BACKGROUND AND OBJECTIVE Epidermal preservation is essential during laser treatment for vascular, hair, and benign pigment dyschromias. Epidermal tolerance is determined by epidermal melanin content, fluence, pulse width, wavelength, skin cooling, and spot size. The authors' objective was to determine the maximum epidermal tolerance for the long-pulse alexandrite 755 nm and the long-pulse neodymium-doped yttrium aluminum garnet (Nd:YAG) 1064-nm lasers for varying epidermal melanin content. MATERIALS AND METHODS Skin melanin measurements were performed at the test sites with a melanin reader, and 0.5 to 1 second of refrigerated air precooled the skin. Then, alexandrite and Nd:YAG laser test spots of 5 to 18 mm were delivered in a series of ascending fluences using 5-, 20-, and 50-ms pulse widths. Skin response at 24 to 48 and 96 hours was scored from 0 to 15 varying from "no reaction" to "severe scabbing." RESULTS Alexandrite laser, mean threshold fluences increased by a factor of 1.2 increasing from 5 to 20 ms, and by a factor of 1.4 increasing from 5 to 50 ms, among subjects with a melanin index (MI) from 9 to 25 (Fitzpatrick skin phototype I-III). The Nd:YAG fluence to reach epidermal tolerance was 6X the fluence with the alexandrite laser for the same MI in subjects with MI 26 to 35. CONCLUSION Epidermal melanin measurements are quantitative and objective, therefore, improving treatment setting determination by decreasing the risk of overtreatment or undertreatment. Address correspondence and reprint requests to: Amanda Abramson Lloyd, MD, Skin & Vein Institute, 477 N. El Camino Real, Suite D304, Encinitas, CA 92024, or e-mail: abramsonmd@gmail.com Cynosure provided support and the equipment for this study. E.V. Ross has received honoraria from Cynosure. The authors have indicated no significant interest with commercial supporters. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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Τρίτη 17 Ιουλίου 2018
Plasma Exeresis Treatment for Epidermoid Cysts: A Minimal Scarring Technique
BACKGROUND Epidermoid cysts are cutaneous benign tumors commonly seen in young or middle-aged adults. Plasma exeresis is an innovative technique for several skin conditions: it causes ionization of the atmospheric gas between the proximal tip of the device and the tissue to be treated, creating sublimation of the tissue. OBJECTIVE To remove the cyst with a novel technique that allows a good cosmetic result. MATERIALS AND METHODS Patients with clinical diagnosis of at least one epidermal cyst, aged between 18 and 70 years were enrolled. A standardized procedure was used. After administration of topical and sometimes local anesthesia (for cysts bigger than 1 cm), a tiny hole was created with plasma exeresis. The content of the cyst was then extruded and Micro Hartman Alligator Ear Forceps pulled out the loosened capsule. RESULTS Twenty patients aged between 18 and 68 years were enrolled: 11 males (55%) and 9 females (45%). Twenty-eight cysts were successfully removed. The diameter ranged from 3 to 24 mm. No side effects were observed. The scar measured not more than 3 mm. CONCLUSION This study suggests that plasma exeresis could represent a good and safe option to remove noninfected cysts on cosmetic areas, although further study is required. Address correspondence and reprint requests to: Elena Rossi, Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy, or e-mail: dr.elenarossi@gmail.com The authors have indicated no significant interest with commercial supporters. Written informed consent was obtained from the patients for publication of this manuscript and accompanying images. A copy of these written consents is available for review from the journal's Editor-in-Chief. All authors made substantive intellectual contributions to the published study and each author listed on the manuscript has seen and approved the submission of the manuscript. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
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https://ift.tt/2LsrivF
Reconstruction of Preauricular Wounds Using a Flipped Island Pedicle Flap: Case Series of 12 Patients
BACKGROUND Island pedicle flaps (IPFs) are a frequently used reconstructive option in dermatologic surgery. With variations in its execution, the flap can be used for an assortment of facial defects. OBJECTIVE To describe the execution of a flipped IPF for the reconstruction of medium to large preauricular wounds after Mohs micrographic surgery. MATERIALS AND METHODS An analysis of the flipped IPF reconstruction of 12 preauricular defects is presented. Patient demographics, surgical defects, aesthetic outcomes, and complications are described. RESULTS Twelve patients with 12 preauricular tumors (9 basal cell carcinomas, 2 squamous cell carcinomas, and 1 malignant melanoma) were treated using Mohs micrographic surgery. A flipped IPF reconstruction was successfully used with good cosmetic outcomes and no complications in all 12 patients. CONCLUSION In this series, the authors demonstrate the effective use of flipped IPFs for the reconstruction of medium to large preauricular defects with good aesthetic outcomes and no complications. Address correspondence and reprint requests to: Corey DeWitt, MD, Division of Dermatology, University of Vermont Medical Center, 196 Hummingbird Lane, South Burlington, VT 05403, or e-mail: corey.dewitt@uvmhealth.org The authors have indicated no significant interest with commercial supporters. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
https://ift.tt/2uxvfZf
https://ift.tt/2uxvfZf
Topically applied hypericin exhibits skin penetrability on nude mice
Abstract
Hypericin, a powerful natural photosensitizer in photodynamic therapy (PDT), is suitable for treating skin diseases involving excess capillary proliferation. In the present study, we aimed to evaluate the skin penetrability of topically applied hypericin, expecting a reduced risk of prolonged skin photosensitivity, which often occurs after systemic administration. Firstly, the Franz diffusion cell assays were performed to evaluate the penetration effects of different enhancers, including menthol, propylene glycol, camphanone, azone, and carbamide. In view of above evaluation results, we selected menthol as the enhancer in the subsequent in vivo studies. The setting groups were as follows: the blank control group, the light-exposure control group, the gel-base control group, the hypericin gel group, and a hypericin gel-containing menthol group. Except for the blank control, all other animals were irradiated by a LED light. Then, fluorescence microscopy was performed to examine the distribution of hypericin in the skin of nude mouse. Macroscopic and microscopic analyses were also carried out to detect pathological changes in the skin after topical hypericin-PDT treatment. Immunohistochemistry was used to determine the expression change of PECAM-1. As shown in the results, menthol facilitated hypericin penetrate the skin of nude mice most. The results of in vivo assays revealed that hypericin penetrated nude mouse skin, spread to the dermis, and resulted in obvious photosensitivity reaction on the dermal capillaries. Moreover, skin injured by the photosensitive reaction induced by hypericin-PDT treatment was replaced by normal skin within 7 days. We concluded that topical applied hypericin could penetrate nude mouse skin well and has a great potential in PDT treatment of skin diseases.
https://ift.tt/2NXkCak
Identification of cervical cancer using laser-induced breakdown spectroscopy coupled with principal component analysis and support vector machine
Abstract
Cervical cancer is one of the most widespread diseases in women. Traditional cancer diagnosis is extremely complicated and relies on subjective interpretation of biopsy material. In this work, laser-induced breakdown spectroscopy (LIBS) was used in cervical cancer recognition. In order to improve identification accuracy of cervical cancer by LIBS, the chemometric methods of principal component analysis (PCA) and support vector machine (SVM) were combined. The results show that the content of trace elements in normal tissues and cervical cancer tissues was significantly different. Normalized peak intensities of Na, Mg, and K in the cervical cancer tissues were significantly higher than normal tissues, and the normalized peak intensities of Ca in the normal tissues were higher than cervical cancer tissues. The identification accuracies of PCA-SVM are better than SVM, with the achieved accuracies of 94.44% and 93.06%, respectively. It can be concluded that LIBS techniques coupled with chemometric method is a potential in cancer tissue identification, which provides a preliminary research basis for real-time diagnosis of cancer tissues using LIBS.
https://ift.tt/2NqFUMm
Antimicrobial effect of bioceramic cements on multispecies microcosm biofilm: a confocal laser microscopy study
Abstract
Objectives
To assess the viability of multispecies microcosm biofilm after contact with NeoMTA Plus, Biodentine, and MTA Angelus.
