Development: Transcriptomic blueprints

http://ift.tt/2fdrlAj

Competition for electrons between pyridine and quinoline during their simultaneous biodegradation

Abstract

Biodegradation of pyridine and quinoline is initiated with mono-oxygenation reactions that require an intracellular electron donor. Simultaneous biodegradation of both substrates should set up competition for the intracellular electron donor that may inhibit one or more of the mono-oxygenation steps. An internal circulation baffled biofilm reactor (ICBBR) was used to evaluate the impacts of competition during pyridine and quinoline biodegradation. Compared with independent biodegradation, pyridine and quinoline removal rates were slowed when biodegraded simultaneously, although the pyridine removal rate decreased more than for quinoline. The first mono-oxygenation of quinoline (to 2-hydroxyquinoline) always was faster than the first mono-oxygenation of pyridine (to 2-hydroxypyridine), and the difference was accentuated with pyridine and quinoline which were biodegraded simultaneously due to the competition for intracellular electron donor. Competition also existed between the second mono-oxygenations, and the removal rate of 2-hydroxypyridine was faster than the rate for 2-hydroxyquinoline, even though the rate was faster for quinoline than pyridine. Adding an exogenous electron donor accelerated all mono-oxygenations in proportion to the amount of donor added, but the increments were greater for quinoline due to its higher affinity for intracellular electron donors than pyridine. When actual coking wastewater was used as the background matrix, removals of pyridine and quinoline exhibited the same competitive trends.

http://ift.tt/2hbmdtG

Fine particle matters induce DNA damage and G2/M cell cycle arrest in human bronchial epithelial BEAS-2B cells

Abstract

There is compelling evidence that exposure to particulate matter (PM) is linked to lung tumorigenesis. However, there is not enough experimental evidence to support the specific mechanisms of PM_2.5-induced DNA damage and cell cycle arrest in lung tumorigenesis. In this study, we investigated the toxic effects and molecular mechanisms of PM_2.5 on bronchial epithelial (BEAS-2B) cells. PM_2.5 exposure reduced cell viability and enhanced LDH activity. The cell growth curves of BEAS-2B cells decreased gradually with the increase in PM_2.5 dosage. A significant increase in MDA content and a decrease in GSH-Px activity were observed. The generation of ROS was enhanced obviously, while apoptosis increased in BEAS-2B cells exposed to PM_2.5 for 24 h. DNA damage was found to be more severe in the exposed groups compared with the control. For in-depth study, we have demonstrated that PM_2.5 stimulated the activation of HER2/ErbB2 while significantly upregulating the expression of Ras/GADPH, p-BRAF/BRAF, p-MEK/MEK, p-ERK/ERK, and c-Myc/GADPH in a dose-dependent manner. In summary, we suggested that exposure to PM_2.5 sustained the activation of HER2/ErbB2, which in turn promoted the activation of the Ras/Raf/MAPK pathway and the expression of the downstream target c-Myc. The overexpression of c-Myc may lead to G2/M arrest and aggravate the DNA damage and apoptosis in BEAS-2B after exposure to PM_2.5.

http://ift.tt/2h9qRvC

Report from the first European Dermato-Epidemiology Network forum

Summary

The first European Dermato-Epidemiology Network (EDEN) forum was held on 30–31 March 2017 in Madrid, Spain. Dermatoepidemiology describes the study of causes, prevention, health services research and evaluation of interventions of skin diseases. EDEN aims to promote high-quality research, share expertise and facilitate collaboration. These aims were achieved during the EDEN forum by including a preconference course on skin cancer epidemiology; having excellent world-leading guest speakers on causality, quality of care, pharmacoepidemiology and missing data analysis; and including delegates who presented and discussed innovative research findings. The meeting brought together delegates from 11 different countries. We welcome everyone with an interest in clinical research and epidemiology related to skin disease to attend next year's meeting in March 2018 in Berlin.

