Πέμπτη 8 Σεπτεμβρίου 2016

JAMA ORL Online First

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

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Online First

September 08, 2016

Original Investigation

Prevalence and Incidence of Diagnosed Chronic Rhinosinusitis in Alberta, Canada

Yuan Xu, MD, MSc; Hude Quan, MD, PhD; Peter Faris, PhD; et al

Chronic Sinusitis and Risk of Head and Neck Cancer in the US Elderly Population

Daniel C. Beachler, PhD, MHS; Eric A. Engels, MD, MPH

Survival and Surgical Outcomes for Pediatric Head and Neck Melanoma

Morgan K. Richards, MD, MPH; Josephine Czechowicz, MD; Adam B. Goldin, MD, MPH; et al

Invited Commentary

Can Chronic Sinusitis Cause Cancer?

Elisabeth H. Ference, MD, MPH; Jeffrey D. Suh, MD

Clinical Challenge

A Young Man With Enlarging Unilateral Tonsil Mass

Casey Hay, MD; Rafal Kozielski, MD; Philomena Behar, MD

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Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial

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Hydrogel injection reduces rectal toxicity after radiotherapy for localized prostate cancer

Abstract

Purpose

Injection of a hydrogel spacer before prostate cancer radiotherapy (RT) is known to reduce the dose to the rectal wall. Clinical results from the patient's perspective are needed to better assess a possible benefit.

Methods

A group of 167 consecutive patients who received prostate RT during the years 2010 to 2013 with 2‑Gy fractions up to 76 Gy (without hydrogel, n = 66) or 76–80 Gy (with hydrogel, n = 101) were included. The numbers of interventions resulting from bowel problems during the first 2 years after RT were compared. Patients were surveyed prospectively before RT, at the last day of RT, and at a median of 2 and 17 months after RT using a validated questionnaire (Expanded Prostate Cancer Index Composite).

Results

Baseline patient characteristics were well balanced. Treatment for bowel symptoms (0 vs. 11 %; p < 0.01) and endoscopic examinations (3 vs. 19 %; p < 0.01) were performed less frequently with a spacer. Mean bowel function scores did not change for patients with a spacer in contrast to patients without a spacer (mean decrease of 5 points) >1 year after RT in comparison to baseline, with 0 vs. 12 % reporting a new moderate/big problem with passing stools (p < 0.01). Statistically significant differences were found for the items "loose stools", "bloody stools", "painful bowel movements" and "frequency of bowel movements".

Conclusion

Spacer injection is associated with a significant benefit for patients after prostate cancer RT.

http://ift.tt/2c3PqIj

Oral Oncology Articles in Press E

Letter to the editor referring to the publication entitled "The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment" by Pai et al.

Published online: August 28, 2016

P. Szturz, S. Faivre

Oral Oncology

http://www.oraloncology.com/article/S1368-8375(16)30135-X/fulltext

m-TOR inhibitor as potential radiosensitizer for head and neck squamous cell carcinoma: A case report of an organ transplant patient and review of the literature

Published online: August 30, 2016

Amaury Daste, Erwan de Mones, Charles Dupin, Louis François, Alain Ravaud, Laurence Digue

Oral Oncology

http://www.oraloncology.com/article/S1368-8375(16)30136-1/fulltext

Prognostic role of negative plasma EBV DNA level in patients with NPC

Published online: August 30, 2016

Enis Ozyar

Oral Oncology

http://www.oraloncology.com/article/S1368-8375(16)30139-7/fulltext

View all Articles in Press at www.oraloncology.com/inpress

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Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

A pill at bedtime, and your heart is fine? Bedtime hypertension chronotherapy: an opportune and advantageous inexpensive treatment strategy

It is commonly assumed that cardiovascular (CV) system rests during the nighttime, the sleep span being a restorative time for the CV system. However, the biology of the CV system is much more complicated than assumed. Convincing evidence now demonstrates the critical importance of the sleep-time blood pressure (BP) level and 24-hour (h) pattern in affecting CV risk. BP is not constant but exhibits distinct temporal patterning during the 24-h, with a circadian (from the Latin 'circa diem', near 24-h) organization.

http://ift.tt/2cdXwbV

Reduction of cardiac and coronary artery doses in irradiation of left-sided breast cancer during inspiration breath hold

Abstract

Background and purpose

The radiation dose received by the heart during adjuvant left-sided breast irradiation plays a crucial role in development of late toxicity. Although the absolute risk of cardiotoxicity can be reduced with modern irradiation techniques, cardiotoxic chemotherapy increases the risk of late damage. Thus, the radiation dose to the heart should be minimized. This study evaluated the influence of different amplitudes of inspiration breath hold (IBH) during simulated left-sided breast irradiation on cardiac doses compared to free breathing (FB).

Patients and methods

CT data of 11 lung cancer patients were retrospectively used as left-sided pseudo-breast cancer cases. Two CT scans were used, one during IBH and one during FB, and two treatment plans were generated. Relevant heart, lung, and left anterior descending artery (LAD) parameters were derived from dose–volume histograms. The normal tissue complication probabilities (NTCPs) for the heart were calculated based on the relative seriality model. Inspiration depth was quantified using chest volume and diameter, and correlated thereafter to a possible sparing of heart tissue.

Results

Mean reduction of heart dose for IBH compared to FB was 40 % (1.65 vs. 0.99 Gy; p = 0.007). Maximum dose to the heart and LAD could be decreased by 33 % (p = 0.011) and 43 % (p = 0.024), respectively. The mean anteroposterior shift was 5 mm (range 0.9–9.5 mm). Significant negative correlations between the relative change in LAD mean dose and the mean thoracic diameter and volume change, as well as with the absolute change in thoracic diameter were seen. The NTCP for cardiac mortality could be decreased by about 78 % (p = 0.017).

