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Παρασκευή 17 Νοεμβρίου 2017

The semantic system is involved in mathematical problem solving

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Publication date: 1 February 2018
Source:NeuroImage, Volume 166
Author(s): Xinlin Zhou, Mengyi Li, Leinian Li, Yiyun Zhang, Jiaxin Cui, Jie Liu, Chuansheng Chen
Numerous studies have shown that the brain regions around bilateral intraparietal cortex are critical for number processing and arithmetical computation. However, the neural circuits for more advanced mathematics such as mathematical problem solving (with little routine arithmetical computation) remain unclear. Using functional magnetic resonance imaging (fMRI), this study (N = 24 undergraduate students) compared neural bases of mathematical problem solving (i.e., number series completion, mathematical word problem solving, and geometric problem solving) and arithmetical computation. Direct subject- and item-wise comparisons revealed that mathematical problem solving typically had greater activation than arithmetical computation in all 7 regions of the semantic system (which was based on a meta-analysis of 120 functional neuroimaging studies on semantic processing). Arithmetical computation typically had greater activation in the supplementary motor area and left precentral gyrus. The results suggest that the semantic system in the brain supports mathematical problem solving.



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Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations

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Publication date: 1 February 2018
Source:NeuroImage, Volume 166
Author(s): Kanad Mandke, Jil Meier, Matthew J. Brookes, Reuben D. O'Dea, Piet Van Mieghem, Cornelis J. Stam, Arjan Hillebrand, Prejaas Tewarie
There is an increasing awareness of the advantages of multi-modal neuroimaging. Networks obtained from different modalities are usually treated in isolation, which is however contradictory to accumulating evidence that these networks show non-trivial interdependencies. Even networks obtained from a single modality, such as frequency-band specific functional networks measured from magnetoencephalography (MEG) are often treated independently. Here, we discuss how a multilayer network framework allows for integration of multiple networks into a single network description and how graph metrics can be applied to quantify multilayer network organisation for group comparison. We analyse how well-known biases for single layer networks, such as effects of group differences in link density and/or average connectivity, influence multilayer networks, and we compare four schemes that aim to correct for such biases: the minimum spanning tree (MST), effective graph resistance cost minimisation, efficiency cost optimisation (ECO) and a normalisation scheme based on singular value decomposition (SVD). These schemes can be applied to the layers independently or to the multilayer network as a whole. For correction applied to whole multilayer networks, only the SVD showed sufficient bias correction. For correction applied to individual layers, three schemes (ECO, MST, SVD) could correct for biases. By using generative models as well as empirical MEG and functional magnetic resonance imaging (fMRI) data, we further demonstrated that all schemes were sensitive to identify network topology when the original networks were perturbed. In conclusion, uncorrected multilayer network analysis leads to biases. These biases may differ between centres and studies and could consequently lead to unreproducible results in a similar manner as for single layer networks. We therefore recommend using correction schemes prior to multilayer network analysis for group comparisons.



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Q-switched 532nm laser energy causes significant vascular damage in the capillary plexus – how does this affect laser tattoo removal?

Abstract

Tattoos can be effectively removed using Q-switched and picosecond lasers at four wavelengths – 1064, 755, 694 and 532nm1,2,3,4. However, there are two particular problems with the 532nm line. Firstly, it is well absorbed by the melanin in the epidermis, due to its relatively high absorption coefficient5, (μa_mel = 56 cm−1 for typical Caucasian skin). Secondly, 532nm is also strongly absorbed in the haemoglobin located in the capillary plexus5a_HbO = 260 cm−1).

This article is protected by copyright. All rights reserved.



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How well are reporting guidelines and trial registration used by dermatology journals to limit bias? A meta-epidemiological study

Abstract

Reporting guidelines were created to ensure research is reported in a transparent, complete manner that minimizes reporting bias. Further, these guidelines assist editors and peer reviewers when reviewing manuscripts for publication and readers when critically appraising published articles 1. Though reporting guidelines and trial registration have been associated with improved reporting quality, the full effect of these guidelines has yet to manifest because many journals do not require their use 2.

This article is protected by copyright. All rights reserved.



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The expanding spectrum of clinical phenotypes associated with PSTPIP1 mutations: from PAPA to PAMI syndrome and beyond

Abstract

Mutations in the PSTPIP1 gene encoding proline-serine-threonine-phosphatase interactive protein 1 were first identified in an autosomal dominant syndrome called PAPA associated with pyogenic sterile arthritis, pyoderma gangrenosum (PG) and cystic acne.1,2. We report a patient with an autoinflammatory syndrome called PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome.3 A 23-year-old man had a 3-year-history of skin ulcerations.

