“Topical pentoxifylline can be an effective and safe adjunctive therapy to NBUVB therapy in treating vitiligo: a split‐side clinical trial”

xlomafota13 shared this article with you from Inoreader "Topical pentoxifylline can be an effective and safe adjunctive therapy to NBUVB therapy in treating vitiligo: a split‐side clinical trial" Via Experimental Dermatology View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Antimicrobial peptides and proteins: Interaction with the skin microbiota

xlomafota13 shared this article with you from Inoreader Antimicrobial peptides and proteins: Interaction with the skin microbiota Via Experimental Dermatology Abstract The cutaneous microbiota comprises all living skin microorganisms. There is increasing evidence that the microbiota plays a crucial role in skin homeostasis. Accordingly, a dysbiosis of the microbiota may trigger cutaneous inflammation. The need for a balanced microbiota requires specific regulatory mechanisms that control and shape the microbiota. In this review we highlight the present knowledge suggesting that antimicrobial peptides (AMPs) may exert a substantial influence on the microbiota by controlling their growth. This is supported by own data showing the differential influence of principal skin-derived AMPs on commensal staphylococci. Vice versa we also illuminate how the cutaneous microbiota interacts with skin-derived AMPs by modulating AMP expression and how microbiota members protect themselves from the antimicrobial activity of AMPs. Taken together, the current picture suggests that a fine-tuned and well-balanced AMP-microbiota interplay on the skin surface may be cr ucial for skin health. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Multimodality‐based knee joint modeling method with bone and cartilage structures for total knee arthroplasty

xlomafota13 shared this article with you from Inoreader Multimodality‐based knee joint modeling method with bone and cartilage structures for total knee arthroplasty Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Objective We propose a robust and accurate knee joint modeling method with bone and cartilage structures to enable accurate surgical guidance for knee surgery. Methods A multimodality registration strategy is proposed to fuse MR and CT images of the femur and tibia separately to remove spatial inconsistency caused by knee bending in CT/MR scans. Automatic segmentation of the femur, tibia, and cartilages is carried out with ROI clustering and intensity analysis based on the multimodal fusion of images. Results Experimental results show that the registration error is 1.13 ± 0.30 mm. The Dice similarity coefficient (DSC) values of the proposed segmentation method of the femur, tibia, femoral and tibial cartilages are 0.969, 0.966, 0.910, and 0.872, respectively. Conclusions This study demonstrates the feasibility and effectiveness of multimodality-based registration and segmentation methods for knee joint modeling. The proposed metho d can provide users with 3D anatomical models of the femur, tibia, and cartilages with few human inputs. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Single assistant vs dual assistant robotic surgery for robot‐assisted laparoscopic hysterectomy using da Vinci Xi or X

xlomafota13 shared this article with you from Inoreader Single assistant vs dual assistant robotic surgery for robot‐assisted laparoscopic hysterectomy using da Vinci Xi or X Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background To verify the usefulness of single assistant robotic surgery (SA-RS) using da Vinci Xi or X performed for total hysterectomy. Methods The SA-RS group (S-group) includes surgeries in which the surgeon performed all surgical operations other than that of the uterine manipulator, while the dual assistant robotic surgery group (D-group) includes surgeries performed by the surgeon with two assistants. In S-group, the forceps and camera were replaced during surgery in cases of a large uterus with limited range of motion of the instrument. A comparative study of patient background, intraoperative and postoperative results and surgery-related cost was performed between the two groups. Results No significant differences were observed between the two groups. On the contrary, S-group showed a significant reduction in preparation time and wound closure time, and a savings of $768. Conclusion SA-RS for total hysterectomy was possible , which is excellent in terms of cost, esthetics, and manpower This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An Observational Study on Association of Clinical Outcome of Diphtheria Cases with Immunization Status: A Tertiary Care Hospital, Jaipur