Conclusion

For left-sided breast cancer patients, cardiac doses can be significantly decreased with tangential irradiation and IBH.

http://ift.tt/2bWn4Pe

Review of quantitative outcome analysis of cranial morphology in craniosynostosis

Outcome measures in craniosynostosis surgery have progressed from those based on the need for surgical revision to linear anthropometric measurements, 2D CT vector analysis and 3D CT vector analysis. However, finding an objective means to assess postoperative cranial morphological improvement remains challenging.A critical review of previous studies used to measure craniosynostosis surgery outcomes is presented. The introduction of novel techniques currently being used in our unit which is described.

http://ift.tt/2chdIfT

Robotic-assisted Nipple Sparing Mastectomy: A feasibility study on cadaveric models

Nipple-sparing mastectomy (NSM) is increasingly popular for the treatment of selected breast cancers and prophylactic mastectomy. Surgical scarring and aesthetic outcomes are important patient related cosmetic considerations.1,2 Today, the concept of minimal invasive surgery has become popular, especially with the use of robotic surgery.

http://ift.tt/2cG0B5K

The learning rate in three dimensional high definition video assisted microvascular anastomosis in a rat model

Three-dimensional (3D)-high definition (HD) video systems are changing microsurgical practice by providing stereoscopic imaging not only for the surgeon and first assistant using the binocular microscope, but also for others involved in the surgery. The purpose of this study was to evaluate the potential to replace the binocular microscope for microarterial anastomoses and assess the rate of learning based on surgeons' experience.Two experienced and two novice microsurgeons performed a total of 88 rat femoral arterial anastomoses: 44 using a 3D HD video device ('Trenion', Carl Zeiss Meditech) and 44, a binocular microscope.

http://ift.tt/2checm7

The Role of Face Transplantation in the Self-Inflicted Gunshot Wound

Facial self-inflicted gunshot wounds (SIGSWs) cause a devastating midfacial defect, and pose a challenging problem to the reconstructive surgeon. Face transplantation (FT) has the potential for near-normal restoration in otherwise non-reconstructable defects. Two out of 7 FT recipients at Brigham and Women's Hospital (BWH) were individuals who sustained SIGSWs. Here, we illustrate the role of FT in the management of SIGSWs through an aesthetic, functional and psychosocial examination of outcomes.

http://ift.tt/2cFYTle

Drug Synergism of Proteasome Inhibitors and Mitotane by Complementary Activation of ER Stress in Adrenocortical Carcinoma Cells

Abstract

Mitotane is the only drug approved for treatment of the orphan disease adrenocortical carcinoma (ACC) and was recently shown to be the first clinically used drug acting through endoplasmic reticulum (ER)-stress induced by toxic lipids. Since mitotane has limited clinical activity as monotherapy, we here study the potential of activating ER-stress through alternative pathways. The single reliable NCI-H295 cell culture model for ACC was used to study the impact MG132, bortezomib (BTZ) and carfilzomib (CFZ) on mRNA and protein expression of ER-stress markers, cell viability and steroid hormone secretion. We found all proteasome inhibitors alone to trigger expression of mRNA (spliced X-box protein 1, XBP1) and protein markers indicative of the inositol-requiring enzyme 1 (IRE1) dependent pathway of ER-stress but not phosphorylation of eukaryotic initiation factor 2α (eIF2α), a marker of the PRKR-like endoplasmic reticulum kinase (PERK)-dependent pathway. Whereas mitotane alone activated both pathways, combination of BTZ and CFZ with low-dose mitotane blocked mitotane-induced eIF2α phosphorylation but increased XBP1-mRNA splicing indicating that proteasome inhibitors can commit signalling towards a single ER-stress pathway in ACC cells. By applying the median effect model of drug combinations using cell viability as a read out, we determined significant drug synergism between mitotane and both BTZ and CFZ. In conclusion, combination of mitotane with activators of ER-stress through the unfolded protein response is synergistic in an ACC cell culture model. Since proteasome inhibitors are readily available clinically, they are attractive candidates to study for ACC treatment in clinical trials in combination with mitotane.

http://ift.tt/2cFMldu

Female specific glucose-sensitivity of GnRH1 neurons leads to sexually dimorphic inhibition of reproduction in medaka

Endocrinology, Early Release.

http://ift.tt/2csweAz

Recent Findings on Quality-of-Life Management in Patients With Cancer

This Viewpoint highlights recent findings on quality-of-life management for patients with cancer and their survivors.

http://ift.tt/2cslIcN

Implications of Moonshot in Hereditary Cancer Syndromes

This Viewpoint discusses the significance of investing billions of dollars in genomic sequencing and the implications of finding a hereditary mutation in patients with metastatic cancer using next-generation sequencing.

http://ift.tt/2c8Hxxw

Prognostic Factors for Local Control in Breast Cancer With Boost vs No Boost

This reanalysis of the EORTC "boost vs no boost" trial examines the long-term impact of prognostic factors on ipsilateral breast tumor recurrence in patients treated with breast-conserving therapy.

http://ift.tt/2c8Hfqb

Breast Cancer Risk Following Diagnosis of Atypical Ductal Hyperplasia

This cohort study uses data from the Breast Cancer Surveillance Consortium to evaluate the 10-year cumulative risk of breast cancer in women with atypical ductal hyperplasia that was diagnosed on needle biopsy vs excisional biopsy.

http://ift.tt/2csleDg

Human Papillomavirus Types Conferring Poor Cancer Prognosis

In Reply Human papillomavirus (HPV)-related oropharynx cancer (OPC) is well known to have a favorable outcome compared with HPV-unrelated OPC. The use of immunohistochemical analysis to detect tumor overexpression of p16 is regarded as a reliable surrogate marker for HPV-driven OPC and is presently used to define this disease for inclusion within clinical trials, including those studying treatment deescalation. Appropriately, these trials also incorporate additional criteria such as tumor extent to define risk groups. For some patients, however, p16 status and tumor extent have limitations in predicting outcome. It is therefore imperative in the era of deescalation to identify additional potential prognostic factors in HPV-related OPC. We recently reported that HPV-16 was associated with favorable survival compared with other HPV types (HPV-other) (HR, 4.8; P = .003), a finding that could not be readily explained by differences in clinical, demographic, or genomic features. Psyrri et al have highlighted several aspects of our analysis, and we appreciate the opportunity to reply.

http://ift.tt/2ccXCTA

Human Papillomavirus Types Conferring Poor Cancer Prognosis

To the Editor In their interesting research letter, Bratman and colleagues report that patients with head and neck squamous cell carcinoma associated with human papillomavirus (HPV) genotypes other than HPV-16 have inferior survival. They propose that this finding will affect patient selection in trials of treatment deintensification, which seek to minimize long-term toxic effects in patients with highly curable HPV-initiated oropharyngeal cancer. Data respecting the relative importance of p16 and HPV status in predicting outcome after chemoradiotherapy, as well as experience in cervical cancer, may be helpful in interpreting these results.