This article is protected by copyright. All rights reserved.



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Response to ‘Clinical presentation of terbinafine-induced severe liver injury and the value of laboratory monitoring: a critically appraised topic’

Abstract

We read with interest the article by Kramer et al entitled "Clinical presentation of terbinafine-induced severe liver injury and the value of laboratory monitoring: a critically appraised topic". 1 We would like to bring to focus our experience in this regard. With increasing concerns of reduced susceptibility to terbinafine2 and an upsurge of recalcitrant cutaneous dermatophytoses, dermatologists in India have been using higher doses of terbinafine for cutaneous dermatophytoses, as used in the early literature with this drug (upto 500mg/day in single or divided doses) 3; and for longer periods of time.

This article is protected by copyright. All rights reserved.



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Response to “IL-36 in hidradenitis suppurativa: Evidence for a distinctive pro-inflammatory role and a key factor in the development of an inflammatory loop”

Abstract

we read with interest the recent paper of Hessam et al.1 regarding the involvement of IL-36 in hidradenitis suppurativa (HS). They have showed that agonist members of IL-36 were significantly overexpressed in HS lesional skin.

This article is protected by copyright. All rights reserved.



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Chronic sun exposure is associated with distinct histone acetylation changes in human skin

Abstract

Background

Photoaging is attributed to continuous sunlight or artificial UV exposure and manifests the clinical and histological changes of skin. Epigenetic changes have been found to be involved in the pathogenesis of photoaging. However, the underlying mechanisms are unclear.

Objectives

To analyse histone modification patterns in sun-exposed and non-exposed skins, and identify the abnormally histone modified-genes related to photoaging.

Methods

Skin biopsies were collected both from the outer forearm (sun-exposed area) and the buttock (sun-protected area) in 20 healthy middle-aged female volunteers. Global histone H3/H4 acetylation and H3K4/H3K9 methylation statuses were assessed by ELISA. Expression levels of HATs and HDACs were measured by RT-qPCR and western blot. ChIP-chip assay with anti-acetyl-histone H3 antibody in sun-exposed Pool (combining six sun-exposed skin samples) and non-exposed Pool (combining six non-exposed skin samples) was conducted to explore the abnormal histone H3 acetylation genes related to photoaging, then ChIP-qPCR was followed to verify the results of ChIP-chip.

Results

We observed higher global histone H3 acetylation level, increased P300 and decreased HDAC1 and SIRT1 expression in sun-exposed skins, compared with matched non-exposed skins. Further, ChIP-chip assay results showed that 227 genes displayed significant hyperacetylation of histone H3, and 81 genes displayed significant hypoacetylation of histone H3 between the two groups. Histone H3 acetylations levels on the promoters of PDCD5, ITIH5, MMP1 and AHR were positively correlated with the mRNA expression of the corresponding gene.

Conclusions

Chronic sun exposure induced histone H3 hyperacetylation may play a critical role in the pathogenesis of skin photoaging.

This article is protected by copyright. All rights reserved.



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Aprepitant improves refractory pruritus in primary cutaneous T-cell lymphomas: experience of the Spanish Working Group on Cutaneous Lymphomas

Abstract

Aprepitant has shown a promising anti-itch activity in several cases of cutaneous T-cell lymphomas (CTCLs)1-8. We sought to determine its antipruritic efficacy in a large multicenter series of CTCLs patients with refractory pruritus and, secondarily, to define possible clinical predictors of response.A retrospective, analytical review of the Spanish Working Group on Cutaneous Lymphoma database was designed to collect patients with CTCLs and refractory pruritus, treated with aprepitant from 2009 to 2013.

This article is protected by copyright. All rights reserved.



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Correction to: A bibliometric analysis of research on haze during 2000–2016

Abstract

The original version of this article unfortunately contains mistakes.



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Copyright

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Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1





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Contributors

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1





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Contents

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1





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Forthcoming Issues

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Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1





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Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Frits van Rhee, Nikhil C. Munshi




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Castleman Disease

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Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Frits Van Rhee, Nikhil C. Munshi




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Epidemiology of Castleman Disease

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Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): David Simpson

Teaser

Castleman disease is a rare entity, including unicentric Castleman disease (UCD), human herpesvirus-8 plus Castleman disease (HHV-8+MCD), and idiopathic multicentric Castleman disease (iMCD). UCD is the most common at 16 per million person years and occurs at every age. HHV-8+MCD incidence varies widely, mostly affecting human immunodeficiency virus–positive men. iMCD is likely a more heterogeneous disease with an estimated incidence of 5 per million person years. Improved definitions should improve understanding of the epidemiology of Castleman disease and its subtypes.


