Ετικέτες

Δευτέρα 17 Σεπτεμβρίου 2018

Assisted phytostabilisation of As, Pb and Sb-contaminated Technosols with mineral and organic amendments using Douglas fir ( Pseudotsuga menziesii (Mirb.) Franco)

Abstract

Phytoremediation of metal(loid)s by conifers is not widely studied, although conifers may be interesting, particularly in temperate-cold areas and/or on acidic soils. In this study, seeds of Douglas fir were sown in greenhouse and cultivated for 3 months on two Technosols highly contaminated with different concentrations of Pb, As and Sb and collected in two French old former mines located in massif Central or close to it: a mine of gold at La Petite Faye and a mine of lead and silver at Pontgibaud. Two amendments, a nutrient solution (NS) and composted sewage sludge (CSS), were tested in order to stimulate Douglas fir growth and to reduce the metal(loid)s mobility and phytoavailability. The speciation determined by sequential extractions as well as mineralogy highlight different geochemical behaviours of Pb, As and Sb as a function of the Technosol. In all cases, CSS amendments significantly reduced Pb phytoavailability as well as the uptake and translocation of Pb and As. Moreover, CSS stimulated the growth of Douglas firs highlighting that this amendment could be a good strategy for a better phytostabilisation of these metal(loid)s.



https://ift.tt/2peDC98

Safety and efficacy of a novel high‐intensity focused electromagnetic technology device for noninvasive abdominal body shaping

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2NnZSfv

In vivo dynamic thermal imaging of skin radiofrequency treatment

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2D3PF32

Effects of radiofrequency on adipose tissue: A systematic review with meta‐analysis

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2NnZNbH

Procedural management of rhinophyma: A comprehensive review

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2D4LYK7

Histological findings correlated with clinical outcomes in telangiectasia treated with ohmic thermolysis and 940 nm laser

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2NitjiO

Comparison of novel dual mode vs conventional single pass of a 1450‐nm diode laser in the treatment of acne vulgaris for Korean patients: A 20‐week prospective, randomized, split‐face study

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2D7TIvb

Association of Irisin Circulating Level with Diabetic Retinopathy: A Case-Control Study

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0723-3749

Obesity and obesity induced diabetes (DM II) development and progression have been associated with sedentary lifestyle. Irisin, a newly discovered myokine, has been demonstrated at lower levels in obese and DM II patients compared to controls. The main aim of this study is to explore association of Irisin with diabetic retinopathy (DR). A total of 233 healthy and DM II adults participated in this study. Participants were divided into four categories: a healthy control group and an age-match subset of patients with DM II; a positive control group of patients with DM II not affected by DR (No DR); and patients with DM II affected by DR (non-proliferative DR (NPDR) and proliferative DR (PDR)). Plasma samples were quantified for Irisin measurement, lipid profile and HbA1c. Comparison of the age-matched groups of healthy controls and patients with DM II revealed lower Irisin plasma level in DM II group. Analyses revealed negative correlations of Irisin to HbA1c and LDL levels and positive correlation to HDL level. Comparing Irisin level in No DR and DR groups revealed a higher level in No DR group and analysis per DR classification indicated higher Irisin level in NPDR group. Our results demonstrate not only correlation of plasma Irisin level with DR stages, but also significantly different Irisin level among them. This is promising in terms of researching Irisin as a potential associating marker for DM II and DR development and progression.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text



https://ift.tt/2DeS1fA

Diagnostic Performance of HMGA2 Gene Expression for Differentiation of Malignant Thyroid Nodules; A Systematic Review and Meta‐analysis

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2Qym04u

Coexisting pituitary and non‐pituitary gigantism in the same family

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xnsf2m

Pro-inflammatory effects of extracted urban fine particulate matter on human bronchial epithelial cells BEAS-2B

