Hypogammaglobulinemia and imaging features in a patient with infantile free sialic acid storage disease (ISSD) and a novel mutation in the SLC17A5 gene

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2DmejvR

Achieving target levels for vascular risk parameters in Polish school-age children with type 1 diabetes – a single center study

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2NxFTef

The role of Wnt/β-catenin signaling in the restoration of induced pluripotent stem cell-derived retinal pigment epithelium after laser photocoagulation

Abstract

To investigate the role of Wnt/β-catenin signaling pathway in the restoration of induced pluripotent stem cell-derived retinal pigment epithelium (hiPSC-RPE) after laser photocoagulation. After differentiation of RPE cells from hiPSCs, laser photocoagulation was performed. Activation of Wnt/β-catenin signaling at days 1 and 5 after laser photocoagulation was evaluated by expression of β-catenin. Cell proliferation and alteration in cell-to-cell contact at day 5 after laser photocoagulation with or without Dickkopf-1 (Dkk-1) treatment were studied using ethynyl-2′-deoxyuridine (EdU) assay and zonula occludens-1 (ZO-1) expression analysis, respectively. The mRNA levels of Wnt genes at day 5 after laser photocoagulation were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Activation of Wnt/β-catenin signaling at days 1 and 5 after laser photocoagulation was confirmed by β-catenin accumulation in the cytoplasm and nucleus of hiPSC-RPE. Many EdU-positive cells also expressed β-catenin, and the number of EdU-positive cells was decreased at day 5 after laser photocoagulation after Dkk-1 treatment, indicating that Wnt/β-catenin signaling mediated hiPSC-RPE proliferation. ZO-1 expression was not decreased with Dkk-1 treatment at day 5 after laser photocoagulation, indicating that Wnt/β-catenin signaling mediated hiPSC-RPE restoration. At day 5, after laser photocoagulation, mRNA levels of Wnt2b, Wnt3, Wnt5a, Wnt7a, and Wnt10b were increased. Wnt/β-catenin signaling has a crucial role in restoration of hiPSC-RPE proliferation after laser photocoagulation. Manipulation of Wnt/β-catenin signaling while elucidating the underlying mechanisms of RPE restoration might have a therapeutic potential in retinal degenerative diseases.

https://ift.tt/2zo3nJS

Wound-healing effects of 635-nm low-level laser therapy on primary human vocal fold epithelial cells: an in vitro study

Abstract

Low-level laser therapy (LLLT) has been promoted for its beneficial effects on tissue healing and pain relief for skin and oral applications. However, there is no corresponding literature reporting on vocal fold wound healing. Our purpose was to assess the potential wound-healing effects of LLLT on primary human vocal fold epithelial cells (VFECs). In this study, normal vocal fold tissue was obtained from a 58-year-old male patient who was diagnosed with postcricoid carcinoma without involvement of the vocal folds and underwent total laryngectomy. Primary VFECs were then cultured. Cells were irradiated at a wavelength of 635 nm with fluences of 1, 4, 8, 12, 16, and 20 J/cm² (50 mW/cm²), which correspond to irradiation times of 20, 80, 160, 240, 320, and 400 s, respectively. Cell viability of VFECs in response to varying doses of LLLT was investigated by the Cell Counting Kit-8 (CCK-8) method. The most effective irradiation dose was selected to evaluate the cell migration capacity by using the scratch wound-healing assay. Real-time polymerase chain reaction (RT-PCR) was used to detect the gene expression of TGF-β1, TGF-β3, EGF, IL-6, and IL-10. Irradiation with doses of 8 J/cm² resulted in 4% increases in cell proliferation differing significantly from the control group (p < 0.05). With subsequent doses at 48 and 72 h after irradiation, the differences between the experimental and the control groups became greater, up to 9.8% (p < 0.001) and 19.5% (p < 0.001), respectively. It also increased cell migration and the expression of some genes, such as EGF, TGF-β1, TGF-β3, and IL-10, involved in the tissue healing process. This study concludes that LLLT at the preset parameters was capable of stimulating the proliferation and migration of human vocal fold epithelial cells in culture as well as increase the expression of some genes involved in tissue healing process. Additionally, successive laser treatments at 24 h intervals have an additive beneficial effect on the healing of injured tissues.

https://ift.tt/2OLHbyG

Gingko flap: The development of a novel flap technique to reduce dog ear formation

