Παρασκευή 6 Ιουλίου 2018
Impact of long-term androgen deprivation therapy on PSMA ligand PET/CT in patients with castration-sensitive prostate cancer
Abstract
Purpose
Since the introduction of PSMA PET/CT with 68Ga-PSMA-11, this modality for imaging prostate cancer (PC) has spread worldwide. Preclinical studies have demonstrated that short-term androgen deprivation therapy (ADT) can significantly increase PSMA expression on PC cells. Additionally, retrospective clinical data in large patient cohorts suggest a positive association between ongoing ADT and a pathological PSMA PET/CT scan. The present evaluation was conducted to further analyse the influence of long-term ADT on PSMA PET/CT findings.
Methods
A retrospective analysis was performed of all 1,704 patients who underwent a 68Ga-PSMA-11 PET/CT scan at our institution from 2011 to 2017 to detect PC. Of 306 patients scanned at least twice, 10 had started and continued ADT with a continuous clinical response between the two PSMA PET/CT scans. These ten patients were included in the current analysis which compared the tracer uptake intensity and volume of PC lesions on PSMA PET/CT before and during ongoing ADT.
Results
Overall, 31 PC lesions were visible in all ten patients before initiation of ADT. However, during ongoing ADT (duration 42–369 days, median 230 days), only 14 lesions were visible in eight of the ten patients. The average tracer uptake values decreased in 71% and increased in 12.9% of the PC lesions. Of all lesions, 33.3% were still visible in six patients with a complete PSA response (≤0.1 ng/ml).
Conclusion
Continuous long-term ADT significantly reduces the visibility of castration-sensitive PC on PSMA PET/CT. If the objective is visualization of the maximum possible extent of disease, we recommend referring patients for PSMA PET/CT before starting ADT.
https://ift.tt/2J1G0aN
Probabilistic electrical stimulation mapping of human medial frontal cortex
Publication date: Available online 6 July 2018
Source: Cortex
Author(s): Gianluca Trevisi, Simon B. Eickhoff, Fahmida Chowdhury, Ashwani Jha, Roman Rodionov, Mark Nowell, Anna Miserocchi, Andrew W. McEvoy, Parashkev Nachev, Beate Diehl
Abstract
The medial frontal cortex remains functionally ill-understood; this is reflected by the heterogeneity of behavioural outcomes following damage to the region. We aim to use the rich information provided by extraoperative direct electrical cortical stimulation to enhance our understanding of its functional anatomy.
Examining a cohort of 38 epilepsy patients undergoing direct electrical cortical stimulation in the context of presurgical evaluation, we reviewed stimulation findings and classified them in a behavioural framework (positive motor, negative motor, somatosensory, speech disturbances, and "other"). The spatially discrete cortical stimulation-derived data points were then transformed into continuous probabilistic maps, thereby enabling the voxel-wise spatial inference widely used in the analysis of functional and structural imaging data.
A functional map of stimulation findings of the medial wall emerged. Positive motor responses occurred in 141 stimulations (31.2%), anatomically located on the paracentral lobule (threshold at p<0.05), extending no further than the vertical anterior commissure (VCA) line. Thirty negative motor responses were observed (6.6%), localised to the VCA line (at p<0.001 uncorrected).In 43 stimulations (9.5%) a somatosensory response localised to the caudal cingulate zone (at p<0.001 uncorrected), with a second region posterior to central sulcus. Speech disturbances were elicited in 38 stimulations (8.4%), more commonly but not exclusively from the language fMRI dominant side, just anterior to VCA (p<0.001 uncorrected). In only 2 stimulations, the patient experienced a subjective "urge" to move in the absence of overt movement.
Classifying motor behaviour along the dimensions of effector, and movement vs arrest, we derive a wholly data-driven stimulation map of the medial wall, powered by the largest number of stimulations of the region reported (n=452) in patients imaged with MRI. This model and the underlying data provide a robust framework for understanding the architecture of the region through the joint analysis of disruptive and correlative anatomical maps.
