Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs

Publication date: 11 January 2017
Source:Cell Host & Microbe, Volume 21, Issue 1
Author(s): Nandan S. Gokhale, Stacy M. Horner
In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3′ untranslated region of Zika virus. This reinforced structure blocks the 5′→3′ exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.

Teaser

In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3′ untranslated region of Zika virus. This reinforced structure blocks the 5′→3′ exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.


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