MHC Class I Cross-Presentation: Stage Lights on Sec22b

Publication date: Available online 22 July 2017
Source:Trends in Immunology
Author(s): Sebastian Montealegre, Peter van Endert
Efficient (cross-)presentation of antigens internalized by dendritic cells (DCs) requires vesicular communication between the early secretory and the endocytic/phagocytic pathways, in which the Sec22b protein has been suggested to have a key role. Here, we undertake a critical assessment of two new studies that evaluate the role of Sec22b using gene-targeted mice and come to contradictory conclusions.



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