We conducted this systematic review to support the U.S. Preventive Services Task Force in updating its recommendation on screening for thyroid cancer. Our review addresses the following Key Questions (KQs): 1) Compared with not screening, does screening adults for thyroid cancer lead to a reduced risk of thyroid-specific mortality or morbidity, reduced all-cause mortality, and/or improved quality of life? 2) What are the test performance characteristics of screening tests for detecting malignant thyroid nodules in adults? 3) What are the harms of screening for thyroid cancer in adults? 4) Does treatment of screen-detected thyroid cancer reduce thyroid-specific mortality or morbidity, reduce all-cause mortality, and/or improve quality of life? 5) What are the harms of treating screen-detected thyroid cancer?
http://ift.tt/2x16CDf
Τρίτη 15 Αυγούστου 2017
Screening for Thyroid Cancer: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].
Ensuring innovation in diagnostics for bacterial infection: Implications for policy [Internet].
The inappropriate use of antibiotics is a primary cause of the ongoing increase in drug resistance amongst pathogenic bacteria. The resulting decrease in the efficacy of antibiotics threatens the ability to combat infectious diseases. Rapid, point-of-care tests to identify pathogens and better target the appropriate treatment could greatly improve the use of antibiotics, yet few such tests are available or being developed, despite the rapid pace of medical innovation. Clearly, something is inhibiting the much-needed development of new and more convenient diagnostic tools.
http://ift.tt/2w7j1ZR
Targeting innovation in antibiotic drug discovery and development: The need for a One Health – One Europe – One World Framework [Internet].
Antimicrobial resistance is a global crisis that threatens public health and modern medicine. The discovery and development of novel antibiotic products are critical components in combating it. Many international, European Union and national initiatives address the scientific, regulatory and economic barriers to antibiotic innovation. This study identifies, reviews and critically assesses these initiatives, and provides policy recommendations for improving the global and European agendas for research and development of antibiotics.
http://ift.tt/2x198t5
The Chemistry of Microbiomes: Proceedings of a Seminar Series.
The 21st century has witnessed a complete revolution in the understanding and description of bacteria in ecosystems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication.
http://ift.tt/2w73GII
Principles and Practices for a Federal Statistical Agency: Sixth Edition.
Publicly available statistics from government agencies that are credible, relevant, accurate, and timely are essential for policy makers, individuals, households, businesses, academic institutions, and other organizations to make informed decisions. Even more, the effective operation of a democratic system of government depends on the unhindered flow of statistical information to its citizens.
http://ift.tt/2x1te6A
An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
http://ift.tt/2w77GZX
Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
http://ift.tt/2x0HGMj
Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study
Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print
http://ift.tt/2w7j2gz
Effect of step-feeding on the performance of lab-scale columns simulating vertical flow-horizontal flow constructed wetlands
Abstract
The effect of step-feeding (untreated wastewater by-pass) on the performance of lab-scale columns simulating a hybrid vertical flow (VF)-horizontal flow (HF) constructed wetland (CW) system was studied. Step-feeding strategies have been adopted in several kinds of CW, but this is the first report about the use of step-feeding in VF + HF hybrid systems treating domestic wastewater. Applied loading rates were 7–11 g BOD5/m2 day and 2.1–3.4 g TN/m2 day (overall system). Removal efficiency reached 98% TSS and COD and 99% BOD5 on average, whilst a 50% by-pass improved TN removal from 31 to 50%. Maximum surface nitrification rate (5.5 g N/m2 day) was obtained in VF unit, whilst maximum denitrification rate (1.8 g N/m2 day) was observed in HF unit. Referred to the overall system, maximum surface nitrification and denitrification rates were 2.2 and 1.6 g N/m2 day, respectively. However, potential nitrifying and denitrifying activities (batch assays) were 15.0 and 58.9 g N/m2 day, respectively. Even at 50% by-pass, operational conditions in HF unit (dissolved oxygen, redox, COD/TN ratio) were not suitable enough for denitrification. However, methane emissions were not observed and nitrous oxide emissions were relatively low.