Materials and methods
Fifty-four human dentin blocks (4 × 5 × 4 mm) were allocated to Hawley retainers, worn by six volunteers for 72 h. The blocks were then individually incubated in BHI broth for 21 days at 37 °C. At the end of experimental time for biofilm growth, the samples were randomly divided into four groups (n = 12): NeoMTA Plus, Biodentine, MTA Angelus, and negative control. The materials were placed in contact with the blocks. All samples were placed in cell-culture plate wells and incubated in BHI broth for 7 days at 37 °C. One sample from each volunteer (n = 6) was analyzed by SEM to describe the biofilm morphology. CLSM was performed to determine the percentage of viable biofilm biovolume. The data were statistically analyzed by one-way ANOVA and Tukey's multiple comparison test (α = 5%).
Results
SEM showed biofilm formed by spherical and rod-shaped bacteria surrounded by an extracellular matrix. No material was able to kill all biofilm cells, and all groups had more than 50% of viable bacteria. NeoMTA Plus was significantly different from the negative control group (P < .05).
Conclusions
All tested materials were not effective against multispecies microcosm biofilm.
Clinical relevance
NeoMTA Plus, Biodentine, and MTA Angelus were not effective against multispecies microcosm biofilm. It is essential to understand that these bioceramic cements are indicated for infected clinical situations. Thus, complementary disinfection procedures should be conducted prior to filling with these materials.
https://ift.tt/2Lr8RHu
Successful Termination of Sustained Transmission of Resident MRSA Following Extensive Neonatal Intensive Care Unit Refurbishment:An Intervention Study.
 | Related Articles |
Successful Termination of Sustained Transmission of Resident MRSA Following Extensive Neonatal Intensive Care Unit Refurbishment:An Intervention Study.
J Hosp Infect. 2018 Jul 12;:
Authors: Semple A, O'Currain E, O'Donovan D, Hanahoe B, Keady D, Ní Riain U, Moylett E
Abstract
BACKGROUND: Neonatal sepsis is a leading cause of morbidity and mortality in neonatal units worldwide. Meticillin resistant Staphylococcus aureus (MRSA) has become a leading causative pathogen. Many neonatal units experience endemic colonization and infection of their infants, which is often very challenging to successfully eradicate.
AIM: To assess the impact of neonatal unit refurbishment and redesign on endemic MRSA colonization and infection.
METHODS: A retrospective review was carried out over an eight year period in a 14 cot, level 2 - 3 neonatal unit in University Hospital Galway, a large university teaching hospital in the West of Ireland. Surveillance, colonization and infection data for a 4-year period pre and 4-year period post neonatal unit refurbishment are described. Clinical and microbiological data were collected on all MRSA colonized and infected infants between 2008 and 2015. Molecular typing data are available for MRSA isolates. An interrupted time series design was used, with unit refurbishment as the intervention.
FINDINGS: Our neonatal unit had a pattern of sustained transmission of endemic resident MRSA strains which we could not eradicate despite repeated standard infection control interventions. Complete unit refurbishment led to successful termination of sustained transmission of these strains. Colonization dropped and no infants were actively infected post refurbishment of the unit.
CONCLUSION: We report successful termination of sustained transmission of endemic strains of MRSA from our neonatal unit following complete unit redesign and refurbishment.
PMID: 30009868 [PubMed - as supplied by publisher]
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Boundary extension is attenuated in patients with ventromedial prefrontal cortex damage
Publication date: Available online 17 July 2018
Source: Cortex
Author(s): Flavia De Luca, Cornelia McCormick, Sinead L. Mullally, Helene Intraub, Eleanor A. Maguire, Elisa Ciaramelli
Abstract
The ventromedial prefrontal cortex (vmPFC) and hippocampus have been implicated in the mental construction of scenes and events. However, little is known about their specific contributions to these cognitive functions. Boundary extension (BE) is a robust indicator of fast, automatic, and implicit scene construction. BE occurs when individuals who are viewing scenes automatically imagine what might be beyond the view, and consequently later misremember having seen a greater expanse of the scene. Patients with hippocampal damage show attenuated BE because of their scene construction impairment. In the current study, we administered BE tasks to patients with vmPFC damage, brain-damaged control patients, and healthy control participants. We also contrasted the performance of these patients to the previously-published data from patients with hippocampal lesions (Mullally et al., 2012). We found that vmPFC-damaged patients showed reduced BE compared to brain-damaged and healthy controls. Indeed, BE attenuation was similar following vmPFC or hippocampal damage. Notably, however, whereas hippocampal damage seems to particularly impair the spatial coherence of scenes, vmPFC damage leads to a difficulty contructing scenes in a broader sense, with the prediction of what should be in a scene, and the monitoring or integration of the scene elements being particularly compromised. We conclude that vmPFC and hippocampus play important and complementary roles in scene construction.
https://ift.tt/2L7PgjK
Femtosecond laser settings for optimal bracket bonding to zirconia
Abstract
Bonding orthodontic brackets to ceramic materials is a challenging procedure; femtosecond (FS) laser conditioning could provide improved results, but the ideal settings for effective bracket-zirconia bonding have never been established. This study aimed to analyze the differences in surface roughness and shear bond strength (SBS) produced by different femtosecond laser settings and establish a protocol to prepare zirconia surfaces for optimal adhesion to metal orthodontic brackets. One hundred eighty zirconia samples were assigned to six groups according to surface treatment: (1) control; (2) air-particle abrasion (APA); (3) FS laser irradiation (300 mW output power, 60 μm inter-groove distance); (4) FS laser irradiation (200 mW, 100 μm); (5) FS laser irradiation (40 mW, 60 μm); and (6) FS laser irradiation (200 mW, 60 μm). Surface roughness was measured. Orthodontic brackets were bonded to the zirconia specimens, and SBS was measured. SBS in groups 3 and 6 was significantly higher than the other groups (5.92 ± 1.12 MPa and 5.68 ± 0.94 MPa). No significant differences were found between groups 1, 2, 4, and 5 (3.87 ± 0.77 MPa, 4.25 ± 0.51 MPa, 3.74 ± 0.10 MPa, and 3.91 ± 0.53 MPa). Surface roughness was significantly greater for FS laser than for control and APA groups (p = 1.28 × 10−8). FS laser at 200 mW, 60 μm can be recommended as the ideal settings for treating zirconia surfaces, producing good SBS and more economical energy use.
https://ift.tt/2zO3roK
Identification of carotid lipid-rich necrotic core and calcification by 3D magnetization-prepared rapid acquisition gradient-echo imaging
Publication date: Available online 17 July 2018
Source: Magnetic Resonance Imaging
Author(s): Huiyu Qiao, Feiyu Li, Dongxiang Xu, Gaifen Liu, Chun Yuan, Xihai Zhao
Abstract
Background and purpose
This study sought to investigate the feasibility of three-dimensional MPRAGE in identifying the lipid-rich necrotic core (LRNC) and calcification (CA) of carotid atherosclerotic plaques.