Abstract

Atmospheric particulate matter (PM) constitutes the major part of urban air pollution and is a heterogeneous mixture of solid and liquid particles of different origin, size, and chemistry. Human exposure to PM in urban areas poses considerable and significant adverse effects on the respiratory system and human health in general. Major contributors to PM content are combustion-related sources such as diesel vehicles, household, and industrial heating. PM is composed of thousands of different high molecular weight organic compounds, including poly-aromatic hydrocarbons (PAHs). The aim of this study was to clarify the cytotoxic effects of the extract of actual urban PM1 with high benzo[a]pyrene (BaP) content collected in Eastern European mid-sized city during winter heating season on human bronchial epithelial cells (BEAS-2B). Decreased cell viability, alteration of cell layer integrity, increased apoptosis, and oxidative stress were observed during the 3-day exposure to the PM extract. In addition, following PM exposure pro-inflammatory cytokine expression was upregulated at gene and protein levels. Morphology and motility changes, i.e., decreased cells' ability to cover scratch area, were also documented. We report here that the extract of urban PM1 may induce bronchial epithelium changes and render it pro-inflammatory and compromised within 3 days.



https://ift.tt/2xiehjb

Controversial Issues In Vitiligo patients: a review of old and recent treatments

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2D4vL7M

Intravenous immunoglobulin for treatment of necrobiotic xanthogranuloma

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pgbEdl

Biphasic Amyloidosis involved in the face: Effective Treatment with 30% Salicylic Acid

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2D4v8Ls

Development of hidradenitis suppurativa in a patient treated with ustekinumab for her psoriasis: a potential paradox reaction?

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pfKUtb

What are the best exercises for bat wings?

Strengthening the arms can help improve the muscles and promote fat loss. This can help to improve the shape of the arms and reduce excess and drooping skin that is there. This excess skin is sometimes known as "bat wings" or "bingo wings." Learn more about how to get rid of bat wings.

https://ift.tt/2D11yXg

Hair loss: Scientists test wearable regrowth device

A study investigating ways to promote hair regrowth takes a look at micro LEDs. The scientists believe that they could be used as a wearable solution.

https://ift.tt/2pdTvwL

Fetal exposure to mitotane/Op’DDD: post‐natal study of four children

Clinical Endocrinology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2NmJL1t

Issue Information ‐ Instructions for Authors

Clinical Endocrinology, Volume 89, Issue 4, Page 530-531, October 2018.


https://ift.tt/2MHyGTz

Issue Information ‐ TOC and Editorial Board

Clinical Endocrinology, Volume 89, Issue 4, Page 383-384, October 2018.


https://ift.tt/2NgDrZv

Valaciclovir: a culprit drug for DRESS not to be neglected. Three cases

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pcnyF0

Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology consensus guidelines

British Journal of Dermatology, Volume 179, Issue 3, Page 582-589, September 2018.


https://ift.tt/2DebRHQ

Image Gallery: Wyburn–Mason syndrome with a chronic wound

British Journal of Dermatology, Volume 179, Issue 3, Page e134-e134, September 2018.


https://ift.tt/2pfy91L

Core outcome sets in dermatology: next steps

British Journal of Dermatology, Volume 179, Issue 3, Page 549-550, September 2018.


https://ift.tt/2D5BDOk

Applying the phenotype approach for rosacea to practice and research

British Journal of Dermatology, Volume 179, Issue 3, Page e148-e148, September 2018.


https://ift.tt/2pgkfwE

Issue Information

British Journal of Dermatology, Volume 179, Issue 3, Page i-vi, September 2018.


https://ift.tt/2D7asCO

Cost‐effectiveness of omalizumab in chronic spontaneous urticaria

British Journal of Dermatology, Volume 179, Issue 3, Page e144-e144, September 2018.


https://ift.tt/2pgkeZC

异位性皮肤压力源对NMF和皮肤细胞因子的作用

British Journal of Dermatology, Volume 179, Issue 3, Page e160-e160, September 2018.


https://ift.tt/2D53EFz

Effect of atopic skin stressors on NMFs and skin cytokines

British Journal of Dermatology, Volume 179, Issue 3, Page e145-e145, September 2018.


https://ift.tt/2pe3QbJ

Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A critically appraised topic

British Journal of Dermatology, Volume 179, Issue 3, Page e147-e147, September 2018.


https://ift.tt/2D3Ng8r

BSPD guidelines for treatment of IH with propranolol

British Journal of Dermatology, Volume 179, Issue 3, Page e146-e146, September 2018.


https://ift.tt/2pdMtIc

奥马珠单抗治疗自发慢性荨麻疹的成本效益

British Journal of Dermatology, Volume 179, Issue 3, Page e159-e159, September 2018.


https://ift.tt/2D3MsAr

使用普萘洛尔治疗IH的BSPD指南

British Journal of Dermatology, Volume 179, Issue 3, Page e161-e161, September 2018.


https://ift.tt/2pmq23P

Subtyping, phenotyping or endotyping rosacea: how can we improve disease understanding and patient care?