https://ift.tt/2tYIi5O
Scholar : These new articles for Archives and Manuscripts are available online
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JSID's Fellowship Shiseido Research Grant
Publication date: August 2018
Source: Journal of Dermatological Science, Volume 91, Issue 2
Author(s):
https://ift.tt/2KVVv5R
The Editor's Choice
Publication date: August 2018
Source: Journal of Dermatological Science, Volume 91, Issue 2
Author(s):
https://ift.tt/2NwQfXX
Editorial board
Publication date: August 2018
Source: Journal of Dermatological Science, Volume 91, Issue 2
Author(s):
https://ift.tt/2J5788K
Intraperitoneal sodium metavanadate exposure induced severe clinicopathological alterations, hepato-renal toxicity and cytogenotoxicity in African giant rats ( Cricetomys gambianus , Waterhouse, 1840)
Abstract
Pollution of environment due to increased exploitation of minerals has been on the rise, and vanadium, a metal in the first transition series essential for mammalian existence, is a major component of air pollution. This study investigated the clinico-pathological, hepato-renal toxicity, and cytogenotoxicity of intraperitoneal exposure of African giant rats (AGRs), a proposed model for ecotoxicological research to sodium metavanadate. A total of 27 adult male African giant rats weighing 975 ± 54.10 g were distributed into two major groups: sodium metavanadate (SMV) treated and control. They were observed daily for clinical signs of toxicity. Four rats from each group were randomly collected and sacrificed after 3, 7, and 14 days of SMV treatment. Liver, kidney, and bone marrow were analyzed for histopathology and micronucleated normochromated and polychromated erythrocytes (MNNCE and MNPCE), respectively. Clinical signs in treated AGR include sluggish and weak movements, un-groomed fur, and labored breathing. Histology of the kidney revealed severe glomerular atrophy, tubular ectasia, and vacuolar degeneration of tubular epithelium, while liver histology showed sinusoidal congestion and severe hepatocellular necrosis after 14 days SMV exposure. Also, MNNCE and MNPCE significantly increased with a decrease in PCE/NCE ratio in SMV-treated AGR, suggestive of alternations in bone marrow cell proliferation. Hence, SMV treatment to AGR resulted to severe clinicopathologic alterations, kidney, and liver dysfunction and cytogenotoxicity evident by somatic mutation induction which could be severe with prolonged exposure. This suggests African giant rat as an ecotoxicological model to measure major health risks to animals and human populations in highly polluted environment.
https://ift.tt/2MXI8mu
Scholar : Behaviour & Information Technology, Volume 37, Issue 8, August 2018 is now available online on Taylor & Francis Online
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Scholar : These new articles for Critical Discourse Studies are available online
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Status, sources and contamination levels of organochlorine pesticide residues in urban and agricultural areas: a preliminary review in central–southern Italian soils
Abstract
Organochlorine pesticides (OCPs) are synthetic chemicals commonly used in agricultural activities to kill pests and are persistent organic pollutants (POPs). They can be detected in different environmental media, but soil is considered an important reservoir due to its retention capacity. Many different types of OCPs exist, which can have different origins and pathways in the environment. It is therefore important to study their distribution and behaviour in the environment, starting to build a picture of the potential human health risk in different contexts. This study aimed at investigating the regional distribution, possible sources and contamination levels of 24 OCP compounds in urban and rural soils from central and southern Italy. One hundred and forty-eight topsoil samples (0–20 cm top layer) from 78 urban and 70 rural areas in 11 administrative regions were collected and analysed by gas chromatography–electron capture detector (GC–ECD). Total OCP residues in soils ranged from nd (no detected) to 1043 ng/g with a mean of 29.91 ng/g and from nd to 1914 ng/g with a mean of 60.16 ng/g in urban and rural area, respectively. Endosulfan was the prevailing OCP in urban areas, followed by DDTs, Drins, Methoxychlor, HCHs, Chlordane-related compounds and HCB. In rural areas, the order of concentrations was Drins > DDTs > Methoxychlor > Endosulfans > HCHs > Chlordanes > HCB. Diagnostic ratios and robust multivariate analyses revealed that DDT in soils could be related to historical application, whilst (illegal) use of technical DDT or dicofol may still occur in some urban areas. HCH residues could be related to both historical use and recent application, whilst there was evidence that modest (yet significant) application of commercial technical HCH may still be happening in urban areas. Drins and Chlordane compounds appeared to be mostly related to historical application, whilst Endosulfan presented a complex mix of results, indicating mainly historical origin in rural areas as well as potential recent applications on urban areas. Contamination levels were quantified by Soil Quality Index (SoQI), identifying high levels in rural areas of Campania and Apulia, possibly due to the intensive nature of some agricultural practices in those regions (e.g., vineyards and olive plantations). The results from this study (which is in progress in the remaining regions of Italy) will provide an invaluable baseline for OCP distribution in Italy and a powerful argument for follow-up studies in contaminated areas. It is also hoped that similar studies will eventually constitute enough evidence to push towards an institutional response for more adequate regulation as well as a full ratification of the Stockholm Convention.
