Ετικέτες

Δευτέρα 6 Μαρτίου 2017

Choosing wisely - preclinical test models in the era of precision medicine

alertIcon.gif

Publication date: Available online 6 March 2017
Source:Cancer Treatment Reviews
Author(s): Konrad Klinghammer, Wolfgang Walther, Jens Hoffmann
Through the introduction of a steadily growing variety of preclinical test models drug development and biomarker research has advanced. Next to classical used 2D cell line cultures, tissue-slice cultures, 3D organoid cell cultures, genetically engineered mouse models, cell line derived mouse models and patient derived xenografts may be selected for a specific question. All models harbor advantages and disadvantages. This review focuses on the available preclinical test models, novel developments such as humanized mice and discusses for which question a particular model should be employed.



http://ift.tt/2mPHwGe

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αναζήτηση αυτού του ιστολογίου