http://ift.tt/2c1XdGB

Atypical Ductal Hyperplasia

Since the 1985 report by Dupont and Page, women with atypical hyperplasia have been found to have an increased risk for developing breast cancer. Recent reports with long-term follow-up have shown the absolute risk for developing breast cancer to be within the range of 1% to 2% per year. Most of these studies were performed in cohorts starting in the 1960s, before the widespread use of screening mammograms and core biopsies. In the modern era, are we overestimating the risk of women with atypical hyperplasia for developing breast cancer?

http://ift.tt/2ccX4Nh

Benefits of Tumor Bed Boost After Whole-Breast Radiotherapy

Beginning in the late 1970s, multiple randomized trials established the equivalence of breast-conserving surgery plus radiotherapy to mastectomy. Uncertainty existed with regard to the required radiation dose, as some of the early trials delivered an additional boost of radiation to the tumor bed after whole-breast radiotherapy while others did not.

http://ift.tt/2c1WEwp

Mucositis (or Stomatitis)

Mucositis (sometimes called stomatitis) is inflammation and damage of the mucous membranes lining the mouth and other parts of the gastrointestinal (GI) tract.

http://ift.tt/2ccXkfw

Arginine Deprivation in ASS1-Deficient Malignant Pleural Mesothelioma

This phase 2 randomized clinical trial examines the effect of arginine deprivation plus best supportive care vs best supportive care alone in patients with argininosuccinate synthetase 1–deficient malignant pleural mesothelioma.

http://ift.tt/2bVKLFU

The ADAM Trial

Until recently, cisplatin and pemetrexed disodium doublet chemotherapy was the only anticancer treatment with a median overall survival benefit in malignant mesothelioma. The MAPS study published in 2016 confirmed a modest improvement in median survival with the addition of bevacizumab to this regimen. Recent sequencing studies point to most mesotheliomas having a low mutational burden and few "druggable" oncogenes. However, with the rapidly expanding field of immuno-oncology, most of the recent excitement in mesothelioma research involves immune checkpoint inhibitors, with some encouraging results but also some disappointment. Despite the lack of oncogenic driver mutations, other mechanisms of "personalized medicine" are under investigation including antimesothelin antibody drug conjugates, vaccines, and small-molecule inhibition of growth factor receptors.

http://ift.tt/2ccXbIT

Oral Cryotherapy for Preventing Oral Mucositis

This synopsis examines the effect of using oral cryotherapy to prevent oral mucositis in patients receiving fluorouracil-based chemotherapy for solid cancers and high-dose melphalan-based chemotherapy before hematopoietic stem cell transplantation.

http://ift.tt/2c1Xolj

Skin Lesions, Recurrent Fever, and Acute Myeloid Leukemia

A 69-year-old man with a history of relapsed acute myeloid leukemia monocytic type presented with intermittent fever and fatigue 2 months after allogeneic stem cell transplantation; home medications included acyclovir, fluconazole, and cyclosporine. What is your diagnosis?

http://ift.tt/2ccYVSe

Treatment of Gastric and Gastroesophageal Cancers—Do We Really Need Anthracyclines?

This Viewpoint questions the use of anthracyclines in the treatment of gastroesophageal cancers.

http://ift.tt/2c1WEws

Novel Management Strategies for Multiple Myeloma

This Viewpoint summarizes recent data supporting novel management strategies for multiple myeloma.

http://ift.tt/2ccX68c

The prognostic value of GLUT-1 staining in the detection of malignant transformation in oral mucosa

Abstract

Background

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common tumor entity worldwide. Unfortunately, the multimodal treatment consisting of surgery, radiation, and chemotherapy does not show the desired efficacy. The intent of this study was to evaluate the sensitivity and specificity of an oral brush biopsy in combination with glucose transporter (GLUT)-1 staining in identifying premalignant and malignant lesions.

Methods

A total of 72 patients were included in the study, divided into four diagnostic subgroups (24 healthy, 15 carcinoma, 18 leukoplakia, 15 oral lichen planus). Oral brush biopsies were taken and analyzed for GLUT-1 expression by immunocytologic staining. Incisional biopsy served as the gold standard.

Results

Twelve (80 %) of the 15 carcinomas, nine (50 %) of the 18 leukoplakia, nine (60 %) of the 15 oral lichen planus, and none of the healthy specimens stained positive for GLUT-1. This resulted in a sensitivity rate of 80 % and a specificity rate of 68.42 %. Diagnostic accuracy was 70.83 % based on the correct diagnoses in 51 of 72 patients.

Conclusion

An oral brush biopsy can easily be performed throughout the entire oral cavity, is noninvasive, and shows high sensitivity and specificity rates with conventional cytology or computer-assisted analysis.

Clinical relevance

The significance of GLUT-1-specific staining with an oral brush biopsy is more limited than expected but could be used as an additional tool in detecting malignant transformation in the oral cavity.

http://ift.tt/2c85Ds6

Dental implants in medically complex patients—a retrospective study

Abstract

Introduction

Dental implant insertion for oral rehabilitation is a worldwide procedure for healthy and medically compromised patients. The impact of systemic disease risks on the outcome of implant therapy is unclear, since there are few if any published randomized controlled trials (RCTs).

Objective

The objective of this study is to investigate the rate of complications and failures following dental implantation in medically compromised patients in order to elucidate risk factors and prevent them.

Material and methods

A retrospective cohort study was conducted from patient files treated with dental implantation between the years 2008–2014. The study group consisted of medically complex patients while the control group consisted of healthy patients. Preoperative, intraoperative, and post operative clinical details were retrieved from patients' files. The survival rate and the success rate of the dental implants were evaluated clinically and radiographically.

Results

A total of 204 patients (1003 dental implants) were included in the research, in the study group, 93 patients with 528 dental implants and in the control group, 111 patients with 475 dental implants. No significant differences were found between the groups regarding implant failures or complications. The failure rate of dental implants among the patients was 11.8 % in the study group and 16.2 % in the control group (P = 0.04). It was found that patients with a higher number of implants (mean 6.8) had failures compared with patients with a lower number of implants (mean 4.2) regardless of their health status (P < 0.01).

