Cancer epigenetics: Therapy-induced transcription is cryptically widespread

http://ift.tt/2sRteFc

Disease genetics: Repeat expansion disorders — going through a phase

http://ift.tt/2s7adlm

Synthetic lethality and cancer

The authors review the concept of synthetic lethality — when the perturbation of one of two genes alone is viable, but the perturbation of both genes simultaneously results in the loss of viability — from model organisms to human cancers, and discuss how genetic interactions can be exploited for the identification of new drug targets in cancer.

http://ift.tt/2sRtnbM

Granuloma faciale associated with IgG4-related disease

http://ift.tt/2t7Rrtm

Therapeutic efficacy and safety of oral tranexamic acid and that of tranexamic acid local infiltration with microinjections in patients with melasma: a comparative study

Summary

Background

Tranexamic acid (TXA) has been used orally, intravenously, topically and intradermally (microinjection, microneedling) for treating melasma. However, the comparative efficacy of these different routes of administration remains underevaluated.

Aim

To ascertain the comparative efficacy of different routes of administration of TXA.

Methods

In total, 100 consecutive patients with melasma (8 men, 92 women, age range 18–55 years) were randomly assigned to one of two groups comprising 50 patients each. Group A (3 men, 47 women) received oral TXA 250 mg twice daily, while group B (5 men, 45 women) received intradermal microinjections of TXA 4 mg/mL every 4 weeks. The treatment continued for 12 weeks in both groups. Percentage reduction in baseline Melasma Area and Severity Index (MASI) was assessed at 4-week intervals, and response was scored as very good (> 75% reduction), good (50% to < 75% reduction), moderate (25% to < 50% reduction), mild (< 25% reduction) or no response.

Results

The study was completed by 39 patients in group A and 41 patients in group B. Very good response was seen in 25 and 32 patients in groups A and B, respectively, while good response was seen in 14 and 9 patients, respectively. Both treatment methods were equally effective, with an average reduction of MASI at 12 weeks of 77.96 ± 9.39 in group A and 79.00 ± 9.64 in group B. The main adverse effects were mild epigastric discomfort, hypomenorrhea, headache and injection site pain, which did not warrant discontinuation of treatment. Two patients in group A had relapses at 24 weeks.

Conclusion

TXA appears to be an effective and safe treatment for melasma, irrespective of its route of administration.

http://ift.tt/2u5aPEw

Long-term management of chronic spontaneous urticaria with omalizumab

Summary

Background

Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking.

Aim

To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens.

Methods

This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines. Patients were started on omalizumab 150 mg subcutaneously every 4 weeks. Dose and interval between administrations were adjusted according to clinical response (189 administrations; treatment duration range 2–38 months).

Results

Mean UAS7 was 36.3 ± 5.4. Of the 13 patients, all had experienced angio-oedema, while in addition, 7 had delayed pressure urticaria (DPU) and 1 had solar urticaria (SU). After omalizumab treatment, 4 (30.8%) of the 13 patients had complete response (CR), and the remaining 8 (61.5%) had partial response. CR was achieved with a dose of 150 mg every 4 (n = 2 patients) or 5 (n = 2) weeks. One of these patients remained disease-free after stopping treatment. Partial responses were achieved with 150 mg every 4 weeks (n = 4) and with 300 mg (n = 4) at intervals of 5 weeks (n = 1), 4 weeks (n = 2) or 3 weeks (n = 1). Only one patient (7.7%) did not show significant improvement, despite a dose of 300 mg every 4 weeks. There were no significant differences in epidemiological, clinical and laboratory data between the different response groups. Only two adverse events were observed: one was mild headache and the other was severe angio-oedema and aggravation of urticaria within 6 h of omalizumab administration.

