Biased Opioid Receptor Ligands: Gain without Pain

Publication date: Available online 16 January 2017
Source:Trends in Endocrinology & Metabolism
Author(s): Ravi Ranjan, Shubhi Pandey, Arun K. Shukla
Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.



http://ift.tt/2j4FQTH