http://ift.tt/2xekgpn

Food avoidance and restriction in adults: a cross-sectional pilot study comparing patients from an immunology clinic to a general practice

Abstract

Background

With the introduction of avoidant/restrictive food intake disorder (ARFID) in the Diagnostic and Statistical Manual – fifth edition, there is an increased need to understand the prevalence and pattern of food avoidance and restriction in adults. High rates of food allergy and intolerance in immunology clinic populations, and subsequent high rates of elimination diets, place these individuals at a greater risk of developing pathological eating behaviours. This descriptive cross sectional pilot study aims to provide preliminary data on the prevalence and nature of food avoidance and restriction in an adult population, and to explore the reasons for this behaviour.

Method

A self-administered questionnaire was designed and distributed to adults presenting to an immunology clinic and a general practice over the course of 6 months to describe the prevalence and nature of avoidant and restrictive eating behaviours in this population. Pearson's chi square test was used to examine the strength of a potential link to a formal diagnosis of avoidant restrictive food intake disorder in these patients.

Results

A total of 102 completed questionnaires were used for data analysis. Food avoidance or restriction was detected in 81 respondents (79%), with rates not significantly higher in the immunology clinic group compared to the general practice group (p = .242). Food allergy and intolerance were the most common reasons for disturbed eating patterns. Life impact secondary to food avoidance and restriction was reported by 26% of respondents, with significantly higher rates observed in the immunology clinic cohort compared to the general practice (p = .011).

Conclusions

Eating disturbances similar to those characteristic of ARFID are very common in adults. Food avoidance and restriction due to perceived food allergy and intolerance are significant reasons for such disordered eating patterns, particularly in an immunology clinic population. Further investigation is needed to determine if such eating behaviours are pathological and whether they qualify for a diagnosis of ARFID.

http://ift.tt/2jChR3h

Scholar : International Journal of Oncology - Volume:51 Number:4

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TABLE OF CONTENTS October-2017 Volume 51 Issue 4

Connexin 43 in the development and progression of breast cancer: What's the connection? (Review) Stephanie L. Phillips, Carly Bess Williams, Joelle N. Zambrano, Christina J. Williams, Elizabeth S. Yeh View Abstract ❯

Trophic and neurotrophic factors in human pituitary adenomas (Review) Marialuisa Spoletini, Samanta Taurone, Mario Tombolini, Antonio Minni, Giancarlo Altissimi, Venceslao Wierzbicki, Felice Giangaspero, Pier Paolo Parnigotto, Marco Artico, Lia Bardella, Enzo Agostinelli, Francesco Saverio Pastore View Abstract ❯

Rho GTPases as therapeutic targets in cancer (Review) G. A. Cardama, N. Gonzalez, J. Maggio, P. Lorenzano Menna, D. E. Gomez View Abstract ❯

Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles George Mattheolabakis, Ruixue Wang, Basil Rigas, Gerardo G. Mackenzie View Abstract ❯

FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis Yan Chen, Yifei Liu, Haosheng Ni, Chuanjin Ding, Xiaobo Zhang, Zhenxin Zhang View Abstract ❯

YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression Zhaoji Pan, Yiqing Tian, Bin Zhang, Xu Zhang, Hui Shi, Zhaofeng Liang, Peipei Wu, Rong Li, Benshuai You, Lunyu Yang, Fei Mao, Hui Qian, Wenrong Xu View Abstract ❯

Prediction of radiosensitive patients with gastric cancer by developing gene signature Jin Zhou, Xiaoyu Wu, Gang Li, Xin Gao, Min Zhai, Weichang Chen, Huagang Hu, Zaixiang Tang View Abstract ❯

Nano Let‑7b sensitization of eliminating esophageal cancer stem‑like cells is dependent on blockade of Wnt activation of symmetric division Yamei Pang, Jian Liu, Xiang Li, Yiwen Zhang, Boxiang Zhang, Jing Zhang, Ning Du, Chongwen Xu, Rui Liang, Hong Ren, Shou-Ching Tang, Xin Sun View Abstract ❯

Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo Li Lu, Ke Li, Yun-Hua Mao, Hu Qu, Bing Yao, Wen-Wen Zhong, Bo Ma, Zhong-Yang Wang View Abstract ❯

SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis Qiang Ma, Xiuxiu Wu, Jing Wu, Zhiyong Liang, Tonghua Liu View Abstract ❯

TUG1 promotes osteosarcoma tumorigenesis by upregulating EZH2 expression via miR-144-3p Jiaqing Cao, Xinyou Han, Xin Qi, Xiangyun Jin, Xiaolin Li View Abstract ❯

Effect of low- and high-linear energy transfer radiation on in vitro and orthotopic in vivo models of osteosarcoma by activation of caspase-3 and -9 Eun Ho Kim, Mi-Sook Kim, Kyung-Hee Lee, Sei Sai, Youn Kyoung Jeong, Jae-Soo Koh, Chang-Bae Kong View Abstract ❯

Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis Caijie Lu, Yifeng He, Juan Duan, Yongguang Yang, Chunqiang Zhong, Jian Zhang, Weiguo Liao, Xiaojie Huang, Runzhi Zhu, Mingyi Li View Abstract ❯

Disrupting mitochondrial Ca2+ homeostasis causes tumor-selective TRAIL sensitization through mitochondrial network abnormalities Yohei Ohshima, Natsuhiko Takata, Miki Suzuki-Karasaki, Yukihiro Yoshida, Yasuaki Tokuhashi, Yoshihiro Suzuki-Karasaki View Abstract ❯

Cx32 suppresses extrinsic apoptosis in human cervical cancer cells via the NF‑κB signalling pathway Yongchang Lai, Lixia Fan, Yifan Zhao, Hui Ge, Xue Feng, Qin Wang, Xiaomin Zhang, Yuexia Peng, Xiyan Wang, Liang Tao View Abstract ❯

Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Yu Jae Hyun, Jeong Eon Park, Kristina Shilnikova, Ao Xuan Zhen, Hee Kyoung Kang, Young Sang Koh, Yong Joo Jeong, Jin Won Hyun View Abstract ❯

Expression of carbonic anhydrase IX is associated with poor prognosis through regulation of the epithelial‑mesenchymal transition in hepatocellular carcinoma Satoshi Hyuga, Hiroshi Wada, Hidetoshi Eguchi, Toru Otsuru, Yoshifumi Iwgami, Daisaku Yamada, Takehiro Noda, Tadafumi Asaoka, Koichi Kawamoto, Kunihito Gotoh, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori View Abstract ❯

GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis Heng Yin, Qing Zhu, Manran Liu, Gang Tu, Qing Li, Jie Yuan, Siyang Wen, Guanglun Yang View Abstract ❯

Establishment of two ovarian cancer orthotopic xenograft mouse models for in vivo imaging: A comparative study Jing Guo, Jing Cai, Yunxia Zhang, Yapei Zhu, Ping Yang, Zehua Wang View Abstract ❯

Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma Dingyuan Luo, Haibo Chen, Xiaojuan Li, Penghui Lu, Miaoyun Long, Xinzhi Peng, Shaojian Lin, Langping Tan, Yue Zhu, Nengtai Ouyang, Honghao Li View Abstract ❯

Silibinin suppresses bladder cancer cell malignancy and chemoresistance in an NF-κB signal-dependent and signal-independent manner Yi Sun, Zhenfeng Guan, Wencai Zhao, Yazhuo Jiang, Qing Li, Yongyi Cheng, Yonggang Xu View Abstract ❯

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy Ramsah Cheah, Rishi Srivastava, Nicholas D. Stafford, Andrew W. Beavis, Victoria Green, John Greenman View Abstract ❯

Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma Zhiyi Wang, Yuan Chen, Yanliang Lin, Xinxing Wang, Xianping Cui, Zhenhai Zhang, Guozhe Xian, Chengkun Qin View Abstract ❯

Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway Sandeep Shrestha, Jiabin Zhu, Qi Wang, Xiaohui Du, Fen Liu, Jianing Jiang, Jing Song, Jinshan Xing, Dongdong Sun, Qingjuan Hou, Yulin Peng, Jun Zhao, Xiuzhen Sun, Xishuang Song View Abstract ❯

Identification of WISP1 as a novel oncogene in glioblastoma Di Jing, Qian Zhang, Haiming Yu, Yajie Zhao, Liangfang Shen View Abstract ❯

PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism Heyang Xu, Yujie Zeng, Lu Liu, Qian Gao, Shaowen Jin, Qiusheng Lan, Wei Lai, Xingxi Luo, Heng Wu, Yongliang Huang, Zhonghua Chu View Abstract ❯

Identification of novel genetic etiology and key molecular pathways for seminoma via network-based studies Yuanlei Chen, Chao Qi, Liqun Xia, Gonghui Li View Abstract ❯

Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo Xiaoni Liu, Jianji Xu, Shuang Wang, Xiaoxiao Yu, Boxin Kou, Mengyin Chai, Yunjin Zang, Dexi Chen View Abstract ❯

Expression of periostin in breast cancer cells Katarzyna Ratajczak-Wielgomas, Jedrzej Grzegrzolka, Aleksandra Piotrowska, Rafal Matkowski, Andrzej Wojnar, Janusz Rys, Maciej Ugorski, Piotr Dziegiel View Abstract ❯

Anoctamin5 regulates cell migration and invasion in thyroid cancer Zhengyan Chang, Chunmiao Cai, Dongyan Han, Yaohui Gao, Qianyu Li, Lijin Feng, Wei Zhang, Jiayi Zheng, Jiaoying Jin, Huizhen Zhang, Qing Wei View Abstract ❯

Cooperative oncogenic effect and cell signaling crosstalk of co‑occurring HER2 and mutant PIK3CA in mammary epithelial cells Lun Dong, Fanyan Meng, Ling Wu, Allison V. Mitchell, C. James Block, Bin Zhang, Douglas B. Craig, Hyejeong Jang, Wei Chen, Qifeng Yang, Guojun Wu View Abstract ❯

Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b‑Myb and miRNA34a expression Yu-Jin Lee, Yeong-Rim Kang, So Young Lee, Yena Jin, Dong Cho Han, Byoung-Mog Kwon View Abstract ❯

APPL1 promotes the migration of gastric cancer cells by regulating Akt2 phosphorylation Yingxun Liu, Chunli Zhang, Lingyu Zhao, Ning Du, Ni Hou, Tusheng Song, Chen Huang View Abstract ❯

5-7 October, 2017, Metropolitan Hotel, Athens, Greece 22nd World Congress on Advances in Oncology & 20th International Symposium on Molecular Medicine 3-4 October 2017, Pre-Congress Workshop: 'Next-Generation Sequencing – Library construction and quality control'

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Investigation of cis - trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo

Abstract

2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.

http://ift.tt/2ft70nR

Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents

Publication date: Available online 15 September 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Cherupally Dayakar, Buddana Sudheer Kumar, Galande Sneha, Gudem Sagarika, Koneru Meghana, Sistla Ramakrishna, Reddy Shetty Prakasham, Bhimapaka China Raju
A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81µg/mL). In vitro anti-inflammatory activity data denoted that compound 8b is effective among the tested compounds against IL-6 (IC50 6.23μM). Docking analysis of compounds 5f, 8a-b, 8e-f and 8h displayed high binding energies for the compounds 8a-b and 8h towards TNF-α dimer (2AZ5 protein) and IL-6 (1ALU protein). In vivo anti-inflammatory activity of compounds 8b and 8h with respect to LPS induced mice model indicated that compound 8h showed significant reduction in TNF-α.