Conclusion

Omalizumab dose and interval between administrations could be individualized for long-term management of CSU.

http://ift.tt/2t7znPQ

Adjuvant therapy with low-dose interferon-beta for stage II and III melanoma: results of a retrospective analysis

Summary

Interferon (IFN)-alfa as an adjuvant therapy has been found to improve relapse-free survival in patients with malignant melanoma (MM). However, the efficacy of IFN-beta has not been studied in detail. This study evaluated the contribution of adjuvant IFN-beta therapy to improvements in the prognosis of patients with MM. We reviewed 63 patients with resected stage II/III primary MM at our institution. Of these, 36 had been treated with IFN-beta adjuvant therapy (subcutaneous injection, 3 × 10⁶ IU/day, 10 days), while 27 patients had undergone observation alone. In comparisons of all patients (stage II/III), overall survival and relapse-free survival were significantly better in the IFN-beta group than in the observation group (P < 0.001 for both). The 75-month overall survival rate was 41.2% in the observation group and 68.7% in the IFN-beta group. Adjuvant therapy with IFN-beta may become a new treatment option for patients with stage II/III MM.

http://ift.tt/2u5CncW

Rationale for two influenza B lineages in seasonal vaccines: A meta-regression study on immunogenicity and controlled field trials

Publication date: Available online 24 June 2017
Source:Vaccine
Author(s): W.E.P. Beyer, A.M. Palache, M. Boulfich, A.D.M.E. Osterhaus
B lineage mismatch prompted introduction of quadri-valent influenza vaccines (QIV) with two influenza B viruses representing distinct antigenic lineages. To explore the impact on antibody induction and vaccine effectiveness predicted from antibody (VEab), we performed a systematic literature search on immunogenicity studies conducted to assess antibody superiority of QIV over trivalent influenza vaccine (TIV). Thirteen relevant articles described 31 trials from 2007 and 2013. Log-transformed GMT trial estimates and their variances were converted to clinical protection rates predicted from antibody (PRab). VEab estimates were calculated from pre- and post-vaccination PRab. Without specific pre-vaccination immunity, average VEab was 69% for match, and −4% for lineage mismatch. With increasing pre-vaccination seropositivity, mismatch impact declined to 2%. We also performed an umbrella literature search for randomised controlled trials and test-negative case-control trials with TIV, and estimated vaccine effectiveness against laboratory-confirmed influenza B (VEf). Sixty-eight eligible clinical articles described 110 season-trials from 1965 to 2012, covering seasons with B lineage match (n=52), lineage drift (n=15) and lineage mismatch (n=43). With no pre-vaccination antibody levels determined, we used chance of previous exposure to influenza B (Ppe) as pre-seasonal immunity measure. When Ppe was 0%, average VEf for matched seasons was 67%, and for mismatched seasons 35%, indicating a moderate, yet significant mismatch impact on VEf. With increasing Ppe, mismatch impact declined to 3%. Thus serological and field trials indicate that B lineage mismatch impact is negatively related to pre-seasonal immunity and that the gain of QIV over TIV most benefits infants and children not yet exposed to influenza B.



http://ift.tt/2u4fgPT

Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice

Characterising the molecular networks that negatively regulate pancreatic β-cell function is essential for understanding the underlying pathogenesis and developing new treatment strategies for type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle. Here, we assessed the role of STK25 in control of progression of non-alcoholic fatty pancreas disease in the context of chronic exposure to dietary lipids in mice. We found that overexpression of STK25 in high-fat-fed transgenic mice aggravated diet-induced lipid storage in the pancreas compared with that of wild-type controls, which was accompanied by exacerbated pancreatic inflammatory cell infiltration, stellate cell activation, fibrosis and apoptosis. Pancreas of Stk25 transgenic mice also displayed a marked decrease in islet β/α-cell ratio and alteration in the islet architecture with an increased presence of α-cells within the islet core, whereas islet size remained similar between genotypes. After a continued challenge with a high-fat diet, lower levels of fasting plasma insulin and C-peptide, and higher levels of plasma leptin, were detected in Stk25 transgenic vs wild-type mice. Furthermore, the glucose-stimulated insulin secretion was impaired in high-fat-fed Stk25 transgenic mice during glucose tolerance test, in spite of higher net change in blood glucose concentrations compared with wild-type controls, suggesting islet β-cell dysfunction. In summary, this study unravels a role for STK25 in determining the susceptibility to diet-induced non-alcoholic fatty pancreas disease in mice in connection to obesity. Our findings highlight STK25 as a potential drug target for metabolic disease.

http://ift.tt/2sb41Uz

Skeletal energy homeostasis: a paradigm of endocrine discovery

Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing the endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research.

http://ift.tt/2sFYjNV

Hypothalamic effects of neonatal diet: reversible and only partially leptin dependent

