Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

Publication date: Available online 10 May 2017
Source:Clinical Imaging
Author(s): Talissa A. Altes, Craig H. Meyer, Jaime F. Mata, Deborah K. Froh, Alix Paget-Brown, W. Gerald Teague, Sean B. Fain, Eduard E. de Lange, Kai Ruppert, Martyn C. Botfield, Mac A. Johnson, John P. Mugler
PurposeTo develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children.Materials and methodsHHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D–spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice.ResultsMotion-artifact–free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases.ConclusionHHe ventilation MRI can aid assessment of pediatric lung disease even at a young age.



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