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Παρασκευή 26 Μαΐου 2017

Relationship between the changes in M1 excitability after motor learning and arousal state as assessed by short-latency afferent inhibition

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Publication date: 14 July 2017
Source:Behavioural Brain Research, Volume 330
Author(s): Yoshiki Koizume, Masato Hirano, Shinji Kubota, Shinya Tanaka, Kozo Funase
To examine the factors that influence the inter-individual differences in the changes in primary motor cortex (M1) excitability seen after motor learning, we investigated the relationship between the amplitude of transcranial magnetic stimulation-induced motor evoked potentials (MEP) and short-latency afferent inhibition (SAI) after motor learning, based on the working hypothesis that SAI can be used to evaluate cortical acetylcholine (ACh) activity. To confirm this working hypothesis, we manipulated the arousal state of the subjects using a vigilance task, the outcomes of which might be correlated with cortical ACh activity, and investigated the effects of arousal state on SAI. As a result, we showed that SAI was significantly affected by arousal state. Consequently, we concluded that the subjects' arousal state during motor learning tasks is one of factors to influence on inter-individual differences in the changes in M1 excitability seen after motor learning tasks.



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