Early life diet influences metabolic programming, increasing the risk for long-lasting metabolic ill health. Neonatally overfed rats have an early increase in leptin that is maintained long term and is associated with a corresponding elevation in body weight. However, the immediate and long-term effects of neonatal overfeeding on hypothalamic anorexigenic pro-opiomelanocortin (POMC) and orexigenic agouti-related peptide (AgRP)/neuropeptide Y (NPY) circuitry, and if these are directly mediated by leptin, have not yet been examined. Here, we examined the effects of neonatal overfeeding on leptin-mediated development of hypothalamic POMC and AgRP/NPY neurons and whether these effects can be normalised by neonatal leptin antagonism in male Wistar rats. Neonatal overfeeding led to an acute (neonatal) resistance of hypothalamic neurons to exogenous leptin, but this leptin resistance was resolved by adulthood. While there were no effects of neonatal overfeeding on POMC immunoreactivity in neonates or adults, the neonatal overfeeding-induced early increase in arcuate nucleus (ARC) AgRP/NPY fibres was reversed by adulthood so that neonatally overfed adults had reduced NPY immunoreactivity in the ARC compared with controls, with no further differences in AgRP immunoreactivity. Short-term neonatal leptin antagonism did not reverse the excess body weight or hyperleptinaemia in the neonatally overfed, suggesting factors other than leptin may also contribute to the phenotype. Our findings show that changes in the availability of leptin during early life period influence the development of hypothalamic connectivity short term, but this is partly resolved by adulthood indicating an adaptation to the metabolic mal-programming effects of neonatal overfeeding.

http://ift.tt/2sbbjaz

MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production

MicroRNAs (MiRNAs) play important regulatory roles in many cellular processes. MiR-143 is highly enriched in the mouse ovary, but its roles and underlying mechanisms are not well understood. In the current study, we show that miR-143 is located in granulosa cells of primary, secondary and antral follicles. To explore the specific functions of miR-143, we transfected miR-143 inhibitor into primary cultured granulosa cells to study the loss of function of miR-143 and the results showed that miR-143 silencing significantly increased estradiol production and steroidogenesis-related gene expression. Moreover, our in vivo and in vitro studies showed that follicular stimulating hormone (FSH) significantly decreased miR-143 expression. This function of miR-143 is accomplished by its binding to the 3'-UTR of KRAS mRNA. Furthermore, our results demonstrated that miR-143 acts as a negative regulating molecule mediating the signaling pathway of FSH and affecting estradiol production by targeting KRAS. MiR-143 also negatively acts in regulating granulosa cells proliferation and cell cycle-related genes expression. These findings indicate that miR-143 plays vital roles in FSH-induced estradiol production and granulosa cell proliferation, providing a novel mechanism that involves miRNA in regulating granulosa cell functions.

http://ift.tt/2sG7az6

The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons

A gain-of-function polymorphism in human neuropeptide Y (NPY) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D). Similarly, mice overexpressing NPY in noradrenergic neurons (OE-NPY^DBH) display obesity and impaired glucose metabolism. In this study, the metabolic syndrome-like phenotype was characterized and mechanisms of impaired hepatic fatty acid, cholesterol and glucose metabolism in pre-obese (2-month-old) and obese (4–7-month-old) OE-NPY^DBH mice were elucidated. Susceptibility to T2D was assessed by subjecting mice to high caloric diet combined with low-dose streptozotocin. Contribution of hepatic Y1-receptor to the phenotype was studied using chronic treatment with an Y1-receptor antagonist, BIBO3304. Obese OE-NPY^DBH mice displayed hepatosteatosis and hypercholesterolemia preceded by decreased fatty acid oxidation and accelerated cholesterol synthesis. Hyperinsulinemia in early obese state inhibited pyruvate- and glucose-induced hyperglycemia, and deterioration of glucose metabolism of OE-NPY^DBH mice developed with aging. Furthermore, streptozotocin induced T2D only in OE-NPY^DBH mice. Hepatic inflammation was not morphologically visible, but upregulated hepatic anti-inflammatory pathways and increased 8-isoprostane combined with increased serum resistin and decreased interleukin 10 pointed to increased NPY-induced oxidative stress that may predispose OE-NPY^DBH mice to insulin resistance. Chronic treatment with BIBO3304 did not improve the metabolic status of OE-NPY^DBH mice. Instead, downregulation of beta-1-adrenoceptors suggests indirect actions of NPY via inhibition of sympathetic nervous system. In conclusion, changes in hepatic fatty acid, cholesterol and glucose metabolism favoring energy storage contribute to the development of NPY-induced metabolic syndrome, and the effect is likely mediated by changes in sympathetic nervous system activity.