Dear Sir,

https://ift.tt/2DwJ5lU

Comment on “How to assess the volume of a DIEP flap using a free online calculator: the DIEP V (volume) method”

Razzano et al. developed a simple method to calculate the predicted volume of a DIEP flap for breast reconstruction.1 They hypothesized that the best representative shape for a DIEP flap was a truncated pyramid. They measured flap thickness using ultrasound (US), and used other variables including flap length and height to calculate the volume of a truncated pyramid-shaped flap. Great value must be given to this study because estimation of DIEP flap volume is crucial in surgical planning and execution for ultimately matching the volume of the breast being reconstructed, and it also can help decrease donor site complications.

https://ift.tt/2NuLVfu

Anatomic Location of a Sensory Nerve to the Transverse Upper Gracilis (TUG) Flap: A Novel Option for Sensate Autologous Tissue Reconstruction

A January 2017 article in the New York Times, "After Mastectomies, an Unexpected Blow: Numb New Breasts," made the concept of hypoesthesia after mastectomy mainstream. This, along with advances in cadaveric nerve grafts, has led to a surge in the number of publications regarding sensate autologous breast reconstruction. Autologous breast reconstruction typically utilizes an abdominal donor site and the majority of research in sensate autologous tissue has been performed in DIEP or TRAM flaps [3, 4].

https://ift.tt/2Dl9Byc

The Helsinki Approach to Face Transplantation

We herein describe the establishment of the Helsinki Vascularized Composite Allotransplantation (VCA) program and its execution in the first two face transplant cases.

https://ift.tt/2NuljeK

When should we use the terms “aponeurotic blepharoptosis” and “reinsertion of the levator aponeurosis”?

It is generally considered that involutional (or senile) blepharoptosis is caused by disinsertion of the levator aponeurosis1. This type of acquired blepharoptosis is therefore also referred to as "aponeurotic blepharoptosis", by reference to its presumed etiology. However, the levator aponeurosis is rarely found to be disinserted peroperatively 2 (at most a dehiscence is found) and it has been suggested that in some cases this disinsertion could be iatrogenic and caused by the surgical procedure itself 3.

https://ift.tt/2Dnpmom

Cyclic fatigue of Reciproc Blue and Reciproc instruments exposed to intracanal temperature in simulated severe apical curvature

Abstract

Objective

The aim of this study was to evaluate the cyclic fatigue resistance of Reciproc and Reciproc Blue by testing in a severe apical curvature at intracanal temperature.

Materials and methods

Eighteen Reciproc R25 (25.08) and Reciproc Blue (25.08) instruments were tested in a cyclic fatigue device at body temperature (37 °C) using a stainless steel block with an artificial canal with a curvature angle of 90° and radius of curvature of 2 mm. The number of cycles to fracture (NCF) was calculated. The instruments were examined by differential scanning calorimetry (DSC). The data were analyzed using both Student's t tests and Weibull analysis.

Results

The NCF values of Reciproc R25 were significantly lower than Reciproc Blue R25 (P < 0.05). There was no significant difference between the instruments regarding the length of fractured fragments (P > 0.05).

Conclusions

Reciproc Blue R25 instruments displayed significantly higher NCF than Reciproc R25.

Clinical relevance

This study reported that novel reciprocating blue wire instruments exhibited higher cyclic fatigue resistance than its precedence M-wire instrument when tested in severely curvatured canals.

https://ift.tt/2MU8FR1

Biochemical changes in injured sciatic nerve of rats after low-level laser therapy (660 nm and 808 nm) evaluated by Raman spectroscopy

Abstract

The aim of this study was to identify biochemical changes in sciatic nerve (SN) after crush injury and low-level laser therapy (LLLT) with 660 nm and 808 nm by Raman spectroscopy (RS) analysis. A number of 32 Wistar rats were used, divided into four groups (control 1, control 2, LASER 660 nm, and LASER 808 nm). All animals underwent surgical procedure of the SN and groups control 2, LASER 660 nm, and LASER 808 nm were submitted to SN crush damage (axonotmesis). The LLLT in the groups LASER 660 nm and LASER 808 nm was applied daily for 21 consecutive days (100 mW, 30 s, 133 J/cm² fluence). The hind paw was removed and the SN was dissected and positioned on an aluminum support to collect dispersive Raman spectra (830 nm excitation, 30 s accumulation). To estimate the biochemical changes in the SN associated with LLLT, the principal component analysis (PCA) was applied. The Raman spectra of the sciatic nerve fragments showed peaks of the major biochemical components of the nerve, especially sphingolipids, phospholipids, glycoproteins, and collagen. The spectral features identified in some of the principal component loading vectors are referred to the biochemical elements present on the SN and were increased in the groups treated with LLLT, mainly lipids (sphingo and phospholipids) and proteins (collagen)—constituents of the myelin sheath. The RS was effective in identifying the biochemical differences in the SN after the crush injury, and LASER 660 nm was more efficient than the LASER 808 nm in cell proliferation and repair of the injured SN.

