Evolution of the hygiene hypothesis into biota alteration theory: What are the paradigms and where are the clinical applications?

Publication date: Available online 10 November 2017
Source:Microbes and Infection
Author(s): Chantal Villeneuve, Henry H. Kou, Henrik Eckermann, Antara Palkar, Lauren G. Anderson, Erin A. McKenney, R Randal Bollinger, William Parker
For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration theory, but modern medical priorities and regulatory policies have resulted in tragic underutilization of the acquired knowledge.



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