Conclusions

We found a similar rate of failure and complications of dental implantation in medically complex patients and in healthy patients.

Clinical relevance

Medically complex patients can undergo dental implantation. There are similar rates of complications and failures of dental implants in medically complex patients and in healthy patients.

http://ift.tt/2cliRoS

Detection in Peripheral Blood of Circulating Tumor Cells in Patient With Head and Neck Squamous Cell Carcinoma

Condition: Head and Neck Cancer
Intervention: Other: experimental
Sponsor: Institut de Cancérologie de Lorraine
Recruiting - verified September 2016

http://ift.tt/2c1lhcO

Pancreatico-biliary Tumor Mutation Profiling in Bile Samples

Condition: Cholangiocarcinoma, Cancer of the Head of the Pancreas
Interventions: Biological: bile sample analysis; Biological: biochemical markers, VEGF and MMPs, in bile samples
Sponsor: CHU de Reims
Recruiting - verified August 2016

http://ift.tt/2ccwd4h

Evaluation of an Active Swallowing Rehabilitation on Quality of Life of Patients Treated by Radiotherapy for Head and Neck Cancer

Condition: Cancer of Head and Neck
Intervention: Other: Swallowing therapy
Sponsor: Rennes University Hospital
Not yet recruiting - verified September 2016

http://ift.tt/2c1lqNd

Pembrolizumab in HNSCC With Residual Disease After Radiation

Condition: Head and Neck Squamous Cell Carcinoma
Intervention: Drug: Pembrolizumab
Sponsors: Yale University; Merck Sharp & Dohme Corp.
Not yet recruiting - verified September 2016

http://ift.tt/2ccxqIK

The prognostic value of GLUT-1 staining in the detection of malignant transformation in oral mucosa

Abstract

Background

Methods

Results

Conclusion

Clinical relevance

The significance of GLUT-1-specific staining with an oral brush biopsy is more limited than expected but could be used as an additional tool in detecting malignant transformation in the oral cavity.

http://ift.tt/2c85Ds6

Dental implants in medically complex patients—a retrospective study

Abstract

Introduction

Objective

Material and methods

Results

Conclusions

We found a similar rate of failure and complications of dental implantation in medically complex patients and in healthy patients.

Clinical relevance

Medically complex patients can undergo dental implantation. There are similar rates of complications and failures of dental implants in medically complex patients and in healthy patients.

http://ift.tt/2cliRoS

Journal of Voice Articles in Press E

Voice Therapy Effect on Mutational Falsetto Patients: A Vocal Aerodynamic Study

Published online: August 30, 2016

Fa-Ya Liang, Xiao-Ming Huang, Liang Chen, Yu-Zhang Huang, Xue-Yuan Zhang, Jin-Hui Su, Ya-Jing Wang, Jin-Shan Yang, Yi-Qing Zheng, Xiang-Sheng Mei, Zhong Guan

Journal of Voice

http://www.jvoice.org/article/S0892-1997(16)30016-9/fulltext

Book Review: Laryngeal Physiology for the Surgeon and Clinician: Second Edition

Published online: August 30, 2016

Amanda Hu

Journal of Voice

http://www.jvoice.org/article/S0892-1997(16)30294-6/fulltext

Immediate Effects of the Vocal Function Exercises Semi-Occluded Mouth Posture on Glottal Airflow Parameters: A Preliminary Study

Published online: August 30, 2016

Daniel J. Croake, Richard D. Andreatta, Joseph C. Stemple

Journal of Voice

http://www.jvoice.org/article/S0892-1997(16)30012-1/fulltext

View all Articles in Press at www.jvoice.org/inpress

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

The Endocrine Society Centennial: 40 years of Aromatase Inhibitors as Targeted Therapy for Breast Cancer

Endocrinology, Early Release.

http://ift.tt/2c6m86w

The cancer drug Dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice

Endocrinology, Early Release.

http://ift.tt/2bSwzua

Perinatal Nicotine Exposure Increases Obesity Susceptibility in Adult Male Rat Offspring by Altering Early Adipogenesis

Endocrinology, Early Release.

http://ift.tt/2bMh0qF

Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells

Endocrinology, Early Release.

http://ift.tt/2bVevQA

Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring

Endocrinology, Early Release.

http://ift.tt/2bHf0g1

Foxl3, a target of miR-9, stimulates spermatogenesis in spermatogonia during natural sex change in Monopterus albus

Endocrinology, Early Release.

http://ift.tt/2bHfmbg

Cardiopulmonary resuscitation training in secondary schools

Opportunities and barriers to cardiopulmonary resuscitation training in English secondary schools: Objectives: Cardiopulmonary resuscitation rates and survival from out-of-hospital cardiac arrest are poor in the UK compared with areas abroad that deliver mandatory training to all school children. We sought to identify barriers to training and develop a strategy to enable delivery of this training.

Methods: Qualitative analysis, comprising semistructured interviews and group discussions, covering 14 schools in the metropolitan borough of Calderdale in West Yorkshire.

Results: Only three schools out of 14 were delivering training to entire year groups. Barriers include lack of resources, lack of training for teachers and difficulty in initiating a programme. Strategies were developed to overcome these barriers with the result that four additional schools are now teaching a whole year group. There is no single solution and bespoke plans may be needed for each school.

Conclusion: The establishment of cardiopulmonary resuscitation training in secondary schools in the UK is achievable. The commonly perceived barriers to establishment of training are all surmountable, but solving them does not necessarily ensure universal coverage. Support from healthcare professionals, in particular public health, is essential to ensure that the training is as widespread as possible. Mandatory inclusion of this training on the school curriculum, as seen in other countries, would result in significantly improved survival rates from out-of-hospital cardiorespiratory arrest. Solutions to improve training have been proposed, which could be used in other parts of Europe where such training is not a mandatory requirement.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Use of radiometric indices to evaluate Zn and Pb stress in two grass species ( Festuca rubra L. and Vulpia myuros L.)