http://ift.tt/2fItTqi
Scholar : These new articles for Computer-Aided Design and Applications are available online
|
Scholar : These new articles for Atmosphere-Ocean are available online
|
Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism
Interventions: Other: Empiric use of Calcium Carbonate and Calcitriol; Other: PTH based Calcium Carbonate and Calcitriol repletion
Sponsor: CHU de Quebec-Universite Laval
Not yet recruiting - verified August 2017
http://ift.tt/2x0hwcf
Scholar : These new articles for Alcoholism Treatment Quarterly are available online
|
Bond strength of etch-and-rinse and self-etch adhesive systems to enamel and dentin irradiated with a novel CO 2 9.3 μm short-pulsed laser for dental restorative procedures
Abstract
The objective of this study was to evaluate the influence of CO2 9.3 μm short-pulsed laser irradiation on the shear bond strength of composite resin to enamel and dentin. Two hundred enamel and 210 dentin samples were irradiated with a 9.3 µm carbon dioxide laser (Solea, Convergent Dental, Inc., Natick, MA) with energies which either enhanced caries resistance or were effective for ablation. OptiBond Solo Plus [OptiBondTE] (Kerr Corporation, Orange, CA) and Peak Universal Bond light-cured adhesive [PeakTE] (Ultradent Products, South Jordan, UT) were used. In addition, Scotchbond Universal [ScotchbondSE] (3M ESPE, St. Paul, MN) and Peak SE self-etching primer with Peak Universal Bond light-cured adhesive [PeakSE] (Ultradent Products) were tested. Clearfil APX (Kuraray, New York, NY) was bonded to the samples. After 24 h, a single plane shear bond test was performed. Using the caries preventive setting on enamel resulted in increased shear bond strength for all bonding agents except for self-etch PeakSE. The highest overall bond strength was seen with PeakTE (41.29 ± 6.04 MPa). Etch-and-rinse systems achieved higher bond strength values to ablated enamel than the self-etch systems did. PeakTE showed the highest shear bond strength with 35.22 ± 4.40 MPa. OptiBondTE reached 93.8% of its control value. The self-etch system PeakSE presented significantly lower bond strength. The shear bond strength to dentin ranged between 19.15 ± 3.49 MPa for OptiBondTE and 43.94 ± 6.47 MPa for PeakSE. Etch-and-rinse systems had consistently higher bond strength to CO2 9.3 µm laser-ablated enamel. Using the maximum recommended energy for dentin ablation, the self-etch system PeakSE reached the highest bond strength (43.9 ± 6.5 MPa).
http://ift.tt/2w6rGMd
A two-stage predictive model to simultaneous control of trihalomethanes in water treatment plants and distribution systems: adaptability to treatment processes
Abstract
The trihalomethanes (TTHMs) and others disinfection by-products (DBPs) are formed in drinking water by the reaction of chlorine with organic precursors contained in the source water, in two consecutive and linked stages, that starts at the treatment plant and continues in second stage along the distribution system (DS) by reaction of residual chlorine with organic precursors not removed. Following this approach, this study aimed at developing a two-stage empirical model for predicting the formation of TTHMs in the water treatment plant and subsequently their evolution along the water distribution system (WDS). The aim of the two-stage model was to improve the predictive capability for a wide range of scenarios of water treatments and distribution systems. The two-stage model was developed using multiple regression analysis from a database (January 2007 to July 2012) using three different treatment processes (conventional and advanced) in the water supply system of Aljaraque area (southwest of Spain). Then, the new model was validated using a recent database from the same water supply system (January 2011 to May 2015). The validation results indicated no significant difference in the predictive and observed values of TTHM (R 2 0.874, analytical variance <17%). The new model was applied to three different supply systems with different treatment processes and different characteristics. Acceptable predictions were obtained in the three distribution systems studied, proving the adaptability of the new model to the boundary conditions. Finally the predictive capability of the new model was compared with 17 other models selected from the literature, showing satisfactory results prediction and excellent adaptability to treatment processes.
http://ift.tt/2uY1OwU
Scholar : These new articles for Arid Land Research and Management are available online
|
Scholar : These new articles for Philosophical Magazine are available online
|
Scholar : These new articles for Journal of Natural History are available online
@media screen and (max-width:400px) { .two .column, .two .left, .two .right{ max-width: 100% !important; } } @media screen and (min-width: 401px) and (max-width:620px){ .two .column, .two .left, .two .right { max-width: 100% !important; } }
|
A Recurrent Episode of Dermatomyositis Associated with Papillary Thyroid Cancer.
| Related Articles |
A Recurrent Episode of Dermatomyositis Associated with Papillary Thyroid Cancer.