xlomafota13 shared this article with you from Inoreader An Observational Study on Association of Clinical Outcome of Diphtheria Cases with Immunization Status: A Tertiary Care Hospital, Jaipur Via Otolaryngology Indian Abstract Background. Diphtheria is an important vaccine preventable disease with varied outcome from mild to death. It was observed that the outcome also gets affected with status of immunization. The outcome is relatively milder in immunized children. Objective. To find out the clinical presentation and outcome of diphtheria cases and its association with the immunization status. Methods. A descriptive analysis of 64 diphtheria cases admitted from January 2019 to May 2020 at SMS hospital, a tertiary care referral hospital in Jaipur. Results. Half of (51.56%, 33/60) patients were in the age group of 6–10 years. The peak load (48.44%) of diphtheria cases was seen in the monsoon season. Around 60% of the patients were fully immunized and around 10% partially immunized, every third case was un-immunized. The most common complication was neurological in 13 cases (20.31%), followed by cardiac complications in 11 cases (17.19%), and respiratory (7.81%). The pro portion of complication was much lower (26.3%) in immunized cases as compare to partially immunized and un immunized. The proportion of myocarditis was significantly higher in un immunized cases (40%) than partially immunized (16.7%) and filly immunized group (5.3%). Similarly, Bronchopneumonia was also significantly higher (20%) in unimmunized. Conclusion. Our study depicted that there has been a shift of age above 5 years for diphtheria which suggests the need for the booster dose. Also high chances of complications are seen in unimmunized and partially immunized calling for public awareness regarding complete immunization. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Large Intraoral Lipoma: Case Report

xlomafota13 shared this article with you from Inoreader A Large Intraoral Lipoma: Case Report Via Otolaryngology Indian Abstract Lipomas of the oral cavity are uncommon. Here we report a case of 85 year old female presenting with a progressively increasing large growth in the oropharynx which was diagnosed as lipoma on histopathology. The clinicoradiological and histopathological findings are discussed. To the best of our knowledge; this is one of the largest intraoral lipoma reported in India till date. The present case highlights the need to be aware of intraoral lipomas which can present as large growths at this unusual site so as to avoid any unwarranted aggressive surgery. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nasopharyngeal Tuberculosis mimicking Nasopharyngeal Carcinoma: A Case Series

xlomafota13 shared this article with you from Inoreader Nasopharyngeal Tuberculosis mimicking Nasopharyngeal Carcinoma: A Case Series Via Otolaryngology Indian Abstract Tuberculosis is a highly contagious granulomatous disease which is endemic in South East Asia. Most common presentation is pulmonary tuberculosis which is spread by droplets inhalation of mycobacterium tuberculosis bacterium. Nasopharyngeal tuberculosis is a rare entity which poses a diagnostic difficulty as its presentation is greatly similar to that of nasopharyngeal carcinoma. Herein, we describe two cases of nasopharyngeal tuberculosis which mimics nasopharyngeal malignancy leading to diagnostic difficulties. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Negative pressure wound therapy in cases of spinal surgery and exposed dura: a case-based review

xlomafota13 shared this article with you from Inoreader Negative pressure wound therapy in cases of spinal surgery and exposed dura: a case-based review Via leak of cerebrospinal fluid Childs Nerv Syst. 2021 Jul 26. doi: 10.1007/s00381-021-05302-9. Online ahead of print. ABSTRACT PURPOSE: Study of negative pressure wound therapy (NPWT) safety for patients with intraoperative exposure of the dura. METHODS: We analyzed the literature on the NPWT usage after spinal surgery in patients with exposure of the dura. We also described our experience of NPWT in 3 pediatric patients with spinal dysraphism. Due to the peculiarities of the anatomy (spina bifida), all of these patients had dural sac exposure during spinal surgery. RESULTS: The reasons for NPWT in all three cases were different. In the first patient with segmental spinal dysgenesis, surgery was complicated by extensive postoperative wound necrosis and the formation of soft tissue deficiency. The second patient with post-myelomeningocele kyphosis had a deficiency of soft tissues during spinal surgery due to a large bedsore at the apex of the deformity. And in t he third patient also with post-myelomeningocele kyphosis, NPWT was applied with surgical site infection. In all three cases, NPWT was used when the dura was exposed, without complications and with satisfactory results. The observation period for the patients was 3 years, 2.5 years, and 2 years, respectively. CONCLUSIONS: The usage of NPWT in cases of wound complications in the spinal surgery may be a useful option, which allows saving implants. NPWT is not contraindicated in cases of intraoperative dural exposure if there are no signs of cerebrospinal fluid (CSF) leak. PMID:34312707 | DOI:10.1007/s00381-021-053 02-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Immunohistochemical study of inflammatory responses in septa arising from type I intestinal atresia