Abstract

Vegetation indices obtained from radiometric measurements have been used to estimate the stress response of plants grown in contaminated sites. The phytotoxicity of Pb and Zn in Festuca rubra L. and Vulpia myuros L. plants grown under hydroponic conditions was evaluated using vegetation indices obtained from radiometric measurements. The plants were supplied with 3 mM Zn (+Zn), 500 μM Pb (+Pb) and 500 μM Pb with EDTA (+PbEDTA) for 3 months. Significantly higher Zn concentrations in F. rubra shoots compared with V. myuros shoots were detected for Zn and Pb treatments. EDTA increased Pb transport to the shoots for both grasses, while Pb-treated plants retained Pb primarily in the roots. All vegetation indices tested showed the highest differences in F. rubra under +PbEDTA treatment and minor effects under +Zn, whereas the major variations for V. myuros corresponded to +Zn treatment, followed by +PbEDTA. Red edge normalized difference vegetation index, yellowness index and anthocyanin concentration index were the most sensitive indices to report Zn and Pb phytotoxicity in these grasses. According to the results obtained, both metal concentrations and radiometric indices suggested that Pb is more phytotoxic to F. rubra, which tolerates high Zn levels, whereas V. myuros was strongly affected by high Zn levels and markedly tolerant to Pb, even when applied in a mobile form (PbEDTA). Both species could be used in the phytostabilization of Zn- and Pb-contaminated soils. The abilities of F. rubra to accumulate Zn and V. myuros to accumulate Pb in the roots would facilitate a more efficient phytoremediation strategy when used in combination.

http://ift.tt/2c7OBKB

Acute toxicity and repellent activity of the Origanum scabrum Boiss. & Heldr. (Lamiaceae) essential oil against four mosquito vectors of public health importance and its biosafety on non-target aquatic organisms

Abstract

The recent outbreaks of dengue, chikungunya, and Zika virus highlighted the pivotal importance of mosquito vector control in tropical and subtropical areas worldwide. However, mosquito control is facing hot challenges, mainly due to the rapid development of pesticide resistance in Culicidae and the limited success of biocontrol programs on Aedes mosquitoes. In this framework, screening botanicals for their mosquitocidal potential may offer effective and eco-friendly tools in the fight against mosquitoes. In the present study, the essential oil (EO) obtained from the medicinal plant Origanum scabrum was analyzed by GC-MS and evaluated for its mosquitocidal and repellent activities towards Anopheles stephensi, Aedes aegypti, Culex quinquefasciatus, and Culex tritaeniorhynchus. GC-MS analysis showed a total of 28 compounds, representing 97.1 % of the EO. The major constituents were carvacrol (48.2 %) and thymol (16.6 %). The EO was toxic effect to the A. stephensi, A. aegypti, C. quinquefasciatus, and C. tritaeniorhynchus larvae, with LC₅₀ of 61.65, 67.13, 72.45, and 78.87 μg/ml, respectively. Complete ovicidal activity was observed at 160, 200, 240, and 280 μg/ml, respectively. Against adult mosquitoes, LD₅₀ were 122.38, 134.39, 144.53, and 158.87 μg/ml, respectively. In repellency assays, the EOs tested at 1.0, 2.5, and 5.0 mg/cm² concentration of O. scabrum gave 100 % protection from mosquito bites up to 210, 180, 150, and 120 min, respectively. From an eco-toxicological point of view, the EO was tested on three non-target mosquito predators, Gambusia affinis, Diplonychus indicus, and Anisops bouvieri, with LC₅₀ ranging from 4162 to 12,425 μg/ml. Overall, the EO from O. scabrum may be considered as a low-cost and eco-friendly source of phytochemicals to develop novel repellents against Culicidae.

http://ift.tt/2ckZTyo

Decomposition approach of the nitrogen generation process: empirical study on the Shimabara Peninsula in Japan

Abstract

Groundwater nitrate pollution is one of the most prevalent water-related environmental problems worldwide. The objective of this study is to identify the determinants of nitrogen pollutant changes with a focus on the nitrogen generation process. The novelty of our research framework is to cost-effectively identify the factors involved in nitrogen pollutant generation using public data. This study focuses on three determinant factors: (1) nitrogen intensity changes, (2) structural changes, and (3) scale changes. This study empirically analyses three sectors, including crop production, farm animals, and the household, on the Shimabara Peninsula in Japan. Our results show that the nitrogen supply from crop production sectors has decreased because the production has been scaled down and shifted towards lower nitrogen intensive crops. In the farm animal sector, the nitrogen supply has also been successfully reduced due to scaling-down efforts. Households have decreased the nitrogen supply by diffusion of integrated septic tank and sewerage systems.

http://ift.tt/2c7MQ09

The application of regenerable sorbents for mercury capture in gas phase

Abstract

Mercury is a well-known toxic element, and flue gas streams emitted from coal-fired utilities are one of the largest anthropogenic sources of this element. This study briefly reviews the proposed technologies for reducing mercury emissions from coal combustion, focusing on an emerging process which involves the use of regenerable sorbents and especially those loaded with noble metals. Among the mercury species formed during coal combustion, elemental mercury is the most difficult to remove from the flue gases due to its low reactivity and insolubility in water. The widespread interest in using regenerable sorbents with metals is due to their ability to retain elemental mercury. With this technology, not only can efficiencies of 100 % be reached in the retention of elemental mercury but also a way to avoid the generation of new wastes loaded with mercury. This study considers the main aspects that must be taken into account when developing effective regenerable sorbents for mercury capture, with special attention to sorbents containing noble metals. The characteristics of this process are compared with those of other processes in a more advanced state of development.

http://ift.tt/2ckZUSY

Lung cancer risk by polycyclic aromatic hydrocarbons in a Mediterranean industrialized area