Case Rep Endocrinol. 2017;2017:7985953
Authors: Eranki VG
Abstract
OBJECTIVE: It is uncommon for dermatomyositis to be associated with papillary thyroid cancer. We report an unusual case of papillary thyroid cancer presenting with dermatomyositis.
METHODS: The case history, imaging and laboratory data is reviewed.
RESULTS: We report the case of a 62-year-old female with a prior history of dermatomyositis and breast cancer who presented with a recurrent episode of dermatomyositis. Extensive evaluation of the cause of the dermatomyositis recurrence revealed no recurrence of the breast cancer but a thyroid nodule was identified. The nodule was biopsied and the patient was noted to have papillary thyroid cancer. The patient subsequently underwent total thyroidectomy and had gradual improvement in her dermatomyositis.
CONCLUSION: It is very uncommon for dermatomyositis to be associated with papillary thyroid cancer.
PMID: 28804657 [PubMed]
http://ift.tt/2uKmpWh
Risk-adapted robotic stereotactic body radiation therapy for inoperable early-stage non-small-cell lung cancer
Abstract
Purpose
To evaluate efficacy and toxicity of stereotactic body radiation therapy (SBRT) with CyberKnife® (Accuray, Sunnyvale, CA, USA) in a selected cohort of primary, medically inoperable early-stage non-small cell lung cancer (NSCLC) patients.
Methods
From 2012 to 2016, 106 patients (median age 74 years, range 50–94 years) with primary NSCLC were treated with SBRT using CyberKnife®. Histologic confirmation was available in 87 patients (82%). For mediastinal staging, 92 patients (87%) underwent 18F-fluorodeoxyglucose positron-emission tomography (18-FDG-PET) and/or endobronchial ultrasound (EBUS)-guided lymph node biopsy or mediastinoscopy. Tumor stage (UICC8, 2017) was IA/B (T1a-c, 1–3 cm) in 86 patients (81%) and IIA (T2a/b, 3–5 cm) in 20 patients (19%). Depending on tumor localization, three different fractionation schedules were used: 3 fractions of 17Gy, 5 fractions of 11Gy, or 8 fractions of 7.5 Gy. Tracking was based on fiducial implants in 13 patients (12%) and on image guidance without markers in 88%.
Results
Median follow-up was 15 months (range 0.5–46 months). Acute side effects were mild (fatigue grade 1–2 in 20% and dyspnea grade 1–2 in 17%). Late effects were observed in 4 patients (4%): 3 patients developed pneumonitis requiring therapy (grade 2) and 1 patient suffered a rib fracture (grade 3). In total, 9/106 patients (8%) experienced a local recurrence, actuarial local control rates were 88% (95% confidence interval, CI, 80–96%) at 2 years and 77% (95%CI 56–98%) at 3 years. The median disease-free survival time was 27 months (95%CI 23–31 months). Overall survival was 77% (95%CI 65–85%) at 2 years and 56% (95%CI 39–73%) at 3 years.
Conclusion
CyberKnife® lung SBRT which allows for real-time tumor tracking and risk-adapted fractionation achieves satisfactory local control and low toxicity rates in inoperable early-stage primary lung cancer patients.
http://ift.tt/2vzSeUE
Re-expression of pro-fibrotic, embryonic preserved mediators in irradiated arterial vessels of the head and neck region
Abstract
Purpose
Surgical treatment of head and neck malignancies frequently includes microvascular free tissue transfer. Preoperative radiotherapy increases postoperative fibrosis-related complications up to transplant loss. Fibrogenesis is associated with re-expression of embryonic preserved tissue developmental mediators: osteopontin (OPN), regulated by sex-determining region Y‑box 9 (Sox9), and homeobox A9 (HoxA9) play important roles in pathologic tissue remodeling and are upregulated in atherosclerotic vascular lesions; dickkopf-1 (DKK1) inhibits pro-fibrotic and atherogenic Wnt signaling. We evaluated the influence of irradiation on expression of these mediators in arteries of the head and neck region.
Materials and methods
DKK1, HoxA9, OPN, and Sox9 expression was examined immunohistochemically in 24 irradiated and 24 nonirradiated arteries of the lower head and neck region. The ratio of positive cells to total cell number (labeling index) in the investigated vessel walls was assessed semiquantitatively.
Results
DKK1 expression was significantly decreased, whereas HoxA9, OPN, and Sox9 expression were significantly increased in irradiated compared to nonirradiated arterial vessels.