Materials and methods
Twelve patients (mean age 68.4 ± 11.8 years; 7 males) with carotid atherosclerotic plaques on ultrasound were included and underwent multicontrast magnetic resonance (MR) vessel wall imaging. The contrast enhanced T1W (CE-T1W) images were considered as reference for identifying LRNC. The signal intensity of LRNC, CA, sterno-cleidomastoid muscle and fibrous tissue (FT) was measured on CE-T1W, T1W, T2W, and MPRAGE images, respectively. The relative signal intensity (rSI) of LRNC and CA against muscle or FT was compared among four sequences. Area under the curve (AUC) of rSIs of LRNC, CA and FT against muscle on MPRAGE, T1W and T2W images in discriminating the LRNC or CA from FT and the other plaque component was calculated.
Results
Of 352 slices, 88 (25.0%) had LRNC, 31 (8.8%) had CA, 14 (4.0%) had both LRNC and CA, and 247 (70.2%) had no components. Among four imaging sequences, MPRAGE images showed the lowest rSI of LRNC (0.34 ± 0.18) and CA (0.20 ± 0.16) against muscle, followed by T1W (0.48 ± 0.18 and 0.33 ± 0.21), CE-T1W (0.58 ± 0.23 and 0.40 ± 0.21) and T2W (0.71 ± 0.47 and 0.43 ± 0.40) images. In contrast, the MPRAGE images showed the lowest rSI of LRNC (0.57 ± 0.26) and CA (0.33 ± 0.23) against FT. MPRAGE showed greater AUC than T2W and T1W in discriminating the LRNC (0.827 vs 0.703 and 0.635) and CA (0.917 vs. 0.838 and 0.825).
Conclusion
MPRAGE sequence might be a potential non-contrast enhanced imaging tool for identification of carotid LRNC and CA.
https://ift.tt/2LgM6JA
Vimentin as antigenic target in autoimmunity: A comprehensive review
Publication date: Available online 17 July 2018
Source: Autoimmunity Reviews
Author(s): Aram Musaelyan, Sergey Lapin, Vladimir Nazarov, Olga Tkachenko, Boris Gilburd, Alexandra Mazing, Lilia Mikhailova, Yehuda Shoenfeld
Abstract
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.
https://ift.tt/2uuJ1Mf
Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia
Publication date: Available online 17 July 2018
Source: Journal of Autoimmunity
Author(s): Hsi-Ju Wei, Ashish Gupta, Wei-Ming Kao, Omar Almudallal, John J. Letterio, Tej K. Pareek
Abstract
Aplastic anemia (AA) is a rare disease characterized by immune-mediated suppression of bone marrow (BM) function resulting in progressive pancytopenia. Stem cell transplant and immunosuppressive therapies remain the major treatment choices for AA patients with limited benefit and undesired side effects. Here, we report for the first time the therapeutic utility of Nrf2-induced metabolically reprogrammed tolerogenic dendritic cells (TolDCs) in the suppression of AA in mice. CDDO-DFPA-induced Nrf2 activation resulted in a TolDC phenotype as evidenced by induction of IL-4, IL-10, and TGF-β and suppression of TNFα, IFN-γ, and IL-12 levels in Nrf2+/+ but not Nrf2−/− DCs. Cellular metabolism holds the key to determining DC immunogenic or tolerogenic cell fate. Although immature and LPS-induced (mature) Nrf2+/+ and Nrf2−/− DCs exhibited similar patterns of oxidative phosphorylation (OXPHOS) and glycolysis, only Nrf2+/+ DCs partially restored OXPHOS and reduced glycolysis during CDDO-DFPA-induced Nrf2 activation. These results were further confirmed by altered glucose uptake and lactate production. We observed significantly enhanced HO-1 and reduced iNOS/NO production in Nrf2+/+ compared to Nrf2−/− DCs, suggesting Nrf2-dependent TolDC induction is linked to suppression of the inhibitory effect of NO on OXPHOS. Furthermore, Nrf2−/− DCs demonstrated higher antigen-specific T cell proliferation. Lastly, TolDC administration improved hematopoiesis and survival in AA murine model, with decreased Th17 and increased Treg cells. Concomitantly, immunohistochemical analysis of AA patient BM biopsies displayed higher DCs, T cells, and iNOS expression accompanied with lower Nrf2 and HO-1 expression when compared to normal subjects. These results provide new insight into the therapeutic utility of metabolically reprogrammed TolDCs by CDDO-DFPA induced Nrf2 signaling in the treatment of AA.
https://ift.tt/2Nohnrj
Less painful and effective intralesional injection method for lichen simplex chronicus
Publication date: Available online 17 July 2018
Source: Journal of the American Academy of Dermatology
Author(s): Han Mi Jung, Sung Hye Eun, Ji Hae Lee, Gyong Moon Kim, Jung Min Bae
https://ift.tt/2Jy4kkP
Femoral artery ultrasound for improving the detection of atherosclerosis in psoriasis
Publication date: Available online 17 July 2018
Source: Journal of the American Academy of Dermatology
Author(s): Alvaro Gonzalez-Cantero, Jorge Gonzalez-Cantero, Ana Isabel Sanchez-Moya, Cristina Perez-Hortet, Salvador Arias-Santiago, Jose Luis Martin-Rodriguez, Cristina Schoendorff-Ortega, Jorge Luis Gonzalez-Calvin
https://ift.tt/2L5SUdR
Early Stage Melanoma and Hematopoietic Stem Cell Transplantation Outcomes
Publication date: Available online 17 July 2018
Source: Journal of the American Academy of Dermatology
Author(s): Charles J. Puza, Paul J. Mosca, Adela R. Cardones
https://ift.tt/2JBBWOG
Bullous disorders associated with anti-PD-1 and anti-PD-L1 therapy: A retrospective analysis evaluating the clinical and histopathologic features, frequency, and impact on cancer therapy
Publication date: Available online 17 July 2018
Source: Journal of the American Academy of Dermatology
Author(s): Jacob Siegel, Mariam Totonchy, William Damsky, Juliana Berk-Krauss, Frank Castiglione, Mario Sznol, Daniel P. Petrylak, Neal Fischbach, Sarah B. Goldberg, Roy H. Decker, Angeliki M. Stamatouli, Navid Hafez, Earl J. Glusac, Mary M. Tomayko, Jonathan S. Leventhal
Abstract
Background
Bullous disorders associated with anti-PD-1/PD-L1 therapy are increasingly reported and may pose distinct therapeutic challenges. Their frequency and impact on cancer therapy are not well established.
Objective
To evaluate the clinical and histopathologic findings, frequency, and impact on cancer therapy of bullous eruptions due to anti-PD-1/PD-L1 therapy.
Methods
We retrospectively reviewed the medical records of patients evaluated by the onco-dermatology clinic and consultative service of Yale New Haven Hospital from 2016 to 2018.
Results
We identified 9 patients who developed bullous eruptions of 853 patients (∼1%) treated with anti-PD-1/PD-L1 therapy at our institution during the study period: 7 presented with bullous pemphigoid, 1 presented with bullous lichenoid dermatitis, and 1 presented with linear IgA bullous dermatosis in the context of vancomycin therapy. 8 patients required systemic steroids, 5 required maintenance therapy, and 8 required interruption of immunotherapy. All 9 patients had an initial positive tumor response or stable disease, but 4 went on to develop disease progression.