British Journal of Dermatology, Volume 179, Issue 3, Page 551-552, September 2018.


https://ift.tt/2D3N0Gv

皮肤癣菌病和STAT3突变

British Journal of Dermatology, Volume 179, Issue 3, Page e158-e158, September 2018.


https://ift.tt/2pmq7Vb

New therapeutics for itch in dermatomyositis

British Journal of Dermatology, Volume 179, Issue 3, Page 559-560, September 2018.


https://ift.tt/2D53D4t

人体测量因素和Breslow厚度

British Journal of Dermatology, Volume 179, Issue 3, Page e157-e157, September 2018.


https://ift.tt/2pe3NN5

Improvements in quality of life and work productivity make omalizumab cost‐effective for the treatment of chronic spontaneous urticaria

British Journal of Dermatology, Volume 179, Issue 3, Page 562-563, September 2018.


https://ift.tt/2D53ldT

润肤剂和局部糖皮质激素治疗成人湿疹

British Journal of Dermatology, Volume 179, Issue 3, Page e156-e156, September 2018.


https://ift.tt/2pfy4uZ

Interventional management of hyperhidrosis in secondary care: where do we go from here?

British Journal of Dermatology, Volume 179, Issue 3, Page 555-556, September 2018.


https://ift.tt/2D538HD

Oral exfoliative cytology and corrosion of metal piercings. Tissue implications

Abstract

Objectives

A group of adolescents with oral piercings was studied to determine the presence of metallic particles in cells exfoliated from the mucosa surrounding their metal oral piercings and the association between such particles and the metal jewelry, and to evaluate subsequent tissue implications.

Materials and methods

Sixteen teenage patients who had tongue and/or lip piercings were included. The clinical features of the oral mucosa and lip skin were evaluated. Exfoliative cytology was performed in the area surrounding the piercing. The surface of used and unused jewelry was studied by scanning electron microscopy and energy dispersive X-ray analysis.

Results

Hyperplastic, leukoedematous, and lichenoid lesions were observed in the mucosa, as well as lesions associated with metallosis of the lip skin. Cytological smears showed the presence of particles inside the epithelial cells; the particles were found to contain aluminum, tungsten, and molybdenum. In one case requiring surgical removal of the piercing, histological examination of the tissue associated with the piece of jewelry showed the presence particles containing aluminum, iron, and tin inside multinucleated giant cells. Although surface finish defects were observed on both unused and used piercing jewelry, they were more evident on the used pieces.

Conclusions

Ion particles are released from the metal piercings and could have been adjuvant factors in the development of the observed lesions. Cells exfoliated from the oral mucosa surrounding metal piercings may serve as bioindicators of corrosion processes.

Clinical relevance

We propose the use of exfoliative cytology to monitor corrosion processes and for routine clinical follow up.



https://ift.tt/2PLuLqW

Dentinal tubule penetration of AH Plus, BC Sealer and a novel tricalcium silicate sealer: a confocal laser scanning microscopy study

Abstract

Objectives

The aim of this in vitro study was to assess the dentinal tubule penetration of three different sealers, AH Plus, BC Sealer and a novel tricalcium silicate sealer (NTS).

Materials and methods

Ninety-six human maxillary central incisors were divided into three experimental groups (n = 32) and were filled with gutta-percha using a single-cone technique in conjunction with one of the three sealers: AH Plus, BC Sealer or NTS. The roots in each group were cross-sectioned at 1 and 5 mm from the root apex, and the surfaces were examined under confocal laser scanning microscopy (CLSM). The sealer penetration depths were measured at their maximum depths and at four circumferential depths (12, 3, 6 and 9 o'clock) and were evaluated using ImageJ software (ImageJ, NIH).

Results

The maximum and mean penetration depths were significantly higher at 5 mm compared to 1 mm from the apex in the AH Plus (p < 0.001), BC Sealer (p < 0.001) and NTS groups (p < 0.001). No significant difference was observed between the groups at 1 mm for both parameters. The maximum and mean penetration depths were significantly lower at 5 mm for AH Plus compared with the other two groups (p = 0.012).

Conclusions

Within the study limitations, the BC Sealer and NTS demonstrated better tubule penetration results than the AH Plus sealer.

