Proton Pump Inhibitors and Capecitabine Efficacy

To the Editor With interest, we read the report by Chu and colleagues investigating the association of proton pump inhibitors (PPIs) with capecitabine efficacy in patients with advanced gastroesophageal cancer. This retrospective analysis revealed a significant difference in treatment efficacy in patients treated with capecitabine and oxaliplatin with and without concomitant PPI use, probably due to an increased intragastric pH and subsequent impaired capecitabine absorption.

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