https://ift.tt/2OGNVhn

Straightforward approach in cultural heritage and environment studies—multivariate analysis and chemometry

https://ift.tt/2xIbpvk

Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis

Publication date: Available online 21 September 2018

Source: Journal of Dermatological Science

Author(s): Takashi Yamashita, Yoshihide Asano, Ryosuke Saigusa, Takashi Taniguchi, Kouki Nakamura, Shunsuke Miura, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Megumi Hirabayashi, Ayumi Yoshizaki, Tomomitsu Miyagaki, Makoto Sugaya, S. Sato

Abstract

Background

Aquaporin-1 (AQP1), a water channel protein controlling the water contents of cells and tissues, exerts pleiotropic effects on various biological activities, including inflammation, angiogenesis, and extracellular matrix remodeling, by regulating cell behaviors and tissue water balance.

Objective

To investigate AQP1 roles in systemic sclerosis (SSc) which is characterized by autoimmune inflammation, vasculopathy, and tissue fibrosis.

Methods

AQP1 expression was evaluated by immunohistochemistry and quantitative reverse transcription PCR in skin samples from human and animal models and by immunoblotting in cultured cells. Fli1 binding to the AQP1 promoter was evaluated by chromatin immunoprecipitation. Cell migration was assessed by scratch assay.

Results

Dermal fibroblasts and endothelial cells highly expressed AQP1 in SSc lesional skin, and AQP1 expression in dermal fibroblasts and endothelial cells positively correlated with the degrees of tissue fibrosis and edema, respectively. Consistently, SSc dermal fibroblasts up-regulated AQP1 compared with normal dermal fibroblasts in vitro. Furthermore, TGF-β stimulation induced AQP1 expression in normal dermal fibroblasts, while TGF-β1 antisense oligonucleotide suppressed AQP1 expression in SSc dermal fibroblasts. In endothelial cells, Fli1 deficiency resulted in AQP1 up-regulation in vivo and in vitro and Fli1 bound to the AQP1 promoter. Importantly, SSc dermal fibroblasts and FLI1 siRNA-treated endothelial cells had a pro-migratory property, which was remarkably diminished by gene silencing of AQP1.

Conclusion

AQP1 is up-regulated in SSc dermal fibroblasts and SSc endothelial cells at least partially due to autocrine TGF-β stimulation and Fli1 deficiency, respectively, possibly contributing to inflammation, vasculopathy, and tissue fibrosis by regulating tissue edema and cell migration.

https://ift.tt/2MUBi0h

Dependence of the frequency distribution around a vessel on the voxel orientation

Publication date: Available online 21 September 2018

Source: Magnetic Resonance Imaging

Author(s): L.R. Buschle, T. Kampf, F.T. Kurz, P. Vogel, F. Piekarek, V.J.F. Sturm, M. Pham, H.-P. Schlemmer, C.H. Ziener

Abstract

In this work the frequency distribution around a vessel inside a cubic voxel is investigated. Therefore, the frequency distribution is calculated in dependence on the orientation of the voxel according to the external magnetic field. The frequency distribution exhibits an interesting peak structure that cannot be explained by the established Krogh's vessel model. The results were validated with phantom measurements and in vivo measurements that agree very well with the developed theory.

