Mammary Stem Cells: Premise, Properties, and Perspectives

Publication date: Available online 6 May 2017
Source:Trends in Cell Biology
Author(s): Bethan Lloyd-Lewis, Olivia B. Harris, Christine J. Watson, Felicity M. Davis
Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the mammary gland, and their longevity and potential have important implications for breast cancer. However, despite intense investigation the identity, location, and differentiation potential of MaSCs remain subject to deliberation. The application of genetic lineage-tracing models, combined with quantitative 3D imaging and biophysical methods, has provided new insights into the mammary epithelial hierarchy that challenge classical definitions of MaSC potency and behaviors. We review here recent advances – discussing fundamental unresolved properties of MaSC potency, dynamics, and plasticity – and point to evolving technologies that promise to shed new light on this intractable debate. Elucidation of the physiological mammary differentiation hierarchy is paramount to understanding the complex heterogeneous breast cancer landscape.



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Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link

Publication date: Available online 6 May 2017
Source:Trends in Cell Biology
Author(s): Giacomo Mancini, Tamas L. Horvath
Despite the well-known role of chronic mitochondrial dysfunction in the pathophysiology of the brain, the impact of acute impairment of mitochondrial activity by cannabinoids on higher brain functions is unknown. In a recent paper in Nature, Hebert-Chatelain et al. elegantly uncovered the essential role that bioenergetic processes have in the regulation of higher brain functions, such as learning and memory.



http://ift.tt/2qPdWyN

eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation

Publication date: Available online 6 May 2017
Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Author(s): Kyung-Won Min, Sylvia Davila, Richard W. Zealy, Lawson T. Lloyd, In Young Lee, Rumi Lee, Kyung Hye Roh, Ahjin Jung, Jacek Jemielity, Eui-Ju Choi, Jeong Ho Chang, Je-Hyun Yoon
Post-transcriptional gene regulation is an important step in eukaryotic gene expression. The last step to govern production of nascent peptides is during the process of mRNA translation. mRNA translation is controlled by many translation initiation factors that are susceptible to post-translational modifications. Here we report that one of the translation initiation factors, eIF4E, is phosphorylated by Mammalian Ste20-like kinase (MST1). Upon phosphorylation, eIF4E weakly interacts with the 5′ CAP to inhibit mRNA translation. Simultaneously, active polyribosome is more associated with long noncoding RNAs (lncRNAs). Moreover, linc00689-derived a micropeptide, STORM (Stress- and TNF-α-activated ORF Micropeptide), is induced by TNF-α-induced and MST1-mediated eIF4E phosphorylation exhibits molecular mimicry of SRP19 and, thus, competes for 7SL RNA. Our findings have uncovered a novel function of MST1 in mRNA and lncRNA translation by direct phosphorylation of eIF4E. This novel signaling pathway will provide new platforms for mRNA regulation of mRNA translation via post-translational protein modification.



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Scholar : These new articles for African Studies are available online

The online platform for Taylor & Francis Online content New for African Studies and online now on Taylor & Francis Online: Original Articles The history of the South African sugar industry illuminates deeply rooted obstacles for sugar reduction anti-obesity interventions Alex Myers, David Fig, Aviva Tugendhaft, Jonathan E Myers & Karen J Hofman Pages: 1-16 | DOI: 10.1080/00020184.2017.1311515 Listening Leaders Free Accessarticles from International Listening Association Lifetime Achievement AwardeesFind out more To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Architecture and Culture, Volume 5, Issue 1, March 2017 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content Architecture and Culture, Volume 5, Issue 1, March 2017 is now available online on Taylor & Francis Online. Villages and Globalization This new issue contains the following articles: Introductory Essay Architecture and Culture: A Villages and Globalization Issue Ben Stringer Pages: 1-4 | DOI: 10.1080/20507828.2017.1299434 Articles Villages and Urbanization Ben Stringer Pages: 5-20 | DOI: 10.1080/20507828.2017.1299435 Designing for Home-Based Work – Lessons from Two English Villages Frances Holliss Pages: 21-39 | DOI: 10.1080/20507828.2017.1283127 Allergic to the Twentieth Century: Intentional Communities and Therapeutic Landscapes in The Village and Safe David Bell Pages: 41-56 | DOI: 10.1080/20507828.2017.1283123 Rural Face, Urban Mask: Architecture of Communal Form and Collective Practice in Two Chinese Villages from 2010 to 2015 Xiang Ren Pages: 57-76 | DOI: 10.1080/20507828.2017.1283124 Rescaling Ruralities through the Art Project Company: Movements, Deals and Drinks Miranda Pope Pages: 77-98 | DOI: 10.1080/20507828.2017.1283125 Interview Makutano Junction: A Village Soap Opera for Kenyan TV. An Interview with Producer and Mediae.org Director and Co-founder David Campbell Ben Stringer & David Campbell Pages: 99-113 | DOI: 10.1080/20507828.2017.1292754 Articles Milan's Potential for a Structured and Interactive Rurality Martina Orsini Pages: 115-134 | DOI: 10.1080/20507828.2017.1283126 Encountering Rural Transformation: A Catalyst for Exchanging Narratives of Place? Mo Michelsen Stochholm Krag Pages: 135-156 | DOI: 10.1080/20507828.2017.1283135 Read selected content from the Journal of Structural Integrity and Maintenance for free! http://ift.tt/2coiFom To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Amyloid are available online