Abstract

This study focuses on characterizing the chronic risk assessment from inhalation of polycyclic aromatic hydrocarbons (PAHs) for people living near the largest chemical complex in the Mediterranean area. Eighteen PAHs were determined in the atmospheric gas and particle phases, counting PM₁₀ and total suspended particles. The lifetime lung cancer risk from PAH exposure was estimated, and the contribution was assessed by phases. The results obtained with the continuous lifetime scenario were compared with those obtained with different chronic scenarios. The estimated chronic risk was also compared with those reported in previous studies. PAHs were present at higher concentration in the gas phase (>84 %) with a major contribution of the most volatile PAHs, and an equitable distribution of heavy PAHs between gas and particle phases was observed. Petroleum combustion and traffic emissions were suggested as the main sources, but the influence of petrogenic sources cannot be ruled out. The estimated average lifetime lung cancer risk in this study ranged between 3.2 × 10⁻⁵ and 4.3 × 10⁻⁵. The gas phase accounted for the most significant contribution to the total risk (>60 %). Fluoranthene (FluT), dibenzo(a,h)anthracene (DahA) and benzo(a)pyrene (BaP), as a whole, made the greatest contribution to the total risk (>80 %). BaP-bound PM₁₀ accounted for a small contribution of the total risk (10 %). Chronic exposures lower than total lifetime hours could even pose a risk >10⁻⁵. The results also showed that BaP-bound PM₁₀, according to current legislation, may not be a good indicator of the real risk by PAH exposure. Concerning previous studies, the economic situation may have an impact on reducing the cancer risk by PAH inhalation.

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Incidence, prevalence, diagnostic delay, and clinical presentation of female 46,XY disorders of sex development

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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Mutations in TBL1X are associated with central hypothyroidism

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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Diazoxide in children with obesity after hypothalamic-pituitary lesions: a randomized, placebo-controlled trial

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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The Association of Weight Loss with Cardiometabolic Outcomes in Obese Children: Systematic Review and Meta-regression

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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Inhibition of Human Adrenocortical Cancer Cell Growth by Temozolomide in Vitro and the Role of the MGMT Gene

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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Ethnic and sex differences in adiponectin: from childhood to adulthood

The Journal of Clinical Endocrinology &Metabolism, Early Release.

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Annals of Surgical Oncology

New Issue Alert

09/08/2016

Dear Reader,

We are pleased to deliver your requested table of contents alert for Annals of Surgical Oncology. Volume 23 Number 11 is now available online.

Important news

In this issue

Breast Oncology

Margins in DCIS: Does Residual Disease Provide an Answer?

Monica Morrow & Kimberly J. Van Zee

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Breast Oncology

Sentinel Lymph Node Biopsy in Breast Cancer Surgery

J. Michael Dixon

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Breast Oncology

Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy for Patients with Axillary Metastases: Can We Avoid the Unavoidable?

Theresa Schwartz & Carla Fisher

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Breast Oncology

Limiting Axillary Surgery for Patients with Initial Biopsy-Proven Axillary Metastases After Preoperative Chemotherapy: To Clip or Not to Clip?

Henry M. Kuerer & Kelly K. Hunt

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Breast Oncology

Surgical Breast Specialists 2.0: Rethinking the Future of Breast Fellowship Training

Peter D. Beitsch & Pat Whitworth

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Breast Oncology

What Does the Future Hold for Surgical Breast Specialists? Implications for Breast Fellowship Training

Scott H. Kurtzman

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Bone and Soft Tissue Sarcomas

Guidelines for the Treatment of Recurrent Retroperitoneal Sarcoma: Are we Trying to Fit a Square Peg into a Round Hole?

Barry Feig & Robert Benjamin

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Healthcare Policy and Outcomes

Association of Distance Traveled for Surgery with Short- and Long-Term Cancer Outcomes

Nabil Wasif, Yu-Hui Chang, Barbara A. Pockaj, Richard J. Gray, Amit Mathur & David Etzioni

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Breast Oncology

Should New "No Ink On Tumor" Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins

Andrea L. Merrill, Rong Tang, Jennifer K. Plichta, Upahvan Rai, Suzanne B. Coopey, Maureen P. McEvoy, Kevin S. Hughes, Michelle C. Specht, Michele A. Gadd & Barbara L. Smith

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Breast Oncology

Troubleshooting Sentinel Lymph Node Biopsy in Breast Cancer Surgery

Ted A. James, Alex R. Coffman, Anees B. Chagpar, Judy C. Boughey, V. Suzanne Klimberg, Monica Morrow, Armando E. Giuliano & Seth P. Harlow

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Breast Oncology

How Often Does Neoadjuvant Chemotherapy Avoid Axillary Dissection in Patients With Histologically Confirmed Nodal Metastases? Results of a Prospective Study

Anita Mamtani, Andrea V. Barrio, Tari A. King, Kimberly J. Van Zee, George Plitas, Melissa Pilewskie, Mahmoud El-Tamer, Mary L. Gemignani, Alexandra S. Heerdt, Lisa M. Sclafani, Virgilio Sacchini, Hiram S. Cody, Sujata Patil & Monica Morrow

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Breast Oncology

How Often Is Treatment Effect Identified in Axillary Nodes with a Pathologic Complete Response After Neoadjuvant Chemotherapy?

Andrea V. Barrio, Anita Mamtani, Marcia Edelweiss, Anne Eaton, Michelle Stempel, Melissa P. Murray & Monica Morrow

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Breast Oncology

Age and Receptor Status Do Not Indicate the Need for Axillary Dissection in Patients with Sentinel Lymph Node Metastases

Anita Mamtani, Sujata Patil, Kimberly J. Van Zee, Hiram S. Cody, Melissa Pilewskie, Andrea V. Barrio, Alexandra S. Heerdt & Monica Morrow

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Breast Oncology

Do LORIS Trial Eligibility Criteria Identify a Ductal Carcinoma In Situ Patient Population at Low Risk of Upgrade to Invasive Carcinoma?

Melissa Pilewskie, Michelle Stempel, Hope Rosenfeld, Anne Eaton, Kimberly J. Van Zee & Monica Morrow

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Breast Oncology

A Picture is Worth a Thousand Words: Intraoperative Photography as a Quality Metric for Axillary Dissection

Brittany L. Murphy, Judy C. Boughey, Amy C. Degnim, Tina J. Hieken, William S. Harmsen, Gary L. Keeney & James W. Jakub

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Breast Oncology

Nomograms for Predicting Axillary Response to Neoadjuvant Chemotherapy in Clinically Node-Positive Patients with Breast Cancer

Jose Vila, Elizabeth A. Mittendorf, Gabriel Farante, Roland L. Bassett, Paolo Veronesi, Viviana Galimberti, Nicolas Peradze, Michael C. Stauder, Mariana Chavez-MacGregor, Jennifer F. Litton, Lei Huo, Henry M. Kuerer, Kelly K. Hunt & Abigail S. Caudle

» Abstract » Full text HTML » Full text PDF

Breast Oncology

Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons' Referrals

Eleftherios Mamounas, Christine Poulos, Hans-Peter Goertz, Juan Marcos González, Amy Pugh & Vincent Antao

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Breast Oncology

How Beneficial is Follow-Up Mammography in Elderly Breast Cancer Survivors?