Clinical relevance

Although no study has confirmed a relationship between the penetration depth of root canal sealers and the prevention of apical periodontitis, dentinal tubule sealer penetration may improve obturation quality.



https://ift.tt/2NS3TIe

Exertional heat illness: knowledge and behavior among construction workers

Abstract

Construction workers are considered one of the most vulnerable health group workers. Exertional heat illness (EHI) is a well-recognized health hazard that causes significant sickness and death. The purpose of this study was to assess construction workers' environment and hydration status and to evaluate the effect of health education program on workers. An interventional study was conducted on 89 construction workers in Port Said City. Assessments of workplace environment and workers' hydration status were done by using workplace evaluation checklist, wet-bulb globe temperature, urine specific gravity, and urine color chart. A pre-post-test design was used in the evaluation of workers' knowledge and behavior regarding EHI. A health education program was conducted to improve workers' knowledge and behavior; then, evaluation was done after 1 month. The most reported symptoms of heat illness were sweating (100.0%), dizziness (98.0%), and muscle pain (82.0%). Most workers showed signs of minimal dehydration (78.7%). There was a significant improvement in workers' knowledge about EHI and behavioral action for prevention after health education. Construction workers are at high risk of exposure to EHI which raised the attention to provide educational programs which can guide workers to follow healthy behaviors and prevent EHI.



https://ift.tt/2pdOXq3

Analysis of soil risk characteristics by comprehensive assessment in an industrial area of China

Abstract

Soil pollution in industrial areas poses a major challenge for China's environmental protection. In this study, comprehensive assessment methodologies for soil risk in industrial areas were developed. The comprehensive assessment covered ecological and human health risks of soil pollution, as well as vulnerability of different types of risk receptors. Comprehensive ecological risk assessment integrated potential ecological risk assessment and landscape vulnerability assessment. Comprehensive social risk assessment specialized human health risk assessment by introducing spatial distribution of population. A typical industrial area in China was studied, and the quantitative and spatial assessments of the comprehensive soil risk were presented. The results showed that the spatial distribution of soil comprehensive ecological and social risks differed. High-risk areas of soil comprehensive ecological risk in the study area were mainly farmlands and nature reserves. Inhabited areas and industrial zones were less affected by comprehensive ecological risk of soil. By contrast, the spatial distribution of soil comprehensive social risk and human activities showed a clear trend of convergence. Vulnerability assessment of the risk receptors provided a suitable complement to the risk assessment of soil pollution.



https://ift.tt/2NQDOcA

Rice single cropping or ratooning agro-system: which one is more environment-friendly?

Abstract

Sustainable development of food production depends on damping the environmental impacts of agricultural production. The aim of this study was to investigate the environmental performance of rice production in single crop and ratooning (main rice + ratoon crop) agro-systems through life cycle assessment (LCA) methodology in Guilan province, Northern Iran, in 2015. The flooding irrigation regime was the dominant irrigation method for single cropping system and main crop rising in ratooning agro-system. The data were gathered through a face to face interview with 215 single crop and 115 ratoon breeder paddy farmers. The environmental risks were determined in six impact categories including global warming, terrestrial eutrophication, acidification, and depletion of fossil fuels, phosphate, and potash resources. The functional unit (FU) was set as 100 kg protein. Results indicated that the CO2, N2O, and CH4 emissions of the rice ratooning agro-system (661.44, 1.96, and 5.42 kg 100 kg−1 protein) were less than the corresponding values in the rice single cropping agro-system (1341.63, 2.88, and 9.20 kg 100 kg−1 protein, respectively). Among all the environmental impact categories, the terrestrial eutrophication had the widest negative environmental effect followed by depletion of phosphate resources in single cropping agro-system with weighted indices of 0.51 and 0.41, respectively. Moreover, the terrestrial eutrophication had the largest negative environmental effect followed by acidification in rice ratooning agro-system with weighted indices of 0.48 and 0.29, respectively. Overall, the results highlighted that the rice ratooning ago-system is more environmentally beneficial than the single cropping system, particularly in terms of depletion of fossil fuels, global warming, and depletion of phosphate and potash resources categories. This priority may be improved through adopting proper management of agronomic practices for main and ratoon rice in ratooning agro-system.

