Frontotemporal degeneration in a child

Publication date: Available online 12 April 2017
Source:Pediatric Neurology
Author(s): Tyler Terrill, Juan M. Pascual
BackgroundThere is a predilection for the frontal and temporal lobes in certain cases of dementia in the adult, leading to the syndrome of frontotemporal dementia. However, this syndrome has seemed to elude the developing brain until now.FindingsWe report a case of apparently selective neurodegeneration of the frontal and temporal regions during development associated with some of the clinical, MRI and FDG-PET scan features of canonical frontotemporal dementia in the adult. This case is not associated with any of the common frontotemporal dementia-causing mutations, nor with other known progressive brain disorders of the child.ConclusionThe case illustrates that symptomatic, selective and progressive vulnerability of the frontal and temporal lobes is not restricted to the adult age, expanding the phenotype of frontotemporal degeneration.



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