Use of Stereotactic Radiosurgery in Elderly and Very Elderly Patients with Brain Metastases to Limit Toxicity Associated with Whole Brain Radiation Therapy

Publication date: Available online 21 February 2017
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): Linda Chen, Colette Shen, Kristin Redmond, Brandi R. Page, Megan Kummerlowe, Todd Mcnutt, Chetan Bettegowda, Daniele Rigamonti, Michael Lim, Lawrence Kleinberg
Stereotactic radiosurgery (SRS) is a well-tolerated ablative therapy for brain metastases, but its role in the management of elderly patients traditionally managed with whole brain radiotherapy (WBRT) is unclear. We retrospectively compared toxicity rates in elderly and very elderly patients. When comparing treatment modalities we found that patients clinically selected for WBRT had poor overall survival and that WBRT was associated with higher rates of acute neurocognitive toxicity compared to SRS using multi-variate analysis.



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