xlomafota13 shared this article with you from Inoreader Immunohistochemical study of inflammatory responses in septa arising from type I intestinal atresia Via Cellular and Molecular Biology Histol Histopathol. 2021 Jul 27:18364. doi: 10.14670/HH-18-364. Online ahead of print. ABSTRACT The purpose of this study was to evaluate defensive functional cells in intestinal septa during recanalization in the embryonic period, and to access immune responses in septa arising from type I intestinal atresia and normal intestinal walls. Tissue samples were of septa located in the intestinal wall at a distance <15cm from the ligament of Treitz, and normal intestine walls obtained from seven neonates who underwent surgery. Following serial tissue sectioning, the samples were subjected to hematoxylin and eosin (HE), periodic acid-Schiff (PAS) and immunohistochemical staining to determine the morphological features and markers of functional cells and immune responses in the septa and normal intestinal walls. Quantitative analysis was conducted to compare differences between them. Compared with normal intestinal wall, the mucosal layer of septa arising from type I intestinal atresia had fewer misaligned villi and no classic epithelial crypts. Immunohistochemical staining showed that the mucosal layer of septa arising from type I intestinal atresia had fewer Paneth cells and goblet cells and lower amounts of lysozyme and MUC2, than normal intestinal walls. The concentration of pro-inflammatory cytokines, including interlukin (IL)-6 and tumor necrosis factor (TNF) -α, as well as macrophage inflammatory protein 3α (MIP-3α) and its receptor, CCR6, were higher in the mucosal layer of septa arising from type I intestinal atresia than in normal intestinal walls. Moreover, the numbers of mature dendritic cells and CD4+ T lymphocytes were higher in the mucosal layer of septa than in normal intestinal walls. The defensive activity of septa arising from type I intestinal atresia is weaker than that of normal intestinal walls. This weaker activity may correlate with increases in mature dendritic cells and CD4+ T lymphocyte s, as well overexpression of proinflammatory cytokines. PMID:34312829 | DOI:10.14670/HH-18-364 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The COVID-19 pandemic and its effects on otorhinolaryngology, head and neck surgery

xlomafota13 shared this article with you from Inoreader The COVID-19 pandemic and its effects on otorhinolaryngology, head and neck surgery Via hno HNO. 2021 Aug;69(8):609-610. doi: 10.1007/s00106-021-01091-4. Epub 2021 Jul 27. NO ABSTRACT PMID:34313793 | DOI: 10.1007/s00106-021-01091-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subjective and objective evaluation of swallowing in lateral decubitus positions examined in healthy volunteers

xlomafota13 shared this article with you from Inoreader Subjective and objective evaluation of swallowing in lateral decubitus positions examined in healthy volunteers Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Jul 27. doi: 10.1007/s00405-021-07001-2. Online ahead of print. ABSTRACT BACKGROUND: Dysphagia can result from shock, trauma, aging, head and neck neoplasms, and some cerebrovascular diseases or neuromotor degenerative disorders. Swallowing rehabilitation therapy combined with postural control of the neck, head, and body can be effective for patients with dysphagia. Though the lateral decubitus posture has been a favorable option for swallowing rehabilitation therapy, available clinical data pertaining to it are scarce. METHODS: Twenty-seven healthy volunteers were enrolled in this study. The subjects underwent a repetitive saliva swallowing test, food swallowing test, and water swallowing test. The trials were performed in four different positions: upright sitting position, lateral decubitus position with the head raised to 60°, lateral decubitus position with the head raised to 30°, and complet e lateral decubitus position. After each trial, the subjects were asked to declare the swallowing difficulty utilizing a visual analogue scale. Swallowing time and swallowing sound level were recorded simultaneously, as objective evaluation in each trial. We analyzed the visual analogue scale scores, swallowing time, and swallowing sound levels for all the four positions. RESULTS: The results of the visual analogue scale of the water swallowing test in the sitting position were significantly lower than those of the complete lateral decubitus position (p < 0.01). However, statistical significance was not detected in swallowing time or the swallowing sound level among the four different positions. Although subjective discomfort in swallowing was identified, difficulty of swallowing was not objectively evident in the trials, irrespective of the position. CONCLUSIONS: A complete lateral decubitus position can be an effective and safe position in swallowing. PMID:34313834 | DOI:10.1007/s00405-021-07001-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mitochondrial encephalomyopathy involves ophthalmology otorhinolaryngology neurology and their clinical features

