New concepts in Chlamydia induced inflammasome responses

Publication date: Available online 14 December 2017
Source:Microbes and Infection
Author(s): Steve J. Webster, Jane C. Goodall
Since the concept of the inflammasome was devised by Martinon and Tschopp in 2002, there has been an exponential increase in our understanding of how inflammasomes (caspase activating molecular platforms) regulate innate inflammatory responses to infectious microorganisms. Advances in understanding inflammasome biology have been developed using a range of bacterial pathogens and recent studies investigating inflammasome responses during Chlamydia infection have provided interesting mechanistic insights in to inflammasome activation during intracellular bacterial infection. This review highlights new concepts regulating inflammasome activation to bacterial infections including: interferon-regulated loss of compartmentalisation, mechanisms of canonical and non-canonical inflammasome activation and their relevance to Chlamydia infections are discussed.



http://ift.tt/2kugroy