Limitations
This was a retrospective study from a single tertiary care center.
Conclusion
Bullous disorders developed in approximately 1% of patients treated with anti-PD-1/PD-L1 therapy at our institution and frequently resulted in interruption of immune therapy and management with systemic corticosteroids and occasionally steroid-sparing agents.
https://ift.tt/2L0xJd7
Scholar : These new articles for Canadian Journal of Latin American and Caribbean Studies / Revue canadienne des études latino-américaines et caraïbes are available online
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A Case of Nivolumab‐Induced Bullous Pemphigoid: Review of Dermatologic Toxicity Associated with Programmed Cell Death Protein‐1/Programmed Death Ligand‐1 Inhibitors and Recommendations for Diagnosis and Management
Immunotherapy has emerged as a highly effective treatment for numerous cancers. Use of checkpoint inhibitors against various molecules including programmed cell death protein‐1 (PD‐1), programmed death ligand‐1 (PD‐L1), and cytotoxic T‐lymphocyte‐associated protein‐4 have become widespread in clinical practice. Compared with conventional chemotherapy, immunotherapy is associated with a unique set of immune reactions known collectively as immune‐related adverse events (irAEs). Of known irAEs, cutaneous toxicity is among the most frequently observed in patients treated with immunotherapy. Although often mild, dermatologic toxicity can occasionally be high grade and potentially life‐threatening. In this article, we report a case of PD‐1 inhibitor‐induced bullous pemphigoid—a serious adverse event that has been increasingly observed with use of PD‐1/PD‐L1 inhibitors. We will also review diagnosis and management of low‐grade cutaneous irAEs and bullous disease with checkpoint inhibitors.Key Points. PD‐1/PD‐L1 inhibitor‐induced bullous pemphigoid (BP) is a rare but potentially serious dermatologic toxicity associated with checkpoint inhibitorsIn patients with pruritus or rash that is refractory to topical steroids, physicians should have a greater index of suspicion for higher‐grade cutaneous immune‐related adverse events.There is no standardized treatment algorithm for management of PD‐1/PD‐L1 inhibitor‐induced BP, but patients frequently require topical and systemic steroids.
https://ift.tt/2mqO2Ru
Selection of Protein Kinase Inhibitors Based on Tumor Tissue Kinase Activity Profiles in Patients with Refractory Solid Malignancies: An Interventional Molecular Profiling Study
AbstractLessons Learned. Clinically applicable tools are needed for treatment selection and repurposing of available protein kinase inhibitors (PKIs) in patients with advanced solid tumors refractory to standard treatment.Using a tyrosine kinase peptide substrate microarray, observed inhibitory activity in vitro could not sufficiently predict clinical benefit of treatment with the selected PKI.Background.This exploratory molecular profiling study determined the feasibility and benefit of the selection of protein kinase inhibitors (PKIs) based on kinase activity profiling in patients with refractory solid malignancies.Methods.Adult patients with biopsy‐accessible refractory solid tumors were eligible. Per patient, the inhibitory potency of sunitinib, dasatinib, erlotinib, sorafenib, everolimus, and lapatinib was determined in tumor lysates from fresh biopsies using a tyrosine kinase peptide substrate microarray. The most active PKI in this in vitro assay was selected for treatment.Results.Thirteen patients were enrolled in the feasibility part and underwent tumor biopsy. Of 12 patients in whom kinase activity profiling was performed, 11 started treatment with a selected PKI: dasatinib in 8, sunitinib in 2, and erlotinib in 1 patient(s). Eight patients were evaluable for response. One patient had stable disease (SD) >4 months on sunitinib; one patient had SD at 6 weeks but progressive disease (PD) at 12 weeks. The remaining patients had PD after 6 weeks of treatment.Conclusion.Kinase inhibition profiles of multiple PKIs can be reliably determined using fresh tumor biopsies from patients with refractory solid tumors. However, the current in vitro microarray selection approach insufficiently predicted clinical benefit of PKI treatment in these patients.
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Adjuvant Subcutaneous Trastuzumab for HER2‐Positive Early Breast Cancer: Subgroup Analyses of Safety and Active Medical Conditions by Body Weight in the SafeHer Phase III Study
AbstractBackground.This SafeHer subgroup analysis assessed the safety of fixed‐dose subcutaneous trastuzumab (H SC) as an adjuvant therapy in HER2‐positive early breast cancer (EBC) by body weight.Patients and Methods.Patients with HER2‐positive EBC not previously treated with anti‐HER2 therapy received H SC 600 mg (every 3 weeks for 18 cycles), with neoadjuvant or adjuvant chemotherapy or without adjuvant chemotherapy. Adverse events (AEs) were assessed throughout treatment and at final follow‐up (28 ±5 days after last treatment). Subgroups were categorized by body weight, Asian origin, and chemotherapy administration. All analyses were descriptive.Results.Of 2,577 patients enrolled, 2,573 received ≥1 dose of study medication and were included in this safety analysis. Median body weight at baseline was 67.0 kg (range 33.6–150.0 kg). Any‐grade AEs occurred in 88.7% (2,282/2,573) of the overall population, versus 87.1% (590/677) of the lowest bodyweight quartile (≤59 kg), 90.0% (561/623) of the highest quartile (>77 kg), and 86.5% (327/378) of the Asian population. Grade ≥3 AEs occurred in 23.2% (596/2,573) of the overall population, 17.9% (121/677) of the lowest bodyweight quartile, 26.8% (167/623) of the highest quartile, and 15.3% (58/378) of the Asian population. The highest bodyweight quartile had the highest incidence of medical conditions at baseline (highest quartile, 75.6%; lowest quartile, 56.1%).Conclusion.These data support the use of fixed‐dose H SC as an adjuvant therapy in HER2‐positive EBC and confirm the comparable safety profile of H SC in patients with low body weight or of Asian origin versus the overall population in SafeHer. ClinicalTrials.gov: NCT01566721.Implications for Practice.The safety profile of fixed‐dose subcutaneous trastuzumab (H SC) was comparable between patients in the lowest bodyweight subgroup and the overall patient population, and also between patients of Asian origin (of whom a higher proportion often fall within the lower bodyweight quartiles) and the overall population. The safety data from this SafeHer subgroup analysis therefore support the use of fixed‐dose H SC 600 mg administered every 3 weeks as an adjuvant therapy for patients with HER2‐positive early breast cancer across different bodyweight subgroups and in the Asian patient population.
