Serum IL 6 and umbilical artery Doppler indices in pre-eclamptic patients

Publication date: March 2017
Source:Alexandria Journal of Medicine, Volume 53, Issue 1
Author(s): Medhat Y. Anwer, Tark A. Karkor, Sally S. El-Tawab, Akram A. Deghady, Ihab M. El Tayeb
ObjectivesTo study the changes in serum IL 6 levels in pre-eclamptic patients and to detect any correlation between these changes and changes in the umbilical artery Doppler velocimetry.MethodsIn Shatby Hospital, 100 pregnant women, at or beyond 32weeks were selected and divided into three groups: group A with severe pre-eclampsia, group B with mild pre-eclampsia, and group C with normal pregnancy as control. Measurement of maternal serum IL 6 using ELISA and umbilical artery Doppler velocimetry was done. Kruskal–Wallis, Mann–Whitney U tests, and Spearman's rank correlation tests were used.ResultsA statistical significant difference (p<0.001) was found regarding serum IL-6 level. Using ROC curve for IL 6 levels, it is suggested that IL 6 of 0.82ng/dl is a cutoff level to early diagnose mild pre-eclampsia (with sensitivity 87.5% and specificity 100%). A statistical significant correlation was found between maternal serum IL 6 levels and S/D ratio and RI in severe pre-eclamptic group (p<0.05).ConclusionMaternal serum IL 6>0.82ng/dl can be implicated as an early laboratory diagnosis of mild pre-eclampsia. The significant correlation between maternal serum IL 6 levels and Doppler velocimetry supports both the immunologic and the systemic endothelial dysfunction theories of pre-eclampsia.



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