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Κυριακή 29 Ιανουαρίου 2017

Epileptiform Abnormalities Predict Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

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Publication date: Available online 29 January 2017
Source:Clinical Neurophysiology
Author(s): J.A. Kim, E.S. Rosenthal, S. Biswal, S. Zafar, A.V. Shenoy, K.L. O'Connor, S.C. Bechek, J. Valdery Moura, M.M. Shafi, A.B. Patel, S.S. Cash, M.B. Westover
ObjectiveTo identify whether abnormal neural activity, in the form of epileptiform discharges and rhythmic or periodic activity, which we term here ictal-interictal continuum abnormalities (IICAs), are associated with delayed cerebral ischemia (DCI).MethodsRetrospective analysis of continuous electroencephalography (cEEG) reports and medical records from 124 patients with moderate to severe grade subarachnoid hemorrhage (SAH). We identified daily occurrence of seizures and IICAs. Using survival analysis methods, we estimated the cumulative probability of IICA onset time for patients with and without delayed cerebral ischemia (DCI).ResultsOur data suggest the presence of IICAs indeed increases the risk of developing DCI, especially when they begin several days after the onset of SAH. We found that all IICA types except generalized rhythmic delta activity occur more commonly in patients who develop DCI. In particular, IICAs that begin later in hospitalization correlate with increased risk of DCI.ConclusionsThus, IICAs represent a new marker for identifying early patients at increased risk for DCI. Moreover, IICAs might contribute mechanistically to DCI and therefore represent a new potential target for intervention to prevent secondary cerebral injury following SAH.SignificanceThese findings imply that IICAs may be a novel marker for predicting those at higher risk for DCI development.



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