Endothelial miRNAs as Cellular Messengers in Cardiometabolic Diseases

Publication date: Available online 15 December 2016
Source:Trends in Endocrinology & Metabolism
Author(s): Makon-Sébastien Njock, Jason E. Fish
Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role. Recently, miRNAs have been implicated as cell–cell messengers that can influence cellular function. This review investigates the known and potential roles for miRNA-based cell–cell communication in the control of cardiovascular health and explores the value of identifying miRNA biomarkers and developing therapeutics that harness or antagonize miRNA-based communication.



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