Quantitative diffusion-weighted magnetic resonance imaging assessment of chemotherapy treatment response of pediatric osteosarcoma and Ewing sarcoma malignant bone tumors

Publication date: Available online 5 August 2017
Source:Clinical Imaging
Author(s): Andrew J. Degnan, Chul Y. Chung, Amisha J. Shah
ObjectiveAssessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection.Subjects and methodsPre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers.ResultsTreated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment.ConclusionsOur study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.



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