http://ift.tt/2saWhlq

Effect of mitotane on mouse ovarian follicle development and fertility

Mitotane (MTT) is an adrenolytic drug used in advanced and adjuvant treatment of adrenocortical carcinoma, in Cushing's disease and in ectopic syndrome. However, knowledge about its effects on the ovary is still scarce. The purpose of this study is to investigate the effect of MTT on the ovary using in vivo and in vitro models. The study was performed in CD1 mice and in the COV-434 human ovarian granulosa cell line. We examined ovarian morphology, follicle development, steroidogenesis and procreative function in mice and the effect of MTT on cell growth in vitro. Our results revealed that treatment of CD1 mice with MTT induces a decrease in early antral follicles with a subsequent increase in the secondary follicles, measured by the increased levels of anti-Mullerian Hormone (P < 0.05) and decreased levels of FSH receptor (P < 0.05). Moreover, we observed a significant decrease in Cyp11a1 (P < 0.01) and Cyp17a1 (P < 0.001) mRNA level in MTT-treated animals. Ovulation, induced by PMSG/hCG stimulation, was also significantly impaired, with a reduction in the number of ovulated oocytes (P < 0.01) and fewer corpora lutea in treated animals. Likewise, the mating experiment demonstrated a delay in the time of conception as well as fewer pups per litter in MTT-treated mice (P < 0.05). Experiments performed on the COV-434 cell line showed a significant inhibition of growth followed by apoptosis (P < 0.01). In conclusion, our study highlights the key points of ovarian folliculogenesis affected by MTT and demonstrates impairment of the ovulation process with a negative impact on conception, which is nevertheless preserved.

http://ift.tt/2sbd07Z

Attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy

Publication date: Available online 24 June 2017
Source:Radiotherapy and Oncology
Author(s): Tanya N. Antonini, M. Douglas Ris, David R. Grosshans, Anita Mahajan, M. Fatih Okcu, Murali Chintagumpala, Arnold Paulino, Amanda E. Child, Jessica Orobio, Heather H. Stancel, Lisa S. Kahalley
Background and purposeThis study examines attention, processing speed, and executive functioning in pediatric brain tumor survivors treated with proton beam radiation therapy (PBRT).Material and methodsWe examined 39 survivors (age 6–19years) who were 3.61years post-PBRT on average. Craniospinal (CSI; n=21) and focal (n=18) subgroups were analyzed. Attention, processing speed, and executive functioning scores were compared to population norms, and clinical/demographic risk factors were examined.ResultsAs a group, survivors treated with focal PBRT exhibited attention, processing speed, and executive functioning that did not differ from population norms (all p>0.05). Performance in the CSI group across attention scales was normative (all p>0.05), but areas of relative weakness were identified on one executive functioning subtest and several processing speed subtests (all p<0.01).ConclusionsSurvivors treated with PBRT may exhibit relative resilience in cognitive domains traditionally associated with radiation late effects. Attention, processing speed, and executive functioning remained intact and within normal limits for survivors treated with focal PBRT. Among survivors treated with CSI, a score pattern emerged that was suggestive of difficulties in underlying component skills (i.e., processing speed) rather than true executive dysfunction. No evidence of profound cognitive impairment was found in either group.



http://ift.tt/2saVP6F

Mind Games: Game Engines as an Architecture for Intuitive Physics

Publication date: Available online 24 June 2017
Source:Trends in Cognitive Sciences
Author(s): Tomer D. Ullman, Elizabeth Spelke, Peter Battaglia, Joshua B. Tenenbaum
We explore the hypothesis that many intuitive physical inferences are based on a mental physics engine that is analogous in many ways to the machine physics engines used in building interactive video games. We describe the key features of game physics engines and their parallels in human mental representation, focusing especially on the intuitive physics of young infants where the hypothesis helps to unify many classic and otherwise puzzling phenomena, and may provide the basis for a computational account of how the physical knowledge of infants develops. This hypothesis also explains several 'physics illusions', and helps to inform the development of artificial intelligence (AI) systems with more human-like common sense.



