Susan Lee Lindquist (1949–2016)

Publication date: Available online 5 January 2017
Source:Trends in Biochemical Sciences
Author(s): James Shorter
Lindquist was a visionary and pioneer who transformed our understanding of how protein folding sculpts biology, evolution, and disease. She revealed several unanticipated mechanisms by which protein folding can buffer, release, and potentiate genetic variation in response to environmental stress, thereby enabling the rapid evolution of beneficial new traits. Her discoveries provide a rich framework for innovative therapeutic interventions in several fatal diseases, including Alzheimer's disease, Parkinson's disease, and cancer.



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