Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway

Publication date: Available online 4 April 2017
Source:Trends in Biochemical Sciences
Author(s): David A. Dougan
The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky's laboratory [1] identifies a new branch of the N-end rule pathway that specifically recognizes the N-terminal Pro residue of key gluconeogenesis enzymes.



http://ift.tt/2oAZFc3