Graphical abstract



https://ift.tt/2NQZ16d

Efficacy of an agonist of α‐MSH, the palmitoyl tetrapeptide‐20, in hair pigmentation

International Journal of Cosmetic Science, Volume 0, Issue ja, -Not available-.


https://ift.tt/2pfT7h0

Maintenance Immune Check-point Inhibitor Following Post-operative Chemo-radiation in Subjects With HPV-negative HNSCC

Condition:   Squamous Cell Head and Neck Carcinoma
Interventions:   Drug: Durvalumab;   Radiation: radiotherapy;   Drug: Placebo;   Drug: Cisplatin
Sponsor:   European Organisation for Research and Treatment of Cancer - EORTC
Not yet recruiting

https://ift.tt/2MIt5MZ

Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

Condition:   Advanced Cancer
Interventions:   Drug: FLX475;   Drug: Pembrolizumab
Sponsor:   FLX Bio, Inc.
Recruiting

https://ift.tt/2xppUoD

Telestroke for Comprehensive Stroke Care in Acute Stroke Ready Hospitals

Condition:   Stroke
Intervention:   Other: Telestroke
Sponsor:   University of Minnesota, MN
Not yet recruiting

https://ift.tt/2MF2tMM

A prospective multicenter evaluation of immediately functionalized tapered conical connection implants for single restorations in maxillary anterior and premolar sites: 3-year results

Abstract

Objectives

This multicenter prospective clinical trial investigated immediately provisionalized, anodized, conical connection, tapered implants with platform shifting in maxillary anterior and premolar sites.

Materials and methods

Patients requiring single-tooth implant-supported restorations in maxillary anterior and premolar sites were enrolled. Implants were immediately provisionalized and evaluated at insertion, 6 months, and annually thereafter. Outcome measures were marginal bone level change (ΔMBL), cumulative survival rate (CSR), and success rate, soft-tissue parameters, and oral health impact profile (OHIP). ΔMBL and Pink Esthetic Score were analyzed using Wilcoxon signed-rank tests. CSR was calculated using life table analysis. Other soft-tissue parameters were analyzed using sign tests.

Results

Of 94 enrolled patients (99 implants), 84 (88 implants) attended the 3-year follow-up. After an initial bone loss between implant insertion and 6 months (− 0.92 ± 1.23 mm), bone levels stabilized from 6 months to 3 years (0.13 ± 0.94 mm) with no significant change. The 3-year CSR was 98.9%, and the cumulative success rate was 96.9%. Papilla index scores of 2 or 3 were observed at 88.6% of sites at the 3-year visit compared with 32.8% at implant insertion. Improvements were observed for all other outcomes, including bleeding on probing, esthetics, plaque, and OHIP.

Conclusions

This restorative protocol was associated with high primary stability, patient satisfaction, stable bone levels, and an overall improvement of the soft tissue outcomes over a 3-year period.

Clinical relevance

The presented treatment is a viable option for single-tooth restorations of maxillary anterior teeth and premolars with successful short- to mid-long-term clinical outcomes.



https://ift.tt/2xy6ux5

Assessing temporal-spatial land use simulation effects with CLUE-S and Markov-CA models in Beijing

Abstract

In order to solve the problem of extensive land use in rural residential areas and promote the construction of a new socialist countryside and farmland protection, it is important to graspe the temporal and spatial evolution of rural settlements. In this study, with Beijing as an example, the efficiencies of CLUE-S and Markov-CA models in simulating spatial temporal evolution of rural residential areas are analyzed. With 14 driving factors chosen, the land uses in Beijing in 2000 and 2005 are simulated and predicted using the two models. Grid size of 220 m × 220 m is used. The accuracies and Kappa coefficients of the simulation and prediction results are analyzed and the following conclusions are made. The core part of CLUE-S model is logistic regression, which grants it obvious advantage in capturing the trends of land use changes with more discrete distributions. Meanwhile, Markov-CA model takes neighborhood into consideration, making it relatively more advantageous in simulating and predicting changes of land uses with the character of nearest-neighbor diffusion. However, among various land uses, only urban land use has this character, the correct prediction rates of the CLUE-S model in 2000 and 2005 were 60.99% and 81.35%, respectively, while the accuracy of the Markov-CA model prediction was 51.33% and 73.68%, and it is the main reason that CLUE-S model returns better simulation and prediction results of rural residential areas for both 2000 and 2005 than Markov-CA model.



https://ift.tt/2MzNkw9

Outcomes after neoadjuvant treatment with gemcitabine and erlotinib followed by gemcitabine–erlotinib and radiotherapy for resectable pancreatic cancer (GEMCAD 10-03 trial)

Abstract

Background

Neoadjuvant therapy (NAT) for pancreatic adenocarcinoma (PDAC) patients has shown promising results in non-randomized trials. This is a multi-institutional phase II trial of NAT in resectable PDAC patients.