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Castleman Disease Pathogenesis

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): David C. Fajgenbaum, Dustin Shilling

Teaser

Castleman disease (CD) describes a group of heterogeneous disorders with common lymph node histopathologic features, including atrophic or hyperplastic germinal centers, prominent follicular dendritic cells, hypervascularization, polyclonal lymphoproliferation, and/or polytypic plasmacytosis. The cause and pathogenesis of the four subtypes of CD (unicentric CD; human herpesvirus-8-associated multicentric CD; polyradiculoneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes [POEMS]-associated multicentric CD; and idiopathic multicentric CD) vary considerably. This article provides a summary of our current understanding of the cause, cell types, signaling pathways, and effector cytokines implicated in the pathogenesis of each subtype.


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The Role of Interleukin-6 in Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Kazuyuki Yoshizaki, Shinichi Murayama, Hiroki Ito, Tomohiro Koga

Teaser

Since its discovery, improvements in treating Castleman disease and its variants have centered on interleukin-6 (IL-6). IL-6 was discovered from T-cell factors (BCDF or BSF-2), which induced B-cell maturation. Most symptoms of the plasma cell variant of Castleman disease are linked to the hyperfunction of IL-6, constitutively produced in the affected lymph nodes (1989), suggesting IL-6 is key in the pathogenesis of multicentric Castleman disease (MCD). The results of several studies have shown that most MCD symptoms and abnormal laboratory results are improved by anti-IL-6 MCD treatments, such as tocilizumab, a humanized anti-IL-6 receptor antibody, and siltuximab, an anti-IL-6 antibody.


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Pathology of Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): David Wu, Megan S. Lim, Elaine S. Jaffe

Teaser

The term Castleman disease encompasses several distinct lymphoproliferative disorders with different underlying disease pathogenesis, and clinical outcomes. It includes unicentric and multicentric diseases with limited versus significant systemic symptoms, respectively. Importantly, the histopathologic features encountered in the various forms of Castleman disease are diverse, and for the most part, lack specificity, because they are seen to varying degrees in different clinical variants of Castleman disease, and in reactive (autoimmune/infectious) and malignant (lymphoma) contexts. Accordingly, accurate clinical diagnosis of Castleman disease requires careful and thorough clinicopathologic correlation. An overview of the key histopathologic features of Castleman disease is presented.


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Diagnosis of Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Raphaël Szalat, Nikhil C. Munshi

Teaser

Castleman disease (CD) is a rare and heterogenous group of disorders sharing in common an abnormal lymph node pathology. CD comprises distinct subtypes with different prognoses. Unicentric CD and multicentric CD are featured by specific systemic manifestations and may be associated with Kaposi sarcoma, non-Hodgkin and Hodgkin lymphoma, and POEMS syndrome. Multicentric CD is classically associated with systemic symptoms and poorer prognosis. In this article, the authors review how to diagnose the disease, keeping in context the clinical findings, biochemical changes and complications associated with CD.


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Unicentric Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Raymond S.M. Wong

Teaser

Unicentric Castleman disease (UCD) is a rare lymphoproliferative disorder that manifests typically as proliferation of a single lymph node or region of lymph nodes. Histologically, hyaline vascular variant is found in a majority of UCDs. UCD commonly presents in younger patient populations. Patients with UCD may be asymptomatic or present with symptoms related to mass effects on surrounding structures. It is difficult to achieve a definitive diagnosis by imaging alone. Histologic examination of the lesion remains the gold standard for diagnosis. Complete surgical resection is the best primary treatment modality for UCD resulting in excellent long-term survival and low recurrence rates.


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Treatment of Kaposi Sarcoma Herpesvirus–Associated Multicentric Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Kathryn Lurain, Robert Yarchoan, Thomas S. Uldrick

Teaser

Kaposi sarcoma herpesvirus (KSHV)-associated multicentric Castleman disease (MCD) is a rare, polyclonal lymphoproliferative disorder characterized by flares of inflammatory symptoms, edema, cytopenias, lymphadenopathy, and splenomegaly. Diagnosis requires a lymph node biopsy. Pathogenesis is related to dysregulated inflammatory cytokines, including human and viral interleukin-6. Rituximab alone or in combination with chemotherapy, such as liposomal doxorubicin, has led to an overall survival of over 90% at 5 years. Experimental approaches to treatment include virus activated cytotoxic therapy with high-dose zidovudine and valganciclovir and targeting human interleukin-6 activity. Despite successful treatment of KSHV-MCD, patients remain at high risk for developing non-Hodgkin lymphomas.