http://ift.tt/2tJnsFK

Controlling the pro-inflammatory function of 6-sulfo LacNAc (slan) dendritic cells with dimethylfumarate

Publication date: Available online 24 June 2017
Source:Journal of Dermatological Science
Author(s): Stephanie Oehrl, Florina Olaru, Anja Kunze, Michael Maas, Silvia Pezer, Marc Schmitz, Knut Schäkel
BackroundThe fumaric acid ester (FAE) dimethylfumarate (DMF) is a small molecule immunomodulator successfully used for the treatment of psoriasis and multiple sclerosis (MS). DMF is thought to inhibit pathogenic immune responses with Th17/Th1T cells, and IL-23/IL-12 producing dendritic cells (DCs). 6-sulfo LacNAc expressing dendritic cells (slanDCs) are a human pro-inflammatory cell type found frequently among the infiltrating leukocytes in skin lesions of psoriasis and brain lesions of MS.ObjectiveTo explore the influence of DMF on functional properties and cell signaling pathways of slanDCs.MethodsIn the context of slanDCs we studied the role of DMF in modulating cell migration, phenotypic maturation, cytokine production, cell signaling and T cell stimulation.ResultsInitially, we observed the reduction of slanDCs numbers in psoriasis skin lesions of FAE treated patients. Studying whether DMF controls the migratory capacity of slanDCs to chemotactic factors expressed in psoriasis we observed an inhibition of the CX3CL1 and C5a depedent cell migration. DMF also attenuated the rapid spontaneous phenotypic maturation of slanDCs, as judged by a reduced CD80, CD86, CD83 and HLA-DR expression. In addition, we observed a DMF-dependent decrease of IL-23, IL-12, TNF-α and IL-10 secretion, and noticed a reduced capacity to stimulate Th17/Th1 responses. DMF targeted in slanDCs different intracellular cell signaling pathways including NFκB, STAT1 and HO-1.ConclusionsWith this study we identify a frequent pro-inflammatory cell type found in psoriasis and MS as a relevant target for the therapeutic immunomodulatory effects of DMF.



http://ift.tt/2rQwsHU

Scholar : Ειδοποίηση Μελετητή - [ ΑΠΟΚΑ

Ειδοποίηση Μελετητή:[ ΑΠΟΚΑΤΑΣΤΑΣΗ ]

Βελτιστοποίηση των ιδιοτήτων νανορευστών για την αποδοτική επιτόπια αποκατάσταση ρυπασμένων υπογείων εδαφών

Α Τερζή - 2017

Αιωρήματα νανοσωματιδίων σιδήρου μηδενικού σθένους (nZVI) χρησιμοποιούνται συνήθως
για την επί τόπια απορρύπανση εδαφών ρυπασμένων με χλωριωμένους διαλύτες. Μια
ποικιλία υδατικών αιωρημάτων νανοσωματιδίων (nanofluids) σιδήρου μηδενικού σθένους

[HTML] Ποιες τροφές μπορούν να βοηθήσουν στην αποκατάσταση μυϊκών τραυματισμών

Γ Μίλεσης - 2017

Τα άσχημα νέα είτε ότι μέχρι να αποκατασταθεί η ζημιά, τέλος οι προπονήσεις. Κάτι που
ούτως ή άλλως θα σε… πάει πίσω προπονητικά, από άποψη φόρμας. Είναι λοιπόν να μην
νιώθεις σαν… θηρίο στο κλουβί;Πέρα λοιπόν από τις φυσικοθεραπείες και τη φαρμακευτική

ΜΕΛΕΤΗ ΕΠΙΣΚΕΥΗΣ ΚΑΙ ΕΝΙΣΧΥΣΗΣ ΤΟΥ ΛΑΔΟΜΥΛΟΥ ΣΤΟ ΘΕΟΛΟΓΟ ΘΑΣΟΥ ΚΑΙ ΔΙΑΧΕΙΡΙΣΗ ΤΟΥ ΤΡΟΠΟΥ ΕΠΕΜΒΑΣΗΣ

Ι ΚΑΛΑΦΑΤΖΗΣ - 2017

... Η μελέτη περίπτωσης που εξετάζουμε αφορά ένα κτίσμα που πρόκειται να κριθεί διατηρητέο.
Με την παρούσα έρευνα προτείνεται μία νέα χρήση αντιμετωπίζοντας την παθολογία του
κτίσματος με εργασίες επέμβασης για τη δομική του αποκατάσταση. ...