https://ift.tt/2IZIczE
Novel Bacillus cereus strain from electrokinetically remediated saline soil towards the remediation of crude oil
Abstract
A new strain SWH-15 was successfully isolated after initial electrokinetic remediation experiment using the same saline soil sampled from Shengli Oilfield, China. Four methods (morphological and biochemical characteristics, whole-cell fatty acid methyl esters (FAMEs) analysis, 16S rRNA sequence analysis and DNA G + C content and DNA–DNA hybridization analysis) were used to identify the taxonomic status of SWH-15 and confirmed that SWH-15 was a novel species of the Bacillus (B.) cereus group. Then, we assessed the degrading ability of the novel strain SWH-15 to crude oil through a microcosm experiment with four treatments, including control (CK), bioremediation using SWH-15 (Bio), electrokinetic remediation (EK), and combined bioremediation and electrokinetic remediation (Bio + EK). The results showed that the Bio + EK combined remediation treatment was more effective than the CK, Bio, and EK treatments in degrading crude oil contaminants. Bioaugmentation, by addition of the strain SWH-15 had synergistic effect with EK in Bio + EK treatment. Bacterial community analysis showed that electrokinetic remediation alone significantly altered the bacterial community of the saline soil. The addition of the strain SWH-15 alone had a weak effect on the bacterial community. However, the strain SWH-15 boosted the growth of other bacterial species in the metabolic network and weakened the impact of electrical field on the whole bacterial community structure in the Bio + EK treatment.
https://ift.tt/2uaIy13
Comparative study of the effect of Er:YAG and Er:Cr;YSGG lasers on porcelain: etching for the bonding of orthodontic brackets
Abstract
This study investigated the effect of Er:YAG (smart 2940 Dplus, DEKA, Italy) and Er:CrYSGG (Waterlase iPlus, Biolase, USA) lasers on the shear bond strength (SBS) between the orthodontic brackets and dental porcelain in comparison with conventional acid etching with 9% hydrofluoric acid (HF, Ultradent, USA). A total of 60 specimens of maxillary incisor crown were prepared and randomly assigned to five groups; each group was subjected to a different porcelain surface conditioning: (1) etching with the 9% HF for 2 min; (2) etching with the 9% HF for 2 min followed by irradiation with the Er:CrYSGG laser (3-W power, 10-Hz frequency for 10 s); (3) etching with the 9% HF for 2 min followed by irradiation with the Er:YAG laser (3-W power, 10-Hz frequency for 10 s); (4) Irradiation with the Er:CrYSGG laser (3-W power, 10-Hz frequency for 10 s without acid etching) and (5) irradiation with the Er:YAG laser (3-W power,10-Hz frequency for 10 s without acid etching). After using Transbond XT primer and Transbond XT adhesive, the metal brackets (Dentaurum, Germany equilibrium 2, optimal design) bonded to the conditioned porcelain surface. Subsequently, the specimens were thermocycled for 5000 cycles and then debonded using the Universal Testing Machine (Zwick). In each group, one specimen was not bonded to brackets to allow further examination with electron microscopy. After debonding, the specimens were examined by stereomicroscope to determine their adhesive remnant index (ARI). The average SBS [Mean (SD)] values in the five groups were as follows: HF (32.58 ± 9.21 MPa), Er:CrYSGG + HF (27.81 ± 7.66 MPa), Er:YAG + HF (23.08 ± 9.55 MPa), Er:CrYSGG (14.11 ± 9.35 MPa), and Er:YAG (6.30 ± 3.09 MPa). A statistically significant difference in SBS existed between the first three groups and the two laser groups (df = 4, F = 18.555, p < 0.001). Evaluation of ARI values showed that bond failures in the first three groups were mostly of cohesive and mixed types, but in the laser groups, they were mostly adhesive. Chi-square was not significant between groups (p = 0.219). The Er:YAG laser with the stated specifications is not a suitable alternative to HF etching. In the case of Er:CrYSGG laser, although the conditioning outcome met the bond strength requirement for orthodontic brackets (that is, 6–8 MPa). Therefore, the bond strength must be further improved by fine-tuning the irradiation details.