The online platform for Taylor & Francis Online content New for Amyloid and online now on Taylor & Francis Online: Original Article Transthyretin amyloidosis: a phenocopy of hypertrophic cardiomyopathy | Alexa M. C. Vermeer, Anneloes Janssen, Peter C. Boorsma, Marcel M. A. M. Mannens, Arthur A. M. Wilde & Imke Christiaans Pages: 1-5 | DOI: 10.1080/13506129.2017.1322573 Journal of HIV/AIDS & Social Services – FREE ACCESS Article Collection - click here To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Creative Industries Journal are available online

The online platform for Taylor & Francis Online content New for Creative Industries Journal and online now on Taylor & Francis Online: Original Articles Changing the world one voice at a time: philanthropy and community choirs in Australia Jane Southcott & Dawn Joseph Pages: 1-13 | DOI: 10.1080/17510694.2017.1324117 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Canadian Society of Forensic Science Journal are available online

The online platform for Taylor & Francis Online content New for Canadian Society of Forensic Science Journal and online now on Taylor & Francis Online: Original Articles Examination of the effects of breath hydrogen and methane levels on the EC/IR II Melissa Kramer-Sarrett, Eugenia Lin, Kathleen Shari Chua, Nipaporn Pichetshote, Ali Rezaie & Mark Pimentel Pages: 1-6 | DOI: 10.1080/00085030.2017.1313474 Free access World Diabetes Day research collection – Eyes on Diabetes. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Asian Geographer are available online

