cGAS Conducts Micronuclei DNA Surveillance

Publication date: Available online 4 September 2017
Source:Trends in Cell Biology
Author(s): Carina C. de Oliveira Mann, Philip J. Kranzusch
DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP–AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.



http://ift.tt/2vH5usg