https://ift.tt/2zhnBqX
Effectiveness of low concentration of sodium hypochlorite activated by Er,Cr:YSGG laser against Enterococcus faecalis biofilm
Abstract
Bacteria living in biofilms exhibit altered growth phenotypes, while the biofilm provides benefits, the foremost of which is a certain protection against both immune system and killing effect by antimicrobials. Laser-activated irrigation (LAI) and passive ultrasonic irrigation (PUI) have been proposed as alternative methods for cleaning and disinfecting the root canal, as an adjuvant to conventional chemo-mechanical preparation in order to improve debridement and disinfection. Nevertheless, the potential antibacterial effect of LAI using 0.5% of sodium hypochlorite (NaOCl) has received little attention. Glass Pasteur pipettes were used to mimic single-tooth root canal and to build Enterococcus faecalis biofilm. Several irrigants and treatments were assayed for 60 s including (I) Saline, (II) NaOCl 0.5%, (III) NaOCl 5%, (IV) Er,Cr:YSGG, (V) Saline + LAI, (VI) NaOCl 0.5% + LAI, (VII) Saline + PUI, and (VIII) NaOCl 0.5% + PUI. Bacterial reduction was measured by counting the colony-forming units (CFUs). Additionally, AFM visualization and measurement of nano-roughness parameters were used to evaluate LAI effect on bacteria. NaOCl 5% unpowered and NaOCl 0.5% + LAI were capable of eliminating all bacteria, whereas non-activated saline solution and NaOCl 0.5% failed to eliminate E. faecalis. Lower efficiencies were achieved by PUI. Surface analysis by AFM revealed apparent alterations in NaOCl + LAI-treated cells. The Er,Cr:YSGG laser-activated irrigation (LAI) increased the bactericidal efficiency of 0.5% NaOCl against E. faecalis biofilm.
https://ift.tt/2KSu7sO
Effects of pasireotide treatment on coagulative profile: a prospective study in patients with Cushing’s disease
Abstract
Introduction
Cushing's disease (CD) is characterized by procoagulative profile. Treatment with cortisol-reducing medications might normalize the coagulation impairment potentially eliminating the risk of thromboembolic complications.
Aim
The aim of this prospective study is to evaluate the effectiveness of 6–12 months of treatment with pasireotide (Signifor®, Novartis) 600 µg twice daily on coagulative factors in 21 patients (16 females, mean age 46 ± 12.2 years) with CD. Biochemical, hormonal (urinary free cortisol, UFC; late night salivary cortisol, LNSC; ACTH) and coagulative parameters as Protrombin time (PT), aPTT, factors VIII, IX and XI, antithrombin III, protein C, protein S, fibrinogen, were evaluated at baseline and during therapy.
Results
UFC showed a significant reduction from baseline (3.2 ± 1.8 vs. 1.0 ± 0.8, p < 0.0001) with normalization in 13/21 (61.9%) and in 7/16 (43.8%) at 6 and 12 months, respectively. On the same way LNSC returned to normal in 5/11 at 6 months, showing a trend to reduction (8.6 ± 5 vs. 4.1 ± 2.9), even though without statistical significance (p = 0.07). Throughout the treatment period there was an increase in serum glycaemia (5.5 ± 2.3 vs. 6.8 ± 2.3 mmol/L, p = 0.09), with a concomitant significant increase in HbA1c after 6 months (40.7 ± 8.4 vs. 50.7 ± 12.3 mmol/mol, p = 0.006). Regarding coagulative parameters, no differences were found neither in clotting nor in anticoagulant factors during therapy. No patients developed thrombotic complication during treatment.
Conclusions
Pasireotide resulted an effective treatment in controlling hypercortisolism in more than half of CD patients with partial restoration also of circadian cortisol secretion. No significant improvements were observed on clotting factors; this fact might depend on persistence of typical alteration of CD, such as obesity and hypertension, and reflects also on the worsening in glucide metabolism induced by the drug. Clinical implications of persistent procoagulative impairment while on medical therapy should be considered.
https://ift.tt/2tYDDRq
To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma
Condition: Nasopharyngeal Carcinoma
Interventions: Drug: Danggui Buxue Tang; Drug: Placebo
Sponsor: China Medical University Hospital
Recruiting
https://ift.tt/2KVgoS9
Interventions: Drug: Danggui Buxue Tang; Drug: Placebo
Sponsor: China Medical University Hospital
Recruiting
https://ift.tt/2KVgoS9
Everolimus in Restoring Salivary Gland Function in Participants With Locally Advanced Head and Neck Cancer Treated With Radiation Therapy
Conditions: Salivary Gland Dysfunction; Xerostomia; Head and Neck Cancer
Interventions: Drug: Everolimus; Other: Laboratory Biomarker Analysis; Other: Survey Administration
Sponsors: University of Arizona; National Cancer Institute (NCI)
Recruiting
https://ift.tt/2MVsmbN
Interventions: Drug: Everolimus; Other: Laboratory Biomarker Analysis; Other: Survey Administration
Sponsors: University of Arizona; National Cancer Institute (NCI)
Recruiting
https://ift.tt/2MVsmbN
Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer
Condition: Esophagus
Interventions: Procedure: Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA); Procedure: Contrast-Enhanced Ultrasound; Procedure: Fine-Needle Aspiration; Drug: Sonazoid (Perflubutane)
