Phenotypic approaches to positional therapy for obstructive sleep apnoea

I thank Drs. Oksenberg and Gadoth for highlighting the important role that positional therapy may play in the treatment of obstructive sleep apnoea (OSA) according to a phenotypic approach [1]. The recent phenotyping review in this journal [2] focused on physiological mechanisms with potential clinical application. Clinical phenotypes such as supine OSA has been the feature of other recent comprehensive reviews and research articles that eloquently highlight the therapeutic potential of positional therapy and how changes in body position alter the phenotypic traits that cause OSA (e.g.

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