Serum insulin in pathogenesis and treatment of osteoarthritis

Publication date: Available online 23 December 2016
Source:Medical Hypotheses
Author(s): Alireza Askari, Elham Ehrampoush, Reza Homayounfar, Ehsan Bahramali, Mojtaba Farjam
Osteoarthritis (OA) is one of the major health problems that's development and progression is obesity-related. We believe that higher levels of insulin may explains this link especially. High levels of insulin in obesity and metabolic syndrome can induce numerous complications. Insulin can increase proliferation of chondrocyte but simultaneously, it prevents their differentiation. Moreover, hyperinsulinemia reduces the circulating level of serum T4 and conversion of T4 to T3, mimicking hypothyroidism, because thyroid hormones are necessary for the maturation of chondrocytes. So maybe decreasing insulin levels, prevents OA progression or improve the treatment process.



http://ift.tt/2hckB0M