A near-infrared luminescent Mn2+-doped NaYF4:Yb,Tm/Fe3+ upconversion nanoparticles redox reaction system for the detection of GSH/Cys/AA

Publication date: 1 September 2017
Source:Talanta, Volume 172
Author(s): Liping Zhang, Bo Ling, Lun Wang, Hongqi Chen
An upconversion luminescence method was developed for the determination of glutathione (GSH), L-cysteine (Cys) or L-ascorbic acid (AA) based on redox reaction. We synthesized poly(acrylic acid) (PAA)-modified Mn²⁺-doped NaYF4:Yb,Tm upconversion nanoparticles (UCNPs), and the luminescence of these UCNPs was effectively quenched due to their carboxyl groups coordinating with Fe³⁺ to form a UCNPs/Fe³⁺ system. GSH, Cys or AA reduced Fe³⁺ to Fe²⁺, which induced the luminescence recovery of the UCNPs. Under the optimized conditions, wide linear concentration ranges from 0.25-300μM for GSH, 0.5–875μM for Cys and 0.5–350μM for AA were found, and the detection limits (3S/K) were 0.2μM, 0.5μM and 0.2μM, respectively. Thus, the UCNPs/Fe³⁺ system was successfully applied for sensing GSH, Cys or AA.

Graphical abstract

http://ift.tt/2qnfPFC