https://ift.tt/2mnS6lz
Impact of Patient Age on Molecular Alterations of Left‐Sided Colorectal Tumors
AbstractBackground.The incidence of colorectal cancer (CRC) in younger patients is rising, mostly due to tumors in the descending colon and rectum. Therefore, we aimed to explore the molecular differences of left‐sided CRC between younger (≤45 years) and older patients (≥65).Subjects, Materials, and Methods.In total, 1,126 CRC tumor samples from the splenic flexure to (and including) the rectum were examined by next‐generation sequencing (NGS), immunohistochemistry, and in situ hybridization. Microsatellite instability (MSI) and tumor mutational burden (TMB) were assessed by NGS.Results.Younger patients (n = 350), when compared with older patients (n = 776), showed higher mutation rates in genes associated with cancer‐predisposing syndromes (e.g., Lynch syndrome), such as MSH6 (4.8% vs. 1.2%, p = .005), MSH2 (2.7% vs. 0.0%, p = .004), POLE (1.6% vs. 0.0%, p = .008), NF1 (5.9% vs. 0.5%, p < .001), SMAD4 (14.3% vs. 8.3%, p = .024), and BRCA2 (3.7% vs. 0.5%, p = .002). Genes involved in histone modification were also significantly more mutated: KDM5C (1.9% vs. 0%, p = .036), KMT2A (1.1% vs. 0%, p = .033), KMT2C (1.6% vs. 0%, p = .031), KMT2D (3.8% vs. 0.7%, p = .005), and SETD2 (3.2% vs. 0.9%, p = .039). Finally, TMB‐high (9.7% vs. 2.8%, p < .001) and MSI‐high (MSI‐H; 8.1% vs. 1.9%, p = .009) were more frequent in younger patients.Conclusion.Our findings highlight the importance of genetic counseling and screening in younger CRC patients. MSI‐H and TMB‐high tumors could benefit from immune‐checkpoint inhibitors, now approved for the treatment of MSI‐H/deficient mismatch repair metastatic CRC patients. Finally, histone modifiers could serve as a new promising therapeutic target. With confirmatory studies, these results may influence our approach to younger adults with CRC.Implications for Practice.The increasing rate of colorectal cancers (CRC), primarily distal tumors, among young adults poses a global health issue. This study investigates the molecular differences between younger (≤45 years old) and older (≥65) adults with left‐sided CRCs. Younger patients more frequently harbor mutations in genes associated with cancer‐predisposing syndromes. Higher rates of microsatellite instability‐high and tumor mutational burden‐high tumors occur in younger patients, who could benefit from immune‐checkpoint inhibitors. Finally, histone modifiers are more frequently mutated in younger patients and could serve as a new promising therapeutic target. This study provides new insights into mutations that may guide development of novel tailored therapy in younger CRC patients.
https://ift.tt/2uGV20A
Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma
AbstractBackground.1p/19q‐codeleted anaplastic gliomas have variable clinical behavior. We have recently shown that the common 9p21.3 allelic loss is an independent prognostic factor in this tumor type. The aim of this study is to identify less frequent genomic copy number variations (CNVs) with clinical importance that may shed light on molecular oncogenesis of this tumor type.Materials and Methods.A cohort of 197 patients with anaplastic oligodendroglioma was collected as part of the French POLA network. Clinical, pathological, and molecular information was recorded. CNV analysis was performed using single‐nucleotide polymorphism arrays. Computational biology and feature selection based on the random forests method were used to identify CNV events associated with overall survival and other clinical‐pathological variables.Results.Recurrent chromosomal events were identified in chromosomes 4, 9, and 11. Forty‐six focal amplification events and 22 focal deletion events were identified. Twenty‐four focal CNV areas were associated with survival, and five of them were significantly associated with survival after multivariable analysis. Nine out of 24 CNV events were validated using an external cohort of The Cancer Genome Atlas. Five of the validated events contain a cancer‐related gene or microRNA: CDKN2A deletion, SS18L1 amplification, RHOA/MIR191 copy‐neutral loss of heterozygosity, FGFR3 amplification, and ARNT amplification. The CNV profile contributes to better survival prediction compared with clinical‐based risk assessment.Conclusion.Several recurrent CNV events, detected in anaplastic oligodendroglioma, enable better survival prediction. More importantly, they help in identifying potential genes for understanding oncogenesis and for personalized therapy.Implications for Practice.Genomic analysis of 197 anaplastic oligodendroglioma tumors reveals recurrent somatic copy number variation areas that may help in understanding oncogenesis and target identification for precision medicine. A machine learning multivariable model built using this genomic information enables better survival prediction.
https://ift.tt/2mozqlR
FDA Supplemental Approval: Blinatumomab for Treatment of Relapsed and Refractory Precursor B‐Cell Acute Lymphoblastic Leukemia
AbstractOn July 11, 2017, the Food and Drug Administration granted approval for blinatumomab for the treatment of relapsed or refractory (R/R) precursor B‐cell acute lymphoblastic leukemia (ALL). Blinatumomab is a bispecific CD19‐directed CD3 T‐cell engager. The basis for the approval included results from two clinical trials, TOWER and ALCANTARA. TOWER, a randomized trial comparing overall survival in patients with Philadelphia chromosome (Ph)‐negative R/R ALL receiving blinatumomab versus standard‐of‐care (SOC) chemotherapy, demonstrated a hazard ratio of 0.71 favoring blinatumomab (p = .012; median survival, 7.7 months with blinatumomab and 4.0 months with SOC chemotherapy). Complete remission (CR) rates were 34% for patients receiving blinatumomab and 16% for those receiving SOC. Adverse events were consistent with those observed in prior trials, with cytokine release syndrome and some neurologic events, including tremor, encephalopathy, peripheral neuropathy, and depression, observed more frequently in the blinatumomab arm, whereas neutropenia and infection were less common among patients receiving blinatumomab. Depression emerged as a rare but potentially severe neurologic event associated with blinatumomab. In ALCANTARA, a single‐arm trial of blinatumomab in patients with Ph‐positive R/R ALL, the CR rate was 31%, and adverse events were similar to those observed previously in Ph‐negative R/R ALL. These results support conversion from accelerated to regular approval of blinatumomab for R/R ALL and broadening of the intended population to include both Ph‐positive and Ph‐negative precursor B‐cell R/R ALL.Implications for Practice.In TOWER, a randomized trial in patients with relapsed or refractory Philadelphia chromosome (Ph)‐negative precursor B‐cell acute lymphoblastic leukemia (ALL), treatment with blinatumomab showed superiority over conventional chemotherapy for complete remission (CR) rate (34% vs. 16%) and survival (3.7‐month improvement in median; hazard ratio, 0.71). In ALCANTARA, a single‐arm trial of blinatumomab for treatment of relapsed or refractory Ph‐positive precursor B‐cell ALL, the CR rate was 31%. Blinatumomab is now approved for treatment of relapsed or refractory precursor B‐cell ALL that is Ph positive or Ph negative.
https://ift.tt/2uIXrYu
Editorial Board and Contents
Publication date: August 2018
Source: Trends in Endocrinology & Metabolism, Volume 29, Issue 8
Author(s):
https://ift.tt/2zNYlJ5
Pink Adipocytes
Publication date: Available online 17 July 2018
Source: Trends in Endocrinology & Metabolism
Author(s): Saverio Cinti
Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition can undergo striking physiologic changes. In standard conditions the organ contains white and brown adipocytes which play opposite roles: lipid storage to meet metabolic requirements and lipid burning for thermogenesis, respectively. During chronic cold exposure, white adipocytes transdifferentiate to brown, to increase thermogenesis, whereas in conditions of chronic positive energy balance brown adipocytes transdifferentiate to white, to increase energy stores. During pregnancy, lactation, and post-lactation, subcutaneous white adipocytes convert to milk-producing glands formed by lipid-rich elements that can be defined as pink adipocytes. Recent fate-mapping data support the conversion of pink to brown adipocytes and the reversible conversion of brown adipocytes to myoepithelial cells of alveoli.
https://ift.tt/2mqwBR2
Ultra Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry–Based Metabonomics Reveal Protective Effect of Terminalia chebula Extract on Ischemic Stroke Rats
Rejuvenation Research, Ahead of Print.
