Cortical thickness changes in adult moyamoya disease assessed by structural magnetic resonance imaging

Publication date: Available online 11 July 2017
Source:Clinical Imaging
Author(s): Peng-Gang Qiao, Zhi-Wei Zuo, Cong Han, Juan Zhou, Hong-Tao Zhang, Lian Duan, Tianyi Qian, Gong-Jie Li
PurposeTo characterize the changes in cortical thickness of adult patients with moyamoya disease (MMD).Methods60 patients with MMD and 60 age and sex-matched healthy volunteers were recruited. Structural images were acquired by MRI. Freesurfer was used to measure cortical thickness in patients and controls, and this was compared with MRA scores and cerebrovascular accident (CVA) scores.ResultsCompared with controls, the average cortical thickness of both cerebral hemispheres was lower in patients than in controls and symmetrical differences were seen in the regional cortex: bilateral precentral gyri were thinner, bilateral postcentral gyri and posterior cingulate gyri were thicker, and thinning and thickening were both found in the insula. CVA scores were negatively correlated with the average cortical thicknesses.ConclusionsCortical thickness can be used as a biological indicator to assess the severity of MMD.



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