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Δευτέρα 2 Οκτωβρίου 2017

A prospective study evaluating the utility of a 2-mm biopsy margin for complete removal of histologically atypical (dysplastic) nevi

Publication date: Available online 2 October 2017
Source:Journal of the American Academy of Dermatology
Author(s): Vitaly Terushkin, Elise Ng, Jennifer A. Stein, Susan Katz, David E. Cohen, Shane Meehan, David Polsky
BackgroundComplete removal of individual dysplastic nevi (DN) is often accomplished by a second surgical procedure after the initial biopsy. The choice to perform the second procedure is strongly influenced by histopathologic margin status of the initial biopsy specimen.ObjectiveTo evaluate the clinical and histopathologic outcomes of in toto biopsy of DN using a predetermined margin of normal skin.MethodsWe conducted a prospective study of a saucerization method using a defined 2-mm margin in patients undergoing biopsy of a pigmented skin lesion.ResultsWe performed 151 biopsies in 138 patients. Overall, 137 of 151 lesions subjected to biopsy (90.7%) were melanocytic: 86 DN (57.0%), 40 nevi without atypia (26.5%), and 11 melanomas (7.3%). Of 78 DN, 68 (87.2%) were removed with clear histopathologic margins (8 DN were excluded because of inadequate processing). There was no clinical evidence of recurrence at any of the biopsy sites that were simply observed (i.e., not re-excised) over a median of 16.9 months.LimitationsThere were few biopsies performed on the face.ConclusionsThe complete histopathologic removal of nearly 9 of 10 DN using a peripheral margin of 2 mm of normal skin and a depth at the dermis and subcutaneous fat junction has the potential to decrease second procedures at DN biopsy sites, thereby decreasing patient morbidity and saving health care dollars.



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