Enlong Ma, Xiaonan Wang, Chunyong Yu, Tao Dong, Wen Zhan, Xuezhong Wei, Guobiao Liang, Sizhe Feng View Abstract ❯

Impact of intense systemic therapy and improved survival on the use of palliative radiotherapy in patients with bone metastases from prostate cancer Carsten Nieder, Ellinor Haukland, Bård Mannsåker, Jan Norum View Abstract ❯

Metastatic extraskeletal Ewing's sarcoma treated with trabectedin: A case report Jorge Hernando‑Cubero, Pilar Sanz‑Moncasi, Alba Hernández‑García, Isabel Pajares‑Bernard, Javier Martínez‑Trufero View Abstract ❯

Contrary melanoma‑associated antigen‑A expression at the tumor front and center: A comparative analysis of stage I and IV head and neck squamous cell carcinoma Stefan Hartmann, Muna Brisam, Stephan Rauthe, Oliver Driemel, Roman Brands, Andreas Rosenwald, Alexander Kübler, Urs Müller‑Richter View Abstract ❯

Lithium chloride has a biphasic effect on prostate cancer stem cells and a proportional effect on midkine levels Mine Erguven, Gulperi Oktem, Ali Kara, Ayhan Bilir View Abstract ❯

Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma Tian‑Yun Shen, Li‑Li Mei, Yun‑Tan Qiu, Zhi‑Zhou Shi View Abstract ❯

Comparable roles of CD44v8‑10 and CD44s in the development of bone metastases in a mouse model Toru Hiraga, Hiroaki Nakamura View Abstract ❯

RANKL: A promising circulating marker for bone metastasis response Toni Ibrahim, Marianna Ricci, Emanuela Scarpi, Alberto Bongiovanni, Rossana Ricci, Nada Riva, Chiara Liverani, Alessandro De Vita, Federico La Manna, Devil Oboldi, Patrizia Serra, Flavia Foca, Lorenzo Cecconetto, Dino Amadori, Laura MercatalI View Abstract ❯

Programmed cell death 4 and BCR‑ABL fusion gene expression are negatively correlated in chronic myeloid leukemia Xia Zhang, Riming Liu, Baohua Huang, Xiaolu Zhang, Weijuan Yu, Cuixia Bao, Jie Li, Chengming Sun View Abstract ❯

Overlap of the cancer genome atlas and the immune epitope database Shaimaa Sait, Timothy Fawcett, George Blanck View Abstract ❯

Effects of Hedera helix L. extracts on rat prostate cancer cell proliferation and motility Hatice Gumushan‑Aktas, Seyhan Altun View Abstract ❯

miRNA regulation of Sirtuin‑1 expression in human astrocytoma Sara Romeo, Alfredo Conti, Francesca Polito, Chiara Tomasello, Valeria Barresi, Domenico La Torre, Maria Cucinotta, Flavio Angileri, Marcello Bartolotta, Rosa Di Giorgio, M'Hammed Aguennouz View Abstract ❯

TGFB2 and BCL2L11 methylation in male laryngeal cancer patients Zhisen Shen, Xiaoying Chen, Qun Li, Huadan Ye, Jinyun Li, Chongchang Zhou, Shiwei Duan View Abstract ❯

Quantitative detection of TUSC3 promoter methylation - a potential biomarker for prognosis in lung cancer Uta Duppel, Matthias Woenckhaus, Christian Schulz, Johannes Merk, Wolfgang Dietmaier View Abstract ❯

MMP-14 and TGFβ-1 methylation in pituitary adenomas Kornelija Ruskyte, Rasa Liutkevicienė, Alvita Vilkeviciute, Paulina Vaitkiene, Indre Valiulytė, Brigita Glebauskiene, Loresa Kriauciuniene, Dalia Zaliuniene View Abstract ❯

Atypical presentation of a gastric stromal tumor masquerading as a giant intraabdominal cyst: A case report Ke‑Kang Sun, Song Xu, Jinzhen Chen, Gang Liu, Xiaojun Shen, Xiaoyang Wu View Abstract ❯

miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells Fang Zheng, Jiahe Zhang, Siyu Luo, Jing Yi, Ping Wang, Quanqing Zheng, Yurong Wen View Abstract ❯

6-8 October, 2016, Metropolitan Hotel, Athens, Greece 21st World Congress on Advances in Oncology & 19th International Symposium on Molecular Medicine

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