Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia

Publication date: Available online 19 May 2017
Source:Clinical Imaging
Author(s): K. Weyts, M.W. Vernooij, R.M.E. Steketee, R. Valkema, M. Smits
18FDG PET-CT is useful for early and differential diagnosis of dementia.ASL-MRI seems an attractive alternative.Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85–0.86, p<0.05).Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement.Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT.(p=0.31).Clinical experience and optimisation may further improve ASL-MRI's performance.



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