Kristen P. Massimino, Maxine S. Jochelson, Imelda E. Burgan, Michelle Stempel & Monica Morrow

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Breast Oncology

Coexistent Loss of the Expressions of BRCA1 and p53 Predicts Poor Prognosis in Triple-Negative Breast Cancer

Min Chong Kim, Jung Eun Choi, Soo Jung Lee & Young Kyung Bae

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Bone and Soft Tissue Sarcomas

Management of Recurrent Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach from the Trans-Atlantic RPS Working Group

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Bone and Soft Tissue Sarcomas

Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group

Najat C. Daw, Nadia N. Laack, Elizabeth J. McIlvaine, Mark Krailo, Richard B. Womer, Linda Granowetter, Holcombe E. Grier, Neyssa M. Marina, Mark L. Bernstein, Mark C. Gebhardt, Karen J. Marcus, Shailesh M. Advani, John H. Healey, George D. Letson, Richard G. Gorlick & R. Lor Randall

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Melanomas

National Evaluation of Hospital Performance on the New Commission on Cancer Melanoma Quality Measures

Christina A. Minami, Jeffrey D. Wayne, Anthony D. Yang, Mary C. Martini, Pedram Gerami, Sunandana Chandra, Timothy M. Kuzel, David P. Winchester, Bryan E. Palis & Karl Y. Bilimoria

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Melanomas

LYMPHA Technique to Prevent Secondary Lower Limb Lymphedema

Francesco Boccardo, Mario Valenzano, Sergio Costantini, Federico Casabona, Matteo Morotti, Paolo Sala, Franco De Cian, Lidia Molinari, Stefano Spinaci, Sara Dessalvi, Corrado Cesare Campisi, Giuseppe Villa & Corradino Campisi

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Medical Oncology

Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System

Kelly L. Harms, Mark A. Healy, Paul Nghiem, Arthur J. Sober, Timothy M. Johnson, Christopher K. Bichakjian & Sandra L. Wong

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Radiation Oncology

Radiation Therapy is Associated with Improved Outcomes in Merkel Cell Carcinoma

Tobin Strom, Michael Carr, Jonathan S. Zager, Arash Naghavi, Franz O. Smith, C. Wayne Cruse, Jane L. Messina, Jeffery Russell, Nikhil G. Rao, William Fulp, Sungjune Kim, Javier F. Torres-Roca, Tapan A. Padhya, Vernon K. Sondak, Andy M. Trotti, Louis B. Harrison & Jimmy J. Caudell

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Head and Neck Oncology

Clinical Impact of Intraoperative Cytological Assessment of Bone Resection Margins in Patients with Head and Neck Carcinoma

Markus Nieberler, Patrick Häußler, Marco Rainer Kesting, Andreas Kolk, Herbert Deppe, Gregor Weirich & Klaus-Dietrich Wolff

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Head and Neck Oncology

Incidence and Risk Factors for Occult Level 3 Lymph Node Metastases in Papillary Thyroid Cancer

Sheila Fraser, Nisar Zaidi, Olov Norlén, Anthony Glover, Schelto Kruijff, Mark Sywak, Leigh Delbridge & Stan B. Sidhu

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Colorectal Cancer

Treatment Interval between Neoadjuvant Chemoradiotherapy and Surgery in Rectal Cancer Patients: A Population-Based Study

A. J. M. Rombouts, N. Hugen, M. A. G. Elferink, I. D. Nagtegaal & J. H. W. de Wilt

» Abstract » Full text HTML » Full text PDF

Colorectal Cancer

Prognostic Impact of Palliative Primary Tumor Resection for Unresectable Stage 4 Colorectal Cancer: Using a Propensity Score Analysis

Dai Shida, Tetsuya Hamaguchi, Hiroki Ochiai, Shunsuke Tsukamoto, Atsuo Takashima, Narikazu Boku & Yukihide Kanemitsu

» Abstract » Full text HTML » Full text PDF

Radiation Oncology

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer

Matthew Susko, Jason Lee, Joseph Salama, Samantha Thomas, Hope Uronis, David Hsu, John Migaly, Christopher Willett, Brian Czito & Manisha Palta

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Thoracic Oncology

Is Survival for Patients with Resectable Lung Metastatic Colorectal Cancer Comparable to Those with Resectable Liver Disease? Results from the South Australian Metastatic Colorectal Registry

Dainik Patel, Amanda R. Townsend, Christos Karapetis, Carol Beeke, Rob Padbury, Amitesh Roy, Guy Maddern, David Roder & Timothy J. Price

» Abstract » Full text HTML » Full text PDF

Thoracic Oncology

Value of Percutaneous Radiologic Gastrostomy for Patients with Advanced Esophageal Cancer

Keitaro Sofue, Yoshito Takeuchi, Masakatsu Tsurusaki, Kentaro Shibamoto, Noriaki Sakamoto, Kazuhiro Kitajima, Miyuki Sone, Kazuro Sugimura & Yasuaki Arai

» Abstract » Full text HTML » Full text PDF

Thoracic Oncology

Impact of Neoadjuvant Chemoradiation on Short-Term Outcomes for Esophageal Squamous Cell Carcinoma Patients: A Meta-analysis

Suun Sathornviriyapong, Akihisa Matsuda, Masao Miyashita, Satoshi Matsumoto, Nobuyuki Sakurazawa, Yoichi Kawano, Marina Yamada & Eiji Uchida

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Endocrine Tumors

Lobectomy is a more Cost-Effective Option than Total Thyroidectomy for 1 to 4 cm Papillary Thyroid Carcinoma that do not Possess Clinically Recognizable High-Risk Features

Brian Hung-Hin Lang & Carlos K. H. Wong

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Endocrine Tumors

Can We Predict the Lateral Compartment Lymph Node Involvement in RET-Negative Patients with Medullary Thyroid Carcinoma?

