Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress

Publication date: Available online 6 May 2017
Source:Trends in Biochemical Sciences
Author(s): Sreenivas Chavali, Alexander Gunnarsson, M. Madan Babu
Intrinsically disordered proteins (IDPs) can protect cells from diverse stresses by forming higher order assemblies such as reversible aggregates or granules. Recently, Boothby et al. show that IDPs protect tardigrades against desiccation by forming a glass-like amorphous matrix, highlighting that material properties of disordered proteins can confer adaptation during stress.



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