Graphical abstract

http://ift.tt/2xr22l2

Tapered US carbon emissions during good times: what’s old, what’s new?

Abstract

In light of a slow buildup in CO₂ emissions since the recovery, this paper revisits the relationship between CO₂ emissions and the US economy using a nonlinear autoregressive distributed lag model, in which the determinants are identified through an expanded real business cycle model. We find convincing evidence that CO₂ emissions decline more rapidly during recessions than increase during expansions over the long run. Of all determinants considered, long-run asymmetry is fostered once vehicle miles traveled is controlled. This calls for a greater attention to public transportation development and vehicle miles traveled tax for slowing down stock buildup of CO₂ emissions during good times.

http://ift.tt/2haGmA8

Study on the sediment characteristics of the snow in a typical residential community and its integrated biological treatment pattern in Harbin

Abstract

Winter cities have severe shortages of water resources. The effective classification and recycling of urban water resources that are available here are therefore significant for the sustainable utilization of water in winter cities, and snow is a potential water resource. In this research, the water quality of the snow and the pollutant composition in the vehicle roads of a typical residential community of Harbin are analyzed. It is concluded that there is a large amount of suspended substances, including chemical oxygen demand (COD), salt, ammonia, and oil in this snow. There are 27 main pollutants. The oily substances are dominated by hexadecane and are accompanied by toxic substances, including benzene, toluene, ethylbenzene, xylene (BTEX), and naphthalene. As snow is a carrier of pollutants, the underground space of the urban shallow green belt is proposed to be used to establish a snow-melting system that would integrate biological treatment devices. This method allows the year-round collection, storage, and utilization of rainwater for use in city planning and municipal technology, realizing multiple objectives and having a significant influence on further urban development.

http://ift.tt/2h8dprZ

The online measured black carbon aerosol and source orientations in the Nam Co region, Tibet

Abstract

Equivalent black carbon (eBC) mass concentrations were measured by an aethalometer (AE-31) in the Nam Co, central Tibet from 2010 to 2014. Different from previous filter-sampling studies (Ming et al., J Environ Sci 22(11):1748–1756, 2010; Zhao et al., Environ Sci Pollut Res 20:5827–5838, 2013), the first high-resolution online eBC measurement conducted in central Tibet is reported here, allowing to discuss the diurnal variations as well as seasonal variabilities of eBC. Average daily eBC concentration was 74 ± 50 ng/m³, reflecting a global background level. Meteorological conditions influenced eBC concentrations largely at seasonal scale, which are higher in February–May but lower in June–January. The highest eBC concentrations (greater than 210 ng/m³) were more associated with the W and WSW winds smaller than 6 m/s. The diurnal variations of eBC showed plateaus from 10:00 to 15:00 with seasonal variations, associated with local anthropogenic activities, such as indigenous Tibetan burning animal waste and tourism traffic. The PBLHs showed a co-variance with eBC concentrations, implicating close sources. The aerosol optical depths derived from the MODIS data over the Nam Co Observatory Station (NCOS)-included sub-area (30° N–40° N, 90° E–100° E) showed significant relationship with eBC concentrations. This suggests that nearby or short-distance sources other than long-distance transported pollutants could be important contributors to eBC concentrations at the NCOS, different from the conclusions suggested by previous studies.

http://ift.tt/2ha7pLI

Removal of arsenic III and V from laboratory solutions and contaminated groundwater by metallurgical slag through anion-induced precipitation.