Methods

Patients with confirmed resectable PDAC after agreement by two expert radiologists were eligible. Patients received three cycles of GEM (1000 mg/m2/week) plus daily erlotinib (ERL) (100 mg/day). After re-staging, patients without progressive disease underwent 5 weeks of therapy with GEM (300 mg/m2/week), ERL 100 mg/day and concomitant radiotherapy (45 Gy). Efficacy was assessed using tumor regression grade (TRG) and resection margin status. Using a single-arm Simon's design, considering the therapy not useful if R0 < 40% and useful if the R0 > 70% (alpha 5%, beta 10%), 24 patients needed to be recruited. This trial was registered at ClinicalTrials.gov, number NCT01389440.

Results

Twenty-five patients were enrolled. Adverse effects of NAT were mainly mild gastrointestinal disorders. Resectability rate was 76%, with a R0 rate of 63.1% among the resected patients. Median overall survival (OS) and disease-free survival (DFS) were 23.8 (95% CI 11.4–36.2) and 12.8 months (95% CI 8.6–17.1), respectively. R0 resection patients had better median OS, compared with patients with R1 resection or not resected (65.5 months vs. 15.5 months, p = 0.01). N0 rate among the resected patients was 63.1%, and showed a longer median OS (65.5 vs. 15.2 months, p = 0.009).

Conclusion

The results of this study confirm promising oncologic results with NAT for patients with resectable PDAC. Therefore, the present trial supports the development of phase II randomized trials comparing NAT vs. upfront surgery in resectable pancreatic cancer.



https://ift.tt/2xsncO4

Autophagy therapeutics: preclinical basis and initial clinical studies

Abstract

Autophagy captures and degrades intracellular components such as proteins and organelles to sustain metabolism and homeostasis. Rapidly accumulating attention is being paid to the role of autophagy in the development of cancer, which makes autophagy attractive tools and targets for novel therapeutic approaches. Functional studies have confirmed that autophagy dysregulation is causal in many cases of cancer, with autophagy acting as tumor suppressors or tumor promoters, and autophagy inhibitor or promoter has shown promise in preclinical studies. The autophagy-targeted therapeutics using chloroquine/hydroxychloroquine have reached clinical development for treating cancer, but these drugs are actually not efficient probably because of a reduced penetration within the tumor. In this review, we first discuss the discoveries related to dual function of autophagy in cancer. Then, we provide an overview of preclinical studies and clinical trials involved in the development of autophagy therapeutics and finally discuss the future of such therapies.



https://ift.tt/2NQnoAQ

Immunostimulatory activity of low-molecular-weight hyaluronan on dendritic cells stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis

Abstract

Objectives

Periodontitis is a chronic inflammatory disease characterized by tooth-supporting tissue destruction, which is elicited by the host's immune response triggered against periodonto-pathogen bacteria. During periodontal tissue destruction, extracellular matrix components are metabolized and fragmented. Some extracellular matrix component-derived fragments, such as low-molecular-weight hyaluronan (LMW-HA), have potent immunogenic potential, playing a role as damage-associated molecular patterns (DAMPs) during activation of immune cells. Dendritic cells (DCs) play a central role in the host's immune response displayed during periodontitis; thus, this study aimed to analyze whether LMW-HA has an immunostimulatory activity on DCs when stimulated with periodonto-pathogen bacteria.

Materials and methods

LMW-HA-treated and non-treated DCs were stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis and the mRNA expression for cytokines tumor necrosis factor-α (TNF-alpha), interleukin-1β (IL-1B), interleukin-6 (IL-6), and interleukin-23 (IL-23A) was quantified by RT-qPCR. In addition, transcription factors interferon regulatory factor 4 (IRF4), interferon regulatory factor 8 (IRF8), neurogenic locus notch homolog protein 2 (NOTCH2), and basic leucine zipper ATF-like transcription factor 3 (BATF3), involved in DC activation, were analyzed.