Sponsors: Sidney Kimmel Cancer Center at Thomas Jefferson University; National Cancer Institute (NCI)
Not yet recruiting
https://ift.tt/2KEY6ow
Interventions: Procedure: Endoscopic Ultrasound-Guided Fine-Needle Aspiration (EUS-FNA); Procedure: Contrast-Enhanced Ultrasound; Procedure: Fine-Needle Aspiration; Drug: Sonazoid (Perflubutane)
Sponsors: Sidney Kimmel Cancer Center at Thomas Jefferson University; National Cancer Institute (NCI)
Not yet recruiting
https://ift.tt/2KEY6ow
Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer
Conditions: Esophageal Neoplasms; Squamous Cell Carcinoma; Concurrent Chemoradiotherapy
Interventions: Drug: Paclitaxel; Drug: Cisplatin; Drug: Fluorouracil; Radiation: chemoradiotherapy; Procedure: Ivor Lewis esophagogastrectomy
Sponsor: Mona Frolova
Recruiting
https://ift.tt/2MVRAq7
Interventions: Drug: Paclitaxel; Drug: Cisplatin; Drug: Fluorouracil; Radiation: chemoradiotherapy; Procedure: Ivor Lewis esophagogastrectomy
Sponsor: Mona Frolova
Recruiting
https://ift.tt/2MVRAq7
HPV-E6-Specific TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer
Conditions: Cervical Cancer; Head and Neck Squamous Cell Carcinoma
Intervention: Drug: HPV E6-specific TCR-T cells
Sponsors: Xinqiao Hospital of Chongqing; TCRCure Biotech Co., Ltd
Not yet recruiting
https://ift.tt/2KGssr6
Intervention: Drug: HPV E6-specific TCR-T cells
Sponsors: Xinqiao Hospital of Chongqing; TCRCure Biotech Co., Ltd
Not yet recruiting
https://ift.tt/2KGssr6
Antibiotics alter the window of competence for natural transformation in streptococci
Molecular Oral Microbiology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2u0lfHN
Neuroendocrine correlates of the critical day length response in the Soay sheep
Journal of Neuroendocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2uc5Raw
Abnormal irisin level in serum and endometrium is associated with metabolic dysfunction in polycystic ovary syndrome patients
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2KCHr5i
The Effect of Lithium on the Progression Free and Overall Survival in Patients with Metastatic Differentiated Thyroid Cancer Undergoing Radioactive Iodine Therapy
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2MQkN5U
Scholar : Asian Security, Volume 14, Issue 2, May-August 2018 is now available online on Taylor & Francis Online
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Extensive Clinical Experience: Hypothalamic‐Pituitary‐Adrenal Axis Recovery after Adrenalectomy for Corticotropin‐Independent Cortisol Excess
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2MSIpXG
The USP8 mutational status may predict long‐term remission in patients with Cushing′s disease
Clinical Endocrinology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2KDINwm
Response to ‘Considering the chemopreventive potential of nicotinamide in Gilmore's Bayesian analysis’
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2u0lgeJ
Pigmented purpura masquerading as acral melanoma
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2ubwBrJ
The effectiveness of combination therapy with 308‐nm excimer laser in vitiligo in Han Chinese People
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2NuFi9t
Vulvo‐vaginal lichen planus: A focussed review for the clinician
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2zdr5L9
Biting down on the truth: A case of a delayed hypersensitivity reaction to lidocaine
Australasian Journal of Dermatology, EarlyView.
https://ift.tt/2NwoTkL
Reflectance Confocal Microscopy Features of Melanomas on the Body and Non‐Glabrous Chronically Sun‐Damaged Skin
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2NwoPBG
Eruptive poromatosis in a patient with breast cancer
Journal of Cutaneous Pathology, EarlyView.
https://ift.tt/2IYm2h4
Pediatric CD8+/CD56+ mycosis fungoides with cytotoxic marker expression: a variant with indolent course
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2tZXAHz
p63 and smooth muscle actin expression in low grade spiradenocarcinomas in a case of CYLD cutaneous syndrome
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2KRdzhn
Hyperplastic sensory corpuscles in nevus sebaceous of labia minora pudendi. A case report
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2tZVyqN
Prevalence and clinicopathological characteristics of lipomatous neurofibromas in Neurofibromatosis 1: an investigation of 229 cutaneous neurofibromas and a systematic review of the literature
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2KQ8NAL
Giant Aneurysmal Benign Fibrous Histiocytoma (Dermatofibroma)
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2u0GRUt
A survey of Australian prosthodontists: the use of posts in endodontically treated teeth
Australian Dental Journal, EarlyView.
https://ift.tt/2uaOFlR
Dento‐maxillofacial Radiology in Australia and Dentist satisfaction with radiology reports
Australian Dental Journal, Volume 0, Issue ja, -Not available-.
https://ift.tt/2lWkoU7
Pregnancy, parity and periodontal disease
Australian Dental Journal, EarlyView.