[PDF] Ανάπτυξη λεξιλογίου σε μαθητές με μέτρια νοητική αναπηρία: μια διερευνητική μελέτη των στρατηγικών αυτορρύθμισης

Α Χατζημπαλάση - 2017

... Τμήμα Εκπαιδευτικής και Κοινωνικής Πολιτικής Πρόγραμμα Μεταπτυχιακών Σπουδών «Ειδική
Αγωγή, Εκπαίδευση και Αποκατάσταση» ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ... Πρόγραμμα Μεταπτυχιακών
Σπουδών «Ειδική Αγωγή, Εκπαίδευση και Αποκατάσταση» ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ...

ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΕΛΛΗΝΙΚΩΝ ΧΡΗΜΑΤΟΠΙΣΤΩΤΙΚΩΝ ΙΔΡΥΜΑΤΩΝ ΜΕ ΤΗΝ ΜΕΘΟΔΟ CAMELS

Γ ΤΣΑΚΑΝΙΚΑΣ - 2017

... πλειονότητα τους. Η πρώτη ανάγκη που εμφανίστηκε, ήταν η αποκατάσταση της
ισορροπίας και η ενίσχυση του χρηματοπιστωτικού συστήματος, διότι μια πιθανή
κατάρρευσή του θα είχε ολέθριες επιπτώσεις στις παγκόσμιες αγορές. Το ...

[PDF] Κυτταρομετρικός προσδιορισμός της ανοσολογικής απόκρισης του ανθρώπινου οργανισμού σε ενθέματα σιλικόνης

ΓΕ Παπανικολάου - 2017

... χρησιμοποιηθούν για την αποκατάσταση συγγενών δυσμορφιών του μαστού, όπως η υποπλασία,
η ανισομαστία, ο σωληνοειδής μαστός και το σύνδρομο Poland, καθώς για την αποκατάσταση ...
αποκατάσταση της συμμετρίας [24-26]. Ασφάλεια και επιπλοκές ...

Μελέτη της ηωσινοφιλικής οισοφαγίτιδας στα παιδιά

Α Αγγελακοπούλου-Πολυζώη - 2017

... εικόνα στα παιδιά με ΕοΕ και στατιστικά μεγαλύτερο αριθμό ηωσινοφίλων συγκριτικά με τη ΓΟΠ,
καθώς επίσης, μειωμένη και αυξημένη έκφραση φιλαγκρίνης και περιοστίνης, αντιστοίχως, στον
οισοφαγικό βλεννογόνο ασθενών με ενεργό ΕοΕ, και αποκατάσταση των μεταβολών ...

[PDF] Νόσος ALZHEIMER και νοσηλευτικες παρεμβάσεις.

Ι Μιμιγιάννη - 2017

... Page 3. 2 ΨΥΧΟΚΟΙΝΩΝΙΚΗ ΑΠΟΚΑΤΑΣΤΑΣΗ……………50 ΟΙΚΟΓΕΝΕΙΑ……………53 ... Τέλος
σε αυτό το κομμάτι γίνεται λόγος και για την ψυχοκοινωνική αποκατάσταση του ανοϊκού ασθενή. ...

[PDF] Επικοινωνιακές και γνωστικές επιπτώσεις της εγκεφαλικής διάσεισης σε ακαδημαϊκό πλαίσιο: διαστάσεις στην ειδική αγωγή

Κ Τσακπουνίδου - 2017

... 18 1.2.4. Διάρκεια των συμπτωμάτων της ΕΔ και Αποκατάσταση ..... 19 ... 63 4.2.1. Οι διαστάσεις
της Ειδικής Αγωγής στην Εκπαίδευση και Αποκατάσταση των ατóμων με ΕΔ ..... 66 4.3. ...

[PDF] Αλτσχάιμερ-Alzheimer και ο ρόλος του νοσηλευτή.