xlomafota13 shared this article with you from Inoreader Mitochondrial encephalomyopathy involves ophthalmology otorhinolaryngology neurology and their clinical features Via cortical auditory Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Jun;35(6):529-534. doi: 10.13201/j.issn.2096-7993.2021.06.010. ABSTRACT Objective:This study aimed to provide better understanding of the otolaryngologic features, combined with ophthalmologic and neurologic characteristics in mitochondrial encephalomyopathy（MEM）, and to help ENT and auditory practitioner making correct diagnosis as well. Methods:Twenty-eight patients with MEM were enrolled between September 2001 and January 2020. Information about family histories and clinical symptoms was retrospectively analyzed. All patients underwent otorhinolaryngological, ophthalmological and neurological examinations, including: pure-tone audiometry, acoustic immittance（AI）, distortion-product otoacoustic emissions（DPOAE）, auditory brainstem response（ABR）, cochlear micropotential（CM）, speech discrimination score（SDS）, electroneurography（ENoG）, computed tomog raphy（CT） of the temporal bone and cranial magnetic resonance weighted imaging scan（MRI）, muscle biopsy and mtDNA gene testing. Results:ENT subjective manifestations were present in 15 cases （53.6%） with sensorineural hearing loss（SNHL）, 4（14.3%） with tinnitus, 4（14.3%） with facial weakness, 3（10.7%） with dysphagia, 1（3.6%） with auditory agnosia. Ophthalmological and neurological symptoms included ptosis in 16 cases （57.1%）, exercise intolerance in 16（57.1%）, optic atrophy in 15（53.6%）, muscular atrophy in 6（21.4%）, and stroke-like episodes in 5（17.9%）. The results of objective examinations were as follows: DPOAE were not elicited in 18（64.3%） cases, ABR abnormalities in 18（64.3%） cases, hearing threshold shift in 15（53.6%） cases, AI normal and CM was not detected in all cases, SDS decreased in 6（21.4%） cases, facial ENoG abnormalities in 4（14.3%） cases, laryngeal ENoG abnormalities in 3（10.7%） cases, EMG abnormalities in 6（21.4%） cases, and ECG abnormalities in 8（28.6%） cases. Temporal CT were normal, but cranial MRI abnormalities were found in 19 cases（67.9%）, including central nerve demyelination, white matter hyperintensities, generalized cerebellar and cerebral atrophy, multiple cortical/subcortical infarct-like lesions, basal ganglia calcification. Conclusion:Multisystemic syndromes in MEM can present as a variety of otolaryngological, ophthalmological and neurological abnormalities, such as ptosis, audio-visual disturbance, exercise intolerance and stroke-like episodes etc. SNHL, tinnitus, auditory agnosia, facial weakness and dysphagia were ENT specific manifestations. SNHL in MEM is bilateral symmetrical progressive or of sudden onset since teenage. mtDNA testing may be helpful for adolescent patient whose SNHL was associated with neuromuscular symptoms. Muscle biopsy should be considered when middle-aged patients developed facial weakness and dysphag ia. DPOAE and ABR are the optimal objective audiometric tests to monitor the progression of MEM associated with SNHL. PMID:34304513 | DOI:10.13201/j.issn.2096-7993.2021.06.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.