The online platform for Taylor & Francis Online content New for Asian Geographer and online now on Taylor & Francis Online: Original Articles An archipelagic tourism development model: the case of Okinawa Prefecture David N. Nguyen Pages: 1-19 | DOI: 10.1080/10225706.2017.1323654 Find out more about the issues and challenges in Governing Asia. This collection includes free access papers on security challenges, the Abe and Modi administration, reflections on the Chinese Governance and more. Browse today! To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Archives of Agronomy and Soil Science, Volume 63, Issue 9, July 2017 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content Archives of Agronomy and Soil Science, Volume 63, Issue 9, July 2017 is now available online on Taylor & Francis Online. This new issue contains the following articles: Original Articles Underground communication of root hormones by common mycorrhizal network between trifoliate orange and white clover Qiang-Sheng Wu, Yi-Can Zhang, Ze-Zhi Zhang & Anoop Kumar Srivastava Pages: 1187-1197 | DOI: 10.1080/03650340.2016.1276570 The effects of cultivation methods and water regimes on root systems of drought-tolerant (RD6) and drought-sensitive (RD10) rice varieties of Thailand Hayat Ullah, Avishek Datta, Sangam Shrestha & Siraj Ud Din Pages: 1198-1209 | DOI: 10.1080/03650340.2016.1266077 Influences of irrigation, nitrogen and zeolite management on the physicochemical properties of rice Taotao Chen, Lloyd Ted Wilson, Qian Liang, Guimin Xia, Wei Chen & Daocai Chi Pages: 1210-1226 | DOI: 10.1080/03650340.2016.1276286 Combined effect of deficit irrigation and foliar-applied salicylic acid on physiological responses, yield, and water-use efficiency of onion plants in saline calcareous soil Wael M. Semida, Taia A. Abd El-Mageed, Sabry E. Mohamed & Nevein A. El-Sawah Pages: 1227-1239 | DOI: 10.1080/03650340.2016.1264579 Efficiency of foliar selenium application on oilseed rape (Brassica napus L.) as influenced by rainfall and soil characteristics Jiřina Száková, Lukáš Praus, Jana Tremlová, Martin Kulhánek & Pavel Tlustoš Pages: 1240-1254 | DOI: 10.1080/03650340.2016.1275581 Improving iron bioavailability and nutritional value of maize (Zea mays L.) in sulfur-treated calcareous soil Pia Muhammad Adnan Ramzani, Muhammad Khalid, Shazia Anjum, Waqas-ud-Din Khan, Muhammad Iqbal & Salma Kausar Pages: 1255-1266 | DOI: 10.1080/03650340.2016.1266484 Amelioration of saline–sodic soil with gypsum can increase yield and nitrogen use efficiency in rice–wheat cropping system Behzad Murtaza, Ghulam Murtaza, Muhammad Sabir, Gary Owens, Ghulam Abbas, Muhammad Imran & Ghulam Mustafa Shah Pages: 1267-1280 | DOI: 10.1080/03650340.2016.1276285 Differential response of soybean genotypes to two lime rates Adônis Moreira, Larissa Alexandra Cardoso Moraes, Isabelle Cristina Vilarino Lara & Thiago Assis Rodrigues Nogueira Pages: 1281-1291 | DOI: 10.1080/03650340.2016.1274976 Agronomic evaluation of testcrosses of drought-tolerant maize (Zea mays L.) inbred lines using different selection index methods Moses Adeolu Adebayo, Adesike Oladoyin Kolawole, Ibraheem Raji & Joseph Ajayi Pages: 1292-1300 | DOI: 10.1080/03650340.2016.1274977 Assessment of AquaCrop model in the simulation of seed yield and biomass of Italian ryegrass Ruzica Stricevic, Aleksandar Simic, Alpaslan Kusvuran & Marija Cosic Pages: 1301-1313 | DOI: 10.1080/03650340.2016.1275580 Promoting deep-sowing germinability of corn (Zea mays) by seed soaking with gibberellic acid Binrong Pan, Tailin Zhong & Guangwu Zhao Pages: 1314-1323 | DOI: 10.1080/03650340.2016.1268256 Impact of top-pruning time on the fertilizer N use efficiency of flue-cured tobacco as assessed by 15N tracing technique Maomao Hou, Qiu Jin, Xueshan Wu, Yao Yao & Zikun Zhang Pages: 1324-1335 | DOI: 10.1080/03650340.2016.1274825 Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for International Journal of Heritage Studies are available online

The online platform for Taylor & Francis Online content New for International Journal of Heritage Studies and online now on Taylor & Francis Online: Original Articles Floating culture: the unrecorded antiquities of England and Wales Adam Daubney Pages: 1-15 | DOI: 10.1080/13527258.2017.1325770 The Monument to Victory in Bolzano: desacralisation of a fascist relic Håkan Hökerberg Pages: 1-16 | DOI: 10.1080/13527258.2017.1321572 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Archives of Agronomy and Soil Science are available online

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The online platform for Taylor & Francis Online content New for Archives of Agronomy and Soil Science and online now on Taylor & Francis Online: Original Articles Foliar calcium spray confers drought stress tolerance in maize via modulation of plant growth, water relations, proline content and hydrogen peroxide activity Muhammad Naeem, Muhammad Shahbaz Naeem, Rashid Ahmad, Muhammad Zahid Ihsan, Muhammad Yasin Ashraf, Yasir Hussain & Shah Fahad This is the author accepted version which has not been proofed or edited Interaction with soil enhances the toxic effect of iodide and iodate on barley (Hordeum vulgare L.) compared to artificial culture media during initial growth stage Eva Duborská, Martin Urík & Jana Kubová This is the author accepted version which has not been proofed or edited Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : New articles have been published for Baltic Journal of Economics, Volume 17, Issue 2

The online platform for Taylor & Francis Online content The following articles have been newly published in the issue Baltic Journal of Economics, Volume 17, Issue 2 on Taylor & Francis Online: Original Articles Effects of population ageing on the pension system in Belarus | Katerina Lisenkova, Kateryna Bornukova Pages: 103-118 | DOI: 10.1080/1406099X.2017.1318000 The issue is in progress. To view all articles already published in this issue, please visit: http://ift.tt/2pOJKWA Find out more about the issues and challenges in Governing Asia. This collection includes free access papers on security challenges, the Abe and Modi administration, reflections on the Chinese Governance and more. Browse today! To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Ειδοποίηση Μελετητή - [ ΜΕΝΙΕ

Ειδοποίηση Μελετητή:[ ΜΕΝΙΕΡΕ ]

Post-Traumatic Dizziness

S Carr, J Rutka - Current Otorhinolaryngology Reports, 2017

... The study did not find a causative link in the TBI patients studied to support a diagnosis for
post-traumatic Meniere's as the incidence of the dis- ease in this cohort was equal to that in the
general population. ... Vertigo . Database . Post-traumatic Meniere's . Controversies ...