https://ift.tt/2zJoo42
Scholar : These new articles for Text and Performance Quarterly are available online
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Performance of ceria/iron oxide nano-composites based on chitosan as an effective adsorbent for removal of Cr(VI) and Co(II) ions from aqueous systems
Abstract
A novel chitosan/ceria/iron oxide (CS/ceria/Fe3O4) nano-composite adsorbent was synthesized for removal of Cr(VI) and Co(II) ions from aqueous systems in a batch system. The adsorbents were characterized by field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and Brunauer- Emmett-Teller (BET) analyses. The behavior of swelling kinetics was also studied. The effect of several adsorption parameters including CeO2 and Fe3O4 contents, initial pH, contact time, initial Cr(VI) and Co(II) concentration, and temperature on the adsorption capacity was studied. The double exponential model revealed a better fit with the kinetic data of Cr(VI) and Co(II) ions. The Cr(VI) and Co(II) adsorption process well fitted the Langmuir model. The maximum adsorption capacities estimated from Langmuir isotherm model were 315.4 and 260.6 mg/g for Cr(VI) and Co(II) ions, respectively. Also, thermodynamic parameters were used to distinguish the nature of Cr(VI) and Co(II) adsorption. The reusability of CS/ceria/Fe3O4 nano-composite was evaluated with stripping agents of 0.1 M NaOH and 0.1 M HNO3. Finally, the evaluation of Cr(VI)-Co(II) coexisting system confirmed that the presence of Co(II) ions played an inhibitor role on the Cr(VI) adsorption.
https://ift.tt/2utNAXg
Surfactants in the sea surface microlayer, subsurface water and fine marine aerosols in different background coastal areas
Abstract
This study aims to determine the concentrations of surfactants in the surface microlayer (SML), subsurface water (SSW) and fine mode aerosol (diameter size < 1.5 μm) at different coastal stations in Peninsular Malaysia. The concentrations of anionic and cationic surfactants were determined through colorimetric methods as methylene blue active substances (MBAS) and disulphine blue active substances (DBAS), respectively. Water-soluble ions, for the determination of fine mode aerosol sources, were determined using ion chromatography (IC) for anions (SO42−, NO3−, Cl− and F−) and cations (Na+, K+, Ca2+ and Mg2+). Principal component analysis (PCA), combined with multiple linear regression (MLR), was used to identify the possible sources of surfactants in fine aerosol. The results showed the concentrations of surfactants as MBAS and DBAS in the SML ranged between 0.23 ± 0.03 and 0.35 ± 0.01 μmol L−1 and between 0.21 ± 0.02 and 0.29 ± 0.01 μmol L−1, respectively. The enrichment factors (Efs) ratios between MBAS and DBAS in the SML and SSW ranged between 1.04 ± 0.01 and 1.32 ± 0.04, respectively. The station that is located near to tourism and industrial activities recorded the highest concentrations of surfactants in SML and SSW. The concentrations of surfactants in fine aerosol ranged between 62.29 and 106.57 pmol m−3. The three possible sources of fine aerosol during the northeast monsoon were aged sea spray/biomass burning (which accounted for 69% of the atmospheric aerosol), nitrate/mineral dust (23%) and sulphate/fresh sea salt (8%). During the southwest monsoon, the three main sources of atmospheric aerosol were biomass burning (71%), secondary inorganic aerosol (23%) and sea spray (6%). This study suggests anthropogenic sources are main contributors to the concentrations of surfactants in SML, SSW and fine aerosols.
https://ift.tt/2L40WE4
Ecological and human health risk assessments in the context of soil heavy metal pollution in a typical industrial area of Shanghai, China
Abstract
The purpose of this study was to identify the concentrations, sources, and potential ecological and health risks of heavy metals in soils from a typical industrial area in Shanghai, China. A total of 28 surface soil samples were collected and analyzed for As, Cd, Cr, Cu, Pb, Ni, Zn, and Hg from the BAO steel industry in June and July 2016. Classic multivariate statistical and geostatistical analysis methods were used to detect the sources of heavy metals, and the ecological risk index (RI) and hazard index (HI) were calculated to assess the potential ecological and health risks. The results showed significant pollution levels, which were derived from the industrial production process and closely related to the spatial layout of the functional areas of the industry. The ecological risk assessment indicated that a very high concentration zone with values ranging from 2045 to 3417 mg kg−1 represented considerable ecological risk in the range of 300 to 600. The main dominant factor affecting the ecological risk is toxicity rather than concentration. The health risk assessment indicated that noncarcinogenic risk was mainly caused by Cr, and the average HI value for adults was 6.48, while it was 39.01 for children. Thus, children face higher threats to heavy metals in soils. The average carcinogenic risk values for Ni, Cr, Cd, and As were 7.97E-09, 5.2E-07, 2.1E-10, and 2.1E-09, respectively, all of which were below the threshold values (1.0E − 04). These results provide basic information for the control and environmental management of heavy metal pollution in steel industrial regions.
https://ift.tt/2Lr3Crl
Scholar : Dramatherapy, Volume 39, Issue 2, July 2018 is now available online on Taylor & Francis Online
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Scholar : Australian Journal of Earth Sciences, Volume 65, Issue 5, July 2018 is now available online on Taylor & Francis Online
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To diet or not to diet in neonatal diabetes responding to sulfonylurea treatment
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
https://ift.tt/2zIkOam
NIH and Prostate Cancer Foundation launch large study on aggressive prostate cancer in African-American men
RESPOND is the largest coordinated study on biological and non-biological factors associated with aggressive prostate cancer in African-American men. The study is an effort to learn why these men disproportionally experience aggressive disease.
https://ift.tt/2uHAHIm
Expression kinetics of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement
Abstract
Purpose
Human periodontal ligament (hPDL) fibroblasts play a crucial mediating role in orthodontic tooth movement (OTM). In this study, we investigated the expression kinetics of genes associated with OTM in its early phase to obtain better insight into the timing and regulation of molecular and cellular signalling and transformation processes occurring in compressive areas of the periodontal ligament during OTM.
Methods
Adherent hPDL fibroblasts were stimulated with physiological orthodontic compressive forces of 2 g/cm2 for 24, 48, 72, and 96 h under cell culture conditions. At each time point, we quantified relative gene expression of genes involved in bone remodelling (ALPL), inflammation (COX2, IL-6), extracellular matrix reorganization (COL1A2, P4HA1, FN1, MMP8) and angiogenesis (VEGF-A) by means of RT-qPCR as well as protein expression of osteoclastogenesis-regulating RANK-L and OPG relative to pressure-untreated controls incubated for corresponding time periods. In addition, coculture experiments with osteoclast precursor cells were performed to determine the extent of hPDL-fibroblast-mediated osteoclastogenesis (TRAP staining).
Results
As primary response to compressive forces within 24 h, we observed an induction of genes associated with angiogenesis, inflammation, osteoblastogenesis, and the remodelling of the extracellular matrix, with RANK-L expression at first slightly inhibited and only increased after 48 h. Major hPDL-mediated osteoclastogenesis was observed after 72 h with minor, non-RANK-L-dependent osteoclastogenesis occurring as early as 24 h after compressive force application.