Abstract

Metallurgical slag was used for the simultaneous removal of high concentrations of arsenite and arsenate from laboratory solutions and severely contaminated groundwater. Apart from demonstrating the high efficiency of arsenic removal in presence of competing species, the work aims to explore the physicochemical mechanisms of the process by means of microscopy observation and a detailed statistical analysis of existing kinetic and isotherm equations. Fitting was performed by non-linear least squares using weighted residuals; ANOVA and bootstrap methods were used to compare the models. Literature suggests that the metal oxides in the slag are efficient adsorbents of As(III) and (V). However, the low surface area of the slag precludes adsorption; SEM observation provide evidence of a mechanism of co-precipitation of lixiviated cations with contaminant anions. The reaction kinetics provide essential information on the interaction between the contaminants, particularly on the common ion effect in groundwater. The Fritz-Schlünder isotherm allows modelling the saturation effect at low slag doses. The efficiency of the process is demonstrated by an arsenic removal of 99% in groundwater using 4-g slag/L, resulting in an effluent with 0.01 mg As/L, which is below Mexican and international standards for drinking water.

http://ift.tt/2xIrUdi

Periodontal screening and referral behaviour of general dental practitioners in Flanders

Abstract

Objectives

The objective of this study was to investigate the screening and referral behaviour of Flemish dentists concerning periodontitis and more specific, the use of the Dutch Periodontal Screening Index (DPSI).

Materials and methods

An online questionnaire was electronically distributed through the different professional dental societies. It consisted of two parts: the first aimed at describing the profile of the dentist. The second part inquired the screening method, when this was applied, periodontal risk factors and referral behaviour.

Results

One thousand fifty dentists attended to the questionnaire. One hundred fifty-nine questionnaires were excluded since they did not match the target audience. Sixty-four percent of Flemish dentists used DPSI as a periodontal screening method, 28% screened based on probing pocket depth, 4% used solely radiographs and 4% had no screening method at all. The usage of DPSI is influenced by the year of graduation: the longer the dentists were graduated, the less they used DPSI. No influence of sex, education centre and location was found. Referral behaviour is influenced by different patient- and dentist-related factors.

Conclusions

Regarding the screening behaviour, there seems a consensus among Flemish dentists that a periodontal probe should be used. For referral, there is no consensus about if and when to refer to a specialist.

Clinical relevance

It is encouraging that 92% of the Flemish general dental practitioners use a probe when screening for periodontitis. However, DPSI is mainly used by younger dentists. An effort should be made to encourage all dentists to use this, so that in every patient, periodontitis can be detected timely, securing the best treatment outcome.

http://ift.tt/2jAEDsc

Frequency, location, and association with dental pathology of mucous retention cysts in the maxillary sinus. A radiographic study using cone beam computed tomography (CBCT)

Abstract

Objectives

The purpose of the present study was to evaluate the frequency, locations, and dimensions of mucous retention cysts of the maxillary sinus and analyze potential associated dental pathology.

Materials and methods

A total of 156 cone beam computed tomography (CBCT) scans were included in the analysis, resulting in an evaluation of 310 maxillary sinuses. The presence of mucous retention cysts (MRC) manifesting as dome-shaped radiopacities in the sinus was diagnosed. Their locations were recorded, and dimensions (mm) were measured in coronal and sagittal/axial slices. The patients were grouped into (a) patients/sinuses with MRCs (test), and (b) patients/sinuses with healthy or any other changes (control) for further comparison and evaluation.

Results

There were 40 sinuses (12.9%) with a presence of a total of 56 MRCs. The mean age of involved patients was 29.0 years. The analysis showed that gender, age, sinus side, status of dentition, endodontic status, and periodontal status did not have a significant influence on the presence of MRCs when compared between test and control groups. Age and endodontic status exhibited a significant association with cyst location.

Conclusions

Most of the sinuses analyzed (79.5%) did not present any MRC, and only 28.6% of the cysts diagnosed were found on the floor of the maxillary sinus. The mean dimension of the MRCs measured 6.28 ± 2.93 mm. No influencing factors on the presence or absence of MRCs were found in the present study.

Clinical relevance

Most MRCs were not located on the floor of maxillary sinus. Future studies should assess their impact on surgical interventions in the sinus.

http://ift.tt/2wlh8t5