https://ift.tt/2uaOzuv
Three patients with advanced cutaneous angiosarcoma treated with eribulin: investigation of serum soluble CD163 and chemokine (C‐X‐C motif) ligand 10 as possible biomarkers predicting the biological behaviour of angiosarcoma
British Journal of Dermatology, EarlyView.
https://ift.tt/2lWj83h
Prospective study in bullous pemphigoid: association of high serum anti‐BP180 IgG levels with increased mortality and reduced Karnofsky score
British Journal of Dermatology, EarlyView.
https://ift.tt/2u93RQj
A smartphone application supporting patients with psoriasis improves adherence to topical treatment: a randomized controlled trial
British Journal of Dermatology, EarlyView.
https://ift.tt/2lYFtNT
Does Lindioil (indirubin) treatment affect the composition of Malassezia species on psoriatic skin?
British Journal of Dermatology, EarlyView.
https://ift.tt/2zcp9Ck
A re‐audit of cervical screening uptake in a dermatology cohort on immunosuppressive medications
British Journal of Dermatology, EarlyView.
https://ift.tt/2lYYKif
A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process
British Journal of Dermatology, EarlyView.
https://ift.tt/2zcp4P2
Reduction in pain following treatment with ranolazine in primary erythromelalgia: a case report
British Journal of Dermatology, EarlyView.
https://ift.tt/2lVe53b
Lipidomics reveals skin surface lipid abnormity in acne in young men
British Journal of Dermatology, EarlyView.
https://ift.tt/2ubnMOL
SunSmart schools: a New Zealand skin cancer primary prevention intervention blueprint for primary school settings
British Journal of Dermatology, EarlyView.
https://ift.tt/2lYExsR
Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation
British Journal of Dermatology, EarlyView.
https://ift.tt/2u6Z16h
Safety of tildrakizumab for moderate‐to‐severe plaque psoriasis: pooled analysis of three randomized controlled trials
British Journal of Dermatology, EarlyView.
https://ift.tt/2lZCGny
Skin microbiome changes in patients with interdigital tinea pedis
British Journal of Dermatology, EarlyView.
https://ift.tt/2zgFEgJ
Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor‐γ agonist trifarotene
British Journal of Dermatology, EarlyView.
https://ift.tt/2lVp9NA
A traditional Chinese remedy points to a natural skin habitat: indirubin (indigo naturalis) for psoriasis and the Malassezia metabolome
British Journal of Dermatology, EarlyView.
https://ift.tt/2u72Fx5
‘Post‐finasteride syndrome’: what to tell our female patients?
British Journal of Dermatology, EarlyView.
https://ift.tt/2lX6AZF
Cardiovascular disease and atopic dermatitis: epidemiological strengths and limitations
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2ubnlnB
Atopic dermatitis: the skin barrier and beyond
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
https://ift.tt/2lZ2S1m
British Teledermatology Society
British Journal of Dermatology, Volume 179, Issue S1, Page 183-186, July 2018.
https://ift.tt/2ubndED
Author Index
British Journal of Dermatology, Volume 179, Issue S1, Page 212-217, July 2018.
https://ift.tt/2lWdzlx
Historical Abstracts
British Journal of Dermatology, Volume 179, Issue S1, Page 187-197, July 2018.
https://ift.tt/2zbiOqS
Clinical, dermoscopic and histopathological features of a rare cutaneous neural tumour
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KBGjii
Clinical, histological and high‐frequency ultrasonographic evaluation (50 MHz) of morphoea treated with ultraviolet A1 phototherapy
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KPVsbI
Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KBc7Um
Atypical variant of trigeminal trophic syndrome successfully treated with pregabalin: a case report series
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KUUUS6
Squamous cell carcinomas in linear epidermal naevi
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KythBY
The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KUV0Js
Diagnostic features of acquired dermal melanocytosis of the face and extremities
Clinical and Experimental Dermatology, EarlyView.
https://ift.tt/2KCGpWZ
Assessment of hepato-renal damage and genotoxicity induced by long-term exposure to five permitted food additives in rats
Abstract
The present study assessed the long-term daily administration of benzoic acid (BA), potassium sorbate (PS), chlorophyll (CPL), tartrazine (TAZ), and butylated hydroxyanisole (BHA) on hepato-renal changes and DNA damage in rats. Animals were orally administered with the 10 times of the acceptable daily intake (ADI) from each tested substance daily for 60 consecutive days. Blood, liver, and kidney samples were collected to evaluate hematological, biochemical, histopathological, and genotoxic alterations. The extent of liver and kidney damage was evaluated by comet assay and histopathologically. Significant reduction of leukocyte numbers and lymphocytes % in CPL- and TAZ-treated rats. However, significant increases in platelet count in all treated groups after 60 days were detected. The levels of serum transaminases enzymes (ALT, AST), alkaline phosphatase (ALP), and creatinine were significantly increased in all treatments except with BHA group, but no substantial differences were found in urea after 60 days. Aside from BHA, results of DNA damage revealed significant increases in tailed nuclei, tail moment, DNA% in the tail, and tail length in liver and kidney at different degrees. Moreover, the histopathological figures of liver and kidneys affirmed destructive and degenerative changes. The study indicates that most of the tested food additives may provoke genotoxicity and hepato-nephropathy, which could be serious for human health. Therefore, it is necessary to be informed about the hazardous effects of food additives and more attention should be focused towards using natural substitutes.