Σ Χουλιάρα - 2017

Page 1. ΣΜΗΜΑ ΝΟ΢ΗΛΔΤΣΙΚΗ΢ ΠΣΤΥΙΑΚΗ ΔΡΓΑ΢ΙΑ «ΑΛΣ΢ΥΑΙΜΔΡ- ALZHEIMER
ΚΑΙ Ο ΡΟΛΟ΢ ΣΟΤ ΝΟ΢ΗΛΔΤΣΗ» ΦΟΙΣΗΣΡΙΑ: ΢ΣΑΤΡΟΤΛΑ ΥΟΤΛΙΑΡΑ ΔΙ΢ΗΓΗΣΡΙΑ:
ΛΔΤΚΟΘΔΑ ΜΑΣ΢ΟΤΛΗ ΙΧΑΝΝΙΝΑ 2017 Page 2. 1 Page 3. 2 ...

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Αυτή η Ειδοποίηση του Μελετητή Google σας προσφέρεται από τη Google

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Scholar : Ειδοποίηση Μελετητή - [ ΛΟΓΟΣ

Ειδοποίηση Μελετητή:[ ΛΟΓΟΣ ]

[PDF] ПРОБЛЕМА ЛЕКСИЧЕСКОЙ СИНОНИМИИ НА ПРИМЕРЕ СЛОВ СО ЗНАЧЕНИЕМ «ЛЕЧИТЬ» И «БОЛЕЗНЬ»

ДВ Горбунов, ОЮ Макарова, АВ Зеленкова - ББК 81 Я 41 Редакционная коллегия …, 2017

... λέξη–слово). Раздел языкознания, в ко- тором изучается слово, его значение и
словарный состав языка называ- ется лексикологией (греч. λέξη–слово, λογος–учение).
В свою очередь Page 60. ... σημασία–обозначение, λογος–учение). ...

ΠΟΛΙΤΙΣΤΙΚΗ ΔΙΠΛΩΜΑΤΙΑ. Η ΑΣΚΗΣΗ ΤΗΣ ΠΟΛΙΤΙΣΤΙΚΗΣ ΔΙΠΛΩΜΑΤΙΑΣ ΑΠΟ ΤΑ ΞΕΝΟΓΛΩΣΣΑ ΠΟΛΙΤΙΣΤΙΚΑ ΙΔΡΥΜΑΤΑ ΚΑΙ ΣΥΓΚΕΚΡΙΜΕΝΑ ΑΠΟ ΤΑ …

Μ ΧΟΣΤΕΛΙΔΟΥ - 2017

... Γίνεται λόγος για τη διμερή πολιτιστική διπλωματία με τη σύναψη μορφωτικών συμφωνιών
και μορφωτικών προγραμμάτων ανάμεσα στα κράτη. Έπεται η διερεύνηση της πολιτιστικής
διπλωματίας της Γερμανίας και της Μεγάλης Βρετανίας. ...

Δημιουργία εφαρμογής MediaPlayer για συσκευές Android

ΔΑ Τάσσης-Φερνάντες - 2017

... Στη χρονική περίοδο που διανύουμε ζούμε την επανάσταση των Smartphones η οποία έχει
κατακτήσει το μεγαλύτερο μέρος της αγοράς ηλεκτρονικών ειδών και ο λόγος είναι ότι ένα
Smartphone δεν αποτελεί απλό τηλέφωνο πλέον αλλά μια πολυχρηστική συσκευή που συνδυάζει ...

Exile in the Flow of Time

C Baracchi - Research in Phenomenology, 2017

... And νοῦς sees all of them at the same time, but λόγος says some first and some after" (Ταῦτα
δὲ ἐγένετο μὲν οὐδέποτε, ἔστι δὲ ἀεί· καὶ ὁ μὲν νοῦς ἅμα πάντα ὁρᾷ, ὁ δὲ λόγος τὰ μὲν
πρῶτα τὰ δὲ δεύτερα λέγει).10 One last remark is in order, concerning poets ...