Conclusions
hPDL fibroblasts seem to play a major mediating role in the early phase of OTM with a differentiated, time-dependent regulation and expression pattern of cytokines and other mediators.
https://ift.tt/2NnkD6p
Scholar : Journal of Clinical and Experimental Neuropsychology, Volume 40, Issue 8, October 2018 is now available online on Taylor & Francis Online
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Expression kinetics of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement
Abstract
Purpose
Human periodontal ligament (hPDL) fibroblasts play a crucial mediating role in orthodontic tooth movement (OTM). In this study, we investigated the expression kinetics of genes associated with OTM in its early phase to obtain better insight into the timing and regulation of molecular and cellular signalling and transformation processes occurring in compressive areas of the periodontal ligament during OTM.
Methods
Adherent hPDL fibroblasts were stimulated with physiological orthodontic compressive forces of 2 g/cm2 for 24, 48, 72, and 96 h under cell culture conditions. At each time point, we quantified relative gene expression of genes involved in bone remodelling (ALPL), inflammation (COX2, IL-6), extracellular matrix reorganization (COL1A2, P4HA1, FN1, MMP8) and angiogenesis (VEGF-A) by means of RT-qPCR as well as protein expression of osteoclastogenesis-regulating RANK-L and OPG relative to pressure-untreated controls incubated for corresponding time periods. In addition, coculture experiments with osteoclast precursor cells were performed to determine the extent of hPDL-fibroblast-mediated osteoclastogenesis (TRAP staining).
Results
As primary response to compressive forces within 24 h, we observed an induction of genes associated with angiogenesis, inflammation, osteoblastogenesis, and the remodelling of the extracellular matrix, with RANK-L expression at first slightly inhibited and only increased after 48 h. Major hPDL-mediated osteoclastogenesis was observed after 72 h with minor, non-RANK-L-dependent osteoclastogenesis occurring as early as 24 h after compressive force application.
Conclusions
hPDL fibroblasts seem to play a major mediating role in the early phase of OTM with a differentiated, time-dependent regulation and expression pattern of cytokines and other mediators.
https://ift.tt/2NnkD6p
TOMO Versus IMRT in Nasopharyngeal Carcinoma Patients
Condition: Nasopharyngeal Carcinoma
Interventions: Radiation: TOMO; Radiation: IMRT
Sponsor: Zhejiang Cancer Hospital
Recruiting
https://ift.tt/2uHbkGv
Interventions: Radiation: TOMO; Radiation: IMRT
Sponsor: Zhejiang Cancer Hospital
Recruiting
https://ift.tt/2uHbkGv
NBTXR3 Activated by SABR for Patients With Advanced HNSCC or NSCLC Treated With an Anti-PD1 Antibody
Conditions: Head and Neck Cancer; NSCLC; Radiotherapy; Immunotherapy
Intervention: Drug: NBTXR3
Sponsor: Nanobiotix
Not yet recruiting
https://ift.tt/2mtBt8p
Intervention: Drug: NBTXR3
Sponsor: Nanobiotix
Not yet recruiting
https://ift.tt/2mtBt8p
Docetaxel-polymeric Micelles(PM) and Oxaliplatin for Esophageal Carcinoma
Conditions: Esophagus Squamous Cell Carcinoma (SCC); Metastatic Cancer
Interventions: Drug: Docetaxel-PM; Drug: Oxaliplatin
Sponsor: Sung Yong Oh
Recruiting
https://ift.tt/2zLDZ37
Interventions: Drug: Docetaxel-PM; Drug: Oxaliplatin
Sponsor: Sung Yong Oh
Recruiting
https://ift.tt/2zLDZ37
Investigation on spatiotemporal distribution of aerosol optical properties over two oceanic regions surrounding Indian subcontinent during summer monsoon season
Abstract
Columnar spectral aerosol optical depths (AODs) and total suspended particulate matter (TSPM) concentrations were collected on board the Oceanographic Research Vessel (ORV) of Sagar Kanya (SK) during 7–21 June 2014 (SK-313) and 31 July–14 August 2015 (SK-323) over the Arabian Sea (AS) and Bay of Bengal (BoB), respectively, for the two successive years during summer monsoon season. AOD measured at 500 nm (AOD500) varied significantly from 0.08 to 0.66 (0.07 to 0.60), with a mean of 0.48 ± 0.13 (0.34 ± 0.13) over the BoB (AS) during SK-313 (SK-323). It simply implies that aerosol load was higher over BoB, not variability as the standard deviations of AOD over both oceans are identical (0.13). Daily AOD500 ranged between 0.15 and 0.60 accounted for 70–75% of the total occurrences over two oceanic regions. Mean Ångström exponent (α or alpha) and Ångström turbidity coefficient (β or beta) were found to be 0.43 ± 0.17 (0.39 ± 0.19) and 0.37 ± 0.15 (0.27 ± 0.13), respectively, which are higher over the AS during SK-323 (SK-313) that indicate predominance of coarse-relative to fine-mode particles. On the other hand, the spectral curvature and second derivative of alpha (α′) also showed significant contribution of coarse-mode particles over fine during the two campaigns. Further, column aerosol size distribution (CSD) derived from the King's inversion also exhibited bimodal distribution with a predominant peak observed in the coarse mode (~1.0 μm) compared to the fine mode at a geometric mean radius at ~0.1 μm over two oceans. The observed data showed that the two marine regions are significantly influenced by various types of aerosols with a predominance of mixed type (MT) of aerosols. From the morphological study, it is inferred that the particles are a flake, spherical, irregular, and in flower and aggregated shapes conducted for the TSPM samples collected during SK-323 over the AS. Finally, the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model is used to study the impact of long-distance transported aerosols and identify their sources.
