Papillary mucinous metaplasia: a distinct precursor of mucinous adenocarcinoma of the endometrium

xlomafota13 shared this article with you from Inoreader Papillary mucinous metaplasia: a distinct precursor of mucinous adenocarcinoma of the endometrium Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2022 Feb 15;15(2):83-87. eCollection 2022. ABSTRACT Mucinous adenocarcinoma of the endometrium is heterogeneous, consisting of endometrioid adenocarcinoma composed of >50% mucinous cells, low-grade mucinous adenocarcinoma, microglandular adenocarcinoma, and gastric (gastrointestinal)-type adenocarcinoma. Previous studies have reported that papillary mucinous metaplasia is a possible precancerous lesion of mucinous adenocarcinoma with frequent KRAS mutations. Recently, we encountered a case of pure mucinous adenocarcinoma of the endometrium with concurrent papillary mucinous metaplasia in a 35-year-old woman. She underwent 6-month hormonal therapy for atypical endometrial hyperplasia. A follow-up biopsy led to a diagnosis of mucinous adenocarcinoma; therefore, total hysterectomy was performed. The tumor showed abundant intracytoplasmic mucin and mild-to-moderate cytologic atypia with papillary architectu re. KRAS mutation analysis revealed a point mutation from GGT to GTT in codon 12. Although papillary mucinous metaplasia showed an overexpression of p16INK4, especially in the intragrandular papillary tufts, and a low MKi67 labeling index, overt mucinous adenocarcinoma with a loss of P16INK4a expression showed a high proliferating index of MKI67. The mass presented with stage ІA disease. During follow-up, the patient was stable and showed no recurrence. Considering the histologic similarity and incidence of KRAS mutations between papillary mucinous metaplasia and mucinous adenocarcinoma, papillary mucinous metaplasia may be a precancerous lesion for a subset of mucinous adenocarcinoma of the endometrium. PMID:35265257 | PMC:PMC8902477 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

18F–FDG–PET/CT May Reduce Unnecessary Thyroid Surgery in Cytologically Indeterminate Thyroid Nodules

xlomafota13 shared this article with you from Inoreader 18F–FDG–PET/CT May Reduce Unnecessary Thyroid Surgery in Cytologically Indeterminate Thyroid Nodules Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 116-118, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Role of a Computer-Aided Diagnosis System in the Interpretation of Thyroid Nodules with Challenging Sonographic Features

xlomafota13 shared this article with you from Inoreader The Role of a Computer-Aided Diagnosis System in the Interpretation of Thyroid Nodules with Challenging Sonographic Features Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 112-115, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Minipterional Approach for Middle Fossa Skull Base Lesions: Technical Note

xlomafota13 shared this article with you from Inoreader Minipterional Approach for Middle Fossa Skull Base Lesions: Technical Note Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/s-0042-1743464 Surgical access to the middle fossa can be technically challenging. As neurosurgery evolves to minimally invasive approaches, the objective of this study is to demonstrate the extension of the Minipterional approach to access the middle fossa. We present a new surgical approach to the middle fossa for the treatment of secondary trigeminal neuralgia. Three cases are reported to illustrate the following techniques: a patient with petrotentorial meningioma and trigeminal neuralgia, a patient with an arachnoid cyst compressing the fifth nerve, and a patient with a middle cerebral artery aneurysm and a long history of TN (trigeminal neuralgia) refractory to medical and surgica l treatments. All three experienced full symptom controls with no permanent neurological deficits. Therefore, the Minipterional technique might represent a feasible, effective, and safe option to treat refractory secondary TN. It also allows approaching these lesions when the posterior fossa approach is compromised by anatomical distortion and enables the simultaneous treatment of secondary trigeminal neuralgia and other lesions, such as aneurysms and meningiomas. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls

xlomafota13 shared this article with you from Inoreader The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Mar 10. doi: 10.1007/s00405-022-07326-6. Online ahead of print. ABSTRACT Salivary gland tumors are diagnostically challenging owing to the morphological diversity within any tumor type and overlapping histomorphology and immunohistochemistry amongst different tumours. In past two decades, rapid progress has been made in the field of understanding the pathogenesis of these tumours with the discovery of many tumour specific translocations and rearrangements. This includes CRTC1-MAML2 and CRTC-MAML2 in mucoepidermoid carcinoma, MYBNFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 in pleomorphic adenoma, ETV6-NTRK3 in secretory carcinoma, NR4A3 rearrangements in acinic cell carcinoma, PRKD1 mutations in polymorphous adenocarcinoma and EWSR1-ATF1 in clear cell carcinoma. This review is a lens for progress made till date in the molecular pathology of salivary gland tumours with a special focus on their role as diagnostic tools and implications on clinical management of the patient as prognostic and predictive markers. PMID:35267084 | DOI:10.1007/s00405-022-07326-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.