High dose rate brachytherapy as monotherapy for localised prostate cancer

Publication date: Available online 23 October 2017
Source:Radiotherapy and Oncology
Author(s): Iosif Strouthos, Nikolaos Tselis, Georgios Chatzikonstantinou, Saeed Butt, Dimos Baltas, Dimitra Bon, Natasa Milickovic, Nikolaos Zamboglou
Background and purposeTo evaluate the oncological outcome of a three-implant high dose rate (HDR) brachytherapy (BRT) protocol as monotherapy for clinically localised prostate cancer.Material and methodsBetween February 2008 and December 2012, 450 consecutive patients with clinically localised prostate cancer were treated with HDR monotherapy. The cohort comprised of 198 low-, 135 intermediate- and 117 high risk patients being treated with three single-fraction implants of 11.5Gy delivered to an intraoperative real-time, transrectal ultrasound defined planning treatment volume up to a total physical dose of 34.5Gy with an interfractional interval of 21days. Fifty-eight patients (12.8%) received ADT, 32 of whom were high- and 26 intermediate-risk. Biochemical failure was defined according to the Phoenix Consensus Criteria and genitourinary/gastrointestinal toxicity evaluated using the Common Toxicity Criteria for Adverse Events version 3.0.ResultsThe median follow-up time was 56.3months. The 60-month overall survival, biochemical control and metastasis-free-survival rates were 96.2%, 95.0% and 99.0%, respectively. Toxicity was scored per event with late Grade 2 and 3 genitourinary adverse events of 14.2% and 0.8%, respectively. Late Grade 2 gastrointestinal toxicity amounted 0.4% with no instances of Grade 3 or greater late adverse events to be reported.ConclusionsOur results confirm HDR BRT to be a safe and effective monotherapeutic treatment modality for clinically localised prostate cancer.



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