Shaping and Reshaping Transcriptome Plasticity during Evolution

Publication date: Available online 14 July 2017
Source:Trends in Biochemical Sciences
Author(s): Shobbir Hussain
Transcriptome plasticity, usually associated with alternative isoform generation, is recognised as a key mechanism driving proteomic diversity and biological complexity. Recent findings of Liscovitch-Brauer et al. and Ma et al. suggest that RNA base modifications are an additional central mode of transcriptome malleability that have the potential to determine evolutionary outcomes.



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