Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia

Publication date: Available online 30 September 2016
Source:Cancer Genetics
Author(s): Mohammad Hashemi, Gholamreza Bahari, Majid Naderi, Simin Sadeghi-Bojd, Mohsen Taheri
MicroRNAs (miRNAs), small noncoding regulatory RNAs, are key regulators of gene expression. The impact of Pri-miR-34b/c rs4938723 variant on development of various cancer is still controversial. In the present study, we examined whether a rs4938723 variant located at promoter region of Pri-miR-34b/c is associated with childhood ALL. A total of 110 children with acute lymphoblastic leukemia (ALL) and 120 healthy children were recruited to participate in this study. The rs4938723 variant was genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. The rs4938723 variant decrease the risk of ALL in heterozygous (TC vs OR=0.48, 95%CI=0.28-0.84, p=0.012, TC vs TT), and overdominant (OR=0.51, 95%CI=0.30-0.89, p=0.0.020, TC vs TT+CC): OR=1.32, 95%CI=0.67-2.59, p=0.498; C vs T: OR = 0.99, 95%CI = 0.75- 1.31, p=0.986) inheritance models tested. The C allele significantly decreased the risk of childhood ALL compared to T allele (OR=0.52, 95%CI=0.33-0.83, p=0.006). Our findings proposed an association between Pri-miR-34 b/c rs4938723 variant and risk of childhood ALL development in a sample of Iranian population.



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