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Treatment of Idiopathic Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Frits van Rhee, Amy Greenway, Katie Stone

Teaser

Important progress has been made in the treatment of idiopathic multicentric Castleman disease (iMCD) with the introduction of interleukin-6 targeting monoclonal antibodies. This article describes the clinical results obtained with different treatment modalities and uses this evidence to provide treatment guidelines for the practicing clinician. Much is still to be learned about the pathophysiology of iMCD and further research is urgently needed to develop novel and curative treatment approaches for all patients.


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TAFRO Syndrome

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Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Takuro Igawa, Yasuharu Sato

Teaser

TAFRO syndrome is a newly recognized variant of idiopathic multicentric Castleman disease (iMCD) that involves a constellation of syndromes: thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Thrombocytopenia and severe anasarca accompanied by relatively low serum immunoglobulin levels are characteristic clinical findings of TAFRO syndrome that are not present in iMCD-not otherwise specified (iMCD-NOS). Lymph node biopsy is recommended to exclude other diseases and to diagnose TAFRO syndrome, which reveals characteristic histopathological findings similar to hyaline vascular-type CD. TAFRO syndrome follows a more aggressive course, compared with iMCD-NOS, and there is no standard treatment.


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POEMS Syndrome

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Angela Dispenzieri, Taxiarchis Kourelis, Francis Buadi

Teaser

POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Recognition of a combination of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasmaproliferative disorder, skin changes, papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis, and Castleman disease is the first step in managing the disease. Increased blood levels of vascular endothelial growth factor are usually confirmatory. This rare disorder should not be missed, especially if the patient has a putative diagnosis of chronic inflammatory polyradiculoneuropathy, a lambda restricted monoclonal gammopathy, and thrombocytosis, and is not responding as expected to immunomodulatory therapy commonly used for chronic inflammatory polyradiculoneuropathy.


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POEMS Syndrome

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Arnaud Jaccard

Teaser

Treatment of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome should be directed at the underlying plasma cell clone with risk-adapted therapy based on the extent of the plasma cell disorder. Radiation therapy is effective for patients with a localized presentation, without bone marrow involvement, and 1 to 3 bone lesions. Patients with disseminated disease should receive, preferably, high-dose chemotherapy with peripheral blood transplantation. Low-dose melphalan and dexamethasone or new agents used in myeloma are also effective. The most promising agent is lenalidomide, which could be given before high-dose therapy or radiation to get rapid neurologic responses.


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The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease

Publication date: February 2018
Source:Hematology/Oncology Clinics of North America, Volume 32, Issue 1
Author(s): Michelle L. Mauermann

Teaser

Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes (POEMS) syndrome is a rare paraneoplastic disorder. The polyneuropathy can be the presenting symptom and is typically a painful, motor-predominant polyradiculoneuropathy often mimicking chronic inflammatory demyelinating polyradiculoneuropathy. The presence of a lambda monoclonal protein, elevated vascular endothelial growth factor, systemic features, and treatment resistance are clues to the diagnosis. Castleman disease (CD) is seen in a subset of these patients, and when present the neuropathy is similar but less severe. In contrast, in those patients with purely CD, the neuropathy is often a mild, painless distal sensory neuropathy.


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8 Cereals proteins

Publication date: 2018
Source:Proteins in Food Processing
Author(s): N. Guerrieri, M. Cavaletto
The cereals are the most important food crop in the world; the proteins of maize, rice, and wheat are the most popular energy food. Since the world demand for food is constantly increasing, minor cereals and pseudocereal proteins are gaining more and more attention. They have been utilized from ancient times for the production of local traditional foods; now, they are introduced on international markets as innovative products and healthy foods. Cereal proteins are mainly stored in the endosperm, the largest portion of the seed, and are traditionally classified in albumin, globulin, prolamin, and glutelin. This chapter highlights the impact of cereal proteins on functional properties for food processing, since the bulk of all cereals, with the exception of rice, are consumed in processed foods.