Intratympanic (IT) Therapies for Menière's Disease: Some Consensus Among the Confusion

DP Schoo, GX Tan, MR Ehrenburg, SE Pross, BK Ward… - Current Otorhinolaryngology …, 2017

Page 1. OTOLOGY: VESTIBULAR DISORDERS (J RUTKA, SECTION EDITOR)
Intratympanic (IT) Therapies for Menière's Disease: Some Consensus Among the
Confusion Desi P. Schoo1 & Grace X. Tan1 & Matthew R. Ehrenburg1 ...

内耳障害の MRI 評価

曾根 三千彦 - 耳鼻咽喉科臨床, 2017

... MRI studies in this field have demonstrated the existence of EH in various otological disorders,
including Meniere's disease. ... 19) Nakashima T, Naganawa S, Sugiura M, et al. : Visualization
of endolymphatic hydrops in patients with Meniere's disease. ...

Otologic nanotechnology

KR Dyer Jr, V Hough, D Jack - US Patent RE46,373, 2017

... WO/2002/056890, July, 2002, NOVEL METHOD AND COMPOSITIONS FOR LOCAL TREATMENT
OF MENIERE'S DISEASE, TINNITUS AND/OR HEARING LOSS. ... The issue of round window
membrane transport is particularly applicable in the treatment of Meniere's disease. ...

Diagnosing B-Cell Lymphoma By Immunoglobulin Gene Rearrangement In Patients With Negative Flow Cytometry

C Quinn, V Pathak - Am J Respir Crit Care Med, 2017

... A 60 year old female with a past medical history significant for Helicobacter pylori induced
gastritis, Meniere's disease, Case Description and gastric bypass (Roux-en-Y) presented
to the hospital with persistent chest pain and abdominal pain. ...

[PDF] Assessment of absorption of four lignan constituents of JingNing particles in rat gut using in situ single-pass intestinal perfusion

C Yang, XB Yin, X Dong, J Fu, W Wang - Tropical Journal of Pharmaceutical …, 2017

... They are used as adjuvant substances in the Page 2. Yang et al Trop J Pharm Res, April 2017;
16(4): 838 treatment of ADHD, Alzheimer's disease, Parkinsonism, and Meniere's diseases [5].
Traditional theories believe that endogenous liver wind is associated with ADHA. ...

Does Ménière's disease exhibit specific cVEMP tuning properties?

T Murofushi, M Tsubota, R Suizu, E Yoshimura - Frontiers in Neurology, 2017

... Conclusion: The tuning property test of cVEMP is useful as a screening test of MD.
Keywords: Endolymphatic Hydrops, Meniere's disease, Saccule and Utricle, Otolith organ,
tuning. Received: 19 Oct 2016; Accepted: 20 Apr 2017. Edited by: ...

Method for treating hearing loss

JM Miller, GE Green, CG Leprell - US Patent RE46,372, 2017

... Systems", J. Agric. Food Chem. 51, 2003, pp. 1077-1080. Takumida et al., "Radical
scavengers for Meniere's disease after failure of conventional therapy: a pilot study",
Acta Otolaryngol. (Stockh). 123, 2003, pp. 697-703. Tanswell et ...

Innovative pharmaceutical approaches for the management of inner ear disorders

UM Musazzi, S Franzé, F Cilurzo - Drug Delivery and Translational Research, 2017

Page 1. REVIEW ARTICLE Innovative pharmaceutical approaches for the management
of inner ear disorders Umberto M. Musazzi1 & Silvia Franzé1 & Francesco Cilurzo1 ©
Controlled Release Society 2017 Abstract The sense ...

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

M Yamada, S Suzuki, T Sugimoto, M Nakamura… - US Patent 20,170,100,384, 2017

The present invention provides a compound having a cholinergic muscarinic
M1 receptor positive allosteric modulator activity and useful as an agent
for the prophylaxis or treatment of Alzheimer's dise.

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