A pill at bedtime, and your heart is fine? Bedtime hypertension chronotherapy: an opportune and advantageous inexpensive treatment strategy

It is commonly assumed that cardiovascular (CV) system rests during the nighttime, the sleep span being a restorative time for the CV system. However, the biology of the CV system is much more complicated than assumed. Convincing evidence now demonstrates the critical importance of the sleep-time blood pressure (BP) level and 24-hour (h) pattern in affecting CV risk. BP is not constant but exhibits distinct temporal patterning during the 24-h, with a circadian (from the Latin 'circa diem', near 24-h) organization.

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