https://ift.tt/2KWkK8l
Fractional 532‐nm KTP diode laser and 595‐nm pulsed dye laser in treatment of facial telangiectatic erythema
Journal of Cosmetic Dermatology, EarlyView.
https://ift.tt/2KUqG4C
Cortical Neuron Migration and Dendrite Morphology are Regulated by Carboxypeptidase E
Abstract
Higher brain function relies on proper development of the cerebral cortex, including correct positioning of neurons and dendrite morphology. Disruptions in these processes may result in various neurocognitive disorders. Mutations in the CPE gene, which encodes carboxypeptidase E (CPE), have been linked to depression and intellectual disability. However, it remains unclear whether CPE is involved in early brain development and in turn contributes to the pathophysiology of neurocognitive disorders. Here, we investigate the effects of CPE knockdown on early brain development and explore the functional significance of the interaction between CPE and its binding partner p150Glued. We demonstrate that CPE is required for cortical neuron migration and dendrite arborization. Furthermore, we show that expression of CPE-C10 redistributes p150Glued from the centrosome and that disruption of CPE interaction with p150Glued leads to abnormal neuronal migration and dendrite morphology, suggesting that a complex between CPE and p150Glued is necessary for proper neurodevelopment.https://ift.tt/2lYSdUM
Sparse Labeling and Neural Tracing in Brain Circuits by STARS Strategy: Revealing Morphological Development of Type II Spiral Ganglion Neurons
Abstract
Elucidating axonal and dendritic projection patterns of individual neurons is a key for understanding the cytoarchitecture of neural circuits in the brain. This requires genetic approaches to achieve Golgi-like sparse labeling of desired types of neurons. Here, we explored a novel strategy of stochastic gene activation with regulated sparseness (STARS), in which the stochastic choice between 2 competing Cre-lox recombination events is controlled by varying the lox efficiency and cassette length. In a created STARS transgenic mouse crossed with various Cre driver lines, sparse neuronal labeling with a relatively uniform level of sparseness was achieved across different brain regions and cell types in both central and peripheral nervous systems. Tracing of individual type II peripheral auditory fibers revealed for the first time that they undergo experience-dependent developmental refinement, which is impaired by attenuating external sound input. Our results suggest that STARS strategy can be applied for circuit mapping and sparse gene manipulation.https://ift.tt/2NsUGDr
Neural Basis of Sensorimotor Plasticity in Speech Motor Adaptation
Abstract
When we speak, we get correlated sensory feedback from speech sounds and from the muscles and soft tissues of the vocal tract. Here we dissociate the contributions of auditory and somatosensory feedback to identify brain networks that underlie the somatic contribution to speech motor learning. The technique uses a robotic device that selectively alters somatosensory inputs in combination with resting-state fMRI scans that reveal learning-related changes in functional connectivity. A partial correlation analysis is used to identify connectivity changes that are not explained by the time course of activity in any other learning-related areas. This analysis revealed changes related to behavioral improvements in movement and separately, to changes in auditory perception: Speech motor adaptation itself was associated with connectivity changes that were primarily in non-motor areas of brain, specifically, to a strengthening of connectivity between auditory and somatosensory cortex and between presupplementary motor area and the inferior parietal lobule. In contrast, connectively changes associated with alterations to auditory perception were restricted to speech motor areas, specifically, primary motor cortex and inferior frontal gyrus. Overall, our findings show that during adaptation, somatosensory inputs result in a broad range of changes in connectivity in areas associated with speech motor control and learning.https://ift.tt/2u6oRr2
Neuronal Mechanisms Recording the Stream of Consciousness–A Reappraisal of Wilder Penfield’s (1891–1976) Concept of Experiential Phenomena Elicited by Electrical Stimulation of the Human Cortex
Abstract