Marie-Maelle Chandeze, Severine Noullet, Matthieu Faron, Christophe Trésallet, Gaelle Godiris-Petit, Frederique Tissier, Camille Buffet, Laurence Leenhardt, Nathalie Chereau & Fabrice Menegaux

» Abstract » Full text HTML » Full text PDF

Gastrointestinal Oncology

A Population-Based Analysis of Three Treatment Modalities for Malignant Obstruction of the Proximal Colon: Acute Resection Versus Stent or Stoma as a Bridge to Surgery

F. J. Amelung, E. C. J. Consten, P. D. Siersema & P. J. Tanis

» Abstract » Full text HTML » Full text PDF

Gastrointestinal Oncology

Low Preoperative Prognostic Nutritional Index Predicts Poor Survival Post-gastrectomy in Elderly Patients with Gastric Cancer

Katsunobu Sakurai, Tatsuro Tamura, Takahiro Toyokawa, Ryosuke Amano, Naoshi Kubo, Hiroaki Tanaka, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Masaichi Ohira & Kosei Hirakawa

» Abstract » Full text HTML » Full text PDF

Gastrointestinal Oncology

Early Gastric Cancer: Trends in Incidence, Management, and Survival in a Well-Defined French Population

Nicolas Chapelle, Anne-Marie Bouvier, Sylvain Manfredi, Antoine Drouillard, Come Lepage, Jean Faivre & Valerie Jooste

» Abstract » Full text HTML » Full text PDF

Gastrointestinal Oncology

Biomarkers of EBV-positive Gastric Cancers: Loss of PTEN Expression is Associated with Poor Prognosis and Nodal Metastasis

Hyo Jeong Kang, In-Seob Lee, Young-Soo Park, Won Jin Ho, DaHye Sohn, Ji-Yong Ahn, Jeong-Hwan Yook & Byung-Sik Kim

» Abstract » Full text HTML » Full text PDF

Gastrointestinal Oncology

Hepatic Resection for Metastatic Neuroendocrine Cancer in Patients with Bone Metastases

Kristopher P. Croome, Justin M. Burns, Florencia G. Que & David M. Nagorney

» Abstract » Full text HTML » Full text PDF

Hepatobiliary Tumors

Safety and Feasibility of Repeatable Hepatic Vascular Isolation Chemotherapy: A Pilot Study

Rodney J. Lane, Nyan Y. Khin, Chris M. Rogan, John Magnussen, Nick Pavlakis, David M. Lane & Stephen Clarke

» Abstract » Full text HTML » Full text PDF

Hepatobiliary Tumors

Oncological Outcomes of Major Liver Resection Following Portal Vein Embolization: A Systematic Review and Meta-analysis

Mariano Cesare Giglio, Alexandros Giakoustidis, Ahmed Draz, Zaynab A. R. Jawad, Madhava Pai, Nagy A. Habib, Paul Tait, Adam E. Frampton & Long R. Jiao

» Abstract » Full text HTML » Full text PDF

Hepatobiliary Tumors

Parenchymal-Sparing Hepatectomy Does Not Increase Intrahepatic Recurrence in Patients with Advanced Colorectal Liver Metastases

Masaru Matsumura, Yoshihiro Mise, Akio Saiura, Yosuke Inoue, Takeaki Ishizawa, Hirofumi Ichida, Ryota Matsuki, Masayuki Tanaka, Yoshinori Takeda & Yu Takahashi

» Abstract » Full text HTML » Full text PDF

Hepatobiliary Tumors

A Randomized Clinical Trial of Preoperative Administration of Branched-Chain Amino Acids to Prevent Postoperative Ascites in Patients with Liver Resection for Hepatocellular Carcinoma

Yutaro Kikuchi, Yukihiko Hiroshima, Kenichi Matsuo, Daisuke Kawaguchi, Takashi Murakami, Yasuhiro Yabushita, Itaru Endo, Masataka Taguri, Keiji Koda & Kuniya Tanaka

» Abstract » Full text HTML » Full text PDF

Hepatobiliary Tumors

Prognostic Implication of KRAS Status after Hepatectomy for Colorectal Liver Metastases Varies According to Primary Colorectal Tumor Location

Kazunari Sasaki, Georgios A. Margonis, Ana Wilson, Yuhree Kim, Stefan Buettner, Nikolaos Andreatos, Faiz Gani, Neda Amini, Gaya Spolverato & Timothy M. Pawlik

» Abstract » Full text HTML » Full text PDF

Gynecologic Oncology

Factors Impacting Use of Robotic Surgery for Treatment of Endometrial Cancer in the United States

Erin A. Blake, Jeanelle Sheeder, Kian Behbakht, Saketh R. Guntupalli & Michael S. Guy

» Abstract » Full text HTML » Full text PDF

Gynecologic Oncology

Sentinel Node Mapping in Cervical and Endometrial Cancer: Indocyanine Green Versus Other Conventional Dyes—A Meta-Analysis

Ilary Ruscito, Maria Luisa Gasparri, Elena Ioana Braicu, Filippo Bellati, Luigi Raio, Jalid Sehouli, Michael D. Mueller, Pierluigi Benedetti Panici & Andrea Papadia

» Abstract » Full text HTML » Full text PDF

Pancreatic Tumors

Modified Appleby Procedure for Pancreatic Adenocarcinoma: Does Improved Neoadjuvant Therapy Warrant Such an Aggressive Approach?

Niek A. Peters, Ammar A. Javed, John L. Cameron, Martin A. Makary, Kenzo Hirose, Timothy M. Pawlik, Jin He, Christopher L. Wolfgang & Matthew J. Weiss

» Abstract » Full text HTML » Full text PDF

Reconstructive Oncology

Feasibility and Outcomes of the Third or More Episodes of Sequential Microvascular Reconstruction for Recurrent or Second Primary Oral Cancer

Anaeze C. Offodile, Kai-Ping Chang, Hsin-Hung Chen, Eric Loesch, Shao-Yu Hung & Huang-Kai Kao

» Abstract » Full text HTML » Full text PDF

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

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Πέμπτη 8 Σεπτεμβρίου 2016

Online First

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