https://ift.tt/2PVxqy8

Cytokine levels in persistent skin lesions of adult-onset Still disease

Publication date: Available online 21 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Elina Zuelgaray, Maxime Battistella, Marie-Dominique Vignon-Pennamen, Sophie Ly Ka So, Michel Rybojad, Antoine Petit, Florence Cordoliani, David Boccara, Maurice Mimoun, Dan Lipsker, François Chasset, Armand Bensussan, Martine Bagot, Jean-David Bouaziz, Laurence Michel, Study Group of Systemic Diseases in Dermatology (EMSED: Etude des Maladies Systémiques en Dermatologie)

https://ift.tt/2DkCDhy

Scholar : Laryngotracheal reconstruction - νέα αποτελ

THE EFFECT OF INJECTION OF INTRA ARTICULAR ALLOGENIC BONE MARROW MESENCHYMAL STEM CELL-PLATELET CELL RICH PLASMA (BMSCs-PRP) …

SA Taufik - Journal of Stem Cell Research and Tissue Engineering, 2018

… Stem cell & Therapy. 3: 25. Henderson JH, Welter JF, Mansour JM, Niyibizi
C, Caplan, AI, and Dennis, JE Cartilage tissue engineering for laryngotracheal
reconstruction: comparison of chondrocytes from three anatomic locations …

Short Term Outcomes of Tracheal Resection in the Society of Thoracic Surgeons Database

BP Stanifer, AC Andrei, M Liu, SL Meyerson, A Bharat… - The Annals of Thoracic …, 2018

… 5. Macchiarini P, Chapelier A, Lenot B, Cerrina J, Dartevelle P. Laryngotracheal resection
and reconstruction for postintubation subglottic stenosis. Lessons learned … 8. Grillo HC,
Mathisen DJ, Wain JC. Laryngotracheal resection and reconstruction for subglottic …

 

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Scholar : Obstructive sleep apnea - νέα αποτελέσματα

Obstructive sleep apnea in pregnancy: performance of a rapid screening tool

BI Balserak, B Zhu, MA Grandner, N Jackson, GW Pien - Sleep and Breathing, 2018

Purpose The Sleep Apnea Symptom Score (SASS) has been commonly used to
assess obstructive sleep apnea (OSA). The aim of this study was to examine the
psychometric properties of the SASS and the predictive value of SASS incorporating …

[PDF] Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea-Overlap Syndrome and its Cognitive Impairments

S Johnson, J Alex - Chron Obstruct Pulmon Dis Vol, 2018

Chronic obstructive pulmonary disease is a very prevalent disorder in the western
world and also in the developing countries. It accounts for a prevalence of 13.9% in
the adult population in USA and it is the fourth leading cause of death in USA [1, 2] …

Techniques for evaluation and management of tongue-base obstruction in pediatric obstructive sleep apnea

SL Ishman, KW Chang, AA Kennedy - Current Opinion in Otolaryngology & Head and …, 2018

TBO is a common and correctable cause of persistent OSA in children. Diagnostic
modalities include awake flexible laryngoscopy, plain neck films, DISE, and cine
MRI. Because DISE and cine MRI are performed in a sleep-like state, they are fairly …

THE OCCURRENCE OF OBSTRUCTIVE SLEEP APNEAHYPOPNEA SYNDROME AMONG CENTRAL INDIAN RURAL POPULATION

S Pawar, V Shende, PR Deshmukh, AR Chaudhari… - … -INDIAN JOURNAL OF …, 2018

… Abstract. Undiagnosed Obstructive Sleep Apnea-hypopnea syndrome (OSAHS)
portrays a major public health problem worldwide. OSAHS is associated
with several co-morbidities … Caples SM, Gami AS, Somers VK. Obstructive …

Drug-Induced Sleep Computed Tomography–Directed Upper Airway Surgery for Obstructive Sleep Apnea: A Pilot Study

LA Lee, CJ Wang, YL Lo, CG Huang, IC Kuo, WN Lin… - Otolaryngology–Head and …, 2018

Objective A surgical response to upper airway (UA) surgery for obstructive sleep
apnea (OSA) depends on adequate correction of collapsible sites in the UA. This
pilot study aimed to examine the surgical response to UA surgery directed by drug …

Effect of HCO3-level on the accuracy of NoSAS screening for obstructive sleep apnea hypopnea syndrome

S Zhang, SM Qing, H Liu, NF Zhang - Zhonghua yi xue za zhi, 2018

Objective: To evaluate the effect of arterial blood HCO3-level on the accuracy of
NoSAS questionnaire screening for obstructive sleep apnea hypopnea syndrome
(OSAHS). Methods: The hospitalized patients with suspected OSAHS were recruited …

