The Ire1 Twist that Links Proteostatic with Lipostatic Control of the Endoplasmic Reticulum

Publication date: Available online 5 September 2017
Source:Trends in Cell Biology
Author(s): Tomás Aragón, Eelco van Anken
The unfolded protein response (UPR) governs homeostasis of both luminal content and membrane of the endoplasmic reticulum (ER). In Molecular Cell, Halbleib et al. identified how a twist in the juxta-membrane amphipathic helix of the UPR transducer Ire1 in yeast is essential for responding to both proteostatic and lipostatic ER stress.



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