Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis

Publication date: Available online 12 March 2017
Source:Critical Reviews in Oncology/Hematology
Author(s): Valentina Pinzi, Elena Biagioli, Anna Roberto, Francesca Galli, Michele Rizzi, Federica Chiappa, Greta Brenna, Laura Fariselli, Irene Floriani
BackgroundRadiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas.MethodsOnline databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity.ResultsThe estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%–98.9% and 53.1%–97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%.ConclusionsRS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.



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