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Τετάρτη 29 Μαρτίου 2017

Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function

Publication date: Available online 28 March 2017
Source:Trends in Cell Biology
Author(s): Jacques Neefjes, Marlieke M.L. Jongsma, Ilana Berlin
The endosomal system constitutes a key negotiator between the environment of a cell and its internal affairs. Comprised of a complex membranous network, wherein each vesicle can in principle move autonomously throughout the cell, the endosomal system operates as a coherent unit to optimally face external challenges and maintain homeostasis. Our appreciation of how individual endosomes are controlled in time and space to best serve their collective purpose has evolved dramatically in recent years. In light of these efforts, the endoplasmic reticulum (ER) – with its expanse of membranes permeating the cytoplasmic space – has emerged as a potent spatiotemporal organizer of endosome biology. We review the latest advances in our understanding of the mechanisms underpinning endosomal transport and positioning, with emphasis on the contributions from the ER, and offer a perspective on how the interplay between these aspects shapes the architecture and dynamics of the endosomal system and drives its myriad cellular functions.



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