Conclusion
Preoperative radiotherapy induces re-expression of embryonic preserved mediators in arterial vessels and may thus contribute to enhanced activation of pro-fibrotic downstream signaling leading to media hypertrophy and intima degeneration comparable to fibrotic development steps in atherosclerosis. These histopathological changes may be promoted by HoxA9-, OPN-, and Sox9-related inflammation and vascular remodeling, supported by downregulation of anti-fibrotic DKK1. Future pharmaceutical strategies targeting these vessel alterations, e. g., bisphosphonates, might reduce postoperative complications in free tissue transfer.
http://ift.tt/2wLwbIZ
Scholar : These new articles for Body, Movement and Dance in Psychotherapy are available online
|
Evaluating Critical Brain Radiation Doses in the Treatment of Multiple Brain Lesions with Gamma Knife Radiosurgery
Stereotact Funct Neurosurg 2017;95:268-278
http://ift.tt/2vEXox7
Comparative Evaluation of Magnetic Resonance-Guided Focused Ultrasound Surgery for Essential Tremor
Stereotact Funct Neurosurg 2017;95:279-286
http://ift.tt/2vXyPOm
Scholar : Acta Orthopaedica, Volume 88, Issue 5, October 2017 is now available online on Taylor & Francis Online
@media screen and (max-width:400px) { .two .column, .two .left, .two .right{ max-width: 100% !important; } } @media screen and (min-width: 401px) and (max-width:620px){ .two .column, .two .left, .two .right { max-width: 100% !important; } }
|
Scholar : These new articles for Criminal Justice Studies are available online
|
Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents Staphylococcus aureus Biofilm Formation.
| Related Articles |
Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents Staphylococcus aureus Biofilm Formation.
Adv Healthc Mater. 2017 Aug 14;:
Authors: Gomez-Carretero S, Nybom R, Richter-Dahlfors A
Abstract
The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed. The resultant PEDOT-MeOH:PSS-AgNP composite presents a consistent coating of covalently linked AgNPs, as shown by scanning electron microscopy and surface plasmon resonance analysis. The efficacy of the coatings, with and without electrical addressing, is then tested against Staphylococcus aureus, a major colonizer of medical implants. Using custom-designed culturing devices, a nearly complete prevention of biofilm growth is obtained in AgNP composite devices addressed with a square wave voltage input. It is concluded that this electroenhancement of the bactericidal effect of the coupled AgNPs offers a novel, efficient solution against biofilm colonization of medical implants.
PMID: 28805046 [PubMed - as supplied by publisher]
http://ift.tt/2w9nDxY
Scholar : Body, Movement and Dance in Psychotherapy, Volume 12, Issue 3, August 2017 is now available online on Taylor & Francis Online
|
Scholar : These new articles for Australian Journal of Political Science are available online
|
Juvenile melanomas: Western Australian Melanoma Advisory Service experience
Abstract
Background/Objectives
Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades.
Method
A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data.
Results
Altogether 95 cases of juvenile melanoma were reported to the Western Australian Cancer Registry between 2000 and 2013. Of these, 27 patients were referred to the Western Australian Melanoma Advisory Service. Over 72% were aged between 13 and 19 years. The most common site for primary melanoma was the head and neck (31.8%). Eight patients (36.4%) had a pre-existing naevus, 13.6% reported 1–5 blistering sunburns in the past and 59.1% had a Fitzpatrick skin grade of 3 or less. Most (88%) were diagnosed with a primary invasive lesion at presentation. Superficial spreading melanomas predominated (27.3%). All but one patient had localised disease at presentation, with six patients undergoing further treatment, including chemotherapy and neck dissection for metastases. At the time of review, two patients had died, due to stroke and metastatic disease.
Conclusions
Juvenile melanoma remains a rarity in Western Australia despite a very high incidence of adult melanoma. Unlike in adults, no definitive risk factors have been established. A significant proportion of this cohort had a pre-existing naevus and while most melanomas occurred in sun-exposed areas in light-skinned individuals the association between sunburn and melanoma was not strong.
http://ift.tt/2i1bAxb
Clinical investigation of 38 cases of oral mucosal melanoma: A multicentre retrospective analysis in Japan
Abstract
Background/Objectives
The aim of the present study was to investigate treatment modalities and outcomes in oral mucosal melanoma.
Methods
The clinical and pathological data of 38 consecutive patients with oral mucosal melanoma were retrospectively analyzed. Patients' characteristics were analyzed and overall survival (OS) rates were calculated.