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Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer

Publication date: December 2017
Source:Oral Oncology, Volume 75
Author(s): Shih-Jung Cheng, Chi-Feng Chang, Hui-Hsin Ko, Yi-Ching Liu, Hsin-Hui Peng, Huei-Jen Wang, Hsiao-Shan Lin, Chun-Pin Chiang
ObjectiveThis study assessed whether hypermethylated ZNF582 and PAX1 genes in oral scrapings are correlated with the progression and prognosis of oral squamous cell carcinoma (OSCC).Materials and methodsMethylation levels of ZNF582 and PAX1 genes in oral scrapings, collected from the cancer and adjacent normal oral mucosal sites of 80 OSCC patients before surgical cancer excision, were quantified using real-time methylation-specific PCR after bisulfite conversion.ResultsBoth the mean methylation (M)-indices of ZNF582 and PAX1 genes in oral scrapings were significantly higher at the cancer sites than at the adjacent normal oral mucosal sites (both P < .001). In the oral scrapings collected from the adjacent normal oral mucosal sites, the higher M-index of methylated ZNF582 (ZNF582m) was significantly correlated with a more advanced clinical stage (P = .04). Moreover, the higher M-index of methylated PAX1 (PAX1m) was significantly related to larger tumor size (P = .046). When the 80 OSCC patients were classified based on gene methylation tests, using the oral scrapings collected from the adjacent normal oral mucosal sites, we found a significantly shorter 3-year overall survival in ZNF582m-positive, PAX1m-positive, and ZNF582m/PAX1m-positive OSCC patients than in ZNF582m-negative (P = .02), PAX1m-negative (P = .04), and ZNF582m/PAX1m-negative OSCC patients (P = .02), respectively. Multivariate Cox regression analyses identified ZNF582m and ZNF582m/PAX1m as independent unfavorable prognostic factors.ConclusionHypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC.



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Scholar : CPAP - νέα αποτελέσματα

… Continuous Positive Airway Pressure Therapy on Right Ventricular Function in Patients With Severe Obstructive Sleep Apnea: Data From Cpap-oasis, A Randomized …

D Kim, CY Shim, IJ Cho, S Park, CJ Lee, HJ Cho… - 2017
Background: We aimed to determine if continuous positive airway pressure (CPAP) therapy
would improve RV function in patients with severe OSA compared to sham intervention
group. Methods: This 3-month, randomized, sham-controlled trial analyzed 52 patients with
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Impact of Cpap on Arterial Stiffness in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-analysis

MS Bittencourt, S Chalegre, TC Lustosa, MV França… - 2017
Introduction: Obstructive sleep apnea (OSA) is a major cause of hypertension, which is
tightly associated with arterial stiffness, a marker of target organ damage and cardiovascular
risk. Although continuous positive airway pressure (CPAP) is considered an effective
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CPAP-vs. BIPAP-Beat-mung bei Patienten mit schwerem Pick-wick-Syndrom

ME Howard - Thorax, 2017
Insgesamt wurden von 170 Patienten 60 randomisiert, wovon 57 die Nachbeobachtung
beendeten. Die Patienten wurden zwischen November 2011 und Dezember 2013
hinsichtlich ihrer Eignung bewertet. Die Datensammlung wurde im Juni 2014
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Impact of the Continued Positive Airway Pressure Breathing on Ablation-outcome in Atrial Fibrillation Patients With Obstructive Sleep Apnea and/or Metabolic …

S Mohanty, C Trivedi, DG Della Rocca, C Gianni… - 2017
Skip to main content. American Heart Association; Science Volunteer; Warning Signs;
Search for this keyword. Search. Advanced Search; Donate. Home; About this Journal:
Editorial Board; General Statistics; Circulation Doodle: Doodle …
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Sleep apneas, metabolic syndrome and cardiovascular risk: Data from the Pays de la Loire sleep cohort

F Gagnadoux, P Priou, T Urban, N Meslier, W Trzepizur - Revue de pneumologie …, 2017
… Continuous positive airway pressure (CPAP) therapy of OSAHS is associated with a modest
but clinically significant blood pressure reduction. Conversely, there is no clear evidence
in support of a metabolic impact of CPAP in OSAHS patients …
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Perioperative respiratory complications: current evidence and strategy discussed in 2017 JA symposium

K Hirota, M Yamakage, S Hashimoto, T Asai, S Isono - Journal of Anesthesia, 2017
… In our expe- rience, the acceptance rate is much higher compared with nasal CPAP
therapy. It should be noted that none of the alter- native treatments to nasal CPAP
are sufficient to fully dilate the pharyngeal airway and therefore …
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粉防己碱对人甲状腺癌细胞 B-CPAP 生长和凋亡的影响

