Aggressive differentiated thyroid cancer

Publication date: Available online 6 October 2017
Source:European Journal of Surgical Oncology (EJSO)
Author(s): Noor Janjua, Volkert B. Wreesmann
Differentiated thyroid cancer is characteristically associated with an innocuous clinical course, but a minority may manifest surprisingly aggressive behaviour. The latter are not only directly responsible for the majority of thyroid cancer related deaths, but also contribute indirectly to increased DTC-related morbidity, because our inability to differentiate these tumours from innocuous DTC at an early stage contributes to a significant degree of overtreatment that is observed for DTC around the globe. In the present paper we describe how improved understanding of the clinicopathological thyroid tumour progression model and optimization of clinical staging systems continues to improve our ability to diagnose and treat aggressive DTC. Early recognition of aggressive DTC allows instillation of an aggressive management strategy which is based upon oncologic completeness, and minimization of treatment-related sequelae through continued development of reconstructive options and focussed delivery of adjuvant treatments.



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