https://ift.tt/2zKX9Gf
Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ
Reactivity and performance characteristics of mosaic lime mortars with different types of ceramic pozzolans
Ε Μαντζάνα - 2018
Ιδρυματικό Αποθετήριο Πανεπιστημίου Πελοποννήσου Reactivity and
performance characteristics of mosaic lime mortars with different types
of ceramic pozzolans. Ιδρυματικό Καταθετήριο DSpace …
performance characteristics of mosaic lime mortars with different types
of ceramic pozzolans. Ιδρυματικό Καταθετήριο DSpace …
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Απομόνωση και χαρακτηρισμός μεσεγχυματικών κυττάρων και μελέτη της επίδρασης βιοϋλικών και μικροπεριβάλλοντος στην ανάπτυξη και διαφοροποίηση
Β Ταρασλιά - 2018
… οδοντίνης και πολφοειδούς ιστού. Ταυτόχρονα, σημαντικό ρόλο διαδραματίζει η
συμβατότητά τους με βιοϋλικά που χρησιμοποιούνται εκτενώς κατά την επιδιόρθωση
ή / και αποκατάσταση τραυματισμών. Χαρακτηριστικά βιοϋλικά που …
συμβατότητά τους με βιοϋλικά που χρησιμοποιούνται εκτενώς κατά την επιδιόρθωση
ή / και αποκατάσταση τραυματισμών. Χαρακτηριστικά βιοϋλικά που …
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[PDF] Συμπεριληπτική εκπαίδευση
Π Σταθά - 2018
… ειδικού παιδαγωγικού κλίματος και ζωής. Δεν αποβλέπει στην «επανόρθωση ή
αποκατάσταση» σε «προτέραυγιά θέση», αλλά «αναπληρώνει, εποικοδομεί» και εν
κατακλείδι είναι μια «εξελικτική βοήθεια και βοήθεια ζωής».3 Σύμφωνα με την Σ …
αποκατάσταση» σε «προτέραυγιά θέση», αλλά «αναπληρώνει, εποικοδομεί» και εν
κατακλείδι είναι μια «εξελικτική βοήθεια και βοήθεια ζωής».3 Σύμφωνα με την Σ …
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[PDF] Πόνος μετά από κάκωση νωτιαίου μυελού
Π Πρασσάκης - 2018
… ασθενούς. Τελικά, αναλύεται η φυσικοθεραπευτική παρέμβαση, οι στόχοι και τα μέσα
που χρησιμοποιού- νται για την αποκατάσταση της βέλτιστης λειτουργικότητας ενός
ατόμου με κάκωση νωτιαίου μυελού. Page 4. iv ΠΕΡΙΕΧΟΜΕΝΑ …
που χρησιμοποιού- νται για την αποκατάσταση της βέλτιστης λειτουργικότητας ενός
ατόμου με κάκωση νωτιαίου μυελού. Page 4. iv ΠΕΡΙΕΧΟΜΕΝΑ …
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[PDF] Η εξέλιξη στη βιομηχανία των ΜΜΕ απο την μεταπολίτευση μέχρι την σημερινή περίοδο κρίσης και τεχνολογικής αλλαγής
Θ ΤΣΟΥΔΗ - 2018
Page 1. ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥ ΣΧΟΛΗ ΔΙΟΙΚΗΣΗΣ ΤΜΗΜΑ ΠΛΗΡΟΦ ΠΤΥΧΙΑΚΗ
Ε Η ΕΞΕΛΙΞΗ ΣΤΗ ΒΙΟΜΗΧΑΝ ΤΗΝ ΜΕΤΑΠΟΛΙΤΕΥΣΗ ΜΕΧΡ ΠΕΡΙΟΔΟ ΚΡΙΣΗΣ ΚΑΙ
ΤΕ ΤΣΟΥΔΗ ΕΠΟΠΤΕΥΩΝ ΚΑΘΗΓΗΤΗΣ: ΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ …
Ε Η ΕΞΕΛΙΞΗ ΣΤΗ ΒΙΟΜΗΧΑΝ ΤΗΝ ΜΕΤΑΠΟΛΙΤΕΥΣΗ ΜΕΧΡ ΠΕΡΙΟΔΟ ΚΡΙΣΗΣ ΚΑΙ
ΤΕ ΤΣΟΥΔΗ ΕΠΟΠΤΕΥΩΝ ΚΑΘΗΓΗΤΗΣ: ΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ …
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[PDF] Μελέτη των επιπτώσεων ραμνολιπιδίων στον μονοκύτταρο φυτοπλαγκτονικό οργανισμό Dunaliella tertiolecta
Ν Χαραλάμπους - 2018
… υποβάθμισης και αποκατάστασης υδρογονανθράκων, στη μικροβιακή αύξηση ανάκτησης
πετρελαίου (ΜΕOR), στην αποκατάσταση μετάλλων, στην Ιατρική, στη βιομηχανία τροφίμων,
στη γεωργία, καθώς και στη βιομηχανία καλλυντικών (Banat et al., 2000) …
πετρελαίου (ΜΕOR), στην αποκατάσταση μετάλλων, στην Ιατρική, στη βιομηχανία τροφίμων,
στη γεωργία, καθώς και στη βιομηχανία καλλυντικών (Banat et al., 2000) …
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[PDF] Η πολιτική διαφήμιση στην Ελλάδα απο την μεταπολίτευση μέχρι την κρίση
Γ ΠΑΡΑΣΚΕΥΟΠΟΥΛΟΥ, Σ ΣΙΔΕΡΗ - 2018
Page 1. ΣΧΟΛΗ ΔΙΟΙΚΗΣΗΣ ΚΑΙ ΟΙΚΟΝΟΜΙΑΣ ΤΜΗΜΑ ΠΛΗΡΟΦΟΡΙΚΗΣ
ΚΑΙ ΜΕΣΩΝ ΜΑΖΙΚΗΣ ΕΝΗΜΕΡΩΣΗΣ Παράρτημα Πύργου ΠΤΥΧΙΑΚΗ
ΕΡΓΑΣΙΑ: "Η πολιτική διαφήμιση στην Ελλάδα από την μεταπολίτευση μέχρι …
ΚΑΙ ΜΕΣΩΝ ΜΑΖΙΚΗΣ ΕΝΗΜΕΡΩΣΗΣ Παράρτημα Πύργου ΠΤΥΧΙΑΚΗ
ΕΡΓΑΣΙΑ: "Η πολιτική διαφήμιση στην Ελλάδα από την μεταπολίτευση μέχρι …
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[PDF] Νορβηγία–Ανγκόλα: μια συγκριτική μελέτη.
ΑΡ Παππά - 2018
Page 1. Α.Τ.Ε.Ι ΗΠΕΙΡΟΥ ΠΑΡΑΡΤΗΜΑ ΗΓΟΥΜΕΝΙΤΣΑΣ ΣΧΟΛΗ ΔΙΟΙΚΗΣΗΣ ΚΑΙ
ΟΙΚΟΝΟΜΙΑΣ ΤΜΗΜΑ ΔΙΟΙΚΗΣΗΣ ΕΠΙΧΕΙΡΗΣΕΩΝ Εφαρμοσμένες Ξένες Γλώσσες στη
Διοίκηση και την Οικονομία ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΤΗΣ ΑΝΝΑΣ ΡΟΛΙΝΣΚΑ-ΠΑΠΠΑ …
ΟΙΚΟΝΟΜΙΑΣ ΤΜΗΜΑ ΔΙΟΙΚΗΣΗΣ ΕΠΙΧΕΙΡΗΣΕΩΝ Εφαρμοσμένες Ξένες Γλώσσες στη
Διοίκηση και την Οικονομία ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΤΗΣ ΑΝΝΑΣ ΡΟΛΙΝΣΚΑ-ΠΑΠΠΑ …
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[PDF] Παλαιοχριστιανικά και μεσοβυζαντινά γλυπτά από τη συλλογή της Ναυπάκτου
Α Ζωγάκη - 2018
Page 1. ΠΑΛΑΙΟΧΡΙΣΤΙΑΝΙΚΑ ΚΑΙ ΜΕΣΟΒΥΖΑΝΤΙΝΑ ΓΛΥΠΤΑ ΑΠΟ ΤΗ
ΣΥΛΛΟΓΗ ΤΗΣ ΝΑΥΠΑΚΤΟΥ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ΜΕΤΑΠΤΥΧΙΑΚΟ
ΠΡΟΓΡΑΜΜΑ «ΒΥΖΑΝΤΙΝΕΣ ΣΠΟΥΔΕΣ» ΦΙΛΟΣΟΦΙΚΗΣ ΣΧΟΛΗΣ …
ΣΥΛΛΟΓΗ ΤΗΣ ΝΑΥΠΑΚΤΟΥ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ΜΕΤΑΠΤΥΧΙΑΚΟ
ΠΡΟΓΡΑΜΜΑ «ΒΥΖΑΝΤΙΝΕΣ ΣΠΟΥΔΕΣ» ΦΙΛΟΣΟΦΙΚΗΣ ΣΧΟΛΗΣ …
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[PDF] Μελέτη διασυνδεδεμένου φωτοβολταϊκού συστήματος
Μ Καλλούσης - 2018
Page 1. ΑΤΕΙ ΠΕΙΡΑΙΑ ΣΤΕΦ ΤΜΗΜΑ ΑΥΤΟΜΑΤΙΣΜΟΥ Πτυχιακή εργασία
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