Results
Sixteen patients had stage III (42%), 19 IVA (50%), and three had stage IVC (8%) disease. Among the therapeutic approaches used, 31 patients (82%) received radical therapy (surgery +/− chemotherapy). The 5-year OS rate was 40%. Five-year OS rates according to the clinical stage were 71% for stage III, 24% for stage IVA, and 0% for stage IVC. Five-year OS rates according to therapeutic approaches were 52% in the radical therapy group and 0% in the palliative therapy and best supportive care groups.
Conclusions
The results of this multicentre retrospective analysis of patients with oral mucosal melanoma suggest that radical therapy based on surgical treatments with complete surgical excision with clear margins leads to a better prognosis.
http://ift.tt/2fH9m5m
Design and evaluation of a compact photocatalytic reactor for water treatment
Abstract
A compact reactor for photocatalytic oxidation and photocatalytic ozonation water treatment was developed and evaluated by using four model pollutants. Additionally, combinations of pollutants were evaluated. Specially produced Al2O3 porous reticulated monolith foams served as TiO2 carriers, offering a high surface area support. UV lamps were placed in the interior to achieve reduced dimensions of the reactor (12 cm in diameter × 20 cm in height). Despite its small size, the overall photocatalytic cleaning capacity was substantial. It was evaluated by measuring the degradation of LAS + PBIS and RB19 as representatives of surfactants and textile dyes, respectively. These contaminants are commonly found in household grey wastewater with phenol as a trace contaminant. Three different commercial photocatalysts and one mixture of photocatalysts (P25, P90, PC500 and P25 + PC500) were introduced in the sol-gel processing and immobilized on foamed Al2O3 monoliths. RB19 and phenol were easily degradable, while LAS and PBIS were more resistant. The experiments were conducted at neutral-acidic pH because alkaline pH negatively influences both photocatalyic ozonation (PCOZ) and photocatalysis. The synergistic effect of PCOZ was generally much more expressed in mineralization reactions. Total organic carbon TOC half lives were in the range of between 13 and 43 min in the case of individual pollutants in double-deionized water. However, for the mixed pollutants in tap water, the TOC half-life only increased to 53 min with the most efficient catalyst (P90). In comparison to photocatalysis, the PCOZ process is more suitable for treating wastewater with a high loading of organic pollutants due to its higher cleaning capacity. Therefore, PCOZ may prove more effective in industrial applications.
http://ift.tt/2w9hHor
Recurrence Rates Over 20 Years in the Treatment of Malignant Melanoma: Immediate Versus Delayed Reconstruction
http://ift.tt/2vWoAdm
Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite for Improving Skin Laxity and Cellulite Appearance
http://ift.tt/2vMm1d3
Patient-Reported Outcomes Are Better after Oncoplastic Breast Conservation than after Mastectomy and Autologous Reconstruction
http://ift.tt/2wsAlp9
Δευτέρα 14 Αυγούστου 2017
Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia
Intervention: Other: Acupuncture
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified August 2017
http://ift.tt/2uWWlX7
Reflections of the Editor-in-Chief.
http://ift.tt/2vWDdNx
Charting Our Future Together: Turning Discovery Science Into Cardiovascular Health.
http://ift.tt/2vDXW6o
Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification.
http://ift.tt/2vWqlqI
"Stressed" About Air Pollution: Time for Personal Action.
http://ift.tt/2vDrwZC
Predictors and Association With Clinical Outcomes of the Changes in Exercise Capacity After Transcatheter Aortic Valve Replacement.
http://ift.tt/2vWM2Ho
Walking as a Window to Risk and Resiliency.
http://ift.tt/2vDZjle
Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi.
http://ift.tt/2vWtkiR
Thrombolytic Potential of N-Acetylcysteine: Evidence for Significant Benefit in Mitigating Arterial Thrombosis.
http://ift.tt/2vDNCv0
Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-[beta] and Cardiac Fibrosis.
http://ift.tt/2vWKY6h
-
Ειδοποίηση Μελετητή:[ ωτα ] [HTML] Gender, identity and material: Film screening C Brand - 2017 ftypM4V *M4V M4A mp42isom*a┌moovlmvhd...
-
Publication date: September 2017 Source: Free Radical Biology and Medicine, Volume 110 Author(s): Lucía Fernández-del-Río, Anish Nag, Elen...