[PDF] The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management

Z Zhou, F Xu - Science, 2018

… The obstructive sleep apnea-hypopnea syndrome, OSAHS refers to the
repeated collapse of the upper airway during sleep, accompanied by
symptoms such as sleep disorder, apnea, hypoxemia, hypercapnia, daytime …

CPAP Mask Connector and Pillow System

S Hodges, S Wagner - US Patent App. 15/450,668, 2018

… Obstructive sleep apnea is the far more common type and occurs when
air is prevented from flowing … pauses are interrupted by the person waking
up and then resetting the obstruction in the … As a result of the serious …

Stimulation of a Hypoglossal Nerve for Controlling the Position of a Patient's Tongue

MG Lima, PM Meadows, J Benke - US Patent App. 15/969,418, 2018

… OSA is characterized by the obstruction of the airway causing breathing to
cease completely … is applied is reduced after an initial treatment while the
number of obstructive sleep apnea occurrences remain … be periodic (eg, the …

Differential Diagnosis and Related Disorders: RBD Mimics

R Manni, M Terzaghi - Rapid-Eye-Movement Sleep Behavior Disorder, 2019

… RBD mimics include arousalrelated motor manifestations in severe obstructive sleep apnea,
disorders of arousal from NREM sleep, sleep-related movement disorders, temporal and
frontal nocturnal epileptic seizures, insulinoma-related hypoglycemia and psychogenic …

 

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CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity

Publication date: Available online 21 September 2018

Source: Journal of Autoimmunity

Author(s): Keqi Fan, Fei Wang, Yiyuan Li, Lu Chen, Zhengjun Gao, Yu Zhang, Jin-yuan Duan, Tao Huang, Jiangyan Zhong, Rong-bei Liu, Xintao Mao, Hengyu Fan, Xing Guo, Jin Jin

Abstract

The proliferation of T cells in peripheral lymphoid tissues requires T cell receptor (TCR)-mediated cell cycle entry. However, the underlying mechanism regulating cell cycle progression in mature T cells is incompletely understood. Here, we have identified an E3 ubiquitin ligase, CRL4^DCAF2, as a critical mediator controlling M phase exit in activated T cells. DCAF2 expression is induced upon TCR stimulation and its deficiency attenuates T cell expansion. Additionally, DCAF2 T cell-specific knockout mice display impaired peripheral T cell maintenance and reduced severity of various autoimmune diseases. Continuous H4K20me1 modification caused by DCAF2 deficiency inhibits the induction of Aurkb expression, which regulates 26S proteasome activity during G2/M phase. CRL4^DCAF2 deficiency causes M phase arrest through proteasome-dependent mechanisms in peripheral T cells. Our findings establish DCAF2 as a novel target for T cell-mediated autoimmunity or inflammatory diseases.

https://ift.tt/2QT5xYG

GPR15+ T cells are Th17 like, increased in smokers and associated with multiple sclerosis

Publication date: Available online 21 September 2018

Source: Journal of Autoimmunity

Author(s): Cecilie Ammitzbøll, Marina R. von Essen, Lars Börnsen, Eva Rosa Petersen, Oskar McWilliam, Rikke Ratzer, Romme Christensen Jeppe, Annette B. Oturai, Helle B. Søndergaard, Finn Sellebjerg

Abstract

Smoking is a risk factor for the development and progression of multiple sclerosis (MS); however, the pathogenic effects of smoking are poorly understood. We studied the smoking-associated chemokine receptor-like molecule GPR15 in relation to relapsing-remitting MS (RRMS). Using microarray analyses and qPCR we found elevated GPR15 in blood cells from smokers, and increased GPR15 expression in RRMS. By flow cytometry we detected increased frequencies of GPR15 expressing T and B cells in smokers, but no difference between patients with RRMS and healthy controls. However, after cell culture with the autoantigens myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein, frequencies of MBP-reactive and non-proliferating GPR15⁺CD4⁺ T cells were increased in patients with RRMS compared with healthy controls. GPR15⁺CD4⁺ T cells produced IL-17 and were enriched in the cerebrospinal fluid (CSF). Furthermore, in the CSF of patients with RRMS, GPR15⁺ T cells were associated with CCR6⁺CXCR3⁺/CCR6⁻CXCR3⁺ phenotypes and correlated positively with concentrations of the newly identified GPR15-ligand (GPR15L), myelin degradation and disability. In conclusion, we have identified a proinflammatory cell type linking smoking with pathogenic immune cell functions in RRMS.

