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Τετάρτη 11 Ιανουαρίου 2023

Cariogenic Diet Consumption

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Abstract

Background

During stressful situations such as pandemic-associated lockdowns, individuals' diets may change towards (cariogenic) "comfort food". This study assessed the dietary patterns in lockdown in Colombia population.

Methods

A cross-sectional online survey was designed. A convenience sample 489 adults was drawn, with 50% of them being in COVID-19 lockdown and the other being not or only partially in lockdown. The questionnaire collected data about the type and frequency of food consumed, with a special focus on cariogenic (i.e. rich in free sugars and starches) food. Descriptive analyses were performed, and a Generalized Linear Model was estimated to predict the frequency of cariogenic diet consumption in this period of time.

Results

Sweet whole wheat bread (38.2%, P= 0.005), flavored milk (26.4%, P= 0.002), sugar-sweetened bubble gums (39.8%, P= 0.001), toffees (35.4%, P= 0.004), soft candies (e. g. gums, etc.) (35.4%, P= 0.018), chocolates (55.3%, P= 0.017) filled donuts (28.5%, P= 0.013) or grapes (51.2%, P= 0.002), among others were significantly more consumed in lockdown. Multivariable generalized linear modeling showed being single, having children and being in lockdown were significantly associated with higher frequency of cariogenic food consumption.

Conclusions

Lockdown was found to be associated with detrimentally altered food consumption patterns and, specifically, a more cariogenic diet. Healthcare professionals should consider this when re-opening services and political decision-makers may want to reflect on unwarranted side effect of lockdown.

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A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy

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Abstract

Even though Helicobacter pylori infection was the most causative factor of gastric cancer, numerous in vivo studies failed to induce gastric cancer using Hpylori infection only. The utilization of established animal studies in cancer research is crucial as they aim to investigate the coincidental association between suspected oncogenes and pathogenesis as well as generate models for the development and testing of potential treatments. The methods to establish gastric cancer using infected animal models remain limited, diverse in methods, and showed different results. This study investigates the differences in animal models, which highlight different pathological results in gaster by literature research. Electronic databases searched were performed in PubMed, Science Direct, and Cochrane, without a period filter. A total of 135 articles were used in this study after a full-text assessment was conducted. The most frequent animal models used for gastric ca ncer were Mice, while Mongolian gerbils and Transgenic mice were the most susceptible model for gastric cancer associated with Hpylori infection. Additionally, transgenic mice showed that the susceptibility to gastric cancer progression was due to genetic and epigenetic factors. These studies showed that in Mongolian gerbil models, Hpylori could function as a single agent to trigger stomach cancer. However, most gastric cancer susceptibilities were not solely relying on Hpylori infection, and numerous factors are involved in cancer progression. Further study using Mongolian gerbils and Transgenic mice is crucial to conduct and establish the best models for gastric cancer associated Hpylori.

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Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

alexandrossfakianakis shared this article with you from Inoreader

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International Journal of Oral Science, Published online: 12 January 2023; doi:10.1038/s41368-022-00215-y

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway
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