Research on memory has been a major focus in the neurosciences over the past decades. An important advance was achieved by Wilder Penfield at the Montreal Neurological Institute, who reported from the 1930s to the 1950s about experiential phenomena induced by electrical brain stimulation in humans, implying neuronal causation of memory. Since then, neuroscientists have addressed the topic of memory from a range of subdisciplines; however, these reports by Penfield and his group as well as those on patient H. M. by Brenda Milner at the same institution continue to be referenced as groundbreaking. Further experimental work by Nobel laureates Eric Kandel and John O'Keefe, as well as by Edvard and May-Britt Moser related Penfield's patient documentation to experiential phenomena. However, our reassessment of Penfield's original patient documentation questions the stance that he had uncovered the "storehouse of memories." Human memory must be regarded more as context sensitive and as representative of an active reconstructive process, than as a simple recording of events. Hence, strategies aiming at naturalizing all phenomena of mind (including memory) to cellular and molecular mechanisms cannot convincingly refer to Penfield's electrophysiological studies alone as evidence that memories are solely caused by neuronal firing patterns.https://ift.tt/2tZ0fRQ
G9a/GLP Complex Acts as a Bidirectional Switch to Regulate Metabotropic Glutamate Receptor-Dependent Plasticity in Hippocampal CA1 Pyramidal Neurons
Abstract
Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) is conventionally considered to be solely dependent on local protein synthesis. Given the impact of epigenetics on memory, the intriguing question is whether epigenetic regulation influences mGluR-LTD as well. G9a/GLP histone lysine methyltransferase complex is crucial for brain development and goal-directed learning as well as for drug-addiction. In this study, we analyzed whether the epigenetic regulation by G9a/GLP complex affects mGluR-LTD in CA1 hippocampal pyramidal neurons of 5–7 weeks old male Wistar rats. In hippocampal slices with intact CA1 dendritic regions, inhibition of G9a/GLP activity abolished mGluR-LTD. The inhibition of this complex upregulated the expression of plasticity proteins like PKMζ, which mediated the prevention of mGluR-LTD expression by regulating the NSF-GluA2-mediated trafficking of AMPA receptors towards the postsynaptic site. G9a/GLP inhibition during the induction of mGluR-LTD also downregulated the protein levels of phosphorylated-GluA2 and Arc. Interestingly, G9a/GLP inhibition could not impede the mGluR-LTD when the cell-body was severed. Our study highlights the role of G9a/GLP complex in intact neuronal network as a bidirectional switch; when turned on, it facilitates the expression of mGluR-LTD, and when turned off, it promotes the expression of long-term potentiation.https://ift.tt/2u9j2cx
Qualitative evaluation of ferritin in serum samples by Raman spectroscopy and principal component analysis
Abstract
Iron molecule is of great importance in the synthesis of hemoglobin which is essential for oxygen transport. Iron levels are quantified by accurately high sensitivity tests, such as serum ferritin (SF). However, common studies to quantify SF are long and strenuous (~ 5 h), for example enzyme-linked immunosorbent assay (ELISA). In this paper, blood serum samples were analyzed by Raman spectroscopy (RS), and a computational analysis of spectra is proposed to detect differences in SF as an alternative procedure. Serum samples were obtained from 22 patients, 9 who were clinically diagnosed with anemia and 13 controls. Patients with anemia had low levels of SF (< 30 ng/ml), and a control group had levels between 30 and 500 ng/ml. The spectra obtained were conditioned with a baseline correction and smoothing, then evaluated by principal component analysis (PCA), and a predictive model was estimated by lineal discrimination analysis (LDA). The results showed a clear differentiation of the study groups by PCA, also 99.69% sensitivity and 100% specificity by LDA. This study suggest that Raman spectroscopy is a fast (~ 5 min) and a powerful tool capable to qualitative differentiate ferritin concentrations.
https://ift.tt/2zlNupI
Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition
Publication date: Available online 5 July 2018
Source: Trends in Endocrinology & Metabolism
Author(s): Dongxing Zhu, Xiaosa Li, Vicky E. Macrae, Tommaso Simoncini, Xiaodong Fu
The risk of osteoporosis and cardiovascular disease increases significantly in postmenopausal women. Until recently, the underlying mechanisms have been primarily attributed to estrogen decline following menopause. However, follicle-stimulating hormone (FSH) levels rise sharply during menopausal transition and are maintained at elevated levels for many years. FSH receptor has been detected in various extragonadal sites, including osteoclasts and endothelial cells. Recent advances suggest FSH may contribute to postmenopausal osteoporosis and cardiovascular disease. Here, we review the key actions through which FSH contributes to the risk of osteoporosis and cardiovascular disease in women as they transition through menopause. Advancing our understanding of the precise mechanisms through which FSH promotes osteoporosis and cardiovascular disease may provide new opportunities for improving health-span for postmenopausal women.
https://ift.tt/2zfVbNV
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