https://ift.tt/2xFuwGs

Scholar : ΣΤΟΜΑΤΙΤΙΣ - νέα αποτελέσματ

Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host from Viral Infection through Amplifying Type I Interferon Responses

Q Xiong, H Huang, N Wang, R Chen, H Han, M Liu… - Frontiers in Immunology, 2018

… Most importantly, overexpression of TGR5 or treatment with the modified bile acid
INT-777 broadly protected host cells from vesicular stomatitis virus (VSV), newcastle
disease virus (NDV) and herpes simplex virus type 1 (HSV-1) infection …

[HTML] 利用 VSV 标记具有特定投射的特异类型神经元的精细结构

文鹏杰， 苏鹏， 王浩， 胡亮， 林坤章， 朱续涛， 邱宇翔… - 波谱学杂志, 2018

… Labeling Fine Morphology of Neurons with Specific Cell Types and Specific
Projection Using Vesicular Stomatitis Virus[J]. Chinese Journal of Magnetic
Resonance, 2018, 35(3): 353-362 … 水泡性口炎病毒（vesicular stomatitis …

Fucan-dendrimer based compounds and complexes

CMK Springate - US Patent App. 15/970,472, 2018

… include central nervous system toxicities such as seizures in children and
hallucinations; dermatologic toxicity such as alopecia; extravasation toxicity
such as vesicant; gastrointestinal toxicities such as nausea, vomiting …

Prevalence of Candida Species in Endodontic Infections: Systematic Review and Meta-analysis

G Mergoni, D Percudani, G Lodi, P Bertani, M Manfredi - Journal of Endodontics, 2018

… can be systemic (invasive candidosis) and associated with high mortality
(2). Three primary oral manifestations (pseudomembranous, erythematous,
and chronic hyperplastic) are described together with some Candida …

[HTML] Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health

B Kumar, A Manuja, BR Gulati, N Virmani, BN Tripathi - The Open Virology Journal, 2018

… A large number of horses and human cases of VEE with fatal encephalitis have
continuously occurred in Venezuela and Colombia. Vesicular stomatitis (VS) is prevalent
in horses in North America and has zoonotic potential causing encephalitis in children …

Intercellular Communication Is Key for Protective IFN α/β Signaling During Viral Central Nervous System Infection

M Hwang, CC Bergmann - Viral immunology, 2018

… Studies of CNS infections by RNA viruses, including La Crosse, rabies virus
(RABV), vesicular stomatitis virus (VSV), and Theiler's encephalomyelitis
virus (TMEV) demonstrated that astrocytes and microglia/macrophages are …

[HTML] Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib

R Sogawa, T Saita, Y Yamamoto, S Kimura… - Journal of Pharmaceutical …, 2018

… growth factor receptor-mutated non-small cell lung cancer [1], [2]. Treatment
with this drug has considerable clinical advantages, but it is also associated
with a high incidence of adverse events such as diarrhea (95.2% of cases) …

[PDF] Hand Foot Mouth Disease–Experience of epidemic in children in Lahore, Punjab, Pakistan

MA Sultan, MF Afzal - 2018

… rapidly in children attending day care or pre-school nurseries, constituting
a commonly infected age group. Clinically, HFMD is characterized by
erosive stomatitis that occurs with a vesicular and maculopapular rash …

[PDF] Prosthodontics Status and Treatment Needs among the Elderly in the Republic of Macedonia. Open Access Maced J Med Sci. 2018 May 20; 6 (5): 874-878

J Nikolovska, V Korunoska-Stevkovska, A Mijoska… - 2018

… Kulak-Ozkanet et al. have found a statistically significant relationship between denture
stomatitis, yeasts' presence and denture cleanliness in their study [24] … Oral hygiene habits,
denture cleanliness, presence of yeasts and stomatitis in elderly people …

[PDF] Monocytes and Macrophages as Viral Targets and Reservoirs

E Nikitina, I Larionova, E Choinzonov, J Kzhyshkowska - International Journal of …, 2018

Viruses manipulate cell biology to utilize monocytes/macrophages as vessels
for dissemination, long-term persistence within tissues and virus replication.
Viruses enter cells through endocytosis, phagocytosis, macropinocytosis or …

 

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