Results

Higher expression levels of TNF-alpha, IL-1B, IL-6, and IL-23A were detected in LMW-HA-treated DCs after bacterial infection, as compared with non-treated DCs. When LMW-HA-treated DCs were infected with A. actinomycetemcomitans, higher levels of IRF4, NOTCH2, and BATF3 were detected compared with non-treated cells; whereas against P. gingivalis infection, increased levels of IRF4 and NOTCH2 were detected.

Conclusion

LMW-HA plays an immunostimulatory role on the immune response triggered by DCs during infection with A. actinomycetemcomitans or P. gingivalis.

Clinical relevance

Detection of extracellular matrix component-derived fragments produced during periodontal tissue destruction, such as LMW-HA, could explain at least partly unsuccessful periodontal treatment and the chronicity of the disease.



https://ift.tt/2OwCokE

The TiO 2 (B) nano-belts with excellent performance prepared via alkaline stirring hydrothermal method and its application to remove 17α-ethynylestradiol

Abstract

In this work, TiO2 (B) nano-belts were synthesized by hydrothermal method under stirring, and static conditions and preparation conditions were optimized. The prepared materials were characterized by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), photoluminescence spectroscopy (PL), and N2 adsorption/desorption measurement. The photocatalytic performance was evaluated by removing synthetic estrogen 17α-ethynylestradiol (EE2), which is the most potent endocrine-disrupting chemical. The results show that the TiO2 nano-belt possesses pure metastable monoclinic TiO2 (B) and has uniform nano-belt shape with 80~120-nm diameters and 62.904 m2 g−1 of specific surface area. Under the best optimal preparation conditions (0.5 g P25, 20 mL 10 mol L−1 NaOH, hydrothermal temperature 180 °C for 18 h under stirring, 400 °C calcination for 2 h), the TiO2 (B) has better catalytic activity with 100.00% removal rate towards 3 mg L−1 EE2 in 120 min. The removal rates of EE2 over catalyst which was prepared under static condition and P25 are 74.66% and 70.71%, respectively. The photocatalytic degradation rate constant of TiO2 (B) prepared under stirring condition (0.0379 min−1) is 4.51 times and 8.42 times than those of TiO2 prepared under static condition (0.0084 min−1) and P25 (0.0045 min−1). The excellent photocatalytic activity is mainly ascribed to longer one-dimensional nano-belt structure and effective suppression of photo-produced electron-hole.



https://ift.tt/2OuDVrs

Accumulation, translocation, and assessment of heavy metals in the soil-rice systems near a mine-impacted region

Abstract

Paddy rice is considered as a main source for human exposure to heavy metal contamination due to its efficient accumulation of heavy metals especially when cultivated in contaminated fields. In the current study, rice grains, straws, roots, and rhizosphere paddy soils were collected from Changsha, a non-ferrous mine-impacted area in China. Heavy metals including Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Ba, and Pb in the samples were determined using ICP-MS. The heavy metal concentrations were found in the ascending order of grain < straw < root < paddy soil except As and Cd. Rice root is a main organ to retain As and Cd through chelation and adsorption. The translocation behaviors of the heavy metals in the soil-rice system were investigated through bioaccumulation factor (BF) and translocation factor (TF). Similar variation tendencies to decrease BFp-r (translocation from paddy soil to root) and TFs-g (translocation from straw to grain) associated with TFr-s (translocation from root to straw) increasing were observed for most of the heavy metals due to heavy metal detoxification and stress tolerance in rice. The potential adverse effects caused by long-term exposure to heavy metals from rice consumption were evaluated via the target hazard quotient. The results indicated potential health risk to human from exposure to Mn, As, and Cd.



https://ift.tt/2D2zJ0F

Blue lesions of the ears: When dermoscopy is not enough!

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2xqttK3

Idiopathic granulomatous vulvitis and subsequent oral granulomatosis: a diagnostic and therapeutic challenge

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2NjnvWq

A novel missense mutation of the STS gene in two siblings with X‐linked ichthyosis, complicated by short stature, bone density reduction, epilepsy, and cryptorchidism

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2OB7BTC

Pachydermodactyly: case report including clinical and histopathologic diagnostic pitfalls

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xmE5d7

Αναζήτηση αυτού του ιστολογίου