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Πέμπτη 3 Αυγούστου 2017

Scholar : Xenobiotica, Volume 47, Issue 10, October 2017 is now available online on Taylor & Francis Online

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Xenobiotica, Volume 47, Issue 10, October 2017 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

General Xenobiochemistry

Gene expression study of phase I and II metabolizing enzymes in RPTEC/TERT1 cell line: application in in vitro nephrotoxicity prediction
Heta Shah, Manish Patel & Neeta Shrivastava
Pages: 837-843 | DOI: 10.1080/00498254.2016.1236299


Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice
Makiko Shimizu , Hiroshi Suemizu, Marina Mitsui, Norio Shibata, F. Peter Guengerich & Hiroshi Yamazaki
Pages: 844-848 | DOI: 10.1080/00498254.2016.1247218


Inhibitory effects of curculigoside on human liver cytochrome P450 enzymes
Jixiao Lang, Wei Li, Jingming Zhao, Kaiyou Wang & Dexi Chen
Pages: 849-855 | DOI: 10.1080/00498254.2016.1257171


Clinical Pharmacokinetics and Metabolism

An open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia
Madhu Sanga, Joyce James, Joseph Marini, Guy Gammon, Christine Hale & Jianke Li
Pages: 856-869 | DOI: 10.1080/00498254.2016.1217100


Pharmacokinetics of guaifenesin, pseudoephedrine and hydrocodone in a combination oral liquid formulation, administered as single and multiple doses in healthy Chinese volunteers, and comparison with data for individual compounds formulated as Antuss®
Shuhua Deng, Wencan Huang, Xiaojia Ni, Ming Zhang, Haoyang Lu, Zhanzhang Wang, Jinqing Hu, Xiuqing Zhu, Chang Qiu, Dewei Shang, Yuefeng Zhang, Linghui Xiong & Yuguan Wen
Pages: 870-878 | DOI: 10.1080/00498254.2016.1241451


Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects
Satish Kumar Bedada & Praveen Kumar Boga
Pages: 879-884 | DOI: 10.1080/00498254.2016.1244368


Animal Pharmacokinetics and Metabolism

Pharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats
Hua Sun, Hui Liu, Huinan Zhao, Ying Wang, Yao-lan Li, Wen-cai Ye & Baojian Wu
Pages: 885-893 | DOI: 10.1080/00498254.2016.1241452


The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration
Gabriel A. Knudsen, J. Michael Sanders, Michael F. Hughes, Ethan P. Hull & Linda S. Birnbaum
Pages: 894-902 | DOI: 10.1080/00498254.2016.1250180


Xenobiotic Transporters

In vitro assessment of the roles of drug transporters in the disposition and drug–drug interaction potential of olaparib
Alex McCormick & Helen Swaisland
Pages: 903-915 | DOI: 10.1080/00498254.2016.1241449


Pharmacogenetics

Effect of hepatic drug transporter polymorphisms on the pharmacokinetics of mycophenolic acid in patients with severe renal dysfunction before renal transplantation
Hideaki Kagaya, Takenori Niioka, Mitsuru Saito, Takamitsu Inoue, Kazuyuki Numakura, Tomonori Habuchi, Shigeru Satoh & Masatomo Miura
Pages: 916-922 | DOI: 10.1080/00498254.2016.1235742


Topics in Xenobiochemistry

Cytochrome P450 2W1 (CYP2W1) – ready for use as the biomarker and drug target for cancer?
Yan Pan & Eng Chin Ong
Pages: 923-932 | DOI: 10.1080/00498254.2016.1244370


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