ΔΙΟΙΚΗΣΗ ΟΛΙΚΗΣ ΠΟΙΟΤΗΤΑΣ ΣΤΟΝ ΙΔΙΩΤΙΚΟ ΚΑΙ ΔΗΜΟΣΙΟ ΤΟΜΕΑ ΥΓΕΙΑΣ (Μελέτη των νοσοκομείων της Θεσσαλονίκης)

Φ ΣΙΕΧΟΥ - 2017

... Βασικότερος λόγος καθυστέρησης της διαδικασίας της έρευνας, για λόγους δεοντολογίας,
αποτέλεσε η απόκτηση των απαραίτητων αδειών για την είσοδο στους χώρους των παραπάνω
γραφείων. Appears in Collections: ΔΜΥ Διπλωματικές Εργασίες. Files in This Item: ...

ΣΤΡΑΤΗΓΙΚΕΣ ΑΝΑΠΤΥΞΗΣ: ΜΕΛΕΤΗ ΠΕΡΙΠΤΩΣΗΣ ΤΗΣ ΜΕΤΡΟ ΣΤΗΝ ΕΛΛΗΝΙΚΗ ΑΓΟΡΑ ΚΑΙ Ο ΡΟΛΟΣ ΤΟΥ ΤΡΑΠΕΖΙΚΟΥ ΔΑΝΕΙΣΜΟΥ

Χ ΠΕΡΙΣΤΕΡΗΣ - 2017

... πρόσφατα προέβη στην εξαγορά της εταιρείας Βερόπουλος. Στο σημείο αυτό θα
γίνει λόγος για το ρόλο και τη συμβολή του τραπεζικού συστήματος στη διαδικασία
εξαγοράς. Οι κεντρικοί άξονες που αναπτυχθούν στα πλαίσια ...

Η ΧΡΥΣΗ ΤΟΜΗ-Ο «ΧΡΥΣΟΣ» ΑΡΙΘΜΟΣ φ–ΠΩΣ ΟΛΟΚΛΗΡΟ ΤΟ ΣΥΜΠΑΝ ΥΠΟΚΛΙΝΕΤΑΙ ΣΤΗ ΧΡΥΣΗ ΑΝΑΛΟΓΙΑ

Δ ΚΟΡΑΚΑ - 2017

... εξέχουσα θέση καταλαμβάνει ο χρυσός αριθμός φ. Μέσα στους αιώνες έχει γνωρίσει
διάφορες ονομασίες, όπως χρυσή τομή, χρυσή αναλογία, χρυσός λόγος, θείος αριθμός ,
θεία αναλογία. Ο αριθμός αυτός καλύπτει ένα μεγάλο ...

ΤΕΧΝΙΚΕΣ ΚΑΤΑΠΟΛΕΜΙΣΗΣ ΑΠΑΤΗΣ ΣΤΟ ΤΡΑΠΕΖΙΚΟ ΣΥΣΤΗΜΑ

Χ ΖΑΓΚΛΙΒΕΡΗΣ - 2017

... Μέσα από αυτή, θα παρουσιάσουμε τις κατηγορίες και τους παράγοντες του κινδύνου της απάτης,
θα γίνει λόγος στις πιο γνωστές κατηγορίες της, στα κίνητρα και τους παράγοντες που οδήγησαν
και ενθάρρυναν τη διάπραξη αυτής, αλλά και τα σημεία κλειδιά, γνωστά και ως Red ...

Αξιολόγηση των μέχρι σήμερα διαδικασιών για τον εκσυγχρονισμό της Ελληνικής Τοπικής Αυτοδιοίκησης. Προτάσεις ενός νέου μοντέλου

Α Πασσά - 2017

... μεθοδευμένες προσπάθειες, αξιοκρατία και διαφάνεια. Αυτά αποτελούν βασικές
προϋποθέσεις για να μπορεί να γίνεται λόγος για αναβάθμιση της ποιότητας των
δημόσιων υπηρεσιών. Καθοριστικά στη μεταρρυθμιστική προσπάθεια ...

[HTML] Learners on the Periphery: Lurkers as Invisible Learners

S Honeychurch, A Bozkurt, L Singh, A Koutropoulos - European Journal of Open, …, 2017

... Τα ευρήματα μας παρουσιάζουν μια εικόνα που δείχνει πως οι δράσεις και η συμπεριφορά των
ενεδρεύων είναι πολυσύνθετη, και δεν υπάρχει ένας και μοναδικός λόγος για τον οποίον οι
ενεδρεύων δρουν με τον τρόπο που δρουν εντός των κοινοτήτων τους. ...

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