张美峰, 丁新德, 费哲为, 吴炜, 高铭 - 现代肿瘤医学, 2017
[摘要]: 目的: 探讨中药粉防己碱(tetrandrine, Tet) 对人甲状腺癌细胞B-CPAP
生长和凋亡的影响及其作用机制. 方法: 以0, 5, 10, 20μg/ml Tet 培养细胞24, 48, 72 h 后, MTT
法测定细胞活力并计算抑制率; 流式细胞仪检测细胞凋亡率; Western blot 法测定Bcl-2, Bax,
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Response to Cognitive Processing Therapy in Veterans With and Without Obstructive Sleep Apnea

F Mesa, BD Dickstein, VD Wooten, KM Chard - Journal of Traumatic Stress, 2017
… Additionally, OSA-positive veterans with access to continuous positive airway
pressure (CPAP) therapy reported less PTSD severity relative to OSA-positive
veterans without access to CPAP (B = −0.421). Apnea appears to be …
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Non‐invasive ventilation use in status asthmaticus: 16 years of experience in a tertiary intensive care

KRL Bond, CAE Horsley, AB Williams - Emergency Medicine Australasia, 2017
… Non-invasive ventilation Facemask CPAP was delivered using a freestanding circuit with an
attached PEEP valve whereas bi-level NIV was delivered by BiPAP Vision (Philips Respironics
Inc., Murrys- ville, PA, USA) or via Puritan Bennet 840 (Covidien, Boulder, CO, USA) …
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[HTML] Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with …

G Bellingan, D Brealey, J Mancebo, A Mercat… - Trials, 2017
… with PEEP or CPAP ≥ 5 cmH 2 O. PaO 2 /FiO 2 … ARDS acute respiratory distress syndrome, CPAP
continuous positive airway pressure, CT computed tomography, PaO 2 /FiO 2 partial pressure
of oxygen/fraction of inspired oxygen, PEEP positive end-expiratory pressure …
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Scholar : Decannulation - νέα αποτελέσματα

Decannulation of Extracorporeal Membrane Oxygenation Guided by Transthoracic Echocardiography Assessment of Left Ventricular Recovery After Refractory …

F Kazmirczak, K Carlson, JA Bartos, C Martin… - 2017
Background: In December 2015, the Minnesota Resuscitation Consortium (MRC) initiated a
protocol to rapidly mobilize patients suffering refractory ventricular tachycardia/ventricular
fibrillation (VT/VF) cardiac arrest and provide advanced hemodynamic support and
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Early ECMO Overcomes Primary Graft Dysfunction After Heart Transplant

S DeRoo, H Takayama, M Farr, P Colombo, AR Garan… - 2017
Skip to main content. American Heart Association; Science Volunteer; Warning Signs;
Search for this keyword. Search. Advanced Search; Donate. Home; About this Journal:
Editorial Board; General Statistics; Circulation Doodle: Doodle …
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Recovery From Prolonged Resuscitation and Multi-Organ System Failure Following Refractory Ventricular Fibrillation Cardiac Arrest

JA Bartos, K Carlson, C Carlson, G Raveendran… - 2017
Skip to main content. American Heart Association; Science Volunteer; Warning Signs;
Search for this keyword. Search. Advanced Search; Donate. Home; About this Journal:
Editorial Board; General Statistics; Circulation Doodle: Doodle …
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Role of ECMO in congenital diaphragmatic hernia

M McHoney, P Hammond - Archives of Disease in Childhood-Fetal and Neonatal …, 2017
Skip to main content. This site uses cookies. More info By continuing to browse
the site you are agreeing to our use of cookies. Find out more here. Viewing from:
Google Indexer. BMJ Journals. Subscribe; Log In More …
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[HTML] Acute coronary artery obstruction after aortic valve replacement surgery and role of transesophageal echocardiography

MS Jang, JH Choi, JH Han, YI Choi, JM Kim, HC Youn - Anesthesia and Pain …, 2017
… Usually, a quick return to CPB and urgent CABG are the ideal solution when an unstable situation
is predicted to persist [10]. However, in our case, decannulation had already been performed,
and it was difficult to localize the exact location of the coronary lesions …
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[PDF] Syllabus Congreso SATI 2013-Mendoza Protocolos de decanulación¿ basados en la evidencia?

D Villalba, N Roux
… Chest 1996; 110:1566-71. 2. O'Connor H., White A. Tracheostomy Decannulation. Respir Care
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