Osteonecrosis of jaw after antiangiogenic agent administration in a renal cell carcinoma patient

Publication date: June 2017
Source:Oral and Maxillofacial Surgery Cases, Volume 3, Issue 2
Author(s): Tae-Young Jung
A 62-year-old patient had characteristics corresponding to the diagnostic criteria of medication-related osteonecrosis of the jaw (MRONJ). She had been treated for renal cell carcinoma with radical nephrectomy and chemotherapy with pazopanib (Votrient^®) and everolimus (Afinitor^®) antiangiogenic agents. There was no history of radiation therapy, obvious metastatic disease or surgical treatment. Bone exposure was observed in both mandibular posterior regions. Bone necrosis had developed surrounding the #35=37 and 46, 47 implants installed 6 years prior. The lesions were diagnosed as MRONJ and the patient was treated by sequestrectomy, saucerization